Effects of UVA and visible light on the photogenotoxicity of benzo[a]pyrene and pyrene
Abstract
This study investigated the role of UVA/visible light (U, 320–800 nm) and visible light (V, 400–800 nm) in the phototoxicity and photogenotoxicity of two ubiquitous polycyclic aromatic hydrocarbons (PAH): benzo[a]pyrene (BaP) and Pyrene (Pyr). These mechanisms were evaluated by the WST‐1 test and the comet assay on normal human keratinocytes (NHK) and by the micronucleus test on CHO cells. The production of reactive oxygen species (ROS) was assessed through the induction of 8‐oxodeoxyguanine (8‐oxodG) lesions by immunofluorescence staining in NHK. Results of the WST‐1 test revealed the phototoxic properties of BaP and Pyr after irradiation with U and V lights. BaP presented the highest phototoxic properties. Results of the comet assay showed that U‐ and V‐irradiated BaP and Pyr induced increasing rates of DNA single‐strand breaks in NHK, in a dose dependent manner. The tested PAH could also induce increased levels of micronuclei in CHO cells after U and V irradiations. Increasing 8‐oxodG levels were detected after U and V irradiations in BaP‐ and Pyr‐treated keratinocytes and confirmed the involvement of ROS in the photogenotoxicity of PAH. Overall, this study highlighted the existence of an alternative pathway of PAH genotoxicity that is induced by UVA and/or visible light. Visible light is suggested to photoactivate PAH by a mechanism which is mainly based on oxidative reactions. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2009.
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In vitro experiments showed that the induction of cytotoxic and oxidative mechanisms by some PAHs was increased when human keratinocytes were exposed to both PAHs and UVA in particular.
“Moreover, in vitro experiments showed that the induction of cytotoxic7, 8 and oxidative8, 52 mechanisms by some PAHs was increased when human keratinocytes were exposed to both PAHs and UVA in particular (for a review53).”
From The impact of airborne pollution on skin (2019) · cites this paper as [52]
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing
Tice, R. R., Agurell, E., Anderson, D. C., Burlinson, B., Hartmann, A., Kobayashi, H., Miyamae, Y., Rojas, E., Ryu, J., & Sasaki, Y. F. (2000) · Environmental and Molecular Mutagenesis · doi:10.1002/(sici)1098-2280(2000)35:3 · Cited by 4,864 · see citing works
Definition of type I and type II photosensitized oxidation
Foote, C. S. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb02071.x · Cited by 1,248 · see citing works
Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: A review
Xue, W., & Warshawsky, D. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.11.006 · Cited by 898 · see citing works
Photodynamic Therapy in Oncology
Triesscheijn, M., Baas, P., Schellens, J. H. M., & Stewart, F. A. (2006) · The Oncologist · doi:10.1634/theoncologist.11-9-1034 · Cited by 738 · see citing works
Sources and measurement of ultraviolet radiation
Diffey, B. L. (2002) · Methods · doi:10.1016/s1046-2023(02)00204-9 · Cited by 704 · see citing works
Report from the in vitro micronucleus assay working group
Kirsch‐Volders, M., Sofuni, T., Aardema, M. J., Albertini, S., Eastmond, D. A., Fenech, M. F., Ishidate, M., Kirchner, S., Lorge, E., Morita, T., et al. (2003) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2003.07.005 · Cited by 630 · see citing works
Shimada, T. (2006) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.21.257 · Cited by 606 · see citing works
Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations
Pfeiffer, P. (2000) · Mutagenesis · doi:10.1093/mutage/15.4.289 · Cited by 462 · see citing works
ENVIRONMENTAL CARCINOGENIC POLYCYCLIC AROMATIC HYDROCARBONS: PHOTOCHEMISTRY AND PHOTOTOXICITY
Yu, H. (2002) · Journal of Environmental Science and Health Part C · doi:10.1081/gnc-120016203 · Cited by 387 · see citing works
Penetration of Ultraviolet Radiation in the Marine Environment. A Review
Tedetti, M., & Sempéré, R. (2005) · Photochemistry and Photobiology · doi:10.1562/2005-11-09-ir-733 · Cited by 364 · see citing works
Photomutagenicity of 16 polycyclic aromatic hydrocarbons from the US EPA priority pollutant list
Yan, J., Wang, L., Fu, P. P., & Yu, H. (2003) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2003.10.004 · Cited by 361 · see citing works
Lasers in dermatology: Four decades of progress
Tanzi, E. L., Lupton, J. R., & Alster, T. S. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.582 · Cited by 353 · see citing works
Dabestani, R., & Ivanov, I. N. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb01945.x · Cited by 314 · see citing works
Arfsten, D. P., Schaeffer, D. J., & Mulveny, D. C. (1996) · Ecotoxicology and Environmental Safety · doi:10.1006/eesa.1996.0001 · Cited by 298 · see citing works
The mutagenic hazards of aquatic sediments: a review
Chen, G., & White, P. A. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2004.08.005 · Cited by 263 · see citing works
Ability of 16 priority PAHs to be directly cytotoxic to a cell line from the rainbow trout gill
Schirmer, K., Dixon, D. G., Greenberg, B. M., & Bols, N. C. (1998) · Toxicology · doi:10.1016/s0300-483x(98)00030-4 · Cited by 215 · see citing works
Use of human hepatoma cells for in vitro metabolic activation of chemical mutagens/carcinogens
Natarajan, A. T., & Darroudi, F. (1991) · Mutagenesis · doi:10.1093/mutage/6.5.399 · Cited by 186 · see citing works
Johnsen, A. R., & Karlson, U. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-007-1045-2 · Cited by 154 · see citing works
Olive, P. L., & Banánth, J. P. (1993) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(93)90010-e · Cited by 135 · see citing works
Factors affecting DNA damage caused by lipid hydroperoxides and aldehydes
Yang, M., & Schaich, K. M. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02039-x · Cited by 119 · see citing works
Bauer, E., Recknagel, R. ‐., Fiedler, U., Wollweber, L., Bock, C., & Greulich, K. O. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)00246-7 · Cited by 108 · see citing works
Genotoxic activity of potassium permanganate in acidic solutions
Méo, M. D., Laget, M., Castegnaro, M., & Duménil, G. (1991) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(91)90038-n · Cited by 103 · see citing works
DNA damage induced by coexposure to PAHs and light
Toyooka, T., & Ibuki, Y. (2006) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2006.09.002 · Cited by 83 · see citing works
Husain, Z., Pathak, M. A., Flotte, T. J., & Wick, M. M. (1991) · PubMed · Cited by 82 · see citing works
Botta, C., Giorgio, C. D., Sabatier, A., & Méo, M. D. (2008) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2008.01.008 · Cited by 79 · see citing works
Self-citationLyons, B. P., Pascoe, C. K., & McFadzen, I. R. B. (2002) · Marine Environmental Research · doi:10.1016/s0141-1136(02)00124-1 · Cited by 77 · cited 1× · see citing works
“The phototoxicity of PAH has been recognized since the beginning of the 20th century (Lyons et al., 2002).”
BackgroundPhotogenotoxicity of Mammalian Cells: A Review of the Different Assays for In Vitro Testing¶
Meunier, J., Sarasin, A. R., & Marrot, L. (2002) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2002)0750437pomcar2.0.co2 · Cited by 64 · see citing works
Pozzoli, L., Gilardoni, S., Perrone, M., de Gennaro, G., de Rienzo, M., & Vione, D. V. (2004) · Annali di Chimica · doi:10.1002/adic.200490002 · Cited by 61 · see citing works
Botta, C., Iarmarcovai, G., Chaspoul, F., Sari-Minodier, I., Pompili, J., Orsière, T. G., Bergé‐Lefranc, J., Botta, A., Gallice, P., & Méo, M. D. (2006) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20205 · Cited by 61 · see citing works
Self-citationPöschl, U. (2002) · Journal of Aerosol Medicine · doi:10.1089/089426802320282329 · Cited by 57 · see citing works
Sauvaigo, S., Serres, C., Signorini, N., Emonet‐Piccardi, N., Richard, M., & Cadet, J. (1998) · Analytical Biochemistry · doi:10.1006/abio.1998.2628 · Cited by 54 · see citing works
Liu, Z., Lu, Y., Rosenstein, B. S., Lebwohl, M., & Wei, H. (1998) · Biochemistry · doi:10.1021/bi980606o · Cited by 52 · see citing works
Wang, S., Sheng, Y., Feng, M., Leszczynski, J., Wang, L., Tachikawa, H., & Yu, H. (2007) · Environmental Toxicology · doi:10.1002/tox.20241 · Cited by 51 · see citing works
Du, H., Olivo, M., Tan, B., & Bay, B. (2003) · International Journal of Oncology · doi:10.3892/ijo.23.5.1401 · Cited by 50 · see citing works
Zhang, X., Wu, R. S. S., Fu, W., Xu, L., & Lam, P. K. S. (2004) · Chemosphere · doi:10.1016/j.chemosphere.2003.12.004 · Cited by 50 · see citing works
UVA Light-Induced DNA Cleavage by Isomeric Methylbenz[a]anthracenes
Dong, S., Fu, P. P., Shirsat, R. N., Hwang, H., Leszczyński, J., & Yu, H. (2002) · Chemical Research in Toxicology · doi:10.1021/tx015567n · Cited by 46 · see citing works
Decome, L., Méo, M. D., Geffard, A., Doucet, O., Duménil, G., & Botta, A. (2005) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2004.11.022 · Cited by 43 · see citing works
UVA Light-Induced DNA Cleavage by Selected Polycyclic Aromatic Hydrocarbons
Dong, S., Hwang, H.-M., Harrison, C., Holloway, L., Shi, X., & Yu, H. (2000) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s001280000027 · Cited by 40 · see citing works
New Method for Testing Phototoxicity of Polycyclic Aromatic Hydrocarbons
Toyooka, T., & Ibuki, Y. (2006) · Environmental Science & Technology · doi:10.1021/es060182i · Cited by 39 · see citing works
Machella, N., Regoli, F., & Santella, R. M. (2005) · Aquatic Toxicology · doi:10.1016/j.aquatox.2004.12.002 · Cited by 38 · see citing works
Shyong, E. Q., Lu, Y., Goldstein, A. E., Lebwohl, M., & Wei, H. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00018-8 · Cited by 37 · see citing works
Diamond, S. A., Mount, D. R., Mattson, V. R., Heinis, L. J., Highland, T. L., Adams, A. D., & Simcik, M. F. (2006) · Environmental Toxicology and Chemistry · doi:10.1897/06-038r.1 · Cited by 37 · see citing works
Wang, Y., Gao, D., Atencio, D. P., Perez, E., Saladi, R., Moore, J., Guevara, D., Rosenstein, B. S., Lebwohl, M., & Wei, H. (2005) · International Journal of Cancer · doi:10.1002/ijc.21039 · Cited by 35 · see citing works
Flora, S. D., Camoirano, A., Izzotti, A., D’Agostini, F., & Bennicelli, C. (1989) · Carcinogenesis · doi:10.1093/carcin/10.6.1089 · Cited by 35 · see citing works
Marie, C., Maı̂tre, A., Douki, T., Gateau, M., Tarantini, A., Guiraud, P., Favier, A. E., & Ravanat, J. (2007) · Journal of Applied Toxicology · doi:10.1002/jat.1306 · Cited by 32 · see citing works
Biodegradation of selected UV-irradiated and non-irradiated polycyclic aromatic hydrocarbons (PAHs)
Lehto, K., Puhakka, J. A., & Lemmetyinen, H. J. (2003) · Biodegradation · doi:10.1023/a:1024704505832 · Cited by 31 · see citing works
Toyooka, T., Ibuki, Y., Takabayashi, F., & Goto, R. (2005) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20166 · Cited by 31 · see citing works
Routledge, M. N. (2001) · Carcinogenesis · doi:10.1093/carcin/22.8.1231 · Cited by 31 · see citing works
Coexposure to benzo[a]pyrene and UVA induces phosphorylation of histone H2AX
Toyooka, T., & Ibuki, Y. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.10.015 · Cited by 30 · see citing works
Solar-simulated light-exposed benzo[a]pyrene induces phosphorylation of histone H2AX
Toyooka, T., Ohnuki, G., & Ibuki, Y. (2007) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2007.11.002 · Cited by 29 · see citing works
Toyooka, T., Ibuki, Y., Koike, M., Ohashi, N., Takahashi, S., & Goto, R. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.174 · Cited by 27 · see citing works
Ibuki, Y., Warashina, T., Noro, T., & Goto, R. (2002) · Environmental Toxicology and Pharmacology · doi:10.1016/s1382-6689(02)00014-5 · Cited by 26 · see citing works
Photo-induced reactions of benzo(a)pyrene with DNA in vitro.
Strniste, G. F., Martínez, E. S. M., Martinez, A. M., & Brake, R. J. (1980) · PubMed · Cited by 25 · see citing works
Machella, N., Regoli, F., Cambria, A., & Santella, R. M. (2004) · Aquatic Toxicology · doi:10.1016/j.aquatox.2003.11.008 · Cited by 22 · see citing works
DNA damage produced in HaCaT cells by combined fluoranthene exposure and ultraviolet A irradiation
Zheng, B., Hwang, H., Yu, H., & Ekunwe, S. I. N. (2004) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20040 · Cited by 21 · see citing works
Crallan, R. A., Ingham, E., & Routledge, M. N. (2005) · Mutagenesis · doi:10.1093/mutage/gei042 · Cited by 21 · see citing works
Yu, H., Yan, J., Jiao, Y., & Fu, P. P. (2005) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph2005010114 · Cited by 21 · see citing works
Light‐dependent mutagenesis by benzo[a]pyrene is mediated via oxidative DNA damage
Kim, S.-R., Kokubo, K., Matsui, K., Yamada, N., Kanke, Y., Fukuoka, M., Yamada, M., & Nohmi, T. (2005) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20141 · Cited by 20 · see citing works
Xia, Q., Chou, M. W., Yin, J. J., Howard, P. C., Yu, H., & Fu, P. P. (2006) · Toxicology and Industrial Health · doi:10.1191/0748233706th259oa · Cited by 19 · see citing works
In vitro genotoxicity testing of the furylethylene derivative UC-245 in human cells
Machado, G. P. (2003) · Mutagenesis · doi:10.1093/mutage/geg039 · Cited by 15 · see citing works
Seagrave, J., & Burchiel, S. W. (2000) · Toxicology Letters · doi:10.1016/s0378-4274(00)00251-4 · Cited by 14 · see citing works
Hong, Y., & Lee, K.-H. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(99)00076-7 · Cited by 12 · see citing works
Sáenz, D. H., Xia, Q., & Fu, P. P. (2007) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph2007040010 · Cited by 8 · see citing works
Zhang, Y. C., Hwang, H., & Ekunwe, S. I. N. (2006) · Environmental Toxicology and Chemistry · doi:10.1897/05-482r.1 · Cited by 4 · see citing works
The rapid screening of photogenotoxic compounds using photo plasmid-relaxation assay
Nakagawa, Y., Takigawa, Y., & Tanaka, N. (2001) · 環境変異原研究 · Cited by 3 · see citing works
Detection of PAH:DNA adducts from auto-oxidation using 32P-postlabeling
Bryła, P., & Weyand, E. H. (1992) · Cancer Letters · doi:10.1016/0304-3835(92)90210-m · Cited by 3 · see citing works
Flagged first, then by citations
1 of the 68 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Sun, K., Song, Y., He, F., Jing, M., Tang, J., & Liu, R. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.145403 · Cited by 435 · see citing works
Fu, P. P., Xia, Q., Sun, X., & Yu, H. (2012) · Journal of Environmental Science and Health, Part C · doi:10.1080/10590501.2012.653887 · Cited by 242 · see citing works
The impact of airborne pollution on skin
Araviiskaia, E., Berardesca, E., Bieber, T., Gontijo, G., Sanchez Viera, M., Marrot, L., Chuberre, B., & Dreno, B. (2019) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15583 · Cited by 214 · see citing works
Soeur, J., Belaïdi, J.-P., Chollet, C., Denat, L., Dimitrov, A., Jones, C., Perez, P., Zanini, M., Zobiri, O., Mezzache, S., et al. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.01.007 · Cited by 131 · see citing works
Pollution and Sun Exposure: A Deleterious Synergy. Mechanisms and Opportunities for Skin Protection
Marrot, L. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867324666170918123907 · Cited by 125 · see citing works
Invisible oil beyond the Deepwater Horizon satellite footprint
Berenshtein, I., Paris, C. B., Perlin, N., Alloy, M. M., Joye, S. B., & Murawski, S. A. (2020) · Science Advances · doi:10.1126/sciadv.aaw8863 · Cited by 105 · see citing works
Trace detection of polycyclic aromatic hydrocarbons in environmental waters by SERS
Zhou, Z., Lu, J., Wang, J., Zou, Y., Liu, T., Zhang, Y., Liu, G., & Tian, Z. (2020) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2020.118250 · Cited by 79 · see citing works
Oliveira, M., Gravato, C., & Guilhermino, L. M. (2011) · Ecological Indicators · doi:10.1016/j.ecolind.2011.08.006 · Cited by 74 · see citing works
A perfusable vascularized full-thickness skin model for potential topical and systemic applications
Salameh, S., Tissot, N., Cache, K., Lima, J., Suzuki, I., Marinho, P. A., Rielland, M., Sœur, J., Takeuchi, S., Germain, S., et al. (2021) · Biofabrication · doi:10.1088/1758-5090/abfca8 · Cited by 59 · see citing works
Comet assay on mouse oocytes: an improved technique to evaluate genotoxic risk on female germ cells
Berthelot-Ricou, A., Perrin, J., Giorgio, C. D., Méo, M. D., Botta, A., & Courbière, B. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.09.016 · Cited by 40 · see citing works
Genotoxic and mutagenic effects of lipid-coated CdSe/ZnS quantum dots
Aye, M., Giorgio, C. D., Berque‐Bestel, I., Aimé, A., Pichon, B. P., Jammes, Y., Barthélémy, P., & Méo, M. D. (2012) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2012.10.010 · Cited by 37 · see citing works
Zhao, L., Zhou, M., Zhao, Y., Yang, J., Pu, Q., Yang, H., Yang, W., Lyu, C., & Li, Y. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191710972 · Cited by 30 · see citing works
Hopf, N. B., Spring, P., Hirt‐Burri, N., Jiménez, S., Sutter, B. M., Vernez, D., & Berthet, A. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.01.024 · Cited by 28 · see citing works
Assessment of 1,2-propanediol (PrOH) genotoxicity on mouse oocytes by comet assay
Berthelot-Ricou, A., Perrin, J., Giorgio, C. D., Méo, M. D., Botta, A., & Courbière, B. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.07.1106 · Cited by 26 · see citing works
Vogeley, C., Rolfes, K. M., Krutmann, J., & Haarmann‐Stemmann, T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.841721 · Cited by 24 · see citing works
Zinflou, C., & Rochette, P. J. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2344-3 · Cited by 17 · see citing works
Struwe, M., Csató, M., Singer, T., & Gocke, E. (2011) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2011.03.017 · Cited by 15 · see citing works
Larnac, E., Montoni, A., Haydont, V., Marrot, L., & Rochette, P. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031905 · Cited by 13 · see citing works
Mokrzynski, K. T., & Szewczyk, G. M. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.171449 · Cited by 11 · see citing works
Cell and tissue-based models for evaluating the cutaneous impact of visible light
Brown, A. E., Trullàs, C., & Jourdan, E. (2023) · Journal of Photochemistry and Photobiology · doi:10.1016/j.jpap.2023.100216 · Cited by 9 · see citing works
Wang, G., Duan, S., Chen, Z., Zeng, Y., Wang, Z., & Zou, P. (2022) · Polyhedron · doi:10.1016/j.poly.2022.116147 · Cited by 8 · see citing works
Excited State Kinetics of Benzo[a]pyrene Is Affected by Oxygen and DNA
Han, Y., Wang, X., He, X., Jia, M., Pan, H., & Chen, J. (2023) · Molecules · doi:10.3390/molecules28135269 · Cited by 6 · see citing works
Photogenotoxicity and Photomutagenicity of Medicines, Carcinogens and Endogenous Compounds
Arimoto‐Kobayashi, S. (2014) · Genes and Environment · doi:10.3123/jemsge.2014.018 · Cited by 5 · see citing works
Aoyama, S., Sano, K., Asahi, C., Machida, M., Okamoto, K., Negishi, T., Kimura, S., Suzuki, T., Hatano, T., & Arimoto‐Kobayashi, S. (2013) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2013.11.009 · Cited by 5 · see citing works
Kersch, C., Masutin, V., Alsaleh, R., & Schmitz‐Spanke, S. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04098-w · Cited by 3 · see citing works
A study of the phototoxic effect of Benzo[a] Pyrene on bacteria
Takáčová, A., Smolinská, M., Olejníková, P., Mackuľak, T., & Čı́k, G. (2013) · Open Life Sciences · doi:10.2478/s11535-013-0221-x · Cited by 3 · see citing works
A Review of Sunlight Induced Cellular DNA Damage
MacDavid, K., & Aebisher, D. (2014) · Cited by 2 · see citing works
Asahi, C., Aoyama, S., Kimura, S., Suzuki, T., Hatano, T., & Arimoto‐Kobayashi, S. (2020) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2020.112621 · Cited by 2 · see citing works
Patel, M. S., Nirmal Kumar, J. I., & Tiwari, K. K. (2014) · International Journal of Applied Sciences and Biotechnology · doi:10.3126/ijasbt.v2i1.9784 · Cited by 1 · see citing works
Dikici, İ. H., Özpolat, S. G., Çelık, H., & Koçyiğit, A. (2025) · Medical Research Reports · doi:10.55517/mrr.1551440
Photoactivatable aryl amide substituted fatty acid protonophores
Rajasekar, S., York, E., McNaughton, D. A., Pacchini, E., Gertner, D. S., Lockwood, T. E., Ryder, W. G., Rawling, T., & Gale, P. A. (2025) · Supramolecular chemistry · doi:10.1080/10610278.2025.2549458
A perfusable vascularized full thickness skin model for topical and systemic applications
Salameh, S. (2019) · theses.fr (ABES) · doi:10.70675/aae82978zf1abz4db1z900cz446510d2a1f9
Wang, J., Valerio-Santiago, M., Yuan, M., Li, Q., García, C., Mola, G., Gómez, E., Qiao, M., Cebrian, J., & Zhu, C. (2026) · Journal of Cosmetics Dermatological Sciences and Applications · doi:10.4236/jcdsa.2026.163014
- Authors
- Botta, C., Di Giorgio, C., Sabatier, A., & De Méo, M.
- Affiliations
- Aix-Marseille Université (FR)
- Venue
- Environmental Toxicology
- Publisher
- Wiley
- Published
- 2008-11-10
- Volume
- 24
- Issue
- 5
- Pages
- 492-505
- ISSN
- 1520-4081 (ISSN-L)
- 1522-7278
- OpenAlex
- W2102725853
- Cited by
- 36
- References
- 68
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2015: 1 · 2014: 5 · 2013: 2 · 2012: 2
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Environmental Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Keywords
- benzo[a]pyrene, pyrene, polycyclic aromatic hydrocarbons, photogenotoxicity, UVA irradiation, visible light irradiation, phototoxicity, reactive oxygen species, single-strand breaks, micronuclei, keratinocytes, CHO cells, oxidative DNA damage
- MeSH terms
- 8-Hydroxy-2'-Deoxyguanosine, Animals, Benzo(a)pyrene, Cell Line, Cells, Cultured, Cricetulus, Deoxyguanosine, DNA Damage, Environmental Pollutants, Cricetinae, Humans, Light, Mutagens, Pyrenes, Ultraviolet Rays, Keratinocytes, CHO Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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