Characterization of saponins and phenolic compounds: antioxidant activity and inhibitory effects on α-glucosidase in different varieties of colored quinoa (Chenopodium quinoa Willd)
Abstract
This study investigated the contents of saponins and phenolic compounds in relation to their antioxidant activity and α-glucosidase inhibition activity of 7 colored quinoa varieties. The total saponin content was significantly different among 7 varieties and ranged from 7.51 to 12.12 mg OAE/g DW. Darker quinoa had a higher content of phenolic compounds, as well as higher flavonoids and antioxidant activity than that of light varieties. Nine individual phenolic compounds were detected in free and bound form, with gallic acid and ferulic acid representing the major compounds. The free and bound phenolic compounds (gallic acid and ferulic acid in particular) exhibited high linear correlation with their corresponding antioxidant values. In addition, the free phenolic extracts from colored quinoa exhibited higher inhibitory activity against α-glucosidase than the bound phenolic extracts. These findings imply that colored quinoa with abundant bioactive phytochemicals could be an important natural source for preparing functional food.
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Quinoa has pronounced antioxidant activity, as shown in in vitro studies.
“Quinoa has pronounced antioxidant activity, as shown in in vitro studies [10,11] or in in vivo experiments, where quinoa consumption showed antihyperlipidemic action against the background of a high-fat diet, leading to increased superoxide dismutase and glutathione peroxidase activities and to decreased levels of malondialdehyde [12] and inflammatory cytokines [13,14].”
From Anxiolytic and Antioxidant Effect of Phytoecdysteroids and Polyphenols from Chenopodium quinoa on an In Vivo Restraint Stress Model (2022) · cites this paper as [11]
Cites
Dewanto, V., Wu, X., Adom, K. K., & Liu, R. H. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0115589 · Cited by 3,469 · see citing works
Ainsworth, E. A., & Gillespie, K. M. (2007) · Nature Protocols · doi:10.1038/nprot.2007.102 · Cited by 3,375 · see citing works
Balasundram, N., Sundram, K., & Samman, S. (2005) · Food Chemistry · doi:10.1016/j.foodchem.2005.07.042 · Cited by 3,128 · see citing works
Shahidi, F., & Ambigaipalan, P. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.06.018 · Cited by 3,081 · cited 1× · see citing works
“phenolics have been extensively studied due to their capability of preventing diseases associated with oxidative stress [2].”
BackgroundAntioxidant Activity of Grains
Adom, K. K., & Liu, R. H. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0205099 · Cited by 1,759 · see citing works
Measurement of antioxidant activity
Shahidi, F., & Zhong, Y. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.01.047 · Cited by 1,331 · see citing works
Antioxidant and Antiproliferative Activities of Common Vegetables
Chu, Y.-F., Sun, J., Wu, X., & Liu, R. H. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020665f · Cited by 937 · see citing works
Cereal dietary fibre: a natural functional ingredient to deliver phenolic compounds into the gut
Vitaglione, P., Napolitano, A., & Fogliano, V. (2008) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2008.02.005 · Cited by 564 · see citing works
Phytochemical Profiles and Antioxidant Activity of Wheat Varieties
Adom, K. K., Sorrells, M. E., & Liu, R. H. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030404l · Cited by 542 · see citing works
Chapter 1 Quinoa (Chenopodium quinoa Willd.)
James, L. A. (2009) · Advances in food and nutrition research · doi:10.1016/s1043-4526(09)58001-1 · Cited by 519 · see citing works
COLOR REACTION OF SOME SAPOGENINS AND SAPONINS WITH VANILLIN AND SULFUR1C ACID
Hiai, S., Oura, H., & Nakajima, T. (1976) · Planta Medica · doi:10.1055/s-0028-1097639 · Cited by 516 · see citing works
Analysis of Phenolic Compounds in White Rice, Brown Rice, and Germinated Brown Rice
Tian, S., Nakamura, K., & Kayahara, H. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049446f · Cited by 483 · see citing works
Phytochemical Profiles and Antioxidant Activity of Adlay Varieties
Wang, L., Chen, J., Xie, H., Ju, X., & Liu, R. H. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf400556s · Cited by 481 · see citing works
Zhang, M. W., Zhang, R. F., Zhang, F. X., et al. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf1007665 · Cited by 412 · see citing works
Self-citationRepo‐Carrasco‐Valencia, R., Hellström, J., Pihlava, J., & Mattila, P. H. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.09.087 · Cited by 405 · see citing works
Tang, Y., Li, X., Zhang, B., Chen, P. X., Liu, R., & Tsao, R. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2014.06.018 · Cited by 397 · see citing works
Antioxidant capacities and phenolic compounds of the husk, bran and endosperm of Thai rice
Butsat, S., & Siriamornpun, S. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.07.001 · Cited by 353 · see citing works
Pang, Y., Ahmed, S., Xu, Y., et al. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.07.095 · Cited by 344 · see citing works
López-Martínez, L. X., Oliart‐Ros, R. M., Valerio‐Alfaro, G., Lee, C., Parkin, K. L., & Garcia, H. S. (2008) · LWT · doi:10.1016/j.lwt.2008.10.010 · Cited by 341 · see citing works
Pereira, E., Encina‐Zelada, C. R., Barros, L., Gonzales‐Barron, U. A., Cadavez, V., & Ferreira, I. C. F. R. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.12.068 · Cited by 287 · see citing works
Antioxidant and α-Glucosidase Inhibitory Activity of Colored Grains in China
Yao, Y., Sang, W., Zhou, M., et al. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903234c · Cited by 277 · see citing works
Release of Covalently Bound Ferulic Acid from Fiber in the Human Colon
Kroon, P. A., Faulds, C. B., Ryden, P., Robertson, J. A., & Williamson, G. (1997) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9604403 · Cited by 263 · see citing works
Pellegrini, M., Lucas-Gonzales, R., Ricci, A., Fontecha, J., Fernández-López, J., Pérez-Álvarez, J. A., & Viuda-Martos, M. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2017.10.006 · Cited by 240 · see citing works
Identification and Biological Activities of Triterpenoid Saponins from Chenopodium quinoa
Woldemichael, G. M., & Wink, M. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0013499 · Cited by 220 · see citing works
Pradeep, P. M., & Sreerama, Y. N. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.08.010 · Cited by 219 · see citing works
Tang, Y., Zhang, B., Li, X., Chen, P. X., Zhang, H., Liu, R., & Tsao, R. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b05761 · Cited by 219 · see citing works
Abderrahim, F., Suárez, E. H., Segura, R., Arribas, S. M., González, M. C., & Condezo‐Hoyos, L. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.03.029 · Cited by 212 · see citing works
Min, B. R., Gu, L., McClung, A. M., Bergman, C. J., & Chen, M. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.01.079 · Cited by 212 · see citing works
Escribano, J., Cabanes, J., Jiménez‐Atiénzar, M., Ibañez-Tremolada, M., Gómez-Pando, L. R., García‐Carmona, F., & Gandía‐Herrero, F. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.04.187 · Cited by 209 · see citing works
A series of cinnamic acid derivatives and their inhibitory activity on intestinal α-glucosidase
Adisakwattana, S., Chantarasinlapin, P., Thammarat, H., & Yibchok‐anun, S. (2009) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360902779326 · Cited by 205 · see citing works
Hydroxycinnamic acid composition and in vitro antioxidant activity of selected grain fractions
Gallardo, C., Jiménez, L., & García‐Conesa, M. (2005) · Food Chemistry · doi:10.1016/j.foodchem.2005.07.053 · Cited by 204 · see citing works
Zhang, R., Zeng, Q., Deng, Y., et al. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.09.085 · Cited by 190 · see citing works
Self-citationBioactivities and Antiradical Properties of Millet Grains and Hulls
Chandrasekara, A., & Shahidi, F. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201849d · Cited by 187 · see citing works
Ti, H., Li, Q., Zhang, R., et al. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.03.029 · Cited by 174 · see citing works
Self-citationHemalatha, P., Bomzan, D. P., Rao, B. V. S., & Sreerama, Y. N. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.12.025 · Cited by 158 · see citing works
Nickel, J., Spanier, L. P., Botelho, F. T., Gularte, M. A., & Helbig, E. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.04.031 · Cited by 155 · see citing works
Gómez-Caravaca, A. M., Iafelice, G., Lavini, A., Pulvento, C., Caboni, M. F., & Marconi, E. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3002125 · Cited by 142 · see citing works
Yao, Y., Yang, X., Shi, Z., & Ren, G. (2014) · Journal of Food Science · doi:10.1111/1750-3841.12425 · Cited by 140 · see citing works
Gómez‐Caravaca, A. M., Segura‐Carretero, A., Fernández‐Gutiérrez, A., & Caboni, M. F. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf202224j · Cited by 136 · see citing works
Medina‐Meza, I. G., Aluwi, N. A., Saunders, S. R., & Ganjyal, G. M. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b02156 · Cited by 109 · see citing works
Kumari, D., Madhujith, T., & Chandrasekara, A. (2016) · Food Science & Nutrition · doi:10.1002/fsn3.415 · Cited by 105 · see citing works
Lavelli, V., Harsha, P. S. C. S., Ferranti, P., et al. (2016) · Food & Function · doi:10.1039/c6fo00073h · Cited by 104 · see citing works
Complex enzyme hydrolysis releases antioxidative phenolics from rice bran
Liu, L., Wen, W., Zhang, R., Wei, Z., Deng, Y., Xiao, J., & Zhang, M. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.07.038 · Cited by 104 · see citing works
Self-citationRocchetti, G., Lucini, L., Lorenzo, J. M., et al. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.07.176 · Cited by 101 · see citing works
Evaluation of phenolic profile and antioxidant capacity in gluten-free flours
Rocchetti, G., Chiodelli, G., Giuberti, G., Masoero, F., Trevisan, M., & Lucini, L. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.01.142 · Cited by 98 · see citing works
Free Radicals, Antioxidants and Disease
Sharma, N. (2014) · Biology and Medicine · doi:10.4172/0974-8369.1000214 · Cited by 86 · see citing works
Suriano, S., Iannucci, A., Codianni, P., Fares, C., Russo, M. A. T., Pecchioni, N., Marciello, U., & Savino, M. (2018) · Food Research International · doi:10.1016/j.foodres.2018.06.072 · Cited by 85 · see citing works
Paśko, P., Zagrodzki, P., Bartoń, H., Chłopicka, J., & Gorinstein, S. (2010) · Plant Foods for Human Nutrition · doi:10.1007/s11130-010-0197-x · Cited by 84 · see citing works
Wu, N., Li, H., Tan, B., et al. (2018) · Journal of Cereal Science · doi:10.1016/j.jcs.2018.06.013 · Cited by 70 · see citing works
ANTIOXIDATIVE FLAVONOID GLYCOSIDES FROM QUINOA SEEDS (<i>CHENOPODIUM QUINOA</i> WILLD)
ZHU, N., SHENG, S., LI, D., LAVOIE, E. J., KARWE, M. V., ROSEN, R. T., & HO, C. (2001) · Journal of Food Lipids · doi:10.1111/j.1745-4522.2001.tb00182.x · Cited by 68 · see citing works
Zhao, G., Zhang, R., Dong, L., et al. (2018) · Molecules · doi:10.3390/molecules23010202 · Cited by 58 · see citing works
Self-citationBhat, F. M., & Riar, C. S. (2017) · Journal of Cereal Science · doi:10.1016/j.jcs.2017.06.018 · Cited by 33 · see citing works
Inhibition of wheat bran and it′s active compoments on α-glucosidase in vitro
Chen, J., Zhu, S., Zhang, C., Chen, H., Liu, Y., & Tu, J. (2013) · Pharmacognosy Magazine · doi:10.4103/0973-1296.117826 · Cited by 28 · see citing works
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Sidorova, Y. S., Shipelin, V. A., Petrov, N. A., Zorin, S. N., & Mazo, V. K. (2022) · Molecules · doi:10.3390/molecules27249003 · Cited by 11 · see citing works
- Authors
- Han, Y., Chi, J., Zhang, M., Zhang, R., Fan, S., Huang, F., Xue, K., & Liu, L.
- Affiliations
- Shanxi University (CN)
- Guangdong Academy of Agricultural Sciences (CN)
- Wuhan Union Hospital (CN)
- Corresponding author
- Liu, Lei
- Venue
- Bioscience Biotechnology and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 2019-11-02
- Volume
- 83
- Issue
- 11
- Pages
- 2128-2139
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2961069628
- Cited by
- 76
- References
- 53
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 14 · 2023: 13 · 2022: 13 · 2021: 13 · 2020: 4
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- the Guangdong Provincial Science and Technology Project (No. 2016B020203004 & 2017B090907022)
- the National Key Research Project of China (No. 2018YFD0401003-05 & 2016YFD0400702-2)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Seed and Plant Biochemistry
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- quinoa, saponins, phenolic compounds, antioxidant activity, α-glucosidase inhibition, flavonoids, gallic acid, ferulic acid, free and bound phenolics, quinoa varieties, functional foods
- MeSH terms
- alpha-Glucosidases, Animals, Antioxidants, Flavonoids, Phenols, Saponins, Chenopodium quinoa, Rats, Glycoside Hydrolase Inhibitors
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