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Loneliness and HIV-related stigma explain depression among older HIV-positive adults
Open accessAbstract
Advances in the treatment of HIV have resulted in a large growing population of older adults with HIV. These aging adults face added social, psychological, and physical challenges associated with the aging process. Correlations between depression, loneliness, health, and HIV/AIDS-related stigma have been studied, but there is little evaluation of these associations among HIV-positive adults over the age of 50. Data for these analyses were taken from the Research on Older Adults with HIV study of 914 New York City-based HIV-positive men and women over the age of 50. In total, 39.1% of participants exhibited symptoms of major depression (CES-D > 23). Multivariate modeling successfully explained 42% of the variance in depression which was significantly related to increased HIV-associated stigma, increased loneliness, decreased cognitive functioning, reduced levels of energy, and being younger. These data underscore the need for service providers and researchers to assert more aggressive and innovative efforts to resolve both psychosocial and physical health issues that characterize the graying of the AIDS epidemic in the USA. Data suggest that focusing efforts to reduce HIV-related stigma and loneliness may have lasting effects in reducing major depressive symptoms and improving perceived health.
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“Finally, a number of studies focused on groups at higher risk of isolation and loneliness and of associated negative health outcomes, including older people who are cancer survivors (Jaremka et al. 2013), unpaid carers (Jaremka et al. 2013), and substance users (Smith and Rosen 2009) who are HIV-positive (Grov et al. 2010) or who have a history of institutionalisation (Smith and Hirdes 2009).”
From Social isolation, loneliness and health in old age: a scoping review (2017) · cites this paper as Grov et al. 2010
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“This finding is different from previous studies which demonstrated decreased risk with older age among PLWHA [1, 3, 11, 12].”
BackgroundResultGuareña, L. A., Kamalyan, L., Watson, C. W., Karcher, K., Umlauf, A., Morgan, E. E., Moore, D. J., Ellis, R. J., Grant, I., Cherner, M., et al. (2023) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617723000188 · Cited by 4
“…higher rates of loneliness, which may contribute to high rates of mood and substance use challenges (Edelman et al., 2014; Greene et al., 2018; Grov et al., 2010; Heywood & Lyons, 2016) and have critical implications for the quality of life and disease progression of PWH. Depressive symptoms…”
BackgroundHumayun, M., Brouillette, M., Fellows, L. K., & Mayo, N. E. (2023) · Quality of Life Research · doi:10.1007/s11136-023-03475-1 · Cited by 3
“Sentiments were extracted and tokenized using annotation [41–43] and through the semantic representations identified via high-level human judgment [44–47].”
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‘Today I feel strong’: African American women overcoming HIV-related stigma
Hampton, C. J., & Gillum, T. L. (2020) · Psychology and Health · doi:10.1080/08870446.2020.1761978 · Cited by 5
“Consequently, these individuals may experience feelings of loneliness ultimately impacting overall psychological well-being and evoking symptoms of depression and anxiety (Bennett et al., 2016; Grov et al., 2010).”
BackgroundMeeting the complex needs of individuals living with HIV: a case study approach
Paparello, J. Z., Zeller, I., & While, A. (2014) · British Journal of Community Nursing · doi:10.12968/bjcn.2014.19.11.526 · Cited by 4
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Shah, B., Mahapatra, A., Singh, U. N., Mishra, V., Daha, S. K., Pande, R., Neupane, M. R., Banjade, A., Khatik, C. B., C., T. B. K., et al. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1276369 · Cited by 3
“Further, such concerns about a disease can result in negative behaviors toward others and a higher stigma (16), Similarly, the relationship between depression and stigma is based on several theoretical models of stigma and infectious disease or disability (59–63).”
BackgroundPatient reported experiences in older adults living with HIV – a scoping review
Lalloo, E. C., Mora, M. A., & Sundler, A. J. (2024) · AIDS Care · doi:10.1080/09540121.2024.2437693 · Cited by 3
“An aspect previously associated with depression among older adults with HIV, is loneliness (Grov et al., 2010), which was prevalent in approximately half of the population of one of the included studies (Mazon-son et al., 2021).”
Sexual Health, Risk and Prevention
Aronowitz, T. B. (2016) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000448559 · Cited by 3
López-Matos, J., Weaver, L., Millar, B. M., Talan, A. J., Gurung, S., & Rendina, H. J. (2021) · Sexuality Research and Social Policy · doi:10.1007/s13178-021-00610-w · Cited by 3
Brennan‐Ing, M., Haberlen, S., Ware, D. P., Meanley, S., Palella, F. J., Bolan, R., Cook, J. Α., Okafor, C. N., Friedman, M. R., & Plankey, M. W. (2024) · Research on Aging · doi:10.1177/01640275241261414 · Cited by 3
“Gay and bisexual men may experience co-occurring inter-related mental health challenges, including depression, anxiety, and loneliness, which may be exacerbated among men living with HIV due to HIV stigma (Grov et al., 2010; Halkitis et al., 2012; Li et al., 2016).”
Impacto emocional del diagnóstico de VIH en personas residentes en Buenos Aires
Radusky, P. D., & Mikulic, I. M. (2019) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 3
Gunshot wounds to the lower extremity: principles and treatment.
Anania, W. C., Rosen, R. C., & Giuffre, A. M. (1987) · PubMed · Cited by 3
Sok, P., Seeman, M. V., Nisenbaum, R. A., Watson, J., Rourke, S. B., & on behalf of the PSHP Team (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182212256 · Cited by 3
“The presence and severity of social determinants of health such as poverty [15] to income insecurity [19], lack of food or appropriate housing [20,21] or social support [24], loneliness [22,23], or psychological hardships such as stigma [19,23,24], depression [25], and substance abuse [25,26] are known to affect the h…”
BackgroundKrause, K. D., & Halkitis, P. N. (2022) · Journal of Gay & Lesbian Mental Health · doi:10.1080/19359705.2022.2152517 · Cited by 3
“Moreover, psychosocial stressors such as HIV-related stigma have been associated with different mental health outcomes including depression (Grov et al., 2010), suicidality (Ferlatte et al., 2017), and increased PTSD symptomology (Gonzalez et al., 2016) in PLWHA.”
BackgroundLawrence, S., & Cross, M. (2013) · Counselling Psychology Review · doi:10.53841/bpscpr.2013.28.1.25 · Cited by 3
Applebaum, J. W., McDonald, S. E., Britton, M. K., Escobar, K., Garofalo, R., Cohen, C. H., Li, Z., Widmeyer, M., Fabelo, H. E., Wang, Y., et al. (2026) · AIDS and Behavior · doi:10.1007/s10461-025-04947-w · Cited by 2
Soliman, S. H., Seal, D. W., Bruce, O. J., Dalton, M., Palmer, A. E., Pardini, M., Quiroga, B., Ryu, J., Welty, J. C., Younus, I., et al. (2020) · Health Behavior Research · doi:10.4148/2572-1836.1078 · Cited by 2
“Depression and anxiety are of particular concern because these conditions are prevalent among PLWH at higher rates compared to the general adult population (Grov et al., 2010; Johnson Shen et al., 2019; McGowan et al., 2018).”
BackgroundDavtyan, M., Nguyen, A. L., Taylor, J., Christensen, C., & Brown, B. J. (2022) · Ageing International · doi:10.1007/s12126-021-09428-8 · Cited by 2
“Furthermore, studies of OALWH have linked HIV-related stigma to disclosure difficulties, loneliness, depression, and internalized shame (Cahill & Valadéz, 2013; Grov et al., 2010; Payne Foster & Gaskins, 2009; Vanable et al., 2006).”
Cahill, S. (2023) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2023.10.007 · Cited by 2
Thanasko, F., Nikoloudi, M., Anemi, K. A., Parpa, E., Kouloulias, V., & Mystakidou, K. (2024) · Cureus · doi:10.7759/cureus.58432 · Cited by 2
“The modes of transmission for HIV, including unprotected sex or needle sharing, contribute to the stigma faced by people living with HIV (PLHIV), distinguishing it from other chronic diseases [8].”
BackgroundRoss, E. J., Jimenez, D. E., Ghanooni, D., Dilworth, S. E., Carrico, A. W., & Williams, R. S. (2024) · Journal of Homosexuality · doi:10.1080/00918369.2024.2440344 · Cited by 2
“Additionally, HIV status was entered as a binary covariate in all regression models given known associations with both discrimination (Parker & Aggleton, 2003) and loneliness (Grov et al., 2010; Hubach et al., 2015).”
Sullivan, K. M., & Inouye, J. (2015) · Asian/Pacific Island Nursing Journal · doi:10.1177/2373665815597231 · Cited by 2
Metadata
- Authors
- Grov, C., Golub, S. A., Parsons, J. T., Brennan, M., & Karpiak, S. E.
- Affiliations
- City University of New York (US)
- The Graduate Center, CUNY (US)
- e AIDS Community Research Initiative of America (ACRIA) , New York , NY , USA
- Corresponding author
- Grov, Christian
- Venue
- AIDS Care
- Publisher
- Informa UK Limited
- Published
- 2010-04-16
- Volume
- 22
- Issue
- 5
- Pages
- 630-639
- ISSN
- 0954-0121 (ISSN-L)
- 1360-0451
- PMC
- PMC2936670
- OpenAlex
- W2068901441
- Cited by
- 381
- References
- 52
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 21 · 2023: 23 · 2022: 28 · 2021: 30 · 2020: 24 · 2019: 38 · 2018: 24 · 2017: 26 · 2016: 29 · 2015: 27 · 2014: 33 · 2013: 26 · 2012: 16
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- AIDS Care (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5t32da007233-40)
- Centers for Disease Control and Prevention
- National Institute on Drug Abuse (T32DA007233, T32DA07233)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Social Sciences › Health › Health disparities and outcomes
- Keywords
- HIV stigma, loneliness, depression, older adults, HIV-infected adults, aging, cognitive function, energy levels, psychosocial health
- MeSH terms
- Acquired Immunodeficiency Syndrome, Aged, Aged, 80 and over, Depression, Female, HIV Seropositivity, Humans, Loneliness, Male, Middle Aged, Social Isolation, United States, Logistic Models, Social Stigma
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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