Mesenchymal stem cell therapy for ischemic stroke: A look into treatment mechanism and therapeutic potential
Abstract
Stroke, a global disease with a high disability rate, has limited options for functional rehabilitation and results in an adverse impact on patients' lives. In recent years, mesenchymal stem cells (MSCs) have become a new focus of treatment owing to their potential for neuroregeneration. MSCs have demonstrated therapeutic efficacy capable of cell migration, angiogenesis, immunomodulation, neuroprotection and neural circuit reconstruction. The paracrine action of MSCs can also exert neurotrophic effects and improve the functional recovery. This review shows the transplantation protocol for MSCs, discusses the potential therapeutic mechanisms, and summarizes clinical trials on MSCs for treating ischemic stroke. The current proofs show that MSC therapy for ischemic stroke is safe and feasible. The timing and optimal dose of MSC administration are the main challenges in its clinical use. Although still under research, MSC therapy has the potential to be a new therapeutic approach for neurological recovery from ischemic stroke in the future.
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A growing body of research has illuminated the therapeutic potential of EVs derived from diverse cell types, including MSCs, iPSCs, brain-derived NSCs, ESCs, and dendritic cells.
“A growing body of research has illuminated the therapeutic potential of EVs derived from a diverse array of cell types [207, 208]. This includes MSCs [209–211], iPSCs [212], brain-derived NSCs [213], embryonic stem cells (ESCs) [214], and dendritic cells (DC) [215].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [210]
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1 retracted
Hou, K., Li, G., Zhao, J., Xu, B., Zhang, Y., Yu, J., & Xu, K. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1725-8 · Cited by 93 · see citing works
Self-citationRetractedDominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766 · see citing works
Human mesenchymal stem cells modulate allogeneic immune cell responses
Aggarwal, S., & Pittenger, M. F. (2005) · Blood · doi:10.1182/blood-2004-04-1559 · Cited by 4,511 · see citing works
Di Nicola, M., Carlo-Stella, C., Magni, M., Milanesi, M., Longoni, P. D., Matteucci, P., Grisanti, S., & Gianni, A. M. (2002) · Blood · doi:10.1182/blood.v99.10.3838 · Cited by 3,226 · see citing works
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651 · see citing works
The immunology of stroke: from mechanisms to translation
Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596 · see citing works
Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells
Rehman, J., Traktuev, D., Li, J., Merfeld-Clauss, S., Temm-Grove, C. J., Bovenkerk, J. E., Pell, C. L., Johnstone, B. H., Considine, R. V., & March, K. L. (2004) · Circulation · doi:10.1161/01.cir.0000121425.42966.f1 · Cited by 2,269 · see citing works
Self-citationHorwitz, E. M., Blanc, K. L., Dominici, M., Mueller, I., Slaper‐Cortenbach, I., Marini, F. C., Deans, R. J., Krause, D. S., & Keating, A. (2005) · Cytotherapy · doi:10.1080/14653240500319234 · Cited by 2,074 · see citing works
Human mesenchymal stem cells modulate B-cell functions
Corcione, A., Benvenuto, F., Ferretti, E., Giunti, D., Cappiello, V., Cazzanti, F., Risso, M., Gualandi, F., Mancardi, G. L., Pistoia, V., et al. (2006) · Blood · doi:10.1182/blood-2005-07-2657 · Cited by 1,767 · see citing works
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
Hyman, C., Hofer, M., Barde, Y., Juhasz, M., Yancopoulos, G. D., Squinto, S. P., & Lindsay, R. M. (1991) · Nature · doi:10.1038/350230a0 · Cited by 1,494 · see citing works
Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1
Thurston, G., Suri, C., Smith, K., McClain, J., Sato, T. T., Yancopoulos, G. D., & McDonald, D. M. (1999) · Science · doi:10.1126/science.286.5449.2511 · Cited by 1,350 · see citing works
VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain
Zhang, Z. G., Zhang, L., Jiang, Q., Zhang, R., Davies, K., Powers, C., Bruggen, N. V., & Chopp, M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9369 · Cited by 1,296 · see citing works
Lalu, M. M., McIntyre, L., Pugliese, C., Fergusson, D. A., Winston, B. W., Marshall, J. C., Granton, J. T., Stewart, D. J., & Canadian Critical Care Trials Group (2012) · PLoS ONE · doi:10.1371/journal.pone.0047559 · Cited by 1,150 · see citing works
Autologous mesenchymal stem cell transplantation in stroke patients
Bang, O. Y., Lee, J. S., Lee, P. H., & Lee, G. (2005) · Annals of Neurology · doi:10.1002/ana.20501 · Cited by 1,101 · see citing works
Concise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells
Lv, F., Tuan, R. S., Cheung, K., & Leung, V. (2014) · Stem Cells · doi:10.1002/stem.1681 · Cited by 986 · see citing works
Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery
Hofstetter, C. P., Schwarz, E. J., Hess, D. A., Widenfalk, J., Manira, A. E., Prockop, D. J., & Olson, L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042678299 · Cited by 967 · see citing works
Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells
Sato, K., Ozaki, K., Oh, I., Meguro, A., Hatanaka, K., Nagai, T., Muroi, K., & Ozawa, K. (2006) · Blood · doi:10.1182/blood-2006-02-002246 · Cited by 952 · see citing works
Mesenchymal stem cells avoid allogeneic rejection
Ryan, J. M., Barry, F., Murphy, M. J., & Mahon, B. P. (2005) · Journal of Inflammation · doi:10.1186/1476-9255-2-8 · Cited by 912 · see citing works
Human marrow stromal cell therapy for stroke in rat
Li, Y., Chen, J., Chen, X. G., Wang, L., Gautam, S. C., Xu, Y. X., Katakowski, M., Zhang, L. J., Lü, M., Janakiraman, N., et al. (2002) · Neurology · doi:10.1212/wnl.59.4.514 · Cited by 867 · see citing works
Zhao, L.-R., Duan, W.-M., Reyes, M., Keene, C. D., Verfaillie, C. M., & Low, W. C. (2002) · Experimental Neurology · doi:10.1006/exnr.2001.7853 · Cited by 824 · see citing works
Lee, J. S., Hong, J. M., Moon, G. J., Lee, P. H., Ahn, Y. H., & Bang, O. Y. (2010) · Stem Cells · doi:10.1002/stem.430 · Cited by 775 · see citing works
Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke
Honmou, O., Houkin, K., Matsunaga, T., Niitsu, Y., Ishiai, S., Onodera, R., Waxman, S. G., & Kocsis, J. D. (2011) · Brain · doi:10.1093/brain/awr063 · Cited by 493 · see citing works
Gerdoni, E., Gallo, B. M., Casazza, S., Musio, S., Bonanni, I., Pedemonte, E., Mantegazza, R., Frassoni, F., Mancardi, G., Pedotti, R., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21076 · Cited by 482 · see citing works
Schäbitz, W., Steigleder, T., Cooper‐Kuhn, C. M., Schwab, S., Sommer, C., Schneider, A., & Kuhn, H. G. (2007) · Stroke · doi:10.1161/strokeaha.106.477331 · Cited by 435 · see citing works
Treatment of stroke in rat with intracarotid administration of marrow stromal cells
Li, Y., Chen, J., Wang, L., Lü, M., & Chopp, M. (2001) · Neurology · doi:10.1212/wnl.56.12.1666 · Cited by 431 · see citing works
Clinical Outcomes of Transplanted Modified Bone Marrow–Derived Mesenchymal Stem Cells in Stroke
Steinberg, G. K., Kondziolka, D. S., Wechsler, L. R., Lunsford, L. D., Coburn, M., Billigen, J. B., Kim, A. S., Johnson, J. N., Bates, D., King, B., et al. (2016) · Stroke · doi:10.1161/strokeaha.116.012995 · Cited by 395 · see citing works
Liu, K., Ji, K., Guo, L., Wu, W., Lu, H., Shan, P., & Yan, C. (2014) · Microvascular Research · doi:10.1016/j.mvr.2014.01.008 · Cited by 391 · see citing works
Hess, D. C., Wechsler, L. R., Clark, W. M., Savitz, S. I., Ford, G. A., Chiu, D. T. W., Yavagal, D. R., Uchino, K., Liebeskind, D. S., Auchus, A. P., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30046-7 · Cited by 370 · see citing works
Hofer, H. R., & Tuan, R. S. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0394-0 · Cited by 360 · see citing works
The microRNA regulatory landscape of MSC-derived exosomes: a systems view
Ferguson, S. W., Wang, J., Lee, C. J., Liu, M., Neelamegham, S., Canty, J. M., & Nguyen, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-19581-x · Cited by 360 · see citing works
Ling, W., Fraser, J. L., Lu, Z.-Y., Hu, X.-Y., & Yu, S. P. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.002 · Cited by 355 · see citing works
Immunosuppressive Effects of Mesenchymal Stem Cells: Involvement of HLA-G
Nasef, A., Mathieu, N., Chapel, A., Frick, J., François, S., Mazurier, C., Boutarfa, A., Bouchet, S., Gorin, N.-C., Thierry, D., et al. (2007) · Transplantation · doi:10.1097/01.tp.0000267918.07906.08 · Cited by 350 · see citing works
Kim, Y. J., Kim, H. K., Cho, H. H., Bae, Y. C., Suh, K. T., & Jung, J. S. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000110447 · Cited by 298 · see citing works
Immunological Aspects of Allogeneic Mesenchymal Stem Cell Therapies
Griffin, M. D., Ritter, T., & Mahon, B. P. (2010) · Human Gene Therapy · doi:10.1089/hum.2010.156 · Cited by 290 · see citing works
Wakabayashi, K., Nagai, A., Sheikh, A. M., Shiota, Y., Narantuya, D., Watanabe, T., Masuda, J., Kobayashi, S., Kim, S. U., & Yamaguchi, S. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22279 · Cited by 249 · see citing works
The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke
Cunningham, C. J., Redondo-Castro, E., & Allan, S. M. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18776802 · Cited by 242 · see citing works
Camilleri, E. T., Gustafson, M. P., Dudakovic, A., Riester, S. M., Galeano‐Garces, C., Paradise, C. R., Takai, H., Karperien, M., Cool, S. M., Sampen, H. I., et al. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0370-8 · Cited by 241 · see citing works
Wang, L., Li, Y., Chen, X., Chen, J., Gautam, S. C., Xu, Y., & Chopp, M. (2002) · Hematology · doi:10.1080/10245330290028588 · Cited by 241 · see citing works
Onda, T., Honmou, O., Harada, K., Houkin, K., Hamada, H., & Kocsis, J. D. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600527 · Cited by 237 · see citing works
Characterization of key mechanisms in transmigration and invasion of mesenchymal stem cells
Steingen, C., Brenig, F., Baumgartner, L., Schmidt, J., Schmidt, A., & Bloch, W. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.03.010 · Cited by 233 · see citing works
Gutiérrez‐Fernández, M., Rodríguez‐Frutos, B., Ramos‐Cejudo, J., Vallejo‐Cremades, M. T., Fuentes, B., Cerdán, S., & Díez‐Tejedor, E. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt159 · Cited by 228 · see citing works
Leu, S., Lin, Y., Yuen, C.-M., Yen, C., Kao, Y. H., Sun, C., & Yip, H. (2010) · Journal of Translational Medicine · doi:10.1186/1479-5876-8-63 · Cited by 220 · see citing works
Stem Cell-Based Therapies for Ischemic Stroke
Hao, L., Zou, Z., Tian, H. Y., Zhang, Y., Zhou, H., & Liu, L. (2014) · BioMed Research International · doi:10.1155/2014/468748 · Cited by 215 · see citing works
One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke
Shen, L. H., Li, Y., Chen, J., Cui, Y., Zhang, C., Kapke, A., Lu, M., Savant-Bhonsale, S., & Chopp, M. (2007) · Stroke · doi:10.1161/strokeaha.106.481218 · Cited by 208 · see citing works
(for the ISIS-HERMES Study Group), Jaillard, A. S., Hommel, M., Moisan, A., Zeffiro, T. A., Favre, I., Barbieux‐Guillot, M., Vadot, W., Marcel, S., Lamalle, L., et al. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00787-z · Cited by 208 · see citing works
Ding, D., Shyu, W., Chiang, M., Lin, S., Chang, Y.-C., Wang, H.-J., Su, C.-Y., & Li, H. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.06.010 · Cited by 204 · see citing works
Bao, X., Wei, J., Feng, M., Lu, S., Li, G., Dou, W., Ma, W., Ma, S., An, Y., Qin, C., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.10.063 · Cited by 204 · see citing works
The Adult Human Brain Harbors Multipotent Perivascular Mesenchymal Stem Cells
Paul, G., Özen, Í., Christophersen, N. S., Reinbothe, T. M., Bengzon, J., Visse, E., Jansson, K., Dannaeus, K., Henriques-Oliveira, C., Roybon, L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035577 · Cited by 202 · see citing works
Haider, H. K., & Ashraf, M. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.05.004 · Cited by 201 · see citing works
Multiple paracrine factors secreted by mesenchymal stem cells contribute to angiogenesis
Kwon, H. M., Hur, S.-M., Park, K.-Y., Kim, C., Kim, Y., Kim, H.-S., Shin, H.-C., Won, M., Ha, K., Kwon, Y., et al. (2014) · Vascular Pharmacology · doi:10.1016/j.vph.2014.06.004 · Cited by 196 · see citing works
Levy, M. L., Crawford, J. R., Dib, N., Verkh, L., Tankovich, N. I., & Cramer, S. C. (2019) · Stroke · doi:10.1161/strokeaha.119.026318 · Cited by 184 · see citing works
Neurorestorative Therapy for Stroke
Chen, J., Venkat, P., Zacharek, A., & Chopp, M. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00382 · Cited by 169 · see citing works
Stem cell therapy: A clinical trial of stroke
Bhasin, A., Srivastava, M. V. P., Mohanty, S., Bhatia, R., Kumaran, S. S., & Bose, S. (2012) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2012.10.015 · Cited by 169 · see citing works
The immunomodulatory properties of mesenchymal stem cells
Marigo, I., & Dazzi, F. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0267-7 · Cited by 168 · see citing works
Jin, K., Sun, Y., Xie, L., Mao, X. O., Childs, J., Peel, A. L., Logvinova, A. V., Banwait, S., & Greenberg, D. A. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.10.010 · Cited by 167 · see citing works
Adult cell therapy for brain neuronal damages and the role of tissue engineering
Delcroix, G. J.-R., Schiller, P. C., Benoît, J., & Montero‐Menei, C. N. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.084 · Cited by 167 · see citing works
Moon, G. J., Sung, J. H., Kim, D. H., Kim, E. H., Cho, Y. H., Son, J. P., Cha, J. M., & Bang, O. Y. (2019) · Translational Stroke Research · doi:10.1007/s12975-018-0668-1 · Cited by 166 · see citing works
Zhang, J., Li, Y., Chen, J., Yang, M., Katakowski, M., Lü, M., & Chopp, M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.09.061 · Cited by 165 · see citing works
Mesenchymal stem cells: therapeutic outlook for stroke
Honmou, O., Onodera, R., Sasaki, M., Waxman, S. G., & Kocsis, J. D. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.02.003 · Cited by 165 · see citing works
Autologous bone marrow stem cell neurotransplantation in stroke patients. An open study
Monteagudo, C. S., Hernández-Ramírez, P., González, L. Á., García-Maeso, I., de la Cuétara-Bernal, K., Díaz, L. C., Bringas-Vega, M. L., Aching, G. T. M., Chacón, L. M. M., Martín, M. M. B., et al. (2009) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2009-0483 · Cited by 165 · see citing works
Therapeutic potential for mesenchymal stem cell transplantation in critical limb ischemia
Liew, A., & O’Brien, T. (2012) · Stem Cell Research & Therapy · doi:10.1186/scrt119 · Cited by 160 · see citing works
Mesenchymal Stem Cells Shape Microglia Effector Functions Through the Release of CX3CL1
Giunti, D., Parodi, B., Usai, C., Vergani, L., Casazza, S., Bruzzone, S., Mancardi, G., & Uccelli, A. (2012) · Stem Cells · doi:10.1002/stem.1174 · Cited by 159 · see citing works
Gunawardena, T. N. A., Rahman, M. T., Abdullah, B. J. J., & Kasim, N. H. A. (2019) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2806 · Cited by 156 · see citing works
Human Umbilical Mesenchymal Stem Cells Promote Recovery After Ischemic Stroke
Lin, Y., Ko, T.-L., Shih, Y., Lin, M.-Y. A., Fu, T.-W., Hsiao, H.-S., Hsu, J.-Y. C., & Fu, Y.-S. (2011) · Stroke · doi:10.1161/strokeaha.110.603621 · Cited by 152 · see citing works
Investigational Therapies for Ischemic Stroke: Neuroprotection and Neurorecovery
Sahota, P., & Savitz, S. I. (2011) · Neurotherapeutics · doi:10.1007/s13311-011-0040-6 · Cited by 146 · see citing works
Pericyte Signaling in the Neurovascular Unit
Fisher, M. (2008) · Stroke · doi:10.1161/strokeaha.108.533117 · Cited by 145 · see citing works
Dabrowska, S., Andrzejewska, A., Strzemecki, D., Muraca, M., Janowski, M., & Łukomska, B. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1602-5 · Cited by 145 · see citing works
Díez‐Tejedor, E., Gutiérrez‐Fernández, M., Martínez‐Sánchez, P., Rodríguez‐Frutos, B., Ares, G. R., Lara, M., & Fuentes, B. (2014) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2014.06.011 · Cited by 140 · see citing works
Mesenchymal Stem Cell-Derived Extracellular Vesicle Therapy for Stroke: Challenges and Progress
Bang, O. Y., & Kim, E. H. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00211 · Cited by 138 · see citing works
Nakajima, M., Nito, C., Sowa, K., Suda, S., Nishiyama, Y., Nakamura-Takahashi, A., Nitahara‐Kasahara, Y., Imagawa, K., Hirato, T., Ueda, M., et al. (2017) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2017.06.005 · Cited by 135 · see citing works
Toyama, K., Honmou, O., Harada, K., Suzuki, J., Houkin, K., Hamada, H., & Kocsis, J. D. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.11.010 · Cited by 131 · see citing works
Darsalia, V., Mansouri, S., Ortsäter, H., Olverling, A., Nozadze, N., Krizhanovskii, C., Iverfeldt, K., Tracy, L. M., Grankvist, N., Sjöholm, Å., et al. (2011) · Clinical Science · doi:10.1042/cs20110374 · Cited by 129 · see citing works
Tsai, L., Wang, Z., Munasinghe, J., Leng, Y., Leeds, P. R., & Chuang, D. (2011) · Stroke · doi:10.1161/strokeaha.110.612788 · Cited by 127 · see citing works
Efficacy of stem cell-based therapies for stroke
Chrostek, M. R., Fellows, E. G., Crane, A. T., Grande, A. W., & Low, W. C. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146362 · Cited by 122 · see citing works
The secretome of mesenchymal stem cells: Potential implications for neuroregeneration
Paul, G., & Anisimov, S. V. (2013) · Biochimie · doi:10.1016/j.biochi.2013.07.013 · Cited by 121 · see citing works
Yoo, S., Chang, D., Lee, H. S., Kim, G., Park, J., Ryu, B., Joe, E.-H., Lee, Y., Kim, S., & Suh‐Kim, H. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.06.001 · Cited by 120 · see citing works
Liu, N., Chen, R., Du, H., Wang, J., Zhang, Y., & Wen, J. (2009) · Cellular and Molecular Immunology · doi:10.1038/cmi.2009.28 · Cited by 114 · see citing works
Liu, Z., Li, Y., Zhang, Z. G., Cui, X., Cui, Y., Lu, M., Savant-Bhonsale, S., & Chopp, M. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.8 · Cited by 111 · see citing works
Toyoshima, A., Yasuhara, T., Kameda, M., Morimoto, J., Takeuchi, H., Wang, F., Sasaki, T., Sasada, S., Shinko, A., Wakamori, T., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127302 · Cited by 109 · see citing works
Mesenchymal stem cell‐based treatments for stroke, neural trauma, and heat stroke
Hsuan, Y. C.-Y., Lin, C., Chang, C., & Lin, M. (2016) · Brain and Behavior · doi:10.1002/brb3.526 · Cited by 109 · see citing works
Ishizaka, S., Horie, N., Satoh, K., Fukuda, Y., Nishida, N., & Nagata, I. (2013) · Stroke · doi:10.1161/strokeaha.112.677328 · Cited by 106 · see citing works
Xin, H., Li, Y., Shen, L. H., Liu, X., Wang, X., Zhang, J., Pourabdollah-Nejad D, S., Zhang, C., Zhang, L., Jiang, H., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009027 · Cited by 101 · see citing works
Kia, N. A., Bahrami, A. R., Ebrahimi, M., Matin, M. M., Neshati, Z., Almohaddesin, M. R., Aghdami, N., & Bidkhori, H. R. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9446-6 · Cited by 101 · see citing works
Jiang, Y., Zhu, W., Zhu, J., Li, W., Xu, G., & Liu, X. (2013) · Cell Transplantation · doi:10.3727/096368912x658818 · Cited by 99 · see citing works
Stem Cell Therapy and Administration Routes After Stroke
Rodríguez‐Frutos, B., Otero‐Ortega, L., Gutiérrez‐Fernández, M., Fuentes, B., Ramos‐Cejudo, J., & Díez‐Tejedor, E. (2016) · Translational Stroke Research · doi:10.1007/s12975-016-0482-6 · Cited by 97 · see citing works
Hess, D. C., Sila, C. A., Furlan, A. J., Wechsler, L. R., Switzer, J. A., & Mays, R. W. (2013) · International Journal of Stroke · doi:10.1111/ijs.12065 · Cited by 95 · see citing works
Deng, J., Zhang, Y., Xie, Y., Zhang, L., & Tang, P. (2018) · Stem Cells International · doi:10.1155/2018/5653787 · Cited by 95 · see citing works
Azad, T. D., Veeravagu, A., & Steinberg, G. K. (2016) · Neurosurgical FOCUS · doi:10.3171/2016.2.focus15637 · Cited by 90 · see citing works
Matsushita, T., Kibayashi, T., Katayama, T., Yamashita, Y., Suzuki, S., Kawamata, J., Honmou, O., Minami, M., & Shimohama, S. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.07.021 · Cited by 89 · see citing works
Deng, Y., Ye, W. B., Hu, Z., Yan, Y., Wang, Y., Takon, B. F., Zhou, G., & Zhou, Y. F. (2009) · Neurological Research · doi:10.1179/174313209x414434 · Cited by 87 · see citing works
Li, J., Zhu, H., Liu, Y., Li, Q., Lu, S., Feng, M., Xu, Y., Huang, L., Ma, C., An, Y., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.080 · Cited by 86 · see citing works
Self-citationWalker, P. A., Harting, M. T., Jiménez, F., Shah, S. K., Pati, S., Dash, P. K., & Cox, C. S. (2009) · Stem Cells and Development · doi:10.1089/scd.2009.0188 · Cited by 85 · see citing works
Song, M., Mohamad, O., Gu, X., Wei, L., & Yu, S. P. (2012) · Cell Transplantation · doi:10.3727/096368912x657909 · Cited by 85 · see citing works
More insight into mesenchymal stem cells and their effects inside the body
Zou, Z., Zhang, Y., Hao, L., Wang, F., Liu, D., Su, Y., & Sun, H. (2010) · Expert Opinion on Biological Therapy · doi:10.1517/14712590903456011 · Cited by 84 · see citing works
Yang, M., Wei, X., Li, J., Heine, L., Rosenwasser, R. H., & Iacovitti, L. (2010) · Cell Transplantation · doi:10.3727/096368910x503415 · Cited by 84 · see citing works
Self-citationEffects of mechanical loading on human mesenchymal stem cells for cartilage tissue engineering
Choi, J. R., Yong, K. W., & Choi, J. Y. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26018 · Cited by 81 · see citing works
Huang, H., Mu, Q., Li, G., Yu, F., Lei, T., Gao, H., Li, P., & Sun, Y. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.184506 · Cited by 77 · see citing works
Mesenchymal Stem Cell Therapy for Ischemic Tissues
Yong, K. W., Choi, J. R., Mohammadi, M., Mitha, A. P., Sanati‐Nezhad, A., & Sen, A. (2018) · Stem Cells International · doi:10.1155/2018/8179075 · Cited by 77 · see citing works
Intranasal delivery of stem cells as therapy for central nervous system disease
Lǐ, Y., Feng, L., Zhang, G., & Ma, C. (2015) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2015.01.016 · Cited by 74 · see citing works
Heiskanen, A., Hirvonen, T., Salo, H., Impola, U., Olonen, A., Laitinen, A., Tiitinen, S. L., Natunen, S., Aitio, O., Miller‐Podraza, H., et al. (2008) · Glycoconjugate Journal · doi:10.1007/s10719-008-9217-6 · Cited by 74 · see citing works
Kim, S. J., Moon, G. J., Chang, W. H., Kim, Y., Bang, O. Y., & collaborators, F. T. S.-2. (. C. A. R. A. T. I. N.-2. (2013) · Trials · doi:10.1186/1745-6215-14-317 · Cited by 73 · see citing works
Zhang, H., Lu, M., Zhang, X., Kuai, Y., Mei, Y., Tan, Q., Zhong, K., Sun, X., & Tan, W. (2019) · Scientific Reports · doi:10.1038/s41598-019-48759-0 · Cited by 69 · see citing works
Khan, S., Villalobos, M. A., Choron, R. L., Chang, S., Brown, S. A., Carpenter, J. P., Tulenko, T. N., & Zhang, P. (2016) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2016.04.034 · Cited by 68 · see citing works
Ryu, B., Sekine, H., Homma, J., Kobayashi, T., Kobayashi, E., Kawamata, T., & Shimizu, T. (2019) · Journal of neurosurgery · doi:10.3171/2018.11.jns182331 · Cited by 68 · see citing works
Liesz, A., Bauer, A. S., Hoheisel, J. D., & Veltkamp, R. C. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.07.003 · Cited by 67 · see citing works
Comparison of Bone Marrow Stromal Cells Derived From Stroke and Normal Rats for Stroke Treatment
Zacharek, A., Shehadah, A., Chen, J., Cui, X., Roberts, C. J., Lü, M., & Chopp, M. (2010) · Stroke · doi:10.1161/strokeaha.109.568881 · Cited by 67 · see citing works
Low dose of extracellular vesicles identified that promote recovery after ischemic stroke
Otero‐Ortega, L., Laso-García, F., Frutos, M. C. G.-D., Diekhorst, L., Martínez-Arroyo, A., Alonso‐López, E., García‐Bermejo, L., Rodríguez‐Serrano, M., Arrúe-Gonzalo, M., Díez‐Tejedor, E., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01601-1 · Cited by 67 · see citing works
Bao, X., Feng, M., Wei, J., Han, Q., Zhao, H., Li, G., Zhu, Z., Xing, H., An, Y., Qin, C., et al. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07733.x · Cited by 64 · see citing works
Lalu, M. M., Montroy, J. R., Dowlatshahi, D. D., Hutton, B., Juneau, P., Wesch, N. L., Zhang, S. Y., McGinn, R. N., Corbett, D., Stewart, D. J., et al. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00736-5 · Cited by 64 · see citing works
Moon, J. Y., Shin, J., Chung, J., Ji, S., Ro, S., & Kim, W. H. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm8010002 · Cited by 64 · see citing works
Cheng, Q., Zhang, Z., Zhang, S., Yang, H., Zhang, X., Pan, J., Weng, L., Sha, D., Zhu, M., Hu, X., et al. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.065 · Cited by 62 · see citing works
Guo, F., Lv, S., Lou, Y., Tu, W., Liao, W., Wang, Y., & Deng, Z. (2012) · Cell Biology International · doi:10.1042/cbi20110596 · Cited by 62 · see citing works
Chau, M. J., Deveau, T. C., Gu, X., Kim, Y. S., Xu, Y., Yu, S. P., & Wei, L. (2018) · BMC Neuroscience · doi:10.1186/s12868-018-0418-z · Cited by 59 · see citing works
Zaman, W. S. W. K., Choi, J. R., Yong, K. W., Ting, I., Adenan, N. A. M., & Pingguan‐Murphy, B. (2017) · Cryobiology · doi:10.1016/j.cryobiol.2017.01.006 · Cited by 57 · see citing works
Shi, Y., Shi, H., Nomi, A., Zhang, L., ZHANG, B., & Qian, H. (2019) · Cytotherapy · doi:10.1016/j.jcyt.2018.11.012 · Cited by 57 · see citing works
Hou, K., Li, G., Zhao, J., Xu, B., Zhang, Y., Yu, J., & Xu, K. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01872-8 · Cited by 57 · see citing works
Self-citationLi, X., Huang, M., Zhao, R., Zhao, C., Liu, Y., Zou, H., Chen, L., Guan, Y., & Zhang, Y. A. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000489384 · Cited by 55 · see citing works
Zhu, J., Liu, Q., Jiang, Y., Wu, L., Xu, G., & Liu, X. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.038 · Cited by 54 · see citing works
Xin, H., Li, Y., Chen, X., & Chopp, M. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20834 · Cited by 53 · see citing works
Chen, B., Tao, J., Lin, Y., Lin, R., Liu, W., & Chen, L. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2334 · Cited by 52 · see citing works
Bioactive Nanofibers Induce Neural Transdifferentiation of Human Bone Marrow Mesenchymal Stem Cells
Ji, W., Álvarez, Z., Edelbrock, A. N., Sato, K., & Stupp, S. I. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b13653 · Cited by 52 · see citing works
Ghazavi, H., Hoseini, S. J., Ebrahimzadeh‐Bideskan, A., Mashkani, B., Mehri, S., Ghorbani, A., Sadri, K., Mahdipour, E., Ghasemi, F., Forouzanfar, F., et al. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-017-9755-z · Cited by 51 · see citing works
Shen, L. H., Xin, H., Li, Y., Zhang, R. L., Cui, Y., Zhang, L., Lu, M., Zhang, Z. G., & Chopp, M. (2011) · Stroke · doi:10.1161/strokeaha.110.593863 · Cited by 51 · see citing works
Wang, Y., Fu, W. E., Zhang, S., He, X., Liu, Z., Gao, D., & Xu, T. (2014) · Brain Research · doi:10.1016/j.brainres.2014.05.035 · Cited by 48 · see citing works
Ma, S., Zhong, D., Chen, H., Zheng, Y., Sun, Y., Luo, J., Li, H., Li, G., & Yin, Y. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.01.007 · Cited by 47 · see citing works
Hazeri, Y., Irani, S., Zandi, M., & Pezeshki‐Modaress, M. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.10.061 · Cited by 45 · see citing works
Zhu, Y., Guan, Y.-M., Huang, H.-L., & Wang, Q. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.9 · Cited by 45 · see citing works
Kasim, N. H. A., Govindasamy, V., Gnanasegaran, N., Musa, S., Pradeep, P. J., Srijaya, T. C., & Aziz, Z. A. C. A. (2012) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1663 · Cited by 44 · see citing works
Zhang, Y., Ma, L., Su, Y., Su, L., Lan, X., Wu, D., Han, S., Li, J., Kvederis, L., Corey, S., et al. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146432 · Cited by 44 · see citing works
Self-citationJiang, W., Liang, G., Li, X., Li, Z., Gao, X., Feng, S., Wang, X., Li, H., & Liu, Y. (2014) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-014-5157-9 · Cited by 44 · see citing works
Meirelles, L. D. S., Malta, T. M., Wagatsuma, V. M. D. D., Palma, P. V. B., Araújo, A. G., Malmegrim, K. C. R., de Oliveira, F. M., Panepucci, R. A., Silva, W. A., Kashima, S. H., et al. (2015) · Stem Cells and Development · doi:10.1089/scd.2015.0153 · Cited by 43 · see citing works
Zong, X., Wu, S., Li, F., Lv, L., Han, D. K., Zhao, N., Yan, X., Hu, S., & Xu, T. J. (2017) · Brain Research · doi:10.1016/j.brainres.2017.08.006 · Cited by 43 · see citing works
Mitkari, B., Nitzsche, F., Kerkelä, E., Kuptsova, K., Huttunen, J. K., Nystedt, J. M., Korhonen, M. O., & Jolkkonen, J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.030 · Cited by 42 · see citing works
A Glycovariant of Human CD44 is Characteristically Expressed on Human Mesenchymal Stem Cells
Pachón-Peña, G., Donnelly, C., Ruiz‐Cañada, C., Katz, A. J., Fernández‐Veledo, S., Vendrell, J. J., & Sackstein, R. (2016) · Stem Cells · doi:10.1002/stem.2549 · Cited by 41 · see citing works
Lin, B., Zhang, J.-Z., Lu, L., Mao, J., Cao, M., Mao, X., Zhang, F., Duan, X., Zheng, C., Zhang, L., et al. (2017) · Nanomaterials · doi:10.3390/nano7050107 · Cited by 41 · see citing works
Cunningham, C. J., Wong, R., Barrington, J., Tamburrano, S., Pinteaux, E., & Allan, S. M. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-1560-y · Cited by 41 · see citing works
Fukuda, Y., Horie, N., Satoh, K., Yamaguchi, S., Morofuji, Y., Hiu, T., Izumo, T., Hayashi, K., Nishida, N., & Nagata, I. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0135-9 · Cited by 40 · see citing works
Park, J., Lee, N., Lee, J., Choe, E. K., Kim, M. K., Lee, J. H., Byun, M. S., Chon, M., Kim, S. W., Lee, C. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10394-y · Cited by 36 · see citing works
Du, S., Guan, J., Mao, G., Liu, Y., Ma, S., Bao, X., Gao, J., Feng, M., Li, G., Ma, W., et al. (2014) · Cell Transplantation · doi:10.3727/096368914x685023 · Cited by 36 · see citing works
Sanberg, P. R., Eve, D. J., Metcalf, C., & Borlongan, C. V. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59544-7.00006-8 · Cited by 35 · see citing works
Oshita, J., Okazaki, T., Mitsuhara, T., Imura, T., Nakagawa, K., Otsuka, T., Kurose, T., Tamura, T., Abiko, M., Takeda, M., et al. (2020) · Neurologia medico-chirurgica · doi:10.2176/nmc.oa.2019-0186 · Cited by 35 · see citing works
Tao, H., Chen, X., Wei, A., Song, X., Wang, W., Liang, L., Zhao, Q., Han, Z., Han, Z., Wang, X., et al. (2018) · Stem Cells International · doi:10.1155/2018/7906531 · Cited by 35 · see citing works
Self-citationMawa, S., Jantan, I., & Husain, K. (2016) · Molecules · doi:10.3390/molecules21010009 · Cited by 33 · see citing works
Cai, F., Hong, X., Tang, X., Liu, N., Wang, F., Zhu, L., Xie, X.-H., Xie, Z., & Wu, X. (2019) · Bioscience Reports · doi:10.1042/bsr20192708 · Cited by 33 · see citing works
Mello, T. G., Rosado-de-Castro, P. H., Campos, R. M. P., Vasques, J. F., Rangel-Junior, W. S., Mattos, R. S. D. A. R. D., Puig‐Pijuan, T., Foerster, B., Gutfilen, B., de Souza, S. A. L., et al. (2020) · Stem Cells and Development · doi:10.1089/scd.2019.0176 · Cited by 33 · see citing works
Li, D. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.909 · Cited by 33 · see citing works
Jahromi, G. P., Shabanzadeh, A. P., Sadr, S. S., Kaka, G., Jafari, M., Seidi, S., & Charish, J. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12466 · Cited by 30 · see citing works
Therapeutic applications of bone marrow-derived stem cells in ischemic stroke
Wang, L., Lin, Z., Shao, B., Zhuge, Q., & Jin, K. (2013) · Neurological Research · doi:10.1179/1743132813y.0000000210 · Cited by 28 · see citing works
the STARTING-2 trial investigators, Bang, O. Y., Moon, G. J., Kim, D. H., Lee, M. J., Kim, S., Son, J. P., Cho, Y. H., Chang, W. H., & Kim, Y. (2017) · Translational Stroke Research · doi:10.1007/s12975-017-0538-2 · Cited by 28 · see citing works
Mesenchymal Stem Cell Therapy for Ischemic Stroke.
Toyoshima, A., Yasuhara, T., & Date, I. (2017) · PubMed · doi:10.18926/amo/55302 · Cited by 28 · see citing works
Cai, A., Qiu, R., Li, L., Zheng, D., Dong, Y., Yu, D., Huang, Y., Rao, S., Zhou, Y., & Mai, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079100 · Cited by 28 · see citing works
Luo, L., Hu, D., Yin, J. Q., & Xu, R.-X. (2018) · Stem Cells International · doi:10.1155/2018/5630802 · Cited by 27 · see citing works
Sung, P., Chen, K., Lin, H.-S., Chu, C., Chiang, J. Y., & Yip, H. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8020190 · Cited by 26 · see citing works
Chen, K., Lin, K., Wallace, C. G., Li, Y., Shao, P., Chiang, J. Y., Sung, P., & Yip, H. (2019) · PubMed Central · Cited by 23 · see citing works
Clinical trial design for stem cell therapies in stroke: What have we learned?
Muir, K. W. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.09.011 · Cited by 22 · see citing works
He, B., Yao, Q., Liang, Z., Lin, J., Xie, Y., Li, S., Wu, G., Yang, Z., & Xu, P. (2016) · Cell Transplantation · doi:10.3727/096368916x692627 · Cited by 22 · see citing works
Feng, Y., Yu, H., Shang, D., Fang, W., He, Z.-Y., & Chen, Y. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1257-7 · Cited by 20 · see citing works
In Vivo Targeted MR Imaging of Endogenous Neural Stem Cells in Ischemic Stroke
Zhang, F., Duan, X., Lu, L., Zhang, X., Zhong, X., Mao, J., Chen, M., & Shen, J. (2016) · Molecules · doi:10.3390/molecules21091143 · Cited by 18 · see citing works
miR-3099 promotes neurogenesis and inhibits astrogliogenesis during murine neural development
Abidin, S. Z., Fam, S.-Z., Chong, C., Abdullah, S., Cheah, P.-S., Nordin, N., & Ling, K. (2019) · Gene · doi:10.1016/j.gene.2019.02.014 · Cited by 17 · see citing works
Liu, G., Pan, Y., Liu, Y., Hu, J., Zhang, X., Zhang, D., Wang, Y., Feng, Y., Yu, J., & Cheng, Y. (2020) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12188 · Cited by 17 · see citing works
Kim, G., Marasini, S., Yoon, J. S., Jo, D., Han, J.-H., Hong, J. M., Kim, S., & Suh‐Kim, H. (2019) · International Journal of Stem Cells · doi:10.15283/ijsc19111 · Cited by 16 · see citing works
Jedari, B., Rahmani, A., Naderi, M., & Nadri, S. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29513 · Cited by 15 · see citing works
Lee, W., Tai, S., Lin, Y., Wu, T., & Lee, E. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9178 · Cited by 13 · see citing works
Geranmayeh, M. H., Nourazarian, A., Avcı, Ç. B., Rahbarghazi, R., & Farhoudi, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0286-4 · Cited by 12 · see citing works
Bone Marrow-Derived NCS-01 Cells Advance a Novel Cell-Based Therapy for Stroke
Brown, J., Park, Y. J., Lee, J.-Y., Chase, T. N., Koga, M., & Borlongan, C. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082845 · Cited by 12 · see citing works
Yang, X., Wang, R., Wang, X., Cai, G., Qian, Y., Feng, S., Tan, F., Chen, K., Tang, K., Huang, X., et al. (2018) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjy013 · Cited by 11 · see citing works
Lam, P. K., Wang, K., Chin, D. W. C., Tong, C. S. W., Wáng, Y. X. J., Lo, K. K. Y., Lai, P. B. S., Ma, H., Zheng, V. Z. Y., Poon, W. S., et al. (2019) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2019.08.051 · Cited by 11 · see citing works
Human Adipose Tissue Micro-fragmentation for Cell Phenotyping and Secretome Characterization
Vezzani, B., Gomez-Salazar, M. A., Casamitjana, J., Tremolada, C., & Péault, B. (2019) · Journal of Visualized Experiments · doi:10.3791/60117 · Cited by 10 · see citing works
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Clinical Trials of Stem Cell Therapy for Cerebral Ischemic Stroke
Kawabori, M., Shichinohe, H., Kuroda, S., & Houkin, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197380 · Cited by 196 · see citing works
Angiogenesis after ischemic stroke
Fang, J., Wang, Z., & Miao, C. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01061-2 · Cited by 194 · see citing works
Zhidu, S., Ying, T., Rui, J., & Chao, Z. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03885-z · Cited by 180 · see citing works
Anti-cerebral ischemia reperfusion injury of polysaccharides: A review of the mechanisms
Yuan, Q., Yuan, Y., Zheng, Y., Sheng, R., Liu, L., Xie, F., & Tan, J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111303 · Cited by 139 · see citing works
Liu, T., Li, X., Zhou, X., Chen, W. J., Wen, A., Liu, M., & Ding, Y. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00568 · Cited by 121 · see citing works
He, J., Liu, J., Huang, Y., Tang, X., Xiao, H., & Hu, Z. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.641157 · Cited by 115 · see citing works
de Celis, E., Fuentes, B., de Leciñana, M. A., Gutiérrez‐Fernández, M., Borobia, A. M., Gutiérrez-Zúñiga, R., Ares, G. R., Otero‐Ortega, L., Laso-García, F., Frutos, M. C. G.-D., et al. (2022) · Cell Transplantation · doi:10.1177/09636897221083863 · Cited by 96 · see citing works
Gao, P., Jiang, Y., Chen, W., Gu, J., Miao, S., Wang, X., Huang, Y., Jiang, T., Li, Q., Zhou, W., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02110-y · Cited by 96 · see citing works
Lee, J., Chang, W. H., Chung, J.-W., Kim, S. J., Kim, S.-K., Lee, J. S., Sohn, S.-I., Kim, Y.-H., Bang, O. Y., Kim, S. J., et al. (2021) · Stroke · doi:10.1161/strokeaha.121.034505 · Cited by 93 · see citing works
Progress in Mesenchymal Stem Cell Therapy for Ischemic Stroke
Guo, Y., Peng, Y., Zeng, H., & Chen, G. (2021) · Stem Cells International · doi:10.1155/2021/9923566 · Cited by 70 · see citing works
Law, Z. K., Tan, H. J., Chin, S. P., Wong, C. Y., Yahya, W. N. N. W., Muda, A. S., Zakaria, R., Ariff, M. I., Ismail, N. A., Cheong, S. K., et al. (2021) · Cytotherapy · doi:10.1016/j.jcyt.2021.03.005 · Cited by 64 · see citing works
Signaling pathways in brain ischemia: Mechanisms and therapeutic implications
Lin, W., Zhao, X., Cheng, J., Li, L., Jiang, Q., Zhang, Y., & Han, F. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108541 · Cited by 60 · see citing works
Potential Mechanisms and Perspectives in Ischemic Stroke Treatment Using Stem Cell Therapies
Zhou, G., Wang, Y., Gao, S., Fu, X., Cao, Y., Peng, Y., Zhuang, J., Hu, J., Shao, A., & Wang, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.646927 · Cited by 49 · see citing works
la Torre, R. S.-D., Quiñones-Vico, M. I., Fernández‐González, A., Sánchez‐Díaz, M., Montero‐Vílchez, T., Sierra-Sánchez, Á., & Arias‐Santiago, S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10132991 · Cited by 47 · see citing works
Zeng, C. (2023) · Biology · doi:10.3390/biology12050653 · Cited by 45 · see citing works
Qu, Q., Wang, L., Bing, W., Bi, Y., Zhang, C., Jing, X., & Liu, L. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01978-z · Cited by 45 · see citing works
He, J., Liu, J., Huang, Y., Tang, X., Xiao, H., Zuo, L., Jiang, Z., Zeng, L., Hu, Z., & Lü, M. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/4805040 · Cited by 42 · see citing works
Bao, H., Mao, S., Hu, X., Lin, L., Tao, H., Zhou, J., Xu, L., Fang, Y., Zhang, Y., & Chu, L. (2024) · Scientific Reports · doi:10.1038/s41598-024-69172-2 · Cited by 38 · see citing works
Taei, A. A., Dargahi, L., Khodabakhsh, P., Kadivar, M., & Farahmandfar, M. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13886 · Cited by 38 · see citing works
Advances in smart delivery of magnetic field-targeted drugs in cardiovascular diseases
Wang, X., & Bai, R. (2023) · Drug Delivery · doi:10.1080/10717544.2023.2256495 · Cited by 33 · see citing works
Du, Z., Li, Y., Jiang, X., & Gao, J. (2025) · Small · doi:10.1002/smll.202410404 · Cited by 32 · see citing works
Regulatory mechanisms of tetramethylpyrazine on central nervous system diseases: A review
Liu, Y., Yang, G., Cui, W., Zhang, Y., & Liang, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.948600 · Cited by 32 · see citing works
Current Status of Mesenchymal Stem/Stromal Cells for Treatment of Neurological Diseases
Soares, M. B. P., Gonçalves, R. G. D. J., Vasques, J. F., da Silva‐Junior, A. J., Gubert, F., Santos, G. C., de Santana, T. A., Sampaio, G. L. D. A., Silva, D. N., Dominici, M., et al. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.883378 · Cited by 30 · see citing works
How neural stem cell therapy promotes brain repair after stroke
Weber, R., Rust, R., & Tackenberg, C. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102507 · Cited by 28 · see citing works
Tan, N., Xin, W., Huang, M., & Mao, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.1048113 · Cited by 28 · see citing works
Zhou, G., Cao, Y., Yan, Y., Xu, H., Zhang, X., Yan, T., & Wan, H. (2024) · Molecules · doi:10.3390/molecules29081705 · Cited by 27 · see citing works
Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions
Choi, H. K., Chen, M., Goldston, L. L., & Lee, K.-B. (2024) · Nano Convergence · doi:10.1186/s40580-024-00426-5 · Cited by 26 · see citing works
Mesenchymal Stromal Cells in Ischemic Brain Injury
Brooks, B., Ebedes, D. M., Usmani, A., Gonzales-Portillo, J. V., Gonzales-Portillo, D., & Borlongan, C. V. (2022) · Cells · doi:10.3390/cells11061013 · Cited by 26 · see citing works
Biomimetic nanoparticles in ischemic stroke therapy
Liu, Z., Xia, Q., Ma, D., Wang, Z., Li, L., Han, M. H., Yin, X., Ji, X., Wang, S., & Xin, T. (2023) · Discover Nano · doi:10.1186/s11671-023-03824-6 · Cited by 26 · see citing works
Self-citationPro-angiogenic approach for skeletal muscle regeneration
Floriano, J. F., Emanueli, C., Vega, S., Barbosa, A. M. P., de Oliveira, R. G., Floriano, E. A. F., Graeff, C. F. O., Abbade, J. F., Herculano, R. D., Sobrevía, L., et al. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2021.130059 · Cited by 25 · see citing works
Hajinejad, M., & Negah, S. S. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30495 · Cited by 24 · see citing works
Yabuno, S., Yasuhara, T., Nagase, T., Kawauchi, S., Sugahara, C., Okazaki, Y., Hosomoto, K., Sasada, S., Sasaki, T., Tajiri, N., et al. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03236-4 · Cited by 24 · see citing works
Mesenchymal stromal cells to fight SARS-CoV-2: Taking advantage of a pleiotropic therapy
Barros, I., Silva, A., de Almeida, L. P., & Miranda, C. O. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.12.002 · Cited by 22 · see citing works
BDNF-overexpressing MSCs delivered by hydrogel in acute ischemic stroke treatment
Wang, C., Tian, C., Cai, D., Jiang, H., Zhang, W., Liu, S., Peng, L., & Hu, X. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-5921 · Cited by 22 · see citing works
Zhang, W., Pu, H., Hu, X., Shi, Y., Leak, R. K., Stetler, R. A., Ye, Q., Lyu, J., Zhang, F., Wechsler, L. R., et al. (2023) · Stroke · doi:10.1161/strokeaha.122.041507 · Cited by 22 · see citing works
Research progress and challenges of stem cell therapy for ischemic stroke
Cha, Z., Qiao, Y., Lu, Q., Wang, Q., Lu, X., Zhou, H., & Li, T. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1410732 · Cited by 22 · see citing works
Stroke: Epidemiology, Risk Factors, Signaling Pathways, and Clinical Management
Ren, H., Liu, Y., Zhao, M., Shen, H., Nie, S., Gao, X., & Huang, Y. (2025) · MedComm · doi:10.1002/mco2.70558 · Cited by 21 · see citing works
Behzadifard, M., Aboutaleb, N., Dolatshahi, M., Khorramizadeh, M., Jahangiri, H. M., Kord, Z., & Nazarinia, D. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03848-x · Cited by 20 · see citing works
Riedel, R. N., Pérez‐Pérez, A., Sánchez‐Margalet, V., Varone, C. L., & Maymó, J. L. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02216-w · Cited by 20 · see citing works
Yang, J., Wang, J., & Saeed, Y. (2022) · Stem Cells International · doi:10.1155/2022/5930244 · Cited by 19 · see citing works
Recent advances in biomaterial-assisted cell therapy
Chen, Y., Pal, S., & Hu, Q. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00583b · Cited by 19 · see citing works
Wang, Y., Yuan, T., Lyu, T., Zhang, L., Wang, M., He, Z., Wang, Y., & Li, Z. (2024) · Neural Regeneration Research · doi:10.4103/1673-5374.393104 · Cited by 19 · see citing works
Xu, J., Zhang, Y., Liu, Y., You, Y., Li, F., Chen, Y., Xie, L., Tong, S., Zhou, S., Liang, K., et al. (2022) · Small · doi:10.1002/smll.202203431 · Cited by 18 · see citing works
Clinical experience: Outcomes of mesenchymal stem cell transplantation in five stroke patients
Erçelen, N., Karasu, N., Kahyaoglu, B., Çerezci, Ö., Akduman, R. C., Ercelen, D., Erturk, G., Gulay, G. R., Alpaydin, N., Boyraz, G., et al. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1051831 · Cited by 18 · see citing works
Nazarinia, D., Sharifi, M., Dolatshahi, M., Maleki, S. N., Neishaboori, A. M., & Aboutaleb, N. (2021) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2021.101918 · Cited by 18 · see citing works
Tang, H., Zhang, X., Hao, X., Dou, H., Zou, C., Zhou, Y., Li, B., Yue, H., Wang, D., Wang, Y., et al. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03251-5 · Cited by 17 · see citing works
Markowska, A., Koziorowski, D., & Szlufik, S. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2810269 · Cited by 17 · see citing works
Hegde, M., Singh, A. K., Kannan, S., Kolkundkar, U., & Seetharam, R. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10787-3 · Cited by 17 · see citing works
Functional material-mediated wireless physical stimulation for neuro-modulation and regeneration
Li, J., Wu, C., Zeng, M., Zhang, Y., Wei, D., Sun, J., & Fan, H. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01354e · Cited by 14 · see citing works
Self-citationAderinto, N., Olatunji, G. D., Kokori, E., Babalola, A. E., Yusuf, I. A., Apampa, O. O., Ukoaka, B. M., Aboje, J. E., Oluwakorede, A. T., Moradeyo, A. A., et al. (2024) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-024-00851-7 · Cited by 14 · see citing works
Astrocytes: Therapeutic targets for stroke
Li, J., Gao, K., Wang, L., Wang, J., Qin, M., Wang, X., Lian, K., Li, C., Gao, S., & Sun, C. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01062 · Cited by 14 · see citing works
Self-citationXu, J., Sun, Y., You, Y., Zhang, Y., Huang, D., Zhou, S., Liu, Y., Tong, S., Ma, F., Song, Q., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.11.009 · Cited by 12 · see citing works
Mesenchymal Stromal Cell Therapy in Spinal Cord Injury: Mechanisms and Prospects
Xie, J., Wang, X.-R., Li, M., Tao, Z.-H., Teng, W.-W., & Saijilafu (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.862673 · Cited by 12 · see citing works
Yan, Q., Yin, Y., Li, X., & Li, M. (2023) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2023.102309 · Cited by 11 · see citing works
Xu, S., Zhong, A., Zhang, Y., Zhao, L., Guo, Y., Bai, X., Yin, P., & Hua, S. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114619 · Cited by 11 · see citing works
Effect of mesenchymal stem cell-derived exosomes on the inflammatory response after stroke
Beylerli, O., Фанилевич, Г. И., Shi, H., & Ilyasova, T. (2024) · Brain Hemorrhages · doi:10.1016/j.hest.2024.04.003 · Cited by 11 · see citing works
Zhang, Y., Yang, Q., Cheng, H., Zhang, Y., Xie, Y., & Zhang, Q. (2024) · Scientific Reports · doi:10.1038/s41598-024-78717-4 · Cited by 11 · see citing works
Self-citationSchirò, G., & Balistreri, C. R. (2021) · Vascular Pharmacology · doi:10.1016/j.vph.2021.106951 · Cited by 11 · see citing works
Li, Y., Zhong, W., & Tang, X. (2021) · Stem Cells International · doi:10.1155/2021/9929128 · Cited by 12 · see citing works
Huang, H., Zhang, J., Lin, J., & Shi, S. (2024) · BMC Neurology · doi:10.1186/s12883-024-03542-1 · Cited by 10 · see citing works
Mesenchymal stromal cell therapies for traumatic neurological injuries
Wang, X., Wang, Q., Xia, Z., Yang, Y., Dai, X., Zhang, C., Wang, J., & Xu, Y. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05725-3 · Cited by 10 · see citing works
Hypoxia and interleukin-1-primed mesenchymal stem/stromal cells as novel therapy for stroke
Salaudeen, M. A., Allan, S. M., & Pinteaux, E. (2023) · Human Cell · doi:10.1007/s13577-023-00997-1 · Cited by 9 · see citing works
Mechanisms of Action of Propofol in Modulating Microglial Activation in Ischemic Stroke
Abdolmohammadi, P., Bietar, B., Zhou, J., & Lehmann, C. (2025) · Molecules · doi:10.3390/molecules30132795 · Cited by 9 · see citing works
Nanoparticle and Stem Cell Combination Therapy for the Management of Stroke
Salatin, S., Farhoudi, M., Sadigh‐Eteghad, S., & Farjami, A. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612829666221213113119 · Cited by 9 · see citing works
Shu, Y., Shen, H., Yao, M., Shen, J., Yang, G., Chen, H., Tang, Y., & Ma, M. (2023) · Smart Medicine · doi:10.1002/smmd.20220037 · Cited by 9 · see citing works
Saleh, R. O., Majeed, A. A., Margiana, R., Alkadir, O. K. A., Almalki, S. G., Ghildiyal, P., Samusenkov, V. O., Jabber, N. K., Mustafa, Y. F., & Elawady, A. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.3957 · Cited by 9 · see citing works
León-Moreno, L. C., Reza-Zaldívar, E. E., Hernández-Sapiéns, M. A., Villafaña-Estarrón, E., García-Martín, M. C., Ojeda-Hernández, D. D., Matías‐Guiu, J. A., Gómez‐Pinedo, U., Matías‐Guiu, J., & Canales-Aguirre, A. A. (2023) · Biomolecules · doi:10.3390/biom14010008 · Cited by 7 · see citing works
Cherkashova, E. A., Namestnikova, D. D., Gubskiy, I. L., Revkova, V. A., Sukhinich, K. K., Melnikov, P., Abakumov, M. A., Савина, Г. Д., Chekhonin, V. P., Gubsky, L. V., et al. (2023) · Life · doi:10.3390/life13020288 · Cited by 7 · see citing works
Extracellular Vesicles as Therapeutic Strategy for Ischemic Stroke
da Silva, E. A., Figueiredo, J. C. Q., Rossi, E. A., Cunha, R. S., Sanches, F. S., de Lima, A. V. R., Loiola, E. C., Costa‐Ferro, Z. S. M., & Souza, B. S. D. F. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70311 · Cited by 6 · see citing works
Yi, L., Qu, Y., Zhang, Q., Shi, S., Li, F., Qu, C., Tang, Y., Wen, S., & Pan, Y. (2024) · Stem Cells · doi:10.1093/stmcls/sxae062 · Cited by 6 · see citing works
Self-citationDual-Double Stem Cell Ovarian Therapy: A Comprehensive Approach in Regenerative Medicine
Ljubić, A., Dinić, M., Švraka, D., & Vujović, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010069 · Cited by 6 · see citing works
Chen, W., Ren, Q., Zhou, J., & Liu, W. (2024) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-023-04752-y · Cited by 6 · see citing works
He, Q., Zhou, T., & He, Q. (2025) · Brain Sciences · doi:10.3390/brainsci15070759 · Cited by 5 · see citing works
Tang, X., Zheng, N., Lin, Q., You, Y., Gong, Z., Zhuang, Y., Wu, J., Wang, Y., Huang, H., Ke, J., et al. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01922 · Cited by 5 · see citing works
Nanomedicine-Mediated Stem Cell Therapeutics in Stroke
Sangwan, N., & Avti, P. (2022) · Springer eBooks · doi:10.1007/978-981-16-8562-0_7 · Cited by 5 · see citing works
Xue, C., Yu, H., Sun, Y., Wang, X., Pei, X., Chen, Y., & Guan, Y. (2024) · Current Stem Cell Research & Therapy · doi:10.2174/011574888x305349240511125540 · Cited by 5 · see citing works
Wang, J., Zhao, J., & Li, S. (2021) · Journal of Neurorestoratology · doi:10.26599/jnr.2021.9040012 · Cited by 5 · see citing works
Self-citationImaging technology in tracking the intravital fate of transplanted stem cells
Shen, L., Li, C., Li, Y., Guan, X., Zou, W., & Liu, J. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107752 · Cited by 4 · see citing works
Kumarapuram, S., Fu, A. Y., Abramyan, A. A., Sreenivasan, S. A., Bhaskar, A., Xu, S., Quraishi, S., Satti, M., Rybinnik, I., Roychowdhury, S., et al. (2025) · Brain Circulation · doi:10.4103/bc.bc_119_24 · Cited by 3 · see citing works
Ma, X., Liu, C., Yang, Y., Ren, L., Xu, Y., Li, J., & Wang, P. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149974 · Cited by 3 · see citing works
Self-citationMohamed, G., Lench, D. H., Grewal, P., Rosenberg, M., & Voeks, J. H. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1419867 · Cited by 3 · see citing works
Грабовий, О. М., Mervinsky, T. S., Savosko, S. I., & Yaremenko, L. M. (2024) · Reports of Morphology · doi:10.31393/morphology-journal-2024-30(3)-03 · Cited by 3 · see citing works
Bai, X., Wang, H., Li, J., Xu, J., & Cai, P. (2024) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.40.11.9563 · Cited by 3 · see citing works
Self-citationDumot, C., Po, C., Capin, L., Hubert, V., Ong, E., Chourrout, M., Bolbos, R. I., Amaz, C., Auxenfans, C., Canet‐Soulas, E., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-08713-z · Cited by 3 · see citing works
Pan, K., Peng, Q., Huang, Z., Dong, Z., Lin, W., & Wang, Y. (2023) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2023.107199 · Cited by 3 · see citing works
From Bench to Bedside: The Evolving Landscape of Stem Cell Therapies for Stroke Rehabilitation
Waszczuk, D., Manikandan, S., Manikandan, V., Stone, E., Buehre, S., Shore, S., Panchatcharam, M., & Miriyala, S. (2025) · Stem Cells International · doi:10.1155/sci/3734659 · Cited by 2 · see citing works
Mesenchymal stem cells and the central nervous system: historical perspectives and future directions
Mazurek, C. Y., Kaniuk, J. K., & Ahuja, C. S. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1742864 · Cited by 2 · see citing works
Konovalov, S. V., Мороз, В. М., Yoltukhovskii, M. V., Gadzhula, N. G., Deryabina, О. G., & Арнольдович, К. В. (2024) · Cell and Organ Transplantology · doi:10.22494/cot.v11i2.169 · Cited by 2 · see citing works
Stroke with White Matter Lesions: Potential Pathophysiology and Therapeutic Targets
Peng, X., Mei, Z., Luo, Z., & Jin-wen, G. (2025) · British Journal of Hospital Medicine · doi:10.12968/hmed.2024.0771 · Cited by 2 · see citing works
Sirtuins Contribute to the Migraine–Stroke Connection
Krekora, J., Fila, M., Mitus-Kenig, M., Pawłowska, E., Ciupińska, J., & Błasiak, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146634 · Cited by 1 · see citing works
Stem Cells Run Like Clockwork for Stroke Therapeutics
Bourgade, P. A., Putthanbut, N., Lee, J.-Y., & Borlongan, C. V. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10895-8 · Cited by 1 · see citing works
Advanced regenerative biomaterials for ischaemic stroke: a comprehensive therapeutic strategy
Niu, S., Liu, X., Wu, Z., Zhu, A., Zhang, Y., Hu, F., Ding, K., Wu, J., & Xiao, A. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb01227a · Cited by 1 · see citing works
Wang, P., Huang, Y., Ma, Q., Zhou, Y., Wang, X., Yang, L., & Meng, T. (2026) · Neurotoxicity Research · doi:10.1007/s12640-026-00781-7 · Cited by 1 · see citing works
Cui, L., Xiao, M., Zhang, Q., Liu, H., Ren, Y., Ma, G., Zhou, D., Ma, Q., Yao, H., Lin, M. V., et al. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.102836 · Cited by 1 · see citing works
Self-citationStem cell therapy for stroke: mechanisms, clinical translation, and future perspectives
Xia, Y., Jin, J., Song, L., Hu, Z., Wang, J., Meng, T., & Zhuang, J. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1801759 · Cited by 1 · see citing works
Danuaji, R., Hambarsari, Y., Hamidi, B. L., Hutabarat, E. A. J., Tedjo, R. A. A., Fairuzya, A. F., & Savitri, M. O. D. (2024) · Jurnal kedokteran dan kesehatan Indonesia · doi:10.20885/jkki.vol15.iss1.art15 · Cited by 1 · see citing works
Primak, A. L., Никитична, С. М., Станиславович, Д. С., Va, T., & Karagyaur, M. N. (2024) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-024-01648-0 · Cited by 1 · see citing works
Konovalov, S. V., Мороз, В. М., Yoltukhivskyy, M., & Gadzhula, N. G. (2024) · Bulletin Of Medical And Biological Research · doi:10.61751/bmbr/2.2024.16 · Cited by 1 · see citing works
Konovalov, S. V., Мороз, В. М., Yoltukhovskii, M. V., & Gadzhula, N. G. (2024) · Reports of Vinnytsia National Medical University · doi:10.31393/reports-vnmedical-2024-28(3)-04 · Cited by 1 · see citing works
Wang, W., Wang, Y., Tang, Z., Chen, Y., Liu, Z., Duan, H., Zhong, Z., & He, F. (2021) · Research Square · doi:10.21203/rs.3.rs-461062/v1
Self-citation
- Authors
- Li, J., Zhang, Q., Wang, W., Lin, F., Wang, S., & Zhao, J.
- Affiliations
- Capital Medical University (CN)
- Corresponding author
- Zhao, Jizong
- Venue
- Journal of Neurology
- Published
- 2020-08-06
- Volume
- 268
- Issue
- 11
- Pages
- 4095-4107
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W3047476089
- Cited by
- 128
- References
- 171
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 32 · 2023: 31 · 2022: 15 · 2021: 17 · 2020: 3
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- mesenchymal stem cells, ischemic stroke, cell transplantation, nerve regeneration, angiogenesis, immunomodulation, neuroprotection, paracrine signaling, neurotrophic factors, functional recovery, timing of transplantation, clinical trials
- MeSH terms
- Ischemic Stroke, Brain Ischemia, Humans, Stroke, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells
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