The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Immune System Stimulation by Probiotic Microorganisms
Abstract
Probiotic organisms are claimed to offer several functional properties including stimulation of immune system. This review is presented to provide detailed informations about how probiotics stimulate our immune system. Lactobacillus rhamnosus GG, Lactobacillus casei Shirota, Bifidobacterium animalis Bb-12, Lactobacillus johnsonii La1, Bifidobacterium lactis DR10, and Saccharomyces cerevisiae boulardii are the most investigated probiotic cultures for their immunomodulation properties. Probiotics can enhance nonspecific cellular immune response characterized by activation of macrophages, natural killer (NK) cells, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in strain-specific and dose-dependent manner. Mixture and type (gram-positive and gram-negative) of probiotic organisms may induce different cytokine responses. Supplementation of probiotic organisms in infancy could help prevent immune-mediated diseases in childhood, whereas their intervention in pregnancy could affect fetal immune parameters, such as cord blood interferon (IFN)-γ levels, transforming growth factor (TGF)-β1 levels, and breast milk immunoglobulin (Ig)A. Probiotics that can be delivered via fermented milk or yogurt could improve the gut mucosal immune system by increasing the number of IgA(+) cells and cytokine-producing cells in the effector site of the intestine.
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Citations
Cites
Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
Artis, D. (2008) · Nature reviews. Immunology · doi:10.1038/nri2316 · Cited by 1,136 · cited 1×
“The role of maintaining the homeostatic balance between tolerance and immunity is crucially played by the intestinal epithelial cells (Artis, 2008).”
BackgroundProbiotics: effects on immunity
Isolauri, E., Sütas, Y., Kankaanpää, P., Arvilommi, H., & Salminen, S. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.444s · Cited by 1,019
Probiotics: an overview of beneficial effects
Ouwehand, A. C., Salminen, S., & Isolauri, E. (2002) · Antonie van Leeuwenhoek · doi:10.1023/a:1020620607611 · Cited by 1,013
Modulation of natural killer cell activity by viruses
Lisnić, V. J., Krmpotić, A., & Jonjić, S. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.05.011 · Cited by 1,003
The interface between innate and adaptive immunity
Hoebe, K., Janssen, E., & Beutler, B. (2004) · Nature Immunology · doi:10.1038/ni1004-971 · Cited by 916
Christensen, H. R., Frøkiær, H., & Pestka, J. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.1.171 · Cited by 902
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Functional cultures and health benefits
Shah, N. P. (2007) · International Dairy Journal · doi:10.1016/j.idairyj.2007.01.014 · Cited by 787
Self-citationKaila, M., Isolauri, E., Soppi, E., Virtanen, E., Laine, S., & Arvilommi, H. (1992) · Pediatric Research · doi:10.1203/00006450-199208000-00002 · Cited by 700
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Cited by
Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health
Mazziotta, C., Tognon, M., Martini, F., Torreggiani, E., & Rotondo, J. C. (2023) · Cells · doi:10.3390/cells12010184 · Cited by 889
Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview
Piqué, N., Berlanga, M., & Miñana-Galbis, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102534 · Cited by 642
Savignac, H. M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12427 · Cited by 418
Probiotics modulate gut microbiota and improve insulin sensitivity in DIO mice
Bagarolli, R. A., Tobar, N., Oliveira, A. G., Araújo, T. G., Carvalho, B. M., Rocha, G. Z., Vecina, J. F., Calisto, K., Guadagnini, D., Prada, P. O., et al. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.08.006 · Cited by 266
Lactobacillus rhamnosus GG: An Overview to Explore the Rationale of Its Use in Cancer
Banna, G. L., Torino, F., Marletta, F., Santagati, M., Salemi, R., Cannarozzo, E., Falzone, L., Ferraù, F., & Libra, M. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00603 · Cited by 150
Metadata
- Authors
- Ashraf, R., & Shah, N. P.
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2014-01
- Volume
- 54
- Issue
- 7
- Pages
- 938-956
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W2049290211
- Cited by
- 549
- References
- 120
- FWCI
- 21.25
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
