The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Development of in vitro systems for nanotoxicology: methodological considerations
Abstract
Due to the rapid development of a diverse array of nanoparticles, used in a wide variety of products, there are now many international activities to assess the potential toxicity of these materials. These particles are developed due to properties such as catalytic reactivity, high surface area, light emission properties, and others. Such properties have the potential to interfere in many well-established toxicity testing protocols. This article outlines some of the most frequently used assays to assess the cytotoxity and biological reactivity of nanoparticles in vitro. The article identifies key issues that need to be addressed in relation to inclusion of relevant controls, assessing particles for their ability to interfere in the assays, and using systematic approaches to prevent misinterpretation of data. The protocols discussed range from simple cytotoxicity assays, to measurement of reactive oxygen species and oxidative stress, activation of proinflammatory signaling, and finally genotoxicity. The aim of this review is to share knowledge relating to nanoparticle toxicity testing in order to provide advice and support for guidelines, regulatory bodies, and for scientists in general.
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Cites
Oops they did it again! Carbon nanotubes hoax scientists in viability assays
Wörle-Knirsch, J. M., Pulskamp, K., & Krug, H. F. (2006) · Nano Letters · doi:10.1021/nl060177c · Cited by 994
Measurement of Reactive Oxygen Species in Cardiovascular Studies
Dikalov, S., Griendling, K. K., & Harrison, D. G. (2007) · Hypertension · doi:10.1161/01.hyp.0000258594.87211.6b · Cited by 532
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Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells
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Self-citationGilmour, P. S., Brown, D. M., Beswick, P. H., MacNee, W., Rahman, I., & Donaldson, K. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s51313 · Cited by 86
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Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications
Wicki, A., Witzigmann, D., Balasubramanian, V., & Huwyler, J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.030 · Cited by 1,901
Graphene-based nanomaterials for drug delivery and tissue engineering
Goenka, S., Sant, V., & Sant, S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.017 · Cited by 1,311
Guidelines for cell viability assays
Kamiloglu, S., Sari, G., Ozdal, T., & Capanoglu, E. (2020) · Food Frontiers · doi:10.1002/fft2.44 · Cited by 769
Mechanisms of genotoxicity. A review of in vitro and in vivo studies with engineered nanoparticles
Magdolenova, Z., Collins, A., Kumar, A., Dhawan, A., Stone, V., & Dusinska, M. (2014) · Nanotoxicology · doi:10.3109/17435390.2013.773464 · Cited by 616
Self-citationOrigin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract
Powell, J. J., Faria, N., Thomas-McKay, E., & Pele, L. C. (2010) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.11.006 · Cited by 543
Metadata
- Authors
- Stone, V., Johnston, H., & Schins, R. P. F.
- Venue
- Critical Reviews in Toxicology
- Publisher
- Informa UK Limited
- Published
- 2009-08
- Volume
- 39
- Issue
- 7
- Pages
- 613-626
- ISSN
- 0045-6446 (ISSN-L)
- 1040-8444
- 1547-6898
- OpenAlex
- W2109732199
- Cited by
- 427
- References
- 6
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stone, V., Johnston, H., & Schins, R. P. F. (2009). Development of in vitro systems for nanotoxicology: methodological considerations. Critical Reviews in Toxicology. https://doi.org/10.1080/10408440903120975
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
