Green tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice
Open accessAbstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder pathologically characterized by deposition of beta-amyloid (Abeta) peptides as senile plaques in the brain. Recent studies suggest that green tea flavonoids may be used for the prevention and treatment of a variety of neurodegenerative diseases. Here, we report that (-)-epigallocatechin-3-gallate (EGCG), the main polyphenolic constituent of green tea, reduces Abeta generation in both murine neuron-like cells (N2a) transfected with the human "Swedish" mutant amyloid precursor protein (APP) and in primary neurons derived from Swedish mutant APP-overexpressing mice (Tg APPsw line 2576). In concert with these observations, we find that EGCG markedly promotes cleavage of the alpha-C-terminal fragment of APP and elevates the N-terminal APP cleavage product, soluble APP-alpha. These cleavage events are associated with elevated alpha-secretase activity and enhanced hydrolysis of tumor necrosis factor alpha-converting enzyme, a primary candidate alpha-secretase. As a validation of these findings in vivo, we treated Tg APPsw transgenic mice overproducing Abeta with EGCG and found decreased Abeta levels and plaques associated with promotion of the nonamyloidogenic alpha-secretase proteolytic pathway. These data raise the possibility that EGCG dietary supplementation may provide effective prophylaxis for AD.
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EGCG increases α-cleavage of APP.
“experimental studies have provided evidence that EGCG increases the α-cleavage of APP (Rezai-Zadeh et al., 2005; Ettcheto et al., 2020)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Rezai-Zadeh et al., 2005
In transgenic APPSWE Tg2576 mice, intraperitoneal EGCG for 2 months significantly reduces Aβ levels.
“In transgenic APPSWE Tg2576 mice, the intraperitoneal treatment with EGCG for 2 months is associated to a significant reduction of the Aβ levels”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Rezai-Zadeh et al., 2005
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- Authors
- Rezai-Zadeh, K., Shytle, D., Sun, N., Mori, T., Hou, H., Jeanniton, D., Ehrhart, J., Townsend, K., Zeng, J., Morgan, D., Hardy, J., Town, T., & Tan, J.
- Affiliations
- University of South Florida (US)
- Saitama Medical University (JP)
- National Institutes of Health (US)
- Yale University (US)
- Corresponding author
- Tan, Jun
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-09-21
- Volume
- 25
- Issue
- 38
- Pages
- 8807-8814
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6725500
- OpenAlex
- W2154508412
- Cited by
- 713
- References
- 40
- Citations by year
- 2026: 23 · 2025: 29 · 2024: 21 · 2023: 25 · 2022: 34 · 2021: 36 · 2020: 36 · 2019: 33 · 2018: 32 · 2017: 31 · 2016: 29 · 2015: 37 · 2014: 48 · 2013: 35 · 2012: 57
- FWCI
- 17.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- University of South Florida
- York University
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- epigallocatechin gallate, green tea polyphenols, Alzheimer's disease, amyloid precursor protein, amyloid-beta, alpha-secretase, transarterial chemoembolization, APP cleavage, soluble APP alpha, cerebral amyloidosis, neurodegeneration, dietary supplementation
- MeSH terms
- Alzheimer Disease, Amyloidosis, Animals, Catechin, Cells, Cultured, Female, Flavonoids, Mice, Transgenic, Tea, Amyloid beta-Protein Precursor, Mice
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