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Cited by 947Dietary Effects on HealthNutritional Studies and DietDiet and metabolism studies

Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome

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Wilkinson, Michael J., Manoogian, Emily N.C., Zadourian, Adena, Lo, Hannah, Fakhouri, Savannah, Shoghi, Azarin, Wang, Xinran, Fleischer, Jason G. +3 more·2020·Cell Metabolism
DOI 10.1016/j.cmet.2019.11.004PMC PMC6953486
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Abstract

In animal models, time-restricted feeding (TRF) can prevent and reverse aspects of metabolic diseases. Time-restricted eating (TRE) in human pilot studies reduces the risks of metabolic diseases in otherwise healthy individuals. However, patients with diagnosed metabolic syndrome often undergo pharmacotherapy, and it has never been tested whether TRE can act synergistically with pharmacotherapy in animal models or humans. In a single-arm, paired-sample trial, 19 participants with metabolic syndrome and a baseline mean daily eating window of ≥14 h, the majority of whom were on a statin and/or antihypertensive therapy, underwent 10 h of TRE (all dietary intake within a consistent self-selected 10 h window) for 12 weeks. We found this TRE intervention improves cardiometabolic health for patients with metabolic syndrome receiving standard medical care including high rates of statin and anti-hypertensive use. TRE is a potentially powerful lifestyle intervention that can be added to standard medical practice to treat metabolic syndrome. VIDEO ABSTRACT.

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  • Recent human trials on TRE have highlighted numerous beneficial metabolic effects of TRE, e.g., improved mean daily glucose levels, fasting glucose levels, insulin resistance or insulin sensitivity, triglyceride levels, total cholesterol, and LDL cholesterol levels.

    “Recent human trials on TRE have highlighted numerous beneficial metabolic effects of TRE, e.g., improved mean daily glucose levels (107, 108), fasting glucose levels (108–110), insulin resistance (108, 110, 111) or insulin sensitivity (112, 113), triglyceride levels (107, 109, 114, 115), total cholesterol (115, 116), and LDL cholesterol levels (116).”

    From Meal timing and its role in obesity and associated diseases (2024) · cites this paper as [116]

  • The presence of metabolic syndrome increases the risk of developing cardiovascular diseases twofold.

    “The presence of MetS increases the risk of developing cardiovascular diseases (CVDs) twofold, and the risk of all-cause mortality by a factor of 1.5 [2, 3].”

    From Machine learning with the body roundness index and associated indicators: a new approach to predicting metabolic syndrome (2025) · cites this paper as [3]

  • The presence of metabolic syndrome increases the risk of all-cause mortality by a factor of 1.5.

    “The presence of MetS increases the risk of developing cardiovascular diseases (CVDs) twofold, and the risk of all-cause mortality by a factor of 1.5 [2, 3].”

    From Machine learning with the body roundness index and associated indicators: a new approach to predicting metabolic syndrome (2025) · cites this paper as [3]

    The Introduction says metabolic syndrome doubles CVD risk and that treating it matters for reducing mortality from T2DM and CVD. It does not give an all-cause mortality risk or the claimed 1.5-fold figure. Searches for all-cause mortality and a 1.5-fold mortality risk found no supporting passage in our copy. (LLM, conf=0.72)

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Authors
Wilkinson, M. J., Manoogian, E. N. C., Zadourian, A., Lo, H., Fakhouri, S., Shoghi, A., Wang, X., Fleischer, J. G., Navlakha, S., Panda, S., & Taub, P. R.
Affiliations
  • University of California San Diego (US)
  • Salk Institute for Biological Studies (US)
Corresponding author
  • Panda, Satchidananda
  • Taub, Pam R.
ORCID
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2020-01
Volume
31
Issue
1
Pages
92-104.e5
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2019.11.004
PMC
PMC6953486
OpenAlex
W2992787906
Cited by
927
References
46
Citations by year
2026: 121 · 2025: 150 · 2024: 143 · 2023: 124 · 2022: 158 · 2021: 125 · 2020: 102 · 2019: 2 · 2012: 1
FWCI
66.37
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • American Ceramic Circle
  • Amgen
  • National Institutes of Health (DK115214, DK118278)
  • Novo Nordisk
  • Merck
  • U.S. Department of Defense (W81XWH1810645)
  • American College of Cardiology Foundation
  • U.S. Department of Homeland Security (EMW-2016-FP-00788)
  • Leona M. and Harry B. Helmsley Charitable Trust (2012-PG-MED002)
  • University of California, San Diego
  • Larry L. Hillblom Foundation
  • Robert Wood Johnson Foundation
Topics
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
Keywords
time-restricted eating, metabolic syndrome, weight loss, blood pressure, atherogenic lipids, statin therapy, antihypertensive therapy, cardiometabolic health, lifestyle intervention
MeSH terms
Antihypertensive Agents, Blood Cell Count, Blood Glucose, Blood Pressure, Body Weight, Circadian Rhythm, Diabetes Mellitus, Type 2, Fasting, Female, Follow-Up Studies, Humans, Lipids, Male, Middle Aged, Obesity, Sleep, Exercise, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Metabolic Syndrome, Lipid Metabolism

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