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Cited by 19

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Dietary supplementation of a high-temperature-processed green tea extract attenuates cognitive impairment in PS2 and Tg2576 mice

Kim, Juewon, Funayama, Shinichiro, Izuo, Naotaka, Shimizu, Takahiko·2019·Bioscience, Biotechnology, and Biochemistry
DOI 10.1080/09168451.2019.1659721
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Abstract

Green tea intake is generally recognized as an effective supplement that promotes mental clarity and cognitive function. These health benefits of green tea have been attributed mainly to its effective component, epigallocatechin gallate (EGCG). Because various catechin derivatives potently enhance these health benefits, we manipulated the extraction process with a high-temperature intervention. High-temperature-processed green tea extract (HTP-GTE) showed an elevated proportion of gallocatechin gallate (GCG) content. To investigate the preventive effects of HTP-GTE on cognitive decline, we found its neuroprotective effects against amyloid β (Aβ)-induced neurotoxicity in neurons and clarified that GCG significantly inhibited Aβ aggregation in vitro. Moreover, we showed that HTP-GTE intake attenuated several cognitive-decline phenotypes in a model mouse of Alzheimer’s disease. These beneficial effects of HTP-GTE against cognitive decline were due to the distinctive composition of the extract and suggest the possibility that HTP-GTE supplementation could attenuate cognitive decline of Alzheimer’s disease.

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Metadata

Authors
Kim, J., Funayama, S., Izuo, N., & Shimizu, T.
Affiliations
Department of Endocrinolog, Hematology, and Geriatrics, Chiba University Graduate School of Medicine, Chiba, Japan
Venue
Bioscience, Biotechnology, and Biochemistry
Publisher
Informa UK Limited
Published
2019-12-02
Volume
83
Issue
12
Pages
2364-2371
ISSN
  • 0916-8451
  • 1347-6947
DOI
10.1080/09168451.2019.1659721
Cited by
19
References
7
Language
en
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)

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CoChat. (2026). Citation check: Dietary supplementation of a high-temperature-processed green tea extract attenuates cognitive impairment in PS2 and Tg2576 mice. https://app.cochat.ai/papers/10.1080/09168451.2019.1659721
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Kim, J., Funayama, S., Izuo, N., & Shimizu, T. (2019). Dietary supplementation of a high-temperature-processed green tea extract attenuates cognitive impairment in PS2 and Tg2576 mice. Bioscience, Biotechnology, and Biochemistry. https://doi.org/10.1080/09168451.2019.1659721

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