The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
MCP-1, MIP-1, IL-8 and Ischemic Cerebral Tissue Enhance Human Bone Marrow Stromal Cell Migration in Interface Culture
Open accessAbstract
Bone marrow stromal cells (MSCs) administered intravenously are effective in reducing neurological deficits after stroke in the rodent. These cells appear to selectively migrate and express neural phenotypes in ischemic brain. To elucidate the mechanisms targeting MSC migration into the ischemic brain, we measured, using a microchemotaxis chamber, the effect of select chemotactic factors and cytokines expressed in injured brain, monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1alpha) and interleukin-8 (IL-8), on migration of human bone marrow stromal cells (hMSCs). In addition, we investigated whether tissue extracts prepared from rat ischemic brain at various times after middle cerebral artery occlusion (MCAo) induce migration of hMSCs. Our data indicate that MCP-1, MIP-1alpha and IL-8 enhance the migration of hMSCs. Ischemic brain tissue extracts at 24, 48 h and 1 week after ischemia significantly increase hMSC migration across the membrane compared to non-ischemic tissue (p<0.05). These data indicate that hMSCs are targeted by inflammatory chemotactic agents and cytokines and that ischemic brain attracts hMSCs.
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Cites
Reversible middle cerebral artery occlusion without craniectomy in rats.
Longa, E. Z., Weinstein, P. R., Carlson, S., & Cummins, R. (1989) · Stroke · doi:10.1161/01.str.20.1.84 · Cited by 7,463
Cited by
Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model
Nakamura, K., Ito, Y., Kawano, Y., Kurozumi, K., Kobune, M., Tsuda, H., Bizen, A., Honmou, O., Niitsu, Y., & Hamada, H. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302276 · Cited by 597
Concise Review: MSC Adhesion Cascade—Insights into Homing and Transendothelial Migration
Nitzsche, F., Müller, C., Lukomska, B., Jolkkonen, J., Deten, A., & Boltze, J. (2017) · Stem Cells · doi:10.1002/stem.2614 · Cited by 382
Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke
Shen, L. H., Li, Y., Chen, J., Zacharek, A., Gao, Q., Kapke, A., Lu, M., Raginski, K., Vanguri, P., Smith, A., et al. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600311 · Cited by 353
Self-citationBoomsma, R. A., & Geenen, D. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035685 · Cited by 308
Li, J., Zhang, Q., Wang, W., Lin, F., Wang, S., & Zhao, J. (2021) · Journal of Neurology · doi:10.1007/s00415-020-10138-5 · Cited by 128
Metadata
- Authors
- Wang, L., Li, Y., Chen, X., Chen, J., Gautam, S. C., Xu, Y., & Chopp, M.
- Venue
- Hematology
- Publisher
- Informa UK Limited
- Published
- 2002-01
- Volume
- 7
- Issue
- 2
- Pages
- 113-117
- ISSN
- 1024-5332 (ISSN-L)
- 1607-8454
- OpenAlex
- W2062932351
- Cited by
- 242
- References
- 1
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, L., Li, Y., Chen, X., Chen, J., Gautam, S. C., Xu, Y., & Chopp, M. (2002). MCP-1, MIP-1, IL-8 and Ischemic Cerebral Tissue Enhance Human Bone Marrow Stromal Cell Migration in Interface Culture. Hematology. https://doi.org/10.1080/10245330290028588
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