Fasting and metabolic syndrome: A systematic review and Meta-analyses
Abstract
Objective: Fasting is considered to be a food structure that can improve body health. Several randomized clinical trials (RCTs) have investigated the effects of fasting in patients with metabolic syndrome (MS). In this review, we performed a meta-analysis to assess the effects of fasting on patients with MS. Methods : Following PRISMA guidelines, a systematic literature search was conducted in PubMed, Embase, and Cochrane Central updated to September 2021. The quality evaluation and heterogeneity detection of the included research literature were carried out by Revman and Stata software through a random-effects model. Results : A total of 268 subjects were included. The pooled results revealed that fasting significantly reduced body weight (WMD: -2.48 kg, 95% CI: -3.22, -1.74), BMI (WMD = -2.72 cm; 95%CI: -4.04, -1.40 cm), body fat percent (WMD: -1.57%, 95%CI: -2.47, -0.68), insulin level (WMD: -2.45 mmol/L; 95%CI: -4.40, -0.49 mmol/L) and HOMA-IR (WMD:-0.65 mmol/L; 95%CI: -0.90, -0.41 mmol/L) in patients with MS, whereas had no effect on glucose, blood pressure and lipids profile. Conclusions : Our findings provide insights into the effect of fasting on the anthropometric outcomes, insulin resistance, and gut microbiota in MS.
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Some studies indicate that IER, including TRE, can reduce HOMA-IR and fasting insulin levels in overweight individuals or those with metabolic syndrome.
“Some studies indicate that IER, including TRE, can reduce HOMA-IR and fasting insulin levels in overweight individuals or those with metabolic syndrome [87–89].”
From Comparing caloric restriction regimens for effective weight management in adults: a systematic review and network meta-analysis (2024) · cites this paper as [88]
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Huang, J., Li, Y., Chen, M., Cai, Z., Cai, Z., & Jiang, Z. (2024) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-024-01657-9 · Cited by 25 · see citing works
- Authors
- Li, X., Nian, B., Li, R., Cao, X., Liu, Y., Liu, Y., & Xu, Y.-J.
- Affiliations
- Jiangnan University (CN)
- Corresponding author
- Liu, Yuanfa
- Xu, Yong-Jiang
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2022-09-07
- Volume
- 64
- Issue
- 7
- Pages
- 1836-1844
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W4294868104
- Cited by
- 5
- References
- 7
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (32172136)
- Jiangsu distinguished professor project and Talent plan of Taihu Lake
- Topics
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- fasting, metabolic syndrome, weight loss, body mass index, body fat percentage, insulin resistance, HOMA-IR, insulin levels, anthropometric outcomes, blood pressure, lipid profile, blood glucose
- MeSH terms
- Blood Glucose, Body Weight, Fasting, Humans, Insulin, Insulin Resistance, Metabolic Syndrome
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