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Phototoxicity and Environmental Transformation of Polycyclic Aromatic Hydrocarbons (PAHs)—Light-Induced Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage

Fu, Peter P., Xia, Qingsu, Sun, Xin, Yu, Hongtao·2012·Journal of Environmental Science and Health, Part C

DOI 10.1080/10590501.2012.653887

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Abstract

Polycyclic aromatic hydrocarbons (PAHs) are a class of mutagenic and tumorigenic environmental contaminants. Although the mechanisms by which PAHs induce cancer in experimental animals have been extensively studied and the metabolic activation pathways have been determined, the environmental fate of PAHs and the phototoxicity exerted by PAHs, as well as their photoreaction products formed in the environment, have received much less attention. In this review, the formation of oxygenated PAHs, PAH quinones, nitro-PAHs, and halogenated PAHs from photoreaction of environmental PAHs are addressed. Upon light irradiation, PAHs and all PAH photoreaction products can absorb light energy to reach photo-excited states, which react with molecular oxygen, medium, and coexisting chemicals to produce reactive oxygen species (ROS) and other reactive intermediates, such as oxygenated PAHs and free radicals. These intermediates, including ROS, induce lipid peroxidation, and DNA damage including DNA strand breakage, oxidation to 8-oxo-2'-deoxyguanosine, and DNA-adducts. Since these toxicological endpoints are associated with age-related diseases, including cancer, environmental PAHs concomitantly exposed to sunlight may potentially promote human skin damage, leading to ageing and skin cancers. Thus, we suggest that (i) in addition to the widely recognized metabolic pathways, more attention must be paid to photoreaction as an important activation pathway for PAHs, (ii) risk assessment of environmental PAHs should take into consideration the complex photochemical reactions leading to mixtures of products that are also phototoxic; and (iii) the study of structure-toxicity relationships should be expanded to cover the complex photoreactions and extrinsic factors that affect phototoxicity endpoints.

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Authors: Fu, P. P., Xia, Q., Sun, X., & Yu, H.
Affiliations: National Center for Toxicological Research (US)
Chinese Center For Disease Control and Prevention (CN)
Jackson State University (US)
ORCID: Fu, Peter P.
Sun, Xin
Yu, Hongtao
Venue: Journal of Environmental Science and Health, Part C
Publisher: Informa UK Limited
Published: 2012-01
Volume: 30
Issue: 1
Pages: 1-41
ISSN: 1059-0501 (ISSN-L)
1532-4095
DOI: 10.1080/10590501.2012.653887
OpenAlex: W2041663243
Cited by: 242
References: 190
Citations by year: 2026: 10 · 2025: 16 · 2024: 20 · 2023: 25 · 2022: 27 · 2021: 16 · 2020: 29 · 2019: 17 · 2018: 14 · 2017: 11 · 2016: 14 · 2015: 15 · 2014: 13 · 2013: 14 · 2012: 1
FWCI: 1.63
Type: journal article
Language: en
Open access: closed
Locations: Journal of Environmental Science and Health Part C (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Keywords: polycyclic aromatic hydrocarbons, phototoxicity, photochemical reactions, reactive oxygen species, lipid peroxidation, DNA damage, 8-hydroxy-2'-deoxyguanosine, DNA adducts, nitro-PAHs, oxygenated PAHs, photochemical transformation, skin cancer, skin aging, structure-toxicity relationship, risk assessment
MeSH terms: 8-Hydroxy-2'-Deoxyguanosine, Animals, Deoxyguanosine, DNA Damage, Environmental Pollutants, Humans, Light, Polycyclic Aromatic Hydrocarbons, Skin, Lipid Peroxidation, Reactive Oxygen Species, Photochemical Processes

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Phototoxicity and Environmental Transformation of Polycyclic Aromatic Hydrocarbons (PAHs)—Light-Induced Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage

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