Measurement of Reactive Oxygen Species in Cardiovascular Studies

Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader11Mention of a trade name, proprietary product, or specific equipment does not constitute a guarantee by the United States Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.

Wang, H., & Joseph, J. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00107-0 · Cited by 2,355 · see citing works

Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression

Zelko, I. N., Mariani, T. J., & Folz, R. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00905-x · Cited by 2,212 · see citing works

Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

Bass, D., Parce, J. W., DeChatelet, L. R., Szejda, P., Seeds, M. C., & Thomas, M. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.130.4.1910 · Cited by 1,811 · see citing works

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660 · see citing works

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652 · see citing works

Topology of superoxide production from different sites in the mitochondrial electron transport chain

St-Pierre, J., Buckingham, J. A., Roebuck, S. J., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207217200 · Cited by 1,545 · see citing works

A Stable Nonfluorescent Derivative of Resorufin for the Fluorometric Determination of Trace Hydrogen Peroxide: Applications in Detecting the Activity of Phagocyte NADPH Oxidase and Other Oxidases

Zhou, M., Diwu, Z. J., Panchuk-Voloshina, N., & Haugland, R. P. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2391 · Cited by 1,400 · see citing works

Genetically encoded fluorescent indicator for intracellular hydrogen peroxide

Belousov, V. V., Fradkov, A. F., Lukyanov, K. A., Staroverov, D. B., Shakhbazov, K., Terskikh, A. V., & Lukyanov, S. (2006) · Nature Methods · doi:10.1038/nmeth866 · Cited by 1,260 · see citing works

Electron Paramagnetic Resonance: Elementary Theory and Practical Applications

Weil, J. A., Bolton, J. R., Wertz, J. E., & Buckmaster, H. A. (1995) · Physics Today · doi:10.1063/1.2808029 · Cited by 1,013 · see citing works

Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus

Guzik, T. J., Mussa, S., Gastaldi, D., Sadowski, J., Ratnatunga, C., Pillai, R. G., & Channon, K. M. (2002) · Circulation · doi:10.1161/01.cir.0000012748.58444.08 · Cited by 979 · see citing works

Modulation of Protein Kinase Activity and Gene Expression by Reactive Oxygen Species and Their Role in Vascular Physiology and Pathophysiology

Griendling, K. K., Sorescu, D., Lassegue, B. P., & Ushio‐Fukai, M. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.10.2175 · Cited by 955 · see citing works

Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

Cadenas, E., Boveris, A., Ragan, C. I., & Stoppani, A. O. M. (1977) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(77)90035-2 · Cited by 855 · see citing works

Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: Potential implications in intracellular fluorescence detection of superoxide

Zhao, H., Kalivendi, S., Zhang, H., Joseph, J., Nithipatikom, K., Vásquez-Vivar, J., & Kalyanaraman, B. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00142-4 · Cited by 803 · see citing works

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction: Linking Mitochondrial Oxidative Damage and Vascular Endothelial Dysfunction

Doughan, A. K., Harrison, D. G., & Dikalov, S. I. (2008) · Circulation Research · doi:10.1161/circresaha.107.162800 · Cited by 710 · see citing works

Angiotensin II Stimulation of NAD(P)H Oxidase Activity

Seshiah, P., Weber, D. S., Ročić, P., Valppu, L., Taniyama, Y., & Griendling, K. K. (2002) · Circulation Research · doi:10.1161/01.res.0000033523.08033.16 · Cited by 709 · see citing works

Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols

Kuzkaya, N., Weissmann, N., Harrison, D. G., & Dikalov, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302227200 · Cited by 692 · see citing works

Effects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase and Components of Nitric Oxide/cGMP Signaling

Mollnau, H., Wendt, M., Szöcs, K., Lassègue, B., Schulz, E., Oelze, M., Li, H., Bodenschatz, M., August, M., Kleschyov, A. L., et al. (2002) · Circulation Research · doi:10.1161/01.res.0000012569.55432.02 · Cited by 676 · see citing works

Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis

Warnholtz, A., Nickenig, G., Schulz, E., Macharzina, R. R., Bräsen, J. H., Skatchkov, M. P., Heitzer, T. A., Stasch, J. P., Griendling, K. K., Harrison, D. G., et al. (1999) · Circulation · doi:10.1161/01.cir.99.15.2027 · Cited by 676 · see citing works

A Targetable Fluorescent Probe for Imaging Hydrogen Peroxide in the Mitochondria of Living Cells

Dickinson, B. C., & Chang, C. J. (2008) · Journal of the American Chemical Society · doi:10.1021/ja802355u · Cited by 642 · see citing works

Superoxide Production in Vascular Smooth Muscle Contributes to Oxidative Stress and Impaired Relaxation in Atherosclerosis

Miller, F. J., Gutterman, D. D., Rios, C., Heistad, D. D., & Davidson, B. L. (1998) · Circulation Research · doi:10.1161/01.res.82.12.1298 · Cited by 623 · see citing works

Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence

Zhao, H., Joseph, J., Fales, H. M., Sokoloski, E. A., Levine, R. L., Vasquez-Vivar, J., & Kalyanaraman, B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501719102 · Cited by 576 · see citing works

Structural Basis of the Redox Switch in the OxyR Transcription Factor

Choi, H., Kim, S.-J., Mukhopadhyay, P., Cho, S., Woo, J.-R., Storz, G., & Ryu, S.-E. (2001) · Cell · doi:10.1016/s0092-8674(01)00300-2 · Cited by 560 · see citing works

Boronate-based fluorescent probes for imaging cellular hydrogen peroxide.

Miller, E. W., Albers, A. E., Pralle, A., Isacoff, E., & Chang, C. J. (2005) · Journal of the American Chemical Society · doi:10.1021/ja054474f · Cited by 530 · see citing works

Validation of Lucigenin (Bis-N-methylacridinium) as a Chemilumigenic Probe for Detecting Superoxide Anion Radical Production by Enzymatic and Cellular Systems

Li, Y., Zhu, H., Kuppusamy, P., Roubaud, V., Zweier, J. L., & Trush, M. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.2015 · Cited by 526 · see citing works

Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space

Han, D., WILLIAMS, E., & Cadenas, E. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530411 · Cited by 516 · see citing works

Oxidative Stress and Hypertension

Harrison, D. G., & Góngora, M. C. (2009) · Medical Clinics of North America · doi:10.1016/j.mcna.2009.02.015 · Cited by 451 · see citing works

Nox1 Overexpression Potentiates Angiotensin II-Induced Hypertension and Vascular Smooth Muscle Hypertrophy in Transgenic Mice

Dikalova, A., Clempus, R., Lassègue, B., Cheng, G., McCoy, J., Dikalov, S., Martin, A. S., Lyle, A., Weber, D. S., Weiss, D., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.538934 · Cited by 438 · see citing works

Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance.

Beckman, J. S., Minor, R. L., White, C. W., Repine, J. E., Rosen, G. M., & Freeman, B. Α. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68727-7 · Cited by 417 · see citing works

Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production

Dikalov, S., Dikalova, A., Bikineyeva, A. T., Schmidt, H. H. H. W., Harrison, D. G., & Griendling, K. K. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.013 · Cited by 386 · see citing works

Evidence for free radical formation during the oxidation of 2′-7′-dichlorofluorescin to the fluorescent dye 2′-7′-dichlorofluorescein by horseradish peroxidase:

Rota, C., Chignell, C. F., & Mason, R. P. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00137-9 · Cited by 383 · see citing works

Atrial Fibrillation Increases Production of Superoxide by the Left Atrium and Left Atrial Appendage

Dudley, S. C., Hoch, N. E., McCann, L. A., Honeycutt, C., Diamandopoulos, L., Fukai, T., Harrison, D. G., Dikalov, S., & Langberg, J. J. (2005) · Circulation · doi:10.1161/circulationaha.105.538108 · Cited by 375 · see citing works

Luminol and lucigenin as detectors for O2ṡ−

Faulkner, K. M., & Fridovich, I. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90044-u · Cited by 342 · see citing works

Redox Mechanisms in Blood Vessels

Mueller, C. F. H., Laude, K. M., McNally, J. S., & Harrison, D. G. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000149143.04821.eb · Cited by 342 · see citing works

The use of acetylated ferricytochrome C for the detection of superoxide radicals produced in biological membranes

Azzi, A., Montecucco, C., & Richter, C. (1975) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(75)80188-4 · Cited by 329 · see citing works

Mitochondrial Sources of H 2 O 2 Generation Play a Key Role in Flow-Mediated Dilation in Human Coronary Resistance Arteries

Liu, Y., Zhao, H., Li, H., Kalyanaraman, B., Nicolosi, A. C., & Gutterman, D. D. (2003) · Circulation Research · doi:10.1161/01.res.0000091261.19387.ae · Cited by 323 · see citing works

Tetrahydrobiopterin-dependent preservation of nitric oxide–mediated endothelial function in diabetes by targeted transgenic GTP–cyclohydrolase I overexpression

Alp, N. J., Mussa, S., Khoo, J. P., Cai, S., Guzik, T. J., Jefferson, A., Goh, N., Rockett, K. A., & Channon, K. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17786 · Cited by 321 · see citing works

Detection of Superoxide in Vascular Tissue

Münzel, T. F., Afanasʹev, I. B., Kleschyov, A. L., & Harrison, D. G. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000034022.11764.ec · Cited by 281 · see citing works

Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay

Fink, B., Laude, K. M., McCann, L. A., Doughan, A. K., Harrison, D. G., & Dikalov, S. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00028.2004 · Cited by 259 · see citing works

Chemiluminescence probe with Cypridina luciferin analog, 2-methyl-6-phenyl-3,7-dihydroimidazo[1,2-a]pyrazin-3-one, for estimating the ability of human granulocytes to generate O2−

Nakano, M., Sugioka, K., Ushijima, Y., & Goto, T. (1986) · Analytical Biochemistry · doi:10.1016/0003-2697(86)90354-4 · Cited by 253 · see citing works

Mitochondria: are they the seat of senescence?

Fridovich, I. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00075.x · Cited by 230 · see citing works

Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: Implications for uncoupling endothelial nitric oxide synthase

Kuzkaya, N., Weißmann, N., Harrison, D. G., & Dikalov, S. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.05.009 · Cited by 225 · see citing works

Vascular Oxidant Stress Enhances Progression and Angiogenesis of Experimental Atheroma

Khatri, J. J., Johnson, C., Magid, R., Lessner, S. M., Laude, K. M., Dikalov, S., Harrison, D. G., Sung, H., Rong, Y., & Galis, Z. S. (2004) · Circulation · doi:10.1161/01.cir.0000109698.70638.2b · Cited by 224 · see citing works

Lucigenin (Bis-N-methylacridinium) as a Mediator of Superoxide Anion Production

Liochev, S. I., & Fridovich, I. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.9766 · Cited by 223 · see citing works

Phenoxyl Free Radical Formation during the Oxidation of the Fluorescent Dye 2′,7′-Dichlorofluorescein by Horseradish Peroxidase

Rota, C., Fann, Y. C., & Mason, R. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28161 · Cited by 221 · see citing works

Opening mitoKATPincreases superoxide generation from complex I of the electron transport chain

Andrukhiv, A., Costa, A. D. T., West, I. C., & Garlid, K. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00272.2006 · Cited by 216 · see citing works

Angiotensin II Induces Endothelial Xanthine Oxidase Activation: Role for Endothelial Dysfunction in Patients With Coronary Disease

Landmesser, U., Spiekermann, S., Preuss, C., Sorrentino, S., Fischer, D., Manes, C., Mueller, M., & Drexler, H. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000258415.32883.bf · Cited by 210 · see citing works

Detection of hydrogen peroxide with Amplex Red: interference by NADH and reduced glutathione auto-oxidation

Votyakova, T. V., & Reynolds, I. J. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.07.025 · Cited by 207 · see citing works

Role of Extracellular Superoxide Dismutase in Hypertension

Gongora, M. C., Qin, Z., Laude, K., Kim, H. W., McCann, L., Folz, J. R., Dikalov, S., Fukai, T., & Harrison, D. G. (2006) · Hypertension · doi:10.1161/01.hyp.0000235682.47673.ab · Cited by 204 · see citing works

Superoxide anion formation from lucigenin: an electron spin resonance spin‐trapping study

Vasquez-Vivar, J. M., Hogg, N., Pritchard, K. A., Pavel Martasek, E., & Kalyanaraman, B. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00036-7 · Cited by 194 · see citing works

Oxidation of 2′,7′-Dichlorofluorescin by Peroxynitrite

Kooy, N. W., Royall, J. A., & Ischlropoulos, H. (1997) · Free Radical Research · doi:10.3109/10715769709065763 · Cited by 181 · see citing works

Photoreduction of the fluorescent dye 2′-7′-dichlorofluorescein: a spin trapping and direct electron spin resonance study with implications for oxidative stress measurements

Marchesi, E., Rota, C., Fann, Y. C., Chignell, C. F., & Mason, R. P. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00174-9 · Cited by 162 · see citing works

Chemiluminescent Detection of Oxidants in Vascular Tissue

Tarpey, M. M., White, C. R., Suarez, E., Richardson, G. R., Radí, R., & Freeman, B. Α. (1999) · Circulation Research · doi:10.1161/01.res.84.10.1203 · Cited by 162 · see citing works

Detection of superoxide anion using an isotopically labeled nitrone spin trap: potential biological applications

Zhang, H., Joseph, J., Vasquez-Vivar, J. M., Karoui, H., Nsanzumuhire, C., Pavel Martasek, E., Tordo, P., & Kalyanaraman, B. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01498-8 · Cited by 152 · see citing works

Detection of Superoxide and Peroxynitrite in Model Systems and Mitochondria by the Luminol Analogue L-012

Daiber, A., Oelze, M. W., August, M., Wendt, M., Sydow, K., Wieboldt, H., Kleschyov, A. L., & Münzel, T. F. (2004) · Free Radical Research · doi:10.1080/10715760410001659773 · Cited by 145 · see citing works

The kinetics of the reduction of cytochrome c by the superoxide anion radical

Koppenol, W. H., Buuren, K. J. H. V., Butler, J., & Braams, R. (1976) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(76)90130-4 · Cited by 126 · see citing works

[22] Spin trapping

Janzen, E. G. (1984) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(84)05025-4 · Cited by 119 · see citing works

Diphenyleneiodonium acutely inhibits reactive oxygen species production by mitochondrial complex I during reverse, but not forward electron transport

Lambert, A. J., Buckingham, J. A., Boysen, H. M., & Brand, M. D. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.03.005 · Cited by 118 · see citing works

Hepatitis C virus‐core and non structural proteins lead to different effects on cellular antioxidant defenses

Abdalla, M. Y., Ahmad, I. M., Spitz, D. R., Schmidt, W. N., & Britigan, B. E. (2005) · Journal of Medical Virology · doi:10.1002/jmv.20388 · Cited by 118 · see citing works

Regulation of Xanthine Oxidoreductase Protein Expression by Hydrogen Peroxide and Calcium

McNally, J. S., Saxena, A., Cai, H. “., Dikalov, S., & Harrison, D. G. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000170827.16296.6e · Cited by 115 · see citing works

Intracellular generation of reactive oxygen species in endothelial cells exposed to anoxia-reoxygenation

Zulueta, J. J., Sawhney, R., Yu, F., Côté, C., & Hassoun, P. M. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.272.5.l897 · Cited by 115 · see citing works

Evaluation of assays for the measurement of bovine neutrophil reactive oxygen species

Rinaldi, M., Moroni, P., Paape, M. J., & Bannerman, D. D. (2006) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2006.09.009 · Cited by 112 · see citing works

Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: Identification of homo- and heterodimers

Zielonka, J., Srinivasan, S., Hardy, M., Ouari, O., López, M., Vasquez-Vivar, J. M., Avadhani, N. G., & Kalyanaraman, B. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.11.013 · Cited by 105 · see citing works

Angiotensin II-induced hypertrophy is potentiated in mice overexpressing p22phox in vascular smooth muscle

Weber, D. S., Ročić, P., Mellis, A. M., Laude, K. M., Lyle, A. N., Harrison, D. G., & Griendling, K. K. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00638.2004 · Cited by 104 · see citing works

Role of Oxalacetate in the Regulation of Mammalian Succinate Dehydrogenase

Ackrell, B. A. C., Kearney, E. B., & Mayr, M. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42790-7 · Cited by 102 · see citing works

Noninvasive diagnostic tool for inflammation-induced oxidative stress using electron spin resonance spectroscopy and an extracellular cyclic hydroxylamine

Dikalov, S., Dikalova, A., & Mason, R. P. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00064-4 · Cited by 85 · see citing works

Functional association of nox1 with p22phox in vascular smooth muscle cells

Hanna, I. R., Hilenski, L. L., Dikalova, A., Taniyama, Y., Dikalov, S., Lyle, A. N., Quinn, M. T., Lassegue, B. P., & Griendling, K. K. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.011 · Cited by 81 · see citing works

Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals: effect of vitamin C

Dikalov, S., Fink, B., Skatchkov, M. P., & Bassenge, E. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00066-0 · Cited by 80 · see citing works

An in vivo ESR spin-trapping study: Free radical generation in rats from formate intoxication— role of the Fenton reaction

Dikalova, A., Kadiiska, M. B., & Mason, R. P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251091098 · Cited by 77 · see citing works

Overstimation of verestimation of NADH-driven vascular oxidase activity due to lucigenin artifacts

Janiszewski, M., de Souza, H. P., Liu, X., Pedro, M. D. A., Zweier, J. L., & Laurindo, F. R. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00828-0 · Cited by 77 · see citing works

Properties of the radical intermediate obtained on oxidation of 2′,7′-dichlorodihydrofluorescein, a probe for oxidative stress

Wrona, M., & Wardman, P. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.006 · Cited by 76 · see citing works

Characterization of the high-resolution ESR spectra of superoxide radical adducts of 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N -oxide (DEPMPO) and 5,5-dimethyl-1-pyrroline N -oxide (DMPO). Analysis of conformational exchange

Dikalov, S., Jiang, J., & Mason, R. P. (2005) · Free Radical Research · doi:10.1080/10715760500155688 · Cited by 69 · see citing works

REESTIMATION OF CYPRIDINA LUCIFERIN ANALOGS (MCLA) AS A CHEMILUMINESCENCE PROBE TO DETECT ACTIVE OXYGEN SPECIES-CAUTIONARY NOTE FOR USE OF MCLA-

Kambayashi, Y., & Ogino, K. (2003) · The Journal of Toxicological Sciences · doi:10.2131/jts.28.139 · Cited by 64 · see citing works

Quantification of Superoxide Radicals and Peroxynitrite in Vascular Cells Using Oxidation of Sterically Hindered Hydroxylamines and Electron Spin Resonance

Dikalov, S., Skatchkov, M. P., Fink, B., & Bassenge, E. (1997) · Nitric Oxide · doi:10.1006/niox.1997.0139 · Cited by 61 · see citing works

Intracellular oxidant production and cytokine responses in lung macrophages: evaluation of fluorescent probes

Imrich, A., Ning, Y., & Kobzik, L. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.4.499 · Cited by 45 · see citing works

Free radicals induced by adriamycin-sensitive and adriamycin-resistant cells: a spin-trapping study

Alegrı́a, A. E., Samuni, A. M., Mitchell, J. B., Riesz, P., & Russo, A. (1989) · Biochemistry · doi:10.1021/bi00447a056 · Cited by 40 · see citing works

A new screening method to detect water-soluble antioxidants: acetaminophen (tylenol®) and other phenols react as antioxidants and destroy peroxynitrite-based luminol-dependent chemiluminescence

Dyke, K. V., Sacks, M., & Qazi, N. (1998) · Journal of Bioluminescence and Chemiluminescence · doi:10.1002/(sici)1099-1271(199811/12)13:6 · Cited by 39 · see citing works

Molecular Mechanisms in Hypertension

(2006) · CRC Press eBooks · doi:10.1201/b14627 · Cited by 36 · see citing works

Hypoxia-induced alterations in Ca2+mobilization in brain microvascular endothelial cells

Kimura, C., Oike, M., & Ito, Y. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.5.h2310 · Cited by 35 · see citing works

Inclusion complexes of EMPO derivatives with 2,6-di-O-methyl-β-cyclodextrin: synthesis, NMR and EPR investigations for enhanced superoxide detection

Bardelang, D., Rockenbauer, A., Karoui, H., Finet, J., Biskupska, I., Banaszak, K., & Tordo, P. (2006) · Organic & Biomolecular Chemistry · doi:10.1039/b606062e · Cited by 33 · see citing works

Superoxide anion impairs contractility in cultured aortic smooth muscle cells

Kimura, C., Cheng, W., Hisadome, K., Wang, Y., Koyama, T., Karashima, Y., Oike, M., & Ito, Y. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00574.2001 · Cited by 29 · see citing works

Hydroxyl radical generation: the effect of bicarbonate, dioxygen and buffer concentration on pH-dependent chemiluminescence

Oosthuizen, M. M. J., & Greyling, D. (2001) · Redox Report · doi:10.1179/135100001101536111 · Cited by 25 · see citing works

The excretion mechanism of the spin label proxyl carboxylic acid (PCA) from the rat monitored by X‐band ESR and PEDRI

Seimenis, I., Foster, M. A., Lurie, D. J., Hutchison, J. M. S., Whiting, P. H., & Payne, S. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910370413 · Cited by 25 · see citing works

Kinetics of nitroxide spin label removal in biological systems: An in vitro and in vivo ESR study

Vianello, F., Momo, F., Scarpa, M., & Rigo, A. (1995) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(94)00121-i · Cited by 24 · see citing works

NADPH-Induced Contractions of Mouse Aorta Do Not Involve NADPH Oxidase: A Role for P2X Receptors

Judkins, C. P., Sobey, C. G., Dang, T. T., Miller, A. A., Dusting, G. J., & Drummond, G. R. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.096610 · Cited by 24 · see citing works

Cu,Zn-Superoxide Dismutase Is an Intracellular Catalyst for the H2O2-dependent Oxidation of Dichlorodihydrofluorescein

Kim, Y., Lim, J.-M., Kim, B.-C., & Han, S. (2006) · Molecules and Cells · doi:10.1016/s1016-8478(23)12915-3 · Cited by 21 · see citing works

Oxygen radical generation and enzymatic properties of mitochondria in hypoxia/reoxygenation.

Zwicker, K., Dikalov, S., MATUSCHKA, S., Mainka, L., Hofmann, M., Khramtsov, V. V., & Zimmer, G. (1998) · PubMed · Cited by 15 · see citing works

The use of acetylated cytochrome c in detecting superoxide anion production in rabbit alveolar macrophages.

Nasrallah, V. N., Shirley, P. S., Myrvik, Q. N., & Waite, M. B. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.131.5.2104 · Cited by 12 · see citing works

Carteolol Hydrochloride Protects Human Corneal Epithelial Cells From UVB-Induced Damage In Vitro

Kuwahara, K., Oizumi, N., Fujisawa, S., Tanito, M., & Ohira, A. (2005) · Cornea · doi:10.1097/01.ico.0000141232.41343.9d · Cited by 10 · see citing works

A reassessment of the product specificity of the NADPH:O2 oxidoreductase of human neutrophils

Green, T. R., & Pratt, K. L. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90473-6 · Cited by 10 · see citing works

Superoxide Ion: Generation and Chemical Implications

Hayyan, M., Hashim, M. A., & AlNashef, I. M. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00407 · Cited by 2,191 · see citing works

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

Kalyanaraman, B., Darley-Usmar, V. M., Davies, K. J. A., Dennery, P. A., Forman, H. J., Grisham, M. B., Mann, G. E., Moore, K. P., Roberts, L. J., & Ischiropoulos, H. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.030 · Cited by 1,795 · see citing works

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

Heumüller, S., Wind, S., Barbosa-Sicard, E., Schmidt, H. H. H. W., Busse, R., Schröder, K., & Brandes, R. P. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.100214 · Cited by 735 · see citing works

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

Dikalova, A., Bikineyeva, A. T., Budzyn, K., Nazarewicz, R. R., McCann, L. A., Lewis, W., Harrison, D. G., & Dikalov, S. (2010) · Circulation Research · doi:10.1161/circresaha.109.214601 · Cited by 737 · see citing works

Hypoxic Pulmonary Vasoconstriction

Sylvester, J. T., Shimoda, L. A., Aaronson, P. I., & Ward, J. P. T. (2012) · Physiological Reviews · doi:10.1152/physrev.00041.2010 · Cited by 727 · see citing works

Methods for Detection of Mitochondrial and Cellular Reactive Oxygen Species

Dikalov, S., & Harrison, D. G. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4886 · Cited by 639 · see citing works

Mitochondrial Control of Cellular Life, Stress, and Death

Galluzzi, L., Kepp, O., Trojel‐Hansen, C., & Kroemer, G. (2012) · Circulation Research · doi:10.1161/circresaha.112.268946 · Cited by 545 · see citing works

Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: Another inconvenient truth

Zielonka, J., & Kalyanaraman, B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.028 · Cited by 535 · see citing works

Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function

Stowe, D. F., & Camara, A. K. S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2331 · Cited by 471 · see citing works

Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System

Griendling, K. K., Touyz, R. M., Zweier, J. L., Dikalov, S., Chilian, W. M., Chen, Y., Harrison, D. G., & Bhatnagar, A. (2016) · Circulation Research · doi:10.1161/res.0000000000000110 · Cited by 452 · see citing works

Development ofin vitrosystems for nanotoxicology: methodological considerations

Stone, V., Johnston, H. J., & Schins, R. P. F. (2009) · Critical Reviews in Toxicology · doi:10.1080/10408440903120975 · Cited by 430 · see citing works

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

Lyle, A. N., Deshpande, N. N., Taniyama, Y., Seidel-Rogol, B., Pounkova, L., Du, P., Papaharalambus, C., Lassègue, B., & Griendling, K. K. (2009) · Circulation Research · doi:10.1161/circresaha.109.193722 · Cited by 428 · see citing works

Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine

Zielonka, J., Vasquez-Vivar, J. M., & Kalyanaraman, B. (2007) · Nature Protocols · doi:10.1038/nprot.2007.473 · Cited by 421 · see citing works

Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease

Panth, N., Paudel, K. R., & Parajuli, K. (2016) · Advances in Medicine · doi:10.1155/2016/9152732 · Cited by 405 · see citing works

Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production

Dikalov, S., Dikalova, A., Bikineyeva, A. T., Schmidt, H. H. H. W., Harrison, D. G., & Griendling, K. K. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.013 · Cited by 386 · see citing works

Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

Dikalova, A., Pandey, A. K., Xiao, L., Arslanbaeva, L. R., Sidorova, T. N., Lopez, M. G., Billings, F. T., Verdin, E. M., Auwerx, J. H., Harrison, D. G., et al. (2019) · Circulation Research · doi:10.1161/circresaha.119.315767 · Cited by 374 · see citing works

Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications

Hsieh, H., Liu, C.-A., Huang, B., Tseng, A. H.-H., & Wang, D. L. (2014) · Journal of Biomedical Science · doi:10.1186/1423-0127-21-3 · Cited by 333 · see citing works

The role of reactive oxygen species and metabolism on cancer cells and their microenvironment

Costa, A., Scholer‐Dahirel, A., & Mechta‐Grigoriou, F. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.12.007 · Cited by 329 · see citing works

Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension

Dikalova, A., Itani, H. A., Nazarewicz, R. R., McMaster, W. G., Flynn, C. R., Uzhachenko, R. V., Fessel, J. P., Gamboa, J. L., Harrison, D. G., & Dikalov, S. (2017) · Circulation Research · doi:10.1161/circresaha.117.310933 · Cited by 317 · see citing works

Nox2-Induced Production of Mitochondrial Superoxide in Angiotensin II-Mediated Endothelial Oxidative Stress and Hypertension

Dikalov, S., Nazarewicz, R. R., Bikineyeva, A. T., Hilenski, L. L., Lassegue, B. P., Griendling, K. K., Harrison, D. G., & Dikalova, A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4918 · Cited by 312 · see citing works

Senescence, Stress, and Reactive Oxygen Species

Jajić, I., Sarna, T., & Strzałka, K. (2015) · Plants · doi:10.3390/plants4030393 · Cited by 299 · see citing works

Inhibition and Genetic Ablation of the B7/CD28 T-Cell Costimulation Axis Prevents Experimental Hypertension

Vinh, A., Chen, W., Blinder, Y., Weiss, D., Taylor, W. R., Goronzy, J. J., Weyand, C. M., Harrison, D. G., & Guzik, T. J. (2010) · Circulation · doi:10.1161/circulationaha.109.930446 · Cited by 299 · see citing works

Methods to Monitor ROS Production by Fluorescence Microscopy and Fluorometry

Wojtala, A., Bonora, M., Malińska, D., Pinton, P., Duszyński, J., & Wieckowski, M. R. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-416618-9.00013-3 · Cited by 289 · see citing works

What does the commonly used DCF test for oxidative stress really show?

Karlsson, M., Kurz, T., Brunk, U. T., NILSSON, S. E. G., & Frennesson, C. I. (2010) · Biochemical Journal · doi:10.1042/bj20100208 · Cited by 278 · see citing works

Methods for the detection of reactive oxygen species

Zhang, Y., Dai, M., & Yuan, Z. (2018) · Analytical Methods · doi:10.1039/c8ay01339j · Cited by 261 · see citing works

NMDA Receptor Activation Increases Free Radical Production through Nitric Oxide and NOX2

Girouard, H., Wang, G., Gallo, E. F., Anrather, J., Zhou, P., Pickel, V. M., & Iadecola, C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0133-09.2009 · Cited by 254 · see citing works

Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species—Studies in White Blood Cells and in Animal Models

Kröller‐Schön, S., Steven, S., Kossmann, S., Scholz, A., Daub, S., Oelze, M. W., Xia, N., Hausding, M., Mikhed, Y., Zinßius, E., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4953 · Cited by 246 · see citing works

Heme Oxygenases in Cardiovascular Health and Disease

Ayer, A., Zarjou, A., Agarwal, A., & Stocker, R. (2016) · Physiological Reviews · doi:10.1152/physrev.00003.2016 · Cited by 243 · see citing works

Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets

Jaquet, V., Scapozza, L., Clark, R. A., Krause, K. H., & Lambeth, J. D. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2585 · Cited by 243 · see citing works

Comparative pharmacology of chemically distinct nadph oxidase inhibitors

Wind, S., Beuerlein, K., Eucker, T., Müller, H., Scheurer, P., Armitage, M., Ho, H., Schmidt, H., & Wingler, K. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00920.x · Cited by 241 · see citing works

Hypertension: Physiology and Pathophysiology

Hall, J. E., Granger, J. P., do Carmo, J. M., da Silva, A. A., Dubinion, J., George, E., Hamza, S., Speed, J., & Hall, M. E. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110058 · Cited by 232 · see citing works

Evaluating Oxidative Stress in Human Cardiovascular Disease: Methodological Aspects and Considerations

Lee, R., Margaritis, M., Channon, K. M., & Antoniades, C. A. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712800493057 · Cited by 228 · see citing works

A Facile Synthesis of PEG-Coated Magnetite (Fe3O4) Nanoparticles and Their Prevention of the Reduction of Cytochrome C

Mukhopadhyay, A., Joshi, N., Chattopadhyay, K., & De, G. (2011) · ACS Applied Materials & Interfaces · doi:10.1021/am201166m · Cited by 225 · see citing works

Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells

Selemidis, S., Dusting, G. J., Peshavariya, H., Kemp‐Harper, B. K., & Drummond, G. R. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.03.030 · Cited by 221 · see citing works

Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension

Dikalov, S., Itani, H. A., Richmond, B. W., Arslanbaeva, L., Vergeade, A., Rahman, S. M. J., Boutaud, O. G., Blackwell, T. S., Massion, P. P., Harrison, D. G., et al. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00595.2018 · Cited by 213 · see citing works

Signaling Components of Redox Active Endosomes: The Redoxosomes

Oakley, F. D., Abbott, D., Li, Q., & Engelhardt, J. F. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2363 · Cited by 209 · see citing works

Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice

Mellor, K. M., Bell, J. R., Young, M. J., Ritchie, R. H., & Delbridge, L. M. D. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.03.002 · Cited by 199 · see citing works

Glutathione‐dependent reductive stress triggers mitochondrial oxidation and cytotoxicity

Zhang, H., Limphong, P., Pieper, J., Liu, Q., Rodesch, C., Christians, E., & Benjamin, I. (2012) · The FASEB Journal · doi:10.1096/fj.11-199869 · Cited by 201 · see citing works

Angiotensin II–Mediated Oxidative DNA Damage Accelerates Cellular Senescence in Cultured Human Vascular Smooth Muscle Cells via Telomere-Dependent and Independent Pathways

Herbert, K. E., Mistry, Y., Hastings, R., Poolman, T. M., Niklason, L. E., & Williams, B. (2007) · Circulation Research · doi:10.1161/circresaha.107.158626 · Cited by 191 · see citing works

Mitochondrial ROS production under cellular stress: comparison of different detection methods

Kuznetsov, A. V., Kehrer, I., Kozlov, A. V., Haller, M., Redl, H. R., Hermann, M., Grimm, M. F., & Troppmair, J. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-4764-2 · Cited by 187 · see citing works

Rosiglitazone Attenuates Chronic Hypoxia–Induced Pulmonary Hypertension in a Mouse Model

Nisbet, R. E., Bland, J. M., Kleinhenz, D. J., Mitchell, P. O., Walp, E. R., Sutliff, R. L., & Hart, C. M. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0132oc · Cited by 188 · see citing works

Global Profiling of Reactive Oxygen and Nitrogen Species in Biological Systems

Zielonka, J., Zielonka, M., Sikora, A., Adamus, J., Joseph, J., Hardy, M., Ouari, O., Dranka, B. P., & Kalyanaraman, B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.309062 · Cited by 182 · see citing works

Detection of superoxide anion and hydrogen peroxide production by cellular NADPH oxidases

Nauseef, W. M. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.04.040 · Cited by 180 · see citing works

Oxidative Stress Gated by Fenton and Haber Weiss Reactions and Its Association With Alzheimer’s Disease

Kanti Das, T., Wati, M. R., & Fatima-Shad, K. (2014) · Archives of Neuroscience · doi:10.5812/archneurosci.20078 · Cited by 177 · see citing works

Optical probes for detection and quantification of neutrophils’ oxidative burst. A review

Freitas, M., Lima, J. L. F. C., & Fernandes, E. G. R. (2009) · Analytica Chimica Acta · doi:10.1016/j.aca.2009.06.063 · Cited by 176 · see citing works

EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines

Dikalov, S., Kirilyuk, I. A., Voinov, M. A., & Григорьев, И. А. (2010) · Free Radical Research · doi:10.3109/10715762.2010.540242 · Cited by 177 · see citing works

The Role of NADPH Oxidase in Chronic Intermittent Hypoxia-Induced Pulmonary Hypertension in Mice

Nisbet, R. E., Graves, A. S., Kleinhenz, D. J., Rupnow, H. L., Reed, A. L., Fan, T. M., Mitchell, P. O., Sutliff, R. L., & Hart, C. M. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/2008-0145oc · Cited by 167 · see citing works

Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells

Jay, D. B., Papaharalambus, C. A., Seidel-Rogol, B., Dikalova, A. E., Lassègue, B., & Griendling, K. K. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.024 · Cited by 166 · see citing works

ROS-induced ROS release in vascular biology: redox-redox signaling

Zinkevich, N. S., & Gutterman, D. D. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01271.2010 · Cited by 163 · see citing works

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes

Sedeek, M. H., Gutsol, A. A., Montezano, A. C. I., Burger, D. E., Cat, A. N. D., Kennedy, C., Burns, K. D., Cooper, M. E., Jandeleit-Dahm, K. A. M., Page, P., et al. (2012) · Clinical Science · doi:10.1042/cs20120330 · Cited by 160 · see citing works

Imaging ROS signaling in cells and animals

Wang, X., Fang, H., Huang, Z., Shang, W. H., Hou, T., Cheng, A., & Cheng, H. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1067-4 · Cited by 163 · see citing works

Oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction

Sommer, N., Strielkov, I. V., Pak, O., & Weißmann, N. (2015) · European Respiratory Journal · doi:10.1183/13993003.00945-2015 · Cited by 157 · see citing works

Detection of reactive oxygen species derived from the family of NOX NADPH oxidases

Maghzal, G. J., Krause, K., Stocker, R., & Jaquet, V. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.09.002 · Cited by 151 · see citing works

HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements

Zielonka, J., Hardy, M., & Kalyanaraman, B. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.10.031 · Cited by 150 · see citing works

Oxidative Stress, Antioxidants and Hypertension

Amponsah-Offeh, M., Diaba‐Nuhoho, P., Speier, S., & Morawietz, H. (2023) · Antioxidants · doi:10.3390/antiox12020281 · Cited by 160 · see citing works

Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia

Jernigan, N. L., Walker, B. R., & Resta, T. C. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00355.2007 · Cited by 146 · see citing works

TFEB inhibits endothelial cell inflammation and reduces atherosclerosis

Lu, H., Fan, Y., Qiao, C., Liang, W., Hu, W., Zhu, T., Zhang, J., & Chen, Y. E. (2017) · Science Signaling · doi:10.1126/scisignal.aah4214 · Cited by 140 · see citing works

TiO2 nanoparticles cause mitochondrial dysfunction, activate inflammatory responses, and attenuate phagocytosis in macrophages: A proteomic and metabolomic insight

Chen, Q., Wang, N., Zhu, M., Lu, J., Zhong, H., Xue, X., Guo, S., Li, M., Wei, X., Tao, Y., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.12.011 · Cited by 143 · see citing works

Precise modulation and use of reactive oxygen species for immunotherapy

Li, X., Gao, J., Wu, C., Wang, C., Zhang, R., He, J., Xia, Z. J., Joshi, N., Karp, J. M., & Kuai, R. (2024) · Science Advances · doi:10.1126/sciadv.adl0479 · Cited by 140 · see citing works

Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats

Dunn, K. M. J., Renić, M., Flasch, A. K., Harder, D. R., Falck, J. R., & Roman, R. J. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00512.2008 · Cited by 136 · see citing works

Nox4 and diabetic nephropathy: With a friend like this, who needs enemies?

Gorin, Y. C., & Block, K. L. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.03.014 · Cited by 135 · see citing works

T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma

Sun, X.-N., Li, C., Liu, Y., Du, L., Zeng, M., Zheng, X., Zhang, W.-C., Liu, Y., Zhu, M., Kong, D., et al. (2017) · Circulation Research · doi:10.1161/circresaha.116.310480 · Cited by 134 · see citing works

Exploiting Oxidative Microenvironments in the Body as Triggers for Drug Delivery Systems

Joshi-Barr, S., Lux, C. D. G., Mahmoud, E., & Almutairi, A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5754 · Cited by 133 · see citing works

Rapid and Specific Measurements of Superoxide Using Fluorescence Spectroscopy

Nazarewicz, R. R., Bikineyeva, A. T., & Dikalov, S. (2012) · SLAS DISCOVERY · doi:10.1177/1087057112468765 · Cited by 128 · see citing works

A noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice

Bernatchez, P. N., Sharma, A., Bauer, P. M., Marin, E. P., & Sessa, W. C. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44778 · Cited by 126 · see citing works

Measurement of reactive oxygen species (ros) and mitochondrial ros in ampk knockout mice blood vessels

Wang, Q., & Zou, M.-H. (2018) · Methods in Molecular Biology · doi:10.1007/978-1-4939-7598-3_32 · Cited by 125 · see citing works

Honokiol is a potent scavenger of superoxide and peroxyl radicals

Dikalov, S., Losik, T., & Arbiser, J. L. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.06.012 · Cited by 125 · see citing works

Spin Biochemistry Modulates Reactive Oxygen Species (ROS) Production by Radio Frequency Magnetic Fields

Usselman, R. J., Hill, I., Singel, D. J., & Martino, C. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093065 · Cited by 125 · see citing works

HPLC-based monitoring of products formed from hydroethidine-based fluorogenic probes — The ultimate approach for intra- and extracellular superoxide detection

Kalyanaraman, B., Dranka, B. P., Hardy, M., Michalski, R., & Zielonka, J. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.05.008 · Cited by 120 · see citing works

Electron Paramagnetic Resonance Measurements of Reactive Oxygen Species by Cyclic Hydroxylamine Spin Probes

Dikalov, S., Polienko, Y. F., & Kirilyuk, I. A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7396 · Cited by 122 · see citing works

Hypertension, Cardiac Hypertrophy, and Impaired Vascular Relaxation Induced by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin are Associated with Increased Superoxide

Kopf, P. G., Huwe, J. K., & Walker, M. K. (2008) · Cardiovascular Toxicology · doi:10.1007/s12012-008-9027-x · Cited by 120 · see citing works

Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart

Bou‐Teen, D., Kaludercic, N., Weissman, D., Turan, B., Maack, C., Lisa, F. D., & Ruiz‐Meana, M. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.043 · Cited by 119 · see citing works

NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence?

Sorce, S., Stocker, R., Seredenina, T. S., Holmdahl, R., Aguzzi, A., Chiò, A., Depaulis, A., Heitz, F., Olofsson, P., Olsson, T. P., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.08.006 · Cited by 113 · see citing works

Nox1, 2, 4, 5: Counting out oxidative stress

Wingler, K., Hermans, J., Schiffers, P., Moens, A., Paul, M., & Schmidt, H. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01249.x · Cited by 113 · see citing works

Detection methodologies and mechanisms of reactive oxygen species generated in Fenton/Fenton-like processes

Zhang, C., Liu, L., Pan, Y., Qin, R., Wang, W., Zhou, M., & Zhang, Y. (2024) · Separation and Purification Technology · doi:10.1016/j.seppur.2024.129578 · Cited by 113 · see citing works

Role of oxidative stress in calcific aortic valve disease and its therapeutic implications

Greenberg, H. Z. E., Zhao, G., Shah, A. M., & Zhang, M. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab142 · Cited by 110 · see citing works

High glucose increases the formation and pro-oxidative activity of endothelial microparticles

Burger, D. E., Turner, M., Xiao, F., Munkonda, M. N., Akbari, S., & Burns, K. D. (2017) · Diabetologia · doi:10.1007/s00125-017-4331-2 · Cited by 110 · see citing works

Assessment of Superoxide Production and NADPH Oxidase Activity by HPLC Analysis of Dihydroethidium Oxidation Products

Laurindo, F. R. M., Fernandes, D. C., & Santos, C. X. C. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)01213-5 · Cited by 104 · see citing works

Reactive Oxygen Species Mediate Mitogenic Growth Factor Signaling Pathways in Human Leiomyoma Smooth Muscle Cells1

Mesquita, F. S., Dyer, S. N., Heinrich, D. A., Bulun, S. E., Marsh, E. E., & Nowak, R. A. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.075887 · Cited by 99 · see citing works

Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress

Nazarewicz, R. R., Dikalova, A., Bikineyeva, A. T., & Dikalov, S. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00063.2013 · Cited by 98 · see citing works

NADPH oxidases and reactive oxygen species at different stages of chronic hypoxia-induced pulmonary hypertension in newborn piglets

Dennis, K. E., Aschner, J. L., Milatović, D., Schmidt, J. W., Aschner, M., Kaplowitz, M. R., Zhang, Y., & Fike, C. D. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90568.2008 · Cited by 94 · see citing works

Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation

Qian, J., Chen, F., Kovalenkov, Y. O., Pandey, D., Moseley, M. A., Foster, M. W., Black, S. M., Venema, R. C., Stepp, D. W., & Fulton, D. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.029 · Cited by 96 · see citing works

Leveraging H2O2Levels for Biomedical Applications

Wang, J., Zhang, Y., Ogunnaike, E. A., Ligler, F. S., & Gu, Z. (2017) · Advanced Biosystems · doi:10.1002/adbi.201700084 · Cited by 96 · see citing works

Cardiovascular Protective Effects of Centella asiatica and Its Triterpenes: A Review

Razali, N. N. M., Ng, C. T., & Fong, L. Y. (2019) · Planta Medica · doi:10.1055/a-1008-6138 · Cited by 95 · see citing works

Detection of cellular redox reactions and antioxidant activity assays

Meng, D., Zhang, P., Zhang, L., Wang, H., Ho, C., Li, S., Shahidi, F., & Zhao, H. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.08.008 · Cited by 95 · see citing works

Angiotensin II Induces a Region-Specific Hyperplasia of the Ascending Aorta Through Regulation of Inhibitor of Differentiation 3

Owens, A. P., Subramanian, V., Moorleghen, J. J., Guo, Z., McNamara, C. A., Cassis, L. A., & Daugherty, A. (2009) · Circulation Research · doi:10.1161/circresaha.109.212837 · Cited by 94 · see citing works

Disruption of the ribosomal P complex leads to stress-induced autophagy

Artero‐Castro, A., Pérez‐Alea, M., Feliciano, A., Leal, J. A., Genestar, M., Castellví, J., Peg, V., y Cajal, S. R., & LLeonart, M. E. (2015) · Autophagy · doi:10.1080/15548627.2015.1063764 · Cited by 89 · see citing works

Approaches for Reactive Oxygen Species and Oxidative Stress Quantification in Epilepsy

Taiwo, R. O., Sandouka, S., Saadi, A., & Shekh‐Ahmad, T. (2020) · Antioxidants · doi:10.3390/antiox9100990 · Cited by 91 · see citing works

Active NF-E2-related Factor (Nrf2) Contributes to Keep Endothelial NO Synthase (eNOS) in the Coupled State

Heiß, E. H., Schachner, D., Werner, E. R., & Dirsch, V. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.009175 · Cited by 89 · see citing works

Health position paper and redox perspectives - Disease burden by transportation noise

Sørensen, M., Pershagen, G., Thacher, J. D., Lanki, T., Wicki, B., Röösli, M., Vienneau, D., Cantuaria, M. L., Schmidt, J. H., Aasvang, G. M., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102995 · Cited by 91 · see citing works

Mitochondrial-Targeted Antioxidant Therapy Decreases Transforming Growth Factor-β–Mediated Collagen Production in a Murine Asthma Model

Jaffer, O. A., Carter, A. B., Sanders, P. N., Dibbern, M. E., Winters, C. J., Murthy, S., Ryan, A. J., Rokita, A. G., Prasad, A. M., Zabner, J., et al. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0519oc · Cited by 86 · see citing works

Surgical vein graft preparation promotes cellular dysfunction, oxidative stress, and intimal hyperplasia in human saphenous vein

Osgood, M. J., Hocking, K. M., Voskresensky, I. V., Li, F. D., Komalavilas, P., Cheung‐Flynn, J., & Brophy, C. M. (2013) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2013.06.004 · Cited by 87 · see citing works

Mitochondrial reactive oxygen species activate the slow force response to stretch in feline myocardium

Caldiz, C. I., Garciarena, C. D., Dulce, R. A., Novaretto, L. P., Yeves, A. M., Ennis, I. L., Cingolani, H. E., de Cingolani, G. C., & Pérez, N. G. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.141689 · Cited by 86 · see citing works

Mitochondrial Cyclophilin D in Vascular Oxidative Stress and Hypertension

Itani, H. A., Dikalova, A., McMaster, W. G., Nazarewicz, R. R., Bikineyeva, A. T., Harrison, D. G., & Dikalov, S. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.07085 · Cited by 86 · see citing works

Analytical methods to assess the oxidative potential of nanoparticles: a review

Hellack, B., Nickel, C., Albrecht, C., Kuhlbusch, T. A. J., Boland, S., Baeza‐Squiban, A., Wohlleben, W., & Schins, R. P. F. (2017) · Environmental Science Nano · doi:10.1039/c7en00346c · Cited by 85 · see citing works

In Vivo Imaging of Inflammatory Phagocytes

Tseng, J., & Kung, A. L. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.08.007 · Cited by 85 · see citing works

Silk Fibroin-Based Therapeutics for Impaired Wound Healing

Lehmann, T., Vaughn, A. E., Seal, S., Liechty, K. W., & Zgheib, C. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030651 · Cited by 84 · see citing works

Elimination of NADPH Oxidase Activity Promotes Reductive Stress and Sensitizes the Heart to Ischemic Injury

Yu, Q., Lee, C. F., Wang, W., Karamanlidis, G., Kuroda, J., Matsushima, S., Sadoshima, J., & Tian, R. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000555 · Cited by 84 · see citing works

Glutathione Peroxidase-1 Deficiency Augments Proinflammatory Cytokine-induced Redox Signaling and Human Endothelial Cell Activation

Lubos, E., Kelly, N. J., Oldebeken, S. R., Leopold, J. A., Zhang, Y., Loscalzo, J., & Handy, D. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.205708 · Cited by 83 · see citing works

Mitochondrial Sirtuin-3 (SIRT3) Prevents Doxorubicin-Induced Dilated Cardiomyopathy by Modulating Protein Acetylation and Oxidative Stress

Tomczyk, M. M., Cheung, K. G., Xiang, B., Tamanna, N., Teixeira, A. L. F., Agarwal, P., Kereliuk, S. M., Spicer, V., Lin, L., Treberg, J., et al. (2022) · Circulation Heart Failure · doi:10.1161/circheartfailure.121.008547 · Cited by 81 · see citing works

Reactive Oxygen Species–Dependent Hypertension in

Escano, C., Jose, P. A., Arm, I., Wang, X., Anthony, V., Villar, M., Jones, J. E., Asico, L. D., Dopamine, D., Arm, I., et al. (2015)

Reactive Oxygen Species Impair Sympathetic Vasoregulation in Skeletal Muscle in

Zhao, W., Swanson, S. A., Ye, J., Li, X., Shelton, J. M., Zhang, W., Thomas, G. D., Hypertension, A. I., Zhao, W., Swanson, S. A., et al. (2006)

on Generation of Reactive Oxygen Species

Bleeke, T., Zhang, H., Madamanchi, N., Patterson, C., & Faber, J. E. (2004)

Dysfunction in Normocholesterolemic Hypertension via Reduced Production of Reactive Oxygen Species

Wassmann, S., Laufs, U., Bäumer, A. T., Müller, K., Ahlbory, K., Itter, G., Rösen, R., Böhm, M., Nickenig, G., Wassmann, S., et al. (2013)

Reactive Oxygen Species–Induced c-fos Expression

Ichiki, T., Tokunou, T., Fukuyama, K., Iino, N., Masuda, S., Ichiki, T., Tokunou, T., Fukuyama, K., Iino, N., Masuda, S., et al. (2013)