Cited by 129Mesenchymal stem cell researchStroke Rehabilitation and RecoveryAcute Ischemic Stroke Management

Mesenchymal stem cell therapy for ischemic stroke: A look into treatment mechanism and therapeutic potential

Li, Junsheng, Zhang, Qian, Wang, Wen, Lin, Fa, Wang, Shuo, Zhao, Jizong·2021·Journal of Neurology

Abstract

Stroke, a global disease with a high disability rate, has limited options for functional rehabilitation and results in an adverse impact on patients' lives. In recent years, mesenchymal stem cells (MSCs) have become a new focus of treatment owing to their potential for neuroregeneration. MSCs have demonstrated therapeutic efficacy capable of cell migration, angiogenesis, immunomodulation, neuroprotection and neural circuit reconstruction. The paracrine action of MSCs can also exert neurotrophic effects and improve the functional recovery. This review shows the transplantation protocol for MSCs, discusses the potential therapeutic mechanisms, and summarizes clinical trials on MSCs for treating ischemic stroke. The current proofs show that MSC therapy for ischemic stroke is safe and feasible. The timing and optimal dose of MSC administration are the main challenges in its clinical use. Although still under research, MSC therapy has the potential to be a new therapeutic approach for neurological recovery from ischemic stroke in the future.

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Crossref · 10.1007/s00415-020-10138-5

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168 of 168 references verified0 citation errors · 0 not checkable

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  • A growing body of research has illuminated the therapeutic potential of EVs derived from diverse cell types, including MSCs, iPSCs, brain-derived NSCs, ESCs, and dendritic cells.

    “A growing body of research has illuminated the therapeutic potential of EVs derived from a diverse array of cell types [207, 208]. This includes MSCs [209–211], iPSCs [212], brain-derived NSCs [213], embryonic stem cells (ESCs) [214], and dendritic cells (DC) [215].”

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Authors
Li, J., Zhang, Q., Wang, W., Lin, F., Wang, S., & Zhao, J.
Affiliations
Capital Medical University (CN)
Corresponding author
Zhao, Jizong
Venue
Journal of Neurology
Published
2020-08-06
Volume
268
Issue
11
Pages
4095-4107
ISSN
  • 0012-1037 (ISSN-L)
  • 0340-5354
  • 1432-1459
OpenAlex
W3047476089
Cited by
128
References
171
Citations by year
2026: 12 · 2025: 18 · 2024: 32 · 2023: 31 · 2022: 15 · 2021: 17 · 2020: 3
FWCI
2.45
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords
mesenchymal stem cells, ischemic stroke, cell transplantation, nerve regeneration, angiogenesis, immunomodulation, neuroprotection, paracrine signaling, neurotrophic factors, functional recovery, timing of transplantation, clinical trials
MeSH terms
Ischemic Stroke, Brain Ischemia, Humans, Stroke, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells

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