Effects of oleanolic acid on inflammation and metabolism in diabetic rats
Abstract
Diabetes mellitus (DM) is a chronic metabolic disease that threatens the health of the world population. We investigated the effects of oleanolic acid (OA) administration on inflammation status and metabolic profile in streptozotocin (STZ) induced diabetic rats. Four experimental groups were established: healthy rats not administered OA, healthy rats administered OA, diabetic rats not administered OA, diabetic rats administered OA. OA, 5 mg/kg, was administered by oral gavage for 21 days. Serum samples collected at the end of the experiment and analyzed for toll-like receptor-9, interleukin-18, nuclear factor kappa B, malondialdehyde MDA, glucose, total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, calcium, phosphorus, magnesium and potassium. Pancreas tissue was examined for pathology. Induction of DM caused increased serum concentrations of inflammation and oxidative damage markers. DM also caused hyperglycemia-hyperlipidemia and decreased serum concentration of minerals. The islets of Langerhans were degenerated and necrotic. Administration of OA reversed the adverse effects of DM. OA treatment can ameliorate inflammation and oxidative damage due to DM by normalizing hyperglycemia and decreasing TLR-9, IL-18, NF-κB and MDA levels.
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Trials in several animal models have reported reductions in serum TC, TG, LDL-C or VLDL-C and/or increased HDL-C concentrations following oral administration of different doses of MA, OA or high but not low doses of ursolic acid.
“Trials in several animal models have also reported reductions in serum TC, TG, LDL-C or VLDL-C and/or increased HDL-C concentrations following oral administration of different doses (15–100 mg/kg/d) of MA [reviewed in 26], OA (5–25 mg/kg/d) [25–29] or high (200 mg/kg/d) but not low (50 mg/kg/d) doses of ursolic acid (UA) [30].”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [29]
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- Authors
- Iskender, H., Dokumacioglu, E., Terim Kapakin, K. A., Yenice, G., Mohtare, B., Bolat, I., & Hayirli, A.
- Affiliations
- Artvin Coruh University
- Atatürk University
- Venue
- Biotechnic & Histochemistry
- Publisher
- Informa UK Limited
- Published
- 2021-07-15
- Volume
- 97
- Issue
- 4
- Pages
- 269-276
- ISSN
- 1052-0295 (ISSN-L)
- 1473-7760
- OpenAlex
- W3179987800
- Cited by
- 32
- References
- 41
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 10 · 2023: 5 · 2022: 5
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biotechnic & Histochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Artvin Coruh University
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- oleanolic acid, diabetes mellitus, streptozotocin-induced diabetes, inflammation, oxidative stress, hyperglycemia, hyperlipidemia, mineral metabolism, TLR9, IL-18, NF-κB, malondialdehyde, pancreatic islets, lipid peroxidation
- MeSH terms
- Animals, Blood Glucose, Diabetes Mellitus, Experimental, Inflammation, Oleanolic Acid, Streptozocin, Oxidative Stress, Rats
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