The DOI matches its Crossref record; 46 of the 47 references it cites were found in a registry or an index.
Glucocorticoid action networks and complex psychiatric and/or somatic disorders
Open accessAbstract
Glucocorticoids contribute fundamentally to the maintenance of basal and stress-related homeostasis in all higher organisms. These hormones influence a large percentage of the expressed human genome and their effects spare almost no organs or tissues. Glucocorticoids influence many functions of the central nervous system, such as arousal, cognition, mood and sleep, the activity and direction of intermediary metabolism, the maintenance of a normal cardiovascular tone, the activity and quality of the immune and inflammatory reaction, including the manifestations of the sickness syndrome, as well as growth and reproduction. The numerous actions of glucocorticoids are mediated by a set of at least 16 glucocorticoid receptor (GR) isoforms forming homo- or hetero-dimers. The GRs consist of multifunctional domain proteins operating as ligand-dependent transcription factors that interact with many other cell signaling systems. The presence of multiple GR monomers and dimers expressed in a cell-specific fashion at different quantities with quantitatively and qualitatively different transcriptional activities suggests that the glucocorticoid signaling system is highly stochastic. Based on ample evidence, we present our conception that glucocorticoids are heavily involved in human pathophysiology and influence life expectancy. Common psychiatric and/or somatic complex disorders, such as anxiety, depression, insomnia, chronic pain and fatigue syndromes, obesity, the metabolic syndrome, essential hypertension, diabetes type 2, atherosclerosis with its cardiovascular sequelae, and osteoporosis, as well as autoimmune inflammatory and allergic disorders, all appear to have a glucocorticoid component.
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“Because the hypothalamic-pituitary-adrenal (HPA) axis regulates a wide range of physiologic processes and is affected by experimental sleep restriction, it is a putative key mediator of the adverse health effects of insufficient sleep (3–11).”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [11]
In the citing paper
“Because the hypothalamic-pituitary-adrenal (HPA) axis regulates a wide range of physiologic processes and is affected by experimental sleep restriction, it is a putative key mediator of the adverse health effects of insufficient sleep (3–11).”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [11]
In the citing paper
“Because the hypothalamic-pituitary-adrenal (HPA) axis regulates a wide range of physiologic processes and is affected by experimental sleep restriction, it is a putative key mediator of the adverse health effects of insufficient sleep (3–11).”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [11]
In the citing paper
“The increase in evening cortisol levels indicates that insufficient sleep may have an impact on the multitude of physiological processes modulated by circulating glucocorticoids (11).”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [11]
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Metadata
- Authors
- Chrousos, G. P., & Kino, T.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Chrousos, George P.
- Venue
- Stress
- Publisher
- Informa UK Limited
- Published
- 2007-01
- Volume
- 10
- Issue
- 2
- Pages
- 213-219
- ISSN
- 1025-3890 (ISSN-L)
- 1607-8888
- OpenAlex
- W2117077354
- Cited by
- 292
- References
- 47
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 6 · 2023: 10 · 2022: 12 · 2021: 15 · 2020: 15 · 2019: 8 · 2018: 15 · 2017: 11 · 2016: 13 · 2015: 16 · 2014: 18 · 2013: 21 · 2012: 20
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stress (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Child Health and Human Development
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- glucocorticoids, glucocorticoid receptor isoforms, glucocorticoid signaling, mental illness, somatic diseases, anxiety, depression, insomnia, chronic pain, fatigue syndrome, obesity, metabolic syndrome, essential hypertension, type 2 diabetes, atherosclerosis, osteoporosis, allergic diseases, transcriptional regulation, life expectancy
- MeSH terms
- Mental Disorders, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Receptors, Glucocorticoid, Stress, Psychological, Metabolic Syndrome
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