Cited by 742Per- and polyfluoroalkyl substances researchPeroxisome Proliferator-Activated ReceptorsCarcinogens and Genotoxicity Assessment

The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.

The Toxicology of Perfluorooctanoate

Kennedy, Gerald L., Butenhoff, John L., Olsen, Geary W., O'Connor, John C., Seacat, Andrew M., Perkins, Roger G., Biegel, Lisa B., Murphy, Sandra R., Farrar, David G.·2004·Critical Reviews in Toxicology

DOI 10.1080/10408440490464705

Open this paper in CoChat — free account

Abstract

PFOA is a peroxisome proliferator (PPAR agonist) and exerts morphological and biochemical effects characteristic of PPAR agonists. These effects include increased beta-oxidation of fatty acids, increases in several cytochrome P-450 (CYP450)-mediated reactions, and inhibition of the secretion of very low-density lipoproteins and cholesterol from the liver. These effects on lipid metabolism and transport result in a reduction of cholesterol and triglycerides in serum and an accumulation of lipids in the liver. The triad of tumors observed (liver, Leydig cell, and pancreatic acinar-cell) is typical of many PPAR agonists and is believed to involve nongenotoxic mechanisms. The hepatocellular tumors observed in rats are likely to have been the result of the activation of the peroxisome proliferator activated receptor alpha (PPARalpha). The tumors observed in the testis (Leydig-cell) have been hypothesized to be associated with an increased level of serum estradiol in concert with testicular growth factors. The mechanism responsible for the acinar-cell tumors of the pancreas in rats remains the subject of active investigation. The mechanism resulting in the hepatocellular tumors in rats (PPARalpha activation) is not likely to be relevant to humans. Similarly, the proposed mechanism for Leydig-cell tumor formation is of questionable relevance to humans. Acinar tumors of the pancreas are rare in humans, and the relevance of the these tumors, as found in rats, to humans is uncertain. Epidemiological investigations and medical surveillance of occupationally exposed workers have not found consistent associations between PFOA exposure and adverse health effects.

Integrity signals

Registry

Crossref · 10.1080/10408440490464705

Cites

136 of 136 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Pancreatic Cancer
Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202
Cancer Epidemiology and Prevention
Breslow, L. (1997) · JAMA · doi:10.1001/jama.1997.03550210090050 · Cited by 1,428
Compound-specific, quantitative characterization of organic fluorochemicals in biological matrices
Hansen, K. J., Clemen, L. A., Ellefson, M. E., & Johnson, H. O. (2001) · Environmental Science & Technology · doi:10.1021/es001489z · Cited by 923
PPARα Agonist-Induced Rodent Tumors: Modes of Action and Human Relevance
Klaunig, J. E., Babich, M. A., Baetcke, K. P., Cook, J. C., Corton, J. C., David, R. M., DeLuca, J. G., Lai, D. Y., McKee, R. H., Peters, J. M., et al. (2003) · Critical Reviews in Toxicology · doi:10.1080/713608372 · Cited by 616
Peroxisome Proliferator Activated Receptor-α Expression in Human Liver
Palmer, C. N. A., Hsu, M.-H., Griffin, K. J., Raucy, J. L., & Johnson, E. F. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.1.14 · Cited by 494
Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643
Peters, J. (1997) · Carcinogenesis · doi:10.1093/carcin/18.11.2029 · Cited by 484
Peroxisome proliferator activated receptor-alpha expression in human liver.
Palmer, C. N., Hsu, M. H., Griffin, K. J., Raucy, J. L., & Johnson, E. F. (1998) · PubMed · Cited by 448
Body weight and food intake as initiating factors for puberty in the rat
Kennedy, G. C., & Mitra, J. (1963) · The Journal of Physiology · doi:10.1113/jphysiol.1963.sp007112 · Cited by 443
Self-citation
Binding of Perfluorooctanoic Acid to Rat and Human Plasma Proteins
Han, X., Snow, T. A., Kemper, R. A., & Jepson, G. W. (2003) · Chemical Research in Toxicology · doi:10.1021/tx034005w · Cited by 422
Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors.
Olsen, G. W., Church, T. R., Miller, J. P., Burris, J. M., Hansen, K. J., Lundberg, J. K., Armitage, J. B., Herron, R., Medhdizadehkashi, Z., Nobiletti, J. B., et al. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6316 · Cited by 401
Self-citation

Show all 135 references

Research works printed but not linked: 53

Alexander, B.H. (2001). Mortality study of workers employed at the 3M Cottage Grove facility. St. Paul, MN: 3M Company. U.S. EPA Public Docket AR-226-1030a018, Washington, D.C.
Armstrong, F.H., and Lowe, K.C. (1989). Effects of emulsified perfluorochemicals on liver CYP450 in rats. Comp. Biochem. Physiol. 94C:345–349.
Burris, J.M., Lundberg, J.K., Olsen, G., Simpson, C., and Mandel, J. (2002). Interim report No. 2, Determination of serum half-lives of several fluorochemicals. St. Paul (MN), 3M Company. U.S. EPA Public Docket AR-226.
Carney, E.W., Scortichini, B.S., and Crissman, J.W. (1998). Feed restriction during (*) and neonatal life: Effects on reproductive and developmental endpoints in the CD rat. Toxicologist 42:102–103.
Christian, M.S., McCarty, R.J., Cox-Sica, D.K., and Cao, C.P. (1987). Recent increases in the incidences of skull, lung and rib alterations in vehicle control New Zealand white rabbits. J. Am. Coll. Toxicol. 6:562.
Clark, R.L. (1999). Endpoints of reproductive system development. In An evaluation and interpretation of reproductive endpoints for human risk assessment, pp. 27–62. Washington, DC: International Life Sciences Institute, Health and Environmental Science Institute.
Cook, J.C., Hurtt, M.E., Frame, S.R., and Biegel, L.B. (1994). Mechanisms of extrahepatic tumor induction by peroxisome proliferators in Crl:CD R®BR (CD) rats. Toxicologist 14:301.
Davis, J.W. II, Vanden Heuvel, J.P., Kuslikis, B.I., and Peterson, R.E. (1991). Castration increases elimination of perfluorooctanoic acid (PFOA) in male rats. Toxicologist 11:95.
DuPont Company. (1965). Effects of fluorocarbon dispersing agents on the livers of rats and dogs. Haskell Laboratory unpublished report. Newark, DE. Available from GLK on request.
DuPont Company. (1979a). Acute dermal toxicity. Haskell Laboratory unpublished report. Newark, DE.
DuPont Company. (1979b). Eye irritation test in rabbits. Haskell Laboratory unpublished report. Newark, DE.
DuPont Company. (1981a). Ammonium perfluorooctanoate blood levels in the female rat. Haskell Laboratory unpublished report. Newark, DE.
DuPont Company. (1981b). Liver weight comparison in castrated and ovariectomized rats vs. normal rats. Haskell Laboratory unpublished report. Newark, DE.
DuPont Company. (1981c). Oral LD50 test in rats. Haskell Laboratory unpublished report. Newark, DE.
DuPont Company. (1981d). Oral LD50 test in rats. Haskell Laboratory unpublished report. Newark, DE.
DuPont Company. (1981e). Oral LD50 test in mice. Haskell Laboratory unpublished report. Newark, DE.
DuPont Company. (1981f). Oral LD50 test in guinea pigs. Haskell Laboratory unpublished report. Newark, DE.
DuPont Company. (1981g). Mouse feeding study—14 day. Haskell Laboratory unpublished report. Newark, DE.
DuPont Company. (1982a). Excretion and disposition of 14C-ammonium perfluorooctanoate in male and female rats, mice, hamsters, and rabbits. Haskell Laboratory unpublished report. Newark, DE.
DuPont Company. (1982b). Placental transfer of 14C-labelled C-8 in the rat. Haskell Laboratory unpublished report. Newark, DE.
DuPont Company. (1982c). Effect of cholestyramine in the elimination of 14C-ammonium perfluorooctanoate in rats and mice. Haskell Laboratory unpublished report. Newark, DE.
DuPont Company. (1983a). Acute oral toxicity of FC-143 as a function of age. Haskell Laboratory unpublished report. Newark, DE.
DuPont Company. (1983b). APFO liver weights in rats and mice. Oral administration to males and females. Haskell Laboratory unpublished report. Newark, DE.
Gavin, C.E., Martin, N.P., and Schlosser, M.J. (1996). Absence of specific CCK-A binding sites on human pancreatic membranes. Toxicologist 30:334.
Gavin, C.E., Malnoske, J.A., White, J., and Schlosser, M.J. (1997). Species differences in expression of pancreatic cholecystokinin-A receptors. Toxicolo-gist 36:1180.
Gilliland, F.D. (1992). Fluorocarbons and human health: Studies in an occupational cohort. PhD dissertation, University of Minnesota, Minneapolis.
Gortner, E.G. (1981). Oral teratology study of T-2998CoC in rats. Safety Evaluation Laboratory and Riker Laboratories, Inc., Experiment No. 0681TR0110, December 1981. U.S. EPA Public Docket AR-226-0463.
Gortner, E.G. (1982). Oral teratology study of T-3141CoC in rabbits. Safety Evaluation Laboratory and Riker Laboratories, Inc., Experiment No. 0681TB0398, February 1982. U.S. EPA Public Docket AR-226-0465.
Guy, W.S. (1973). Fluorocompounds of human plasma: Analysis, prevalence, purification, and characterization. PhD dissertation, University of Rochester, Rochester, NY.
Hazleton, Inc. (1990). Primary dermal irritation/ corrosion study in rabbits. HLA number 91201740. U.S. EPA Public Docket AR-226-0666, Washington, DC.
Hazleton, Inc. (1995a). Mutagenicity test with T-6342 in the Salmonella–E. coli/mammalian microsome reverse mutation assay. Corning Hazleton, Inc. Final Report CHV Study No. 17073-0-409. December 14, 1995. U.S. EPA Public Docket AR-226-0436, Washington, DC.
Hazleton, Inc. (1995b). Mutagenicity test with T-6342 in an in vivo mouse micronucleus assay. Corning Hazleton, Inc. Final Report CHV Study No. 17073-0-455. December 14, (1995). U.S. EPA Public Docket AR-226-0435, Washington, DC.
Hazleton, Inc. (1995c). Acute dermal toxicity study of T-6342 in rabbits. Corning Hazleton, Inc. HWI 50800374. U.S. EPA Public Docket AR-226-0427, Washington, DC.
Hazleton, Inc. (1996a). Mutagenicity test with T-6564 in the Salmonella-E. coli/mammalian microsome reverse mutation assay with a confirmatory assay. Corning Hazleton, Inc. Final Report CHV Study No. 17750-0-409R. September 13, 1996. U.S. EPA Public Docket AR-226-0432, Washington, DC.
Hazleton, Inc. (1996b). Mutagenicity test with T-6342 measuring chromosomal aberrations in cultured whole blood lymphocytes with a confirmatory assay with multiple harvests. Corning Hazleton, Inc. Final Report CHV Study No. 17073-0-449CO. November 1, 1996. U.S. EPA Public Docket AR-226-0433, Washington, DC.
Hazleton, Inc. (1996c). Mutagenicity test with T-6564 measuring chromosomal aberrations in Chinese hamster ovary (CHO) cells with a confirmatory assay with multiple harvests. Corning Hazleton, Inc. Final Report CHV Study No. 17750-0-437CO. September 16, 1996. U.S. EPA Public Docket AR-226.
Hazleton, Inc. (1996d). Mutagenicity test with T-6342 measuring chromosomal aberrations in Chinese hamster ovary (CHO) cells with a confirmatory assay with multiple harvests. Corning Hazleton, Inc. Final Report CHV Study No. 17073-0-437CO. September 16, 1996. U.S. EPA Public Docket AR-226-0434, Washington, DC.
Hazleton, Inc. (1996e). Mutagenicity test with T-6564 in an in vivo mouse micronucleus assay. Corning Hazleton, Inc. Final Report CHV Study No. 17750-0-455, 1996. U.S. EPA Public Docket AR-226-0430, Washington, DC.
Hazleton, Inc. (1997). Acute oral toxicity study of T-6669 in rats. Corning Hazleton, Inc. CHW 61001760. U.S. EPA Public Docket AR-226-0420, Washington, DC.
Johnson, J.D., and Ober, R.E. (1980). Extent and route of excretion and tissue distribution of total carbon-14 in male and female rats after a single IV dose of FC-143-14C. St. Paul, MN,: Riker Laboratories, Inc. U.S. EPA Public Docket AR-226-0457, Washington, DC.
Kerstner-Wood, C., Coward, L., and Gorman, G. (2003). Protein binding of perfluoroobutane sulfonate, perfluorohexane sulfonate, perfluorooctane sulfonate, and perfluorooctanoate to plasma (human, rat, and monkey), and various human-derived plasma protein fractions. Unpublished report, Southern Research Institute, Study 9921.7. U.S. EPA Public Docket AR-226-1354, Washington, DC.
Litton Bionetics. (1978). Mutagenic evaluation of T-2015 CoC in the Ames Salmonella microsome plate test. Final Report LBI Project No. 20838, February 1978. U.S. EPA Public Docket AR-226-0429, Washington, DC.
Moore, G.E. (2001). H-24921: Dermal sensitization test—Buehler method. Product Safety Labs, Study No. 11321. December 17. Dayton, NJ. Available from GLK on request.
Noker, P. (2003). A pharmacokinetic study of potassium perfluorooctanoate in the cynomologus monkey. Southern Research Institute Study ID: 99214. South Research Institute, submitted to U.S. EPA AR 226-1228, Washington, DC.
Olsen, G.W., Butenhoff, J.L., and Mandel, J.H. (2003c). Assessment of lipid, hepatic and thyroid function in relation to an occupational biologic limit value for perfluorooctanoate. U.S. EPA Public Docket AR-226-1351, Washington, DC.
10.1345/aph.10228 · DOI · Paper page
Perkins, R.G. (1992). Investigation of ammonium perfluorooctanoate effect on hormone levels and peroxisomal proliferation in the rat. Toxicologist 12:52.
Peterson, R.E., Kuslikis, B.I., and Vanden Heuvel, J.P. (1991). Protein acylation by the peroxisome proliferators perfluorodecanoic acid (PFDA) and perfluorooctanoic acid (PFOA) in rats. Toxicologist 11:185.
Reddy, J.K., and Rao, M.S. (1995). Postulated mechanisms of carcinogenicity mediated by peroxi-some proliferators. IARC Technical Report No. 24, pp. 41–53. Lyon, France.
Riker. (1981). Final Report: Repeat Application 28-Day Percutaneous Absorption Study with T-2618 CoC in Albino Rabbits. Riker Laboratories Report 09790AB0485, March 15, 1981. U.S. EPA Public Docket AR-226-0446, Washington, DC.
Schottenfeld, D. (1996). Testicular cancer. In Cancer epidemiology and prevention, eds. D. Schottenfeld and J.F. Fraumeni, pp. 1207–1219. New York: Oxford University Press.
Stone Research Laboratories. (1981). An assay of cell transformation and cytotoxicity in the C3H 10T 1/2 clonal cell line for the test chemical T-2942 CoC. Environmental Pathology Laboratory, Stone Research Laboratories, University of Minnesota, March 5, 1981. U.S. EPA Public Docket AR-226-0428, Washington, DC.
Toxicon. (2002). CHO/HGPRT Forward mutation assay—ISO Toxicon Final Report: 01-7019-G1. U.S. EPA Public Docket AR-226-1101, Washington, DC.

Sorted by citations

Items 601–700 of 741

The therapeutic potential of isosakuranetin against perfluorooctane sulfonate instigated cardiac toxicity via modulating Nrf‐2/Keap‐1 pathway, inflammatory, apoptotic, and histological profile
Ijaz, M. U., SHAHID, H., Hayat, M. F., Khan, H. A., Al‐Ghanim, K. A., & Riaz, M. N. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4060 · Cited by 9
Toward Strengthened Regulation of PFAS in South Korea: Health Risks, Global Standards, and Policy Recommendations
Kim, K., Son, S., An, S., Choe, S.-H., & Jung, S. P. (2025) · 대한환경공학회지 · doi:10.4491/ksee.2025.47.6.410 · Cited by 10
Analysis of gene expression changes in relation to hepatotoxicity induced by perfluorinated chemicals in a human hepatoma cell line
Song, M., Cho, Y., Jeong, S.-C., & Ryu, J. (2016) · Toxicology and Environmental Health Sciences · doi:10.1007/s13530-016-0269-x · Cited by 9
Per- and polyfluoroalkyl substances (PFAS) as environmental drivers of antimicrobial resistance: insights from genome sequences of Klebsiella grimontii and Citrobacter braakii isolated from contaminated soil
Calcagnile, M., Giuliano, A., Tredici, M. S., Gualandris, D., Rotondo, D., Calisi, A., Leo, C., Martelli, M., Rocchi, A., Klint, K. E., et al. (2025) · Environmental Science Advances · doi:10.1039/d4va00359d · Cited by 12
The relationship between multiple perfluoroalkyl substances and cardiorespiratory fitness in male adolescents
Zeng, G., Zhang, Q., Wang, X., & Wu, K. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-19685-y · Cited by 8
Density and Dynamic Viscosity of Perfluorodecalin-Added n-Hexane Mixtures: Deciphering the Role of Fluorous Liquids
Deepika, D., & Pandey, S. (2023) · Liquids · doi:10.3390/liquids3010005 · Cited by 8
Carbon chain length of perfluoroalkylated carboxylic acids determines inhibitory strength on gonadal 3β-hydroxysteroid dehydrogenases in humans, rats, and mice
Zhang, H., Wang, S., Chen, Y., Li, J., Zhai, Y., Tang, Y., Li, H., Sang, J., Wang, H., Lv, J., et al. (2023) · Toxicology Letters · doi:10.1016/j.toxlet.2023.10.011 · Cited by 8
Subchronic, Reproductive, and Developmental Toxicity of a Fluorotelomer-Based Urethane Polymeric Product
Stadler, J. C., Delker, D. A., Malley, L. A., Frame, S. R., Everds, N. E., Mylchreest, E., Munley, S. M., Loveless, S. E., & Buck, R. C. (2008) · Drug and Chemical Toxicology · doi:10.1080/01480540701873418 · Cited by 8
Optimization of the synthesis of 4′-nonafluorobutylacetophenone by metal catalysed cross-coupling reaction
Ceretta, F., Zaggia, A., Conte, L., & Ameduri, B. M. (2011) · Journal of Fluorine Chemistry · doi:10.1016/j.jfluchem.2011.11.006 · Cited by 8
Rapid analysis of perfluorinated carboxylic acids in textiles by dielectric barrier discharge ionization-mass spectrometry
Wang, C., Li, W., Lv, Y., Bai, H., Zhao, P. F., Wen, L., Wang, C., & Ma, Q. (2020) · Microchemical Journal · doi:10.1016/j.microc.2020.104773 · Cited by 8
In vitro microarray analysis identifies genes in acute-phase response pathways that are down-regulated in the liver of chicken embryos exposed in ovo to PFUdA
O’Brien, J. M., Williams, A., Yauk, C. L., Crump, D., & Kennedy, S. W. (2013) · Toxicology in Vitro · doi:10.1016/j.tiv.2013.04.003 · Cited by 8
Perfluorooctane sulfonate and perfluorooctanoic acid in the fingernails of urban and rural children
Xu, L., Liu, W., & Jin, Y. (2010) · Chinese Science Bulletin · doi:10.1007/s11434-010-4156-6 · Cited by 8
Application of On-Line SPE-LC/MSD to Measure Perfluorinated Compounds (PFCs) in Water
Son, H.-J., Yoom, H.-S., Jung, J.-M., & Jang, S.-H. (2013) · 대한환경공학회지 · doi:10.4491/ksee.2013.35.2.075 · Cited by 8
ADME/Tox WEB in silico predictions of longer chain perfluoroalkyl carboxylic acid pKa values are more accurate than other computational methodsPreprint
Rayne, S., & Kaya Forest, B. (2009) · Nature Precedings · doi:10.1038/npre.2009.2936.1 · Cited by 8
Amino Acid-Based Biosurfactants: Promising and Ecofriendly Biomolecules for Attaining Sustainable Agriculture and Environmental Safety
Ansari, N. H., Shahid, S., Khan, M. S., Rizvi, N. Z., Iqubal, S. M. S., & Bahafi, A. A. (2025) · Colloid Journal · doi:10.1134/s1061933x24601021 · Cited by 7
Per‐ and polyfluoroalkyl substances in untreated and treated sludge/biosolids from 27 water resource recovery facilities across the United States and Canada
Oza, S., Li, H., Huang, Q., Norton, J., Winchell, L. J., Wells, M. J. M., Nangle, T., Perez, N., DeLaughter, D., Hauser, J. M., et al. (2025) · Water Environment Research · doi:10.1002/wer.70039 · Cited by 8
Global Performance, Trends, and Challenges for Assessment and Management of Per- and Polyfluoroalkyl Substances (PFASs): A Critical Review
Seo, S., Park, Y. J., Na, S., Lee, J., Lee, W. S., & Kim, M. (2024) · JOURNAL OF ENVIRONMENTAL ANALYSIS, HEALTH AND TOXICOLOGY · doi:10.36278/jeaht.27.1.1 · Cited by 7
Perfluorooctane Sulfonate and Perfluorooctanoic Acid
Viberg, H., & Eriksson, P. O. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804239-7.00043-3 · Cited by 7
Effect of endosulfan and bisphenol A on the expression of SUMO and UBC9
Jayaram, V. Y., Somesh, B. P., Reddy, D., Sistla, S., & Malempati, R. (2018) · Drug and Chemical Toxicology · doi:10.1080/01480545.2018.1526179 · Cited by 7
Dose‐Response Assessment (Cancer and Non‐Cancer)
Paustenbach, D. J., & Cox, L. A. (2024) · doi:10.1002/9781119742975.ch4 · Cited by 7
Perfluorooctanoate and nano-titanium dioxide modulate male gonadal function in the mussel Mytilus coruscus
Sun, B., Pan, Y., Sokolova, I. M., Shao, Y., Hu, M., & Wang, Y. (2025) · Aquatic Toxicology · doi:10.1016/j.aquatox.2025.107251 · Cited by 6
Toxicity of three F‐substituent aromatics in anaerobic systems
Zhao, Z., Xu, L., Li, W., Wang, M., Shen, X., Ma, G., & Shen, D. (2012) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.3774 · Cited by 6
Investigation of perfluorooctanoic acid induced DNA damage using electrogenerated chemiluminescence associated with charge transfer in DNA
Lü, L., Guo, L., Li, M., Kang, T., Cheng, S., & Miao, W. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9559-z · Cited by 6
Perfluorooctanoic acid exposure during pregnancy alters the apoptosis of uterine cells in pregnant mice.
Li, D., Song, P., Liu, L., & Wang, X. (2018) · Europe PMC (PubMed Central) · Cited by 6
Peroxisome Proliferators
Jiang, M., & Yang, N. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386454-3.00346-8 · Cited by 6
The association between maternal perfluoroalkylated substances exposure and neonatal birth weight: a system review and meta-analysis
Fu, Z., Sun, X., Yang, X., Li, X., Zhang, Y., Zhang, X., Guo, H., Liu, Y., & Liu, X. (2025) · Reviews on Environmental Health · doi:10.1515/reveh-2023-0174 · Cited by 5
Developmental and neurobehavioural toxicity of per- and polyfluoroalkyl substances in aquatic organisms: mechanistic insights from molecular disruption to behavioural dysfunction
Hamed, M., Abbas, M., Hasan, A. K. M. M., Kteeba, S. M., Taher, H., Abdel-Wahab, M., Said, R. E. M., Bakr, Z., Chivers, D. P., Lee, J.-S., et al. (2026) · Aquatic Toxicology · doi:10.1016/j.aquatox.2026.107719 · Cited by 6
Relationship between the Consumption of Fermented Red Beetroot Juice and Levels of Perfluoroalkyl Substances in the Human Body’s Fluids and Blood Parameters
Surma, M., Sawicki, T., Piskuła, M. K., & Wiczkowski, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813956 · Cited by 6
Eurasian Otter Lutra lutra (Linnaeus, 1758)
Loy, A., Chanin, P., Kranz, A., & Roos, A. M. (2024) · Handbook of the mammals of Europe · doi:10.1007/978-3-319-65038-8_127-1 · Cited by 6
Leydig cell development in pubertal male rats is blocked by perfluorotetradecanoic acid through decreasing AMPK-mTOR-autophagy pathway
Tang, Y., Shi, L., Wang, S., Han, L., Li, H., Lv, J., Ge, R., & Ying, Y. (2023) · Toxicology Letters · doi:10.1016/j.toxlet.2023.05.012 · Cited by 5
Mortality of Employees of an Ammonium Perfluorooctanoate Production Facility
Lundin, J. I. (2007) · Cited by 5
Review of the Predatory Bird Monitoring Scheme (PBMS).
Shore, R. F., Walker, L. A., Thomas, G. O., Barber, J. L., Martin, F., Jones, K. C., Beresford, N. A., Rowland, P., & Pickup, R. W. (2006) · Lancaster EPrints (Lancaster University) · Cited by 5
In-Thema: Perfluorierte Verbindungen
Schulte, C. (2006) · Umweltwissenschaften und Schadstoff-Forschung · doi:10.1065/uwsf2006.07.121 · Cited by 5
Emerging Pollutants in Chinstrap Penguins and Krill from Deception Island (South Shetland Islands, Antarctica)
Motas, M., Jerez, S., Veiga-del-Baño, J. M., Ramos, J. J., Oliva, J. M., Cámara, M. Á., Andreo‐Martínez, P., & Corsolini, S. (2025) · Toxics · doi:10.3390/toxics13070549 · Cited by 4
Perfluorooctane sulfonate and perfluorooctanoic acid
Kuzukıran, Ö., Şimşek, İ., Filazı, A., & Yurdakök-Di̇kmen, B. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89773-0.00041-2 · Cited by 4
General toxicity and screening of reproductive and developmental toxicity following bioaccumulation of oral-dosed perfluorooctanoic acid: Loss of the Golgi apparatus
Jung, W., Park, H.-J., Lee, B., Chang, Y., Kim, J., Yang, M., Lim, J., Choi, H., & Park, E. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.114867 · Cited by 4
Persistent Organic Pollutants (Part II): The New POPs – Sources and Adverse Effects
Prabhu, R. N., & Lakshmipraba, J. (2021) · Emerging contaminants and associated treatment technologies · doi:10.1007/978-3-030-72441-2_2 · Cited by 5
Brominated flame retardants and perfluorinated chemicals
Kodavanti, P. R. S., & Loganathan, B. G. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385926-6.00075-2 · Cited by 4
Environmental fate and transportation of perfluorinated compounds
Sungur, Ş. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85160-2.00017-2 · Cited by 4
Brominated Flame Retardants and Perfluorinated Chemicals
Kodavanti, P. R. S., Valdez, M. C., & Yamashita, N. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811410-0.00052-0 · Cited by 5
3D-QSAR study of the endocrine disrupting effect of perfluorooctane sulfonates (PFOS) and perfluorooctanoic acid (PFOA) on human estrogen, androgen and thyroid receptors
Cheng, Y., Chen, H., Yu, W., Cui, Y., Zhou, L.-L., & Zhou, X. (2010) · Collection of Czechoslovak Chemical Communications · doi:10.1135/cccc2009547 · Cited by 4
Monitoring of Perfluorinated Compounds (PFCs) in the Yeongsan River Water System
Kwon, B. G., Lim, C.-S., Lim, H.-J., Na, S.-H., Kwon, J., & Chung, S.-Y. (2015) · 대한환경공학회지 · doi:10.4491/ksee.2015.37.5.303 · Cited by 4
Alternatives to Detergents for Handling Membrane Proteins in Aqueous Solutions
Popot, J. (2018) · Biological and medical physics, biomedical engineering · doi:10.1007/978-3-319-73148-3_3 · Cited by 4
Congener specific organic carbon normalized soil and sediment-water partitioning coefficients for the C~1~ through C~8~ perfluoroalkyl carboxylic and sulfonic acidsPreprint
Rayne, S., & Kaya Forest, B. (2009) · Nature Precedings · doi:10.1038/npre.2009.3011.2 · Cited by 4
Temporal effects of perfluorononanoic acid (PFNA) exposure on metabolic disorders and gut-liver axis injury in large yellow croaker (Larimichthys crocea)
Fang, Q., Yuan, M., Sun, Z., Xue, Y., Chong, C., & Wang, X. (2025) · Environmental Research · doi:10.1016/j.envres.2025.123211 · Cited by 3
Impact of Redox Imbalance and Mitochondrial Dysfunction on Neurotoxicity Induced by Perfluorooctanoic Acid in Male Wistar Albino Rats ( Rattus norvegicus )
Hongal, L., & David, M. (2025) · Journal of Applied Toxicology · doi:10.1002/jat.70009 · Cited by 4
PFAS exposure induces hearing loss by targeting cochlear hair cells and spiral ganglion neurons
Bhatia, P., Roth, K., Yang, Z., Petriello, M. C., & Jamesdaniel, S. (2026) · Scientific Reports · doi:10.1038/s41598-026-51693-7 · Cited by 3
Effects of perfluorododecanoic acid on testicular function in mice
Liu, Z., Liu, Y., Huang, S., Wu, C.-L., & Zang, Z. (2023) · Toxicology Research · doi:10.1093/toxres/tfad027 · Cited by 3
A valence bond study of the activation of methyl halides bonds by electric fields
Pozo-Guerrón, P., Armijos-Capa, G., Rincón, L., Mora, J. R., Torres, F. J., & Rodríguez, V. (2019) · Journal of Theoretical and Computational Chemistry · doi:10.1142/s021963361950007x · Cited by 3
Effects of perfluoroundecanoic acid on the function of Leydig cells in adult male rats
Xin, X. L., Chen, H., Tian, F., Li, J., Yan, H., Yu, Y., Ma, F., Li, H., Wang, Y., Li, X., et al. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.115903 · Cited by 3
Synthesis and characterization of light-fluorous NHC-ligands and their palladium complexes
Lo, A. S. W., Yiu, S., & Horváth, I. T. (2020) · Journal of Organometallic Chemistry · doi:10.1016/j.jorganchem.2020.121634 · Cited by 3
Determination of Perfluorooctane Sulfonates (PFOS) in Four Chemical Materials by HPLC/MS/MS
Cheng, Y., Chen, H. M., Chen, W., Cui, Y., Li, X. J., Chen, D. D., Li, S. J., Yu, W. L., & Zhou, X. (2012) · Advanced materials research · doi:10.4028/www.scientific.net/amr.554-556.1872 · Cited by 3
Radiologic appearance of chronic parapharyngeal Teflon granuloma
Hacein‐Bey, L., Conneely, M., Hijaz, T. A., & Leonetti, J. P. (2009) · American Journal of Otolaryngology · doi:10.1016/j.amjoto.2009.05.003 · Cited by 3
A preliminary study of temporal differences in serum concentrations of perfluoroalkyl acids, among New York anglers, in the absence of known changes in manufacturing practices
Bloom, M. S., Kannan, K., Spliethoff, H. M., Tao, L., Aldous, K. M., & Vena, J. E. (2009) · Toxicological & Environmental Chemistry Reviews · doi:10.1080/02772240802590301 · Cited by 3
Serum perfluorooctanoic acid (PFOA) concentrations in normal and hyperlipidemic female hamsters dosed orally with ammonium perfluorooctanoate (APFO) for up to 30 days
Everds, N. E., & Kennedy, G. L. (2015) · Toxicology Reports · doi:10.1016/j.toxrep.2015.01.013 · Cited by 4
Self-citation
A Fourteen-Day Repeated Dose Oral Toxicity Study of APFO in Rats
Iwai, H., & Yamashita, K. (2006) · Drug and Chemical Toxicology · doi:10.1080/01480540600653143 · Cited by 3
Overview on the Mechanisms Underlying Chemical‐Induced Immunotoxicity
Corsini, E. (2014) · doi:10.1002/9783527676965.ch2 · Cited by 3
Comment on “Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans” by Fletcher et al., Environment International 57-58 (2013) 2–10
Heuvel, J. P. V. (2013) · Environment International · doi:10.1016/j.envint.2013.09.004 · Cited by 3
Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) in an Aquatic Ecosystem - Distribution and Fate
Becker, A. M. (2009) · EPub Bayreuth (University of Bayreuth) · Cited by 3
Peroxisome proliferators
Abdelmalak, S., Yang, N., & Ray, S. D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824315-2.00218-9 · Cited by 3
Network Pharmacology and In Vivo Evaluation of Lycium barbarum Polysaccharide in Preventing Perfluorooctanoic Acid-Induced Damage in Broilers
Gao, N., Yao, W., Li, Y., Liu, X., Bai, H., & Wang, X. (2025) · Poultry Science · doi:10.1016/j.psj.2025.105522 · Cited by 2
Exploring Approaches for Accelerated Mass Spectrometric Detection of Fluorochemicals from Aqueous Solutions Using Indirect, Adsorbent-Facilitated Desorption Ionization
Bays, N., Kruse, S. M., Shohel, M., LaFond, J. A., Schäfer, D., Benally, B. A., Griffus, T., Kustas, J., Kruichak, J. N., Rigali, M. J., et al. (2026) · ACS Omega · doi:10.1021/acsomega.5c08128 · Cited by 2
Analysis of Perfluorinated Compounds (PFCs) in Water using a Delay Column and an On-line SPE LC-MS/MS System
Han, G., Kang, H., Park, J., & Lee, S. (2021) · JOURNAL OF ENVIRONMENTAL ANALYSIS, HEALTH AND TOXICOLOGY · doi:10.36278/jeaht.24.2.91 · Cited by 2
Assessing perfluorooctanoic acid toxicity in lung, heart, and testis tissues of mice: Evaluation of protective effects of taurine and coenzyme Q10
Endirlik, B. Ü., Eken, A., Öztürk, F., & Gürbay, A. (2023) · Journal of Research in Pharmacy · doi:10.29228/jrp.326 · Cited by 2
A Study on the Detection Characteristics of PFOA, PFOS, and PFHxS among Perfluorinated Compounds in the Geum River Basin
Min, D. R., Lee, J., Joo, J. C., Kim, D. J., Choi, J., & Kim, S. (2025) · 대한환경공학회지 · doi:10.4491/ksee.2025.47.2.79 · Cited by 2
Characteristics of Removal of Perfluorinated Compounds (PFCs) Using Magnetic Ion Exchange Resin (MIEX®) in Water
Son, H.-J., Yoom, H.-S., Kim, K., Ryu, S.-W., & Kwon, K.-W. (2013) · Journal of Environmental Science International · doi:10.5322/jesi.2013.22.8.1009 · Cited by 2
Microencapsulation and application of fluorine‐free water repellent agent‐AH102
Li, Y., & Cai, Z. (2010) · Journal of Applied Polymer Science · doi:10.1002/app.32597 · Cited by 2
Determination of perfluorooctane sulfonates in fire-fighting foam and other materials by high performance liquid chromatography-tandem mass spectrometry
Chen, H.-M., Cheng, Y., Chen, W., Yu, W., Li, X., & Wang, Z. (2010) · Chinese Journal of Chromatography · doi:10.3724/sp.j.1123.2012.00185 · Cited by 2
COMPOSTOS PERFLUORADOS: UMA AMEAÇA AO OCEANO LIMPO
Leonel, J., Nascimento, R. A., & Miranda, D. A. (2023) · Química Nova · doi:10.21577/0100-4042.20230049 · Cited by 3
Immunomodulation by Persistent Organic Pollutants
Luebke, R. W., DeWitt, J. C., Germolec, D. R., Salazar, K. D., & Kerkvliet, N. I. (2012) · Wiley eBooks · doi:10.1002/9781118184141.ch6 · Cited by 2
Radiosynthesis of Perfluoroalkyl Substances : Chemical analysis, uptake, distribution, and partitioning studies
Sundström, M. (2012) · DiVA (Stockholm University) · Cited by 2
Exploring sources of human and environmental fluorochemical contamination
D’eon, J. C. (2010) · TSpace (University of Toronto) · Cited by 2
Toxicity and Health Risks of PFAS
Dhanasinghe, C., Lin, W., Kao, C., Surampalli, R. Y., & Zhang, T. C. (2025) · Wiley eBooks · doi:10.1002/9781394343935.ch9 · Cited by 2
A comparative toxicological and epidemiological evaluation of dioxins and PFAS chemicals
Paustenbach, D. J., Kissell, K., & Shakya, A. (2025) · Critical Reviews in Toxicology · doi:10.1080/10408444.2025.2560827 · Cited by 1
Perfluoroalkyl and polyfluoroalkyl substances exposure and liver disease: A review
Peng, J., Gong, R., Li, R., Li, L., Yu, H., & Wen, Q. (2026) · Toxicology · doi:10.1016/j.tox.2026.154509 · Cited by 1
PFAS Exposure and Metabolic Disorders: Mechanistic Insights into Lipid and Glucose Homeostasis
Chen, X., Wen, W., Gu, S., Guo, F., Mo, Z., Chen, Z., Yan, S., & Wang, X. F. (2026) · Biomolecules · doi:10.3390/biom16071056 · Cited by 1
A Study on the Self-cleaning Surface Finishing Using PFOA Free Fluoric Polymer and Silica Nano-sol
Park, S., Kwon, I.-J., Kim, R., Yeum, J.-H., Yoon, N.-S., & Lee, K.-N. (2009) · Textile Coloration and Finishing · doi:10.5764/tcf.2009.21.6.001 · Cited by 1
Effect of Treatment Conditions of Eco-friendly Fluorinated Water-repellent Agent and Design Applications: Silk Fabrics with DTP Finishing
Choi, K., & Kim, J.-J. (2014) · Fashion business · doi:10.12940/jfb.2014.18.5.159 · Cited by 1
Die Eignung des Wildschweins als Bioindikator für die Kontamination der Umwelt mit perfluorierten Alkylsubstanzen
Stark, M. L., Wagner, B., Kowalczyk, J., Spolders, M., Schafft, H. A., & Lahrssen‐Wiederholt, M. (2016) · Journal of Consumer Protection and Food Safety · doi:10.1007/s00003-015-1010-4 · Cited by 1
Transcriptomic effects of Perfluoralkyl acids on the adipose tissue of a songbird species at environmentally relevant concentrations
López‐Antia, A., Piña, B., Lacorte, S., Bervoets, L., & Eens, M. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121478 · Cited by 1
Impact of perfluorooctanoic acid on sperm function and early development in Prochilodus magdalenae : implications for aquatic species reproduction
Espinosa-Araujo, J. A., Sierra-Marquez, L., Atencio-García, V., & Olivero‐Verbel, J. (2025) · Environmental Toxicology and Chemistry · doi:10.1093/etojnl/vgaf223 · Cited by 1
The Evaluation of Adsorption Characteristics of Perfluorinated Compounds (PFCs) in GAC Process Using Continuous Column Adsorption Test
Son, H.-J., Yoo, S.-J., & Jang, S.-H. (2013) · 대한환경공학회지 · doi:10.4491/ksee.2013.35.3.206 · Cited by 1
Perfluorinated Compound Exposure and Health Effects in Humans
Li, J., & Ge, R. (2019) · Springer eBooks · doi:10.1007/978-981-32-9535-3_9 · Cited by 1
Immunotoxic Effects of Perfluoroalkylated Compounds: Mechanisms of Action
DeWitt, J. C., Peden‐Adams, M. M., & Keil, D. E. (2014) · Wiley eBooks · doi:10.1002/9783527676965.ch13 · Cited by 1
The Toxicity of Perfluoroalkyl Acids in Zebrafish (Danio rerio)
Haq, M. U. (2013) · Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences)) · Cited by 1
Tissue distribution studies and risk assessment of perfluoroalkylated and polyfluoroalkylated substances (pfass)
Borg, D. (2013) · Figshare · Cited by 1
Efecto del ácido perfluorooctanoico sobre el flujo del Ca2+ intracelular durante la capacitación in vitro de espermatozoides de cerdo doméstico
Ojeda, G. H. (2017) · doi:10.24275/uami.7p88cg523 · Cited by 1
Mätningar av PFOS i bröstmjölk och blod
Kärrman, A., Ericson, I., van Bavel, B., & Lindström, G. (2006) · Diva portal (Dalarna University Library) · Cited by 1
Analysis and Occurrence of Perfluorinated Chemicals in Breast Milk and Serum from Swedish Women, 1996-2005
Kärrman, A., Ericson, I., van Bavel, B., & Lindström, G. (2006) · Cited by 1
Perfluorooctanoic Acid and its Inorganic Salts [MAK Value Documentation, 2006]
Arbeitsstoffe, D. F. S. S. Z. P. G., & Greim, H. (2015) · Wiley eBooks · doi:10.1002/3527600418.mb33567e4115 · Cited by 2
Perfluorooctanoic Acid—A Water and Oil Repellent
Sergi, C. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-409548-9.11314-4 · Cited by 1
Faculty Opinions recommendation of Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population.
Taylor, D., & DeWitt, J. C. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.2638970.2302072 · Cited by 2
The Effects of Perfluoroalkyl Compounds on In Ovo Toxicity and Hepatic mRNA Expression in the Domestic Chicken (Gallus gallus domesticus)
O’Brien, J. M. (2011) · Library and Archives Canada (Government of Canada) · doi:10.20381/ruor-4542 · Cited by 1
Mammary Gland as a Sensitive Tissue to Developmental Exposures of Perfluorooctanoic Acid (PFOA) in the Mouse
White, S. S., Fenton, S. E., Yang, C., & Haslam, S. Z. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9896-5_8 · Cited by 2
Cancer mortality in 3M chemical workers
Raleigh, K. K. (2013) · University of Minnesota Digital Conservancy (University of Minnesota)
Analytical and Toxicological Analysis of Perfluorinated Compounds Present in the Environment
Naile, J. E. (2011) · University Library - University of Saskatchewan (University of Saskatchewan)
Perfluoroctansäure und ihre anorganischen Salze [BAT Value Documentation in German language, 2007]
Rettenmeier, A. W. (2012) · Wiley eBooks · doi:10.1002/3527600418.bb33567d0014
Immunohepatotoxicity of the persistent environmental pollutants perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS)
Qazi, M. R. (2011)
Eco-Toxicological Effect of Perfluorooctanoic Acid on Soil Enzymatic Activities
Zhang, W., Lin, K., Long, Y., Li, X., & Liu, L. (2010) · International Conference on Bioinformatics and Biomedical Engineering · doi:10.1109/icbbe.2010.5516158
Structure-Activity Relationships Between Perfluorinated Chemicals and Mitochondrial Respiration Rates
Ray, J. N. (2010) · University of Minnesota Digital Conservancy (University of Minnesota)

Authors: Kennedy, G. L., Butenhoff, J. L., Olsen, G. W., O'Connor, J. C., Seacat, A. M., Perkins, R. G., Biegel, L. B., Murphy, S. R., & Farrar, D. G.
Affiliations: DuPont (United States) (US)
3M (United States) (US)
DuPont, Newark, Delaware, USA
Covance, Madison, Wisconsin, USA
Atofina, Philadelphia, Pennsylvania, USA
Ineos (United Kingdom) (GB)
Corresponding author: Kennedy, Gerald L.
ORCID: Kennedy, Gerald L.
Olsen, Geary W.
Murphy, Sandra R.
Venue: Critical Reviews in Toxicology
Publisher: Informa UK Limited
Published: 2004-01
Volume: 34
Issue: 4
Pages: 351-384
ISSN: 0045-6446 (ISSN-L)
1040-8444
1547-6898
DOI: 10.1080/10408440490464705
OpenAlex: W2111493612
Cited by: 742
References: 135
Citations by year: 2026: 8 · 2025: 26 · 2024: 15 · 2023: 25 · 2022: 15 · 2021: 32 · 2020: 30 · 2019: 27 · 2018: 34 · 2017: 32 · 2016: 34 · 2015: 29 · 2014: 42 · 2013: 45 · 2012: 36
FWCI: 4.28
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Toxicology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords: perfluorooctanoic acid, PPAR agonists, PPARα, hepatocellular tumors, Leydig cell tumor, lipid metabolism, cytochrome P450, very low density lipoprotein secretion, non-genotoxic carcinogenesis, occupational exposure, toxicokinetics
MeSH terms: Animals, Caprylates, Female, Fluorocarbons, Humans, Leydig Cell Tumor, Liver Neoplasms, Male, Mutagenicity Tests, Pancreatic Neoplasms, Skin, Testicular Neoplasms, Tissue Distribution, Peroxisome Proliferators, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Toxicology of Perfluorooctanoate

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks