Cited by 156Advanced Glycation End Products researchPhytochemicals and Antioxidant ActivitiesAlzheimer's disease research and treatments

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Dietary polyphenols: regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases

Li, Yueqin, Peng, Yao, Shen, Yingbin, Zhang, Yunzhen, Liu, Lianliang, Yang, Xinquan·2023·Critical Reviews in Food Science and Nutrition

DOI 10.1080/10408398.2022.2076064

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Abstract

Advanced glycation end products (AGEs) are formed in non-enzymatic reaction, oxidation, rearrangement and cross-linking between the active carbonyl groups of reducing sugars and the free amines of amino acids. The Maillard reaction is related to sensory characteristics in thermal processed food, while AGEs are formed in food matrix in this process. AGEs are a key link between carbonyl stress and neurodegenerative disease. AGEs can interact with receptors for AGEs (RAGE), causing oxidative stress, inflammation response and signal pathways activation related to neurodegenerative diseases. Neurodegenerative diseases are closely related to gut microbiota imbalance and intestinal inflammation. Polyphenols with multiple hydroxyl groups showed a powerful ability to scavenge ROS and capture α-dicarbonyl species, which led to the formation of mono- and di- adducts, thereby inhibiting AGEs formation. Neurodegenerative diseases can be effectively prevented by inhibiting AGEs production, and interaction with RAGEs, or regulating the microbiota-gut-brain axis. These strategies include polyphenols multifunctional effects on AGEs inhibition, RAGE-ligand interactions blocking, and regulating the abundance and diversity of gut microbiota, and intestinal inflammation alleviation to delay or prevent neurodegenerative diseases progress. It is a wise and promising strategy to supplement dietary polyphenols for preventing neurodegenerative diseases via AGEs-RAGE axis and microbiota-gut-brain axis regulation.

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Authors: Li, Y., Peng, Y., Shen, Y., Zhang, Y., Liu, L., & Yang, X.
Affiliations: Ningbo University (CN)
Guangzhou University (CN)
Corresponding author: Liu, Lianliang
Yang, Xinquan
ORCID: Li, Yueqin
Zhang, Yunzhen
Liu, Lianliang
Venue: Critical Reviews in Food Science and Nutrition
Publisher: Informa UK Limited
Published: 2022-05-19
Volume: 63
Issue: 29
Pages: 9816-9842
ISSN: 1040-8398 (ISSN-L)
1549-7852
DOI: 10.1080/10408398.2022.2076064
OpenAlex: W4280616897
Cited by: 156
References: 256
Citations by year: 2026: 24 · 2025: 42 · 2024: 29 · 2023: 58 · 2022: 3
FWCI: 22.93
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Food Science and Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (32172210)
Zhejiang Provincial Natural Science Foundation (LY21C200005)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: dietary polyphenols, advanced glycation end products, RAGE, Maillard reaction, neurodegenerative diseases, gut microbiota, microbiota-gut-brain axis, oxidative stress, intestinal inflammation, AGE formation inhibition, dietary supplementation
MeSH terms: Brain-Gut Axis, Humans, Inflammation, Glycation End Products, Advanced, Dietary Supplements, Neurodegenerative Diseases, Polyphenols

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Dietary polyphenols: regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases

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