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Cited by 242Toxic Organic Pollutants ImpactCarcinogens and Genotoxicity AssessmentEnvironmental Toxicology and Ecotoxicology

The DOI matches its Crossref record; 189 of the 190 references it cites were found in a registry or an index.

Phototoxicity and Environmental Transformation of Polycyclic Aromatic Hydrocarbons (PAHs)—Light-Induced Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage

Fu, Peter P., Xia, Qingsu, Sun, Xin, Yu, Hongtao·2012·Journal of Environmental Science and Health, Part C
DOI 10.1080/10590501.2012.653887
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Abstract

Polycyclic aromatic hydrocarbons (PAHs) are a class of mutagenic and tumorigenic environmental contaminants. Although the mechanisms by which PAHs induce cancer in experimental animals have been extensively studied and the metabolic activation pathways have been determined, the environmental fate of PAHs and the phototoxicity exerted by PAHs, as well as their photoreaction products formed in the environment, have received much less attention. In this review, the formation of oxygenated PAHs, PAH quinones, nitro-PAHs, and halogenated PAHs from photoreaction of environmental PAHs are addressed. Upon light irradiation, PAHs and all PAH photoreaction products can absorb light energy to reach photo-excited states, which react with molecular oxygen, medium, and coexisting chemicals to produce reactive oxygen species (ROS) and other reactive intermediates, such as oxygenated PAHs and free radicals. These intermediates, including ROS, induce lipid peroxidation, and DNA damage including DNA strand breakage, oxidation to 8-oxo-2'-deoxyguanosine, and DNA-adducts. Since these toxicological endpoints are associated with age-related diseases, including cancer, environmental PAHs concomitantly exposed to sunlight may potentially promote human skin damage, leading to ageing and skin cancers. Thus, we suggest that (i) in addition to the widely recognized metabolic pathways, more attention must be paid to photoreaction as an important activation pathway for PAHs, (ii) risk assessment of environmental PAHs should take into consideration the complex photochemical reactions leading to mixtures of products that are also phototoxic; and (iii) the study of structure-toxicity relationships should be expanded to cover the complex photoreactions and extrinsic factors that affect phototoxicity endpoints.

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Crossref · 10.1080/10590501.2012.653887

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Cites

Research works printed but not linked: 22

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Metadata

Authors
Fu, P. P., Xia, Q., Sun, X., & Yu, H.
Affiliations
  • National Center for Toxicological Research (US)
  • Chinese Center For Disease Control and Prevention (CN)
  • Jackson State University (US)
ORCID
Venue
Journal of Environmental Science and Health, Part C
Publisher
Informa UK Limited
Published
2012-01
Volume
30
Issue
1
Pages
1-41
ISSN
  • 1059-0501 (ISSN-L)
  • 1532-4095
DOI
10.1080/10590501.2012.653887
OpenAlex
W2041663243
Cited by
242
References
190
Citations by year
2026: 10 · 2025: 16 · 2024: 20 · 2023: 25 · 2022: 27 · 2021: 16 · 2020: 29 · 2019: 17 · 2018: 14 · 2017: 11 · 2016: 14 · 2015: 15 · 2014: 13 · 2013: 14 · 2012: 1
FWCI
1.63
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Environmental Science and Health Part C (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Keywords
polycyclic aromatic hydrocarbons, phototoxicity, photochemical reactions, reactive oxygen species, lipid peroxidation, DNA damage, 8-hydroxy-2'-deoxyguanosine, DNA adducts, nitro-PAHs, oxygenated PAHs, photochemical transformation, skin cancer, skin aging, structure-toxicity relationship, risk assessment
MeSH terms
8-Hydroxy-2'-Deoxyguanosine, Animals, Deoxyguanosine, DNA Damage, Environmental Pollutants, Humans, Light, Polycyclic Aromatic Hydrocarbons, Skin, Lipid Peroxidation, Reactive Oxygen Species, Photochemical Processes

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