Design and development of polymers for gene delivery

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

Boussif, O., Lezoualc’h, F., Zanta, M. A., Djavaheri‐Mergny, M., Scherman, D., DEMENEIX, B. A., & Behr, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,256 · see citing works

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., RINGOLD, G. M., & Danielsen, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7413 · Cited by 4,954 · see citing works

Starburst Dendrimers: Molecular‐Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter

Tomalia, D. A., Naylor, A. M., & Goddard, W. A. (1990) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199001381 · Cited by 3,212 · see citing works

Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin

Skehel, J. J., & Wiley, D. C. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.531 · Cited by 2,706 · see citing works

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease.

Cavazzana-Calvo, M., Hacein-Bey, S., Basile, G. D. S., Gross, F., Yvon, E., Nusbaum, P., Selz, F., Hue, C., Certain, S., Casanova, J., et al. (2000) · Science · doi:10.1126/science.288.5466.669 · Cited by 2,703 · see citing works

Cyclodextrin-based pharmaceutics: past, present and future

Davis, M. E., & Brewster, M. E. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1576 · Cited by 2,002 · see citing works

The Basic Science of Gene Therapy

Mulligan, R. C. (1993) · Science · doi:10.1126/science.8493530 · Cited by 1,734 · see citing works

Gene therapy - promises, problems and prospects

Verma, I. M., & Somia, N. (1997) · Nature · doi:10.1038/38410 · Cited by 1,681 · see citing works

T Lymphocyte-Directed Gene Therapy for ADA − SCID: Initial Trial Results After 4 Years

Blaese, R. M., Culver, K. W., Miller, A. D., Carter, C. S., Fleisher, T. A., Clerici, M., Shearer, G. M., Chang, L., Chiang, Y. L., Tolstoshev, P., et al. (1995) · Science · doi:10.1126/science.270.5235.475 · Cited by 1,546 · see citing works

An Inverted Hexagonal Phase of Cationic Liposome-DNA Complexes Related to DNA Release and Delivery

Koltover, I., Salditt, T., Rädler, J. O., & Safinya, C. R. (1998) · Science · doi:10.1126/science.281.5373.78 · Cited by 1,336 · see citing works

Endocytosis

Mukherjee, S., Ghosh, R. K., & Maxfield, F. R. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.759 · Cited by 1,299 · see citing works

Polyamidoamine cascade polymers mediate efficient transfection of cells in culture

Haensler, J., & Szoka, F. C. (1993) · Bioconjugate Chemistry · doi:10.1021/bc00023a012 · Cited by 1,208 · see citing works

PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

Ogris, M., Brunner, S., Schüller, S., Kircheis, R., & Wagner, E. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300900 · Cited by 1,178 · see citing works

A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

Khuri, F. R., Nemunaitis, J. J., Ganly, I., Arseneau, J. C., Tannock, I. F., Romel, L., Gore, M. E., Ironside, J. A. D., MacDougall, R. H., Heise, C. C., et al. (2000) · Nature Medicine · doi:10.1038/78638 · Cited by 1,099 · see citing works

Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes

Sonawane, N. D., Szoka, F. C., & Verkman, A. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308643200 · Cited by 1,083 · see citing works

Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector

Kay, M. A., Manno, C. S., Ragni, M. V., Larson, P. J., Couto, L. B., McClelland, A., Glader, B. E., Chew, A. K., Tai, S. J., Herzog, R. W., et al. (2000) · Nature Genetics · doi:10.1038/73464 · Cited by 1,019 · see citing works

The proton sponge: a trick to enter cells the viruses did not exploit

Behr, J.-P. (1997) · CHIMIA · doi:10.2533/chimia.1997.34 · Cited by 933 · see citing works

Degradable poly (β-amino esters): synthesis, characterization, and self-assembly with plasmid DNA

Lynn, D. M., & Langer, R. (2000) · Journal of the American Chemical Society · doi:10.1021/ja0015388 · Cited by 924 · see citing works

Receptor-mediated in vitro gene transformation by a soluble DNA carrier system.

Wu, G. Y., & Wu, C. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61209-8 · Cited by 855 · see citing works

The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes

Tang, M., & Szoka, F. C. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300454 · Cited by 814 · see citing works

In Vitro Gene Delivery by Degraded Polyamidoamine Dendrimers

Tang, M. X., Redemann, C. T., & Szoka, F. C. (1996) · Bioconjugate Chemistry · doi:10.1021/bc9600630 · Cited by 809 · see citing works

Evidence for the role of proteoglycans in cation-mediated gene transfer.

Mislick, K. A., & Baldeschwieler, J. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12349 · Cited by 774 · see citing works

Size-dependent DNA Mobility in Cytoplasm and Nucleus

Lukács, G. L., Haggie, P. M., Seksek, O., Lechardeur, D., Freedman, N. D., & Verkman, A. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1625 · Cited by 752 · see citing works

PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles

Mishra, S., Webster, P. C., & Davis, M. E. (2004) · European Journal of Cell Biology · doi:10.1078/0171-9335-00363 · Cited by 733 · see citing works

The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.

Plank, C., Oberhauser, B., Mechtler, K., Koch, C., & Wagner, E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99963-1 · Cited by 666 · see citing works

Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle.

Wagner, E., Plank, C., Zatloukal, K., Cotten, M. L., & Birnstiel, M. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.7934 · Cited by 657 · see citing works

Transferrin-polycation conjugates as carriers for DNA uptake into cells.

Wagner, E., Zenke, M., Cotten, M. L., Beug, H., & Birnstiel, M. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.9.3410 · Cited by 655 · see citing works

Receptor-mediated gene delivery and expression in vivo.

Wu, G. Y., & Wu, C. H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68081-0 · Cited by 636 · see citing works

Mechanism of oligonucleotide release from cationic liposomes.

Zelphati, O., & Szoka, F. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11493 · Cited by 634 · see citing works

Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer

Lechardeur, D., Sohn, K.-J., Haardt, M., Joshi, P. B., Monck, M. A., Graham, R. W., Beatty, B., Squire, J. A., O'Brodovich, H. M., & Lukács, G. L. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300867 · Cited by 632 · see citing works

A Powerful Nonviral Vector for In Vivo Gene Transfer into the Adult Mammalian Brain: Polyethylenimine

Abdallah, B., Hassan, A., Benoist, C., Goula, D., Behr, J. P., & DEMENEIX, B. A. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.16-1947 · Cited by 541 · see citing works

Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus

Brunner, S., Sauer, T., Carotta, S., Cotten, M. L., Saltik, M., & Wagner, E. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301102 · Cited by 534 · see citing works

Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery

Schaffer, D. V., Fidelman, N. A., Dan, N. R., & Lauffenburger, D. A. (2000) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(20000305)67:5 · Cited by 525 · see citing works

Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini

Putnam, D. A., Gentry, C. A., Pack, D. W., & Langer, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1200 · Cited by 510 · see citing works

Polylysine-based transfection systems utilizing receptor-mediated delivery

Zauner, W., Ogris, M., & Wagner, E. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00110-5 · Cited by 507 · see citing works

Efficient Gene Transfer by Histidylated Polylysine/pDNA Complexes

Midoux, P., & Monsigny, M. L. P. (1999) · Bioconjugate Chemistry · doi:10.1021/bc9801070 · Cited by 503 · see citing works

Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells.

Wagner, E., Cotten, M. L., Foisner, R., & Birnstiel, M. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4255 · Cited by 484 · see citing works

Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells

Thomas, M., & Klibanov, A. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192581499 · Cited by 483 · see citing works

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.

Wagner, E., Zatloukal, K., Cotten, M. L., Kirlappos, H., Mechtler, K., Curiel, D., & Birnstiel, M. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.6099 · Cited by 481 · see citing works

Efficient Gene Transfer Using Reversibly Cross-Linked Low Molecular Weight Polyethylenimine

Gosselin, M. A., Guo, W., & Lee, R. J. (2001) · Bioconjugate Chemistry · doi:10.1021/bc0100455 · Cited by 455 · see citing works

Design, Synthesis, and Characterization of a Cationic Peptide That Binds to Nucleic Acids and Permeabilizes Bilayers

Wyman, T. B., Nicol, F., Zelphati, O., Scaria, P. V., Plank, C., & Szoka, F. C. (1997) · Biochemistry · doi:10.1021/bi9618474 · Cited by 454 · see citing works

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.

Curiel, D. T., Agarwal, S., Wagner, E., & Cotten, M. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8850 · Cited by 423 · see citing works

The design and synthesis of polymers for eukaryotic membrane disruption

Murthy, N., Robichaud, J. R., Tirrell, D. A., Stayton, P. S., & Hoffman, A. S. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00114-5 · Cited by 403 · see citing works

Hindered diffusion of inert tracer particles in the cytoplasm of mouse 3T3 cells.

Luby‐Phelps, K., Castle, P. E., Taylor, D. L., & Lanni, F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.14.4910 · Cited by 399 · see citing works

Accelerated Discovery of Synthetic Transfection Vectors: Parallel Synthesis and Screening of a Degradable Polymer Library

Lynn, D. M., Anderson, D. G., Putnam, D. A., & Langer, R. (2001) · Journal of the American Chemical Society · doi:10.1021/ja016288p · Cited by 395 · see citing works

Ionization of Poly(ethylenimine) and Poly(allylamine) at Various pH′s

Suh, J., Paik, H., & Hwang, B. K. (1994) · Bioorganic Chemistry · doi:10.1006/bioo.1994.1025 · Cited by 393 · see citing works

A Degradable Polyethylenimine Derivative with Low Toxicity for Highly Efficient Gene Delivery

Forrest, M. L., Koerber, J. T., & Pack, D. W. (2003) · Bioconjugate Chemistry · doi:10.1021/bc034014g · Cited by 387 · see citing works

Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery

Dash, P. R., Read, M. L., Barrett, L. B., Wolfert, M. A., & Seymour, L. W. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300843 · Cited by 386 · see citing works

A peptide nucleic acid–nuclear localization signal fusion that mediates nuclear transport of DNA

Brandén, L. J., Mohamed, A. J., & Smith, C. I. E. (1999) · Nature Biotechnology · doi:10.1038/11726 · Cited by 376 · see citing works

Polyethylenimine-based intravenous delivery of transgenes to mouse lung

Goula, D., Benoist, C., Mantero, S., Merlo, G. R., Levi, G., & DEMENEIX, B. A. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300717 · Cited by 374 · see citing works

Efficient active transport of gene nanocarriers to the cell nucleus

Suh, J., Wirtz, D., & Hanes, J. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0636277100 · Cited by 362 · see citing works

Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery

Kircheis, R., Kichler, A., Wallner, G., Kursa, M., Ogris, M., Felzmann, T., Buchberger, M., & Wagner, E. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300418 · Cited by 359 · see citing works

Transferrin-Containing, Cyclodextrin Polymer-Based Particles for Tumor-Targeted Gene Delivery

Bellocq, N. C., Pun, S. H., Jensen, G. S., & Davis, M. E. (2003) · Bioconjugate Chemistry · doi:10.1021/bc034125f · Cited by 350 · see citing works

Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application

Kircheis, R., Wightman, L., Schreiber, A. D., Robitza, B., Roessler, V., Kursa, M., & Wagner, E. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301351 · Cited by 350 · see citing works

From Virus Evolution to Vector Revolution: Use of Naturally Occurring Serotypes of Adeno-associated Virus (AAV) as Novel Vectors for Human Gene Therapy

Grimm, D., & Kay, M. A. (2003) · Current Gene Therapy · doi:10.2174/1566523034578285 · Cited by 349 · see citing works

DNA vaccines: a review

Liu, M. A. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01140.x · Cited by 346 · see citing works

In Vitro Gene Delivery to Hepatocytes with Galactosylated Polyethylenimine

Zanta, M.-A., Boussif, O., Adib, A., & Behr, J. (1997) · Bioconjugate Chemistry · doi:10.1021/bc970098f · Cited by 339 · see citing works

Receptor-mediated gene delivery in vivo. Partial correction of genetic analbuminemia in Nagase rats

Wu, G. Y., Wilson, J. M., Shalaby, F., S, M. G. B., Shafritz, D. A., & Wu, C. H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98689-8 · Cited by 338 · see citing works

Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels.

Cotten, M. L., Längle-Rouault, F., Kirlappos, H., Wagner, E., Mechtler, K., Zenke, M., Beug, H., & Birnstiel, M. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4033 · Cited by 337 · see citing works

Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand

Plank, C., Zatloukal, K., Cotten, M. L., Mechtler, K., & Wagner, E. (1992) · Bioconjugate Chemistry · doi:10.1021/bc00018a012 · Cited by 324 · see citing works

High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.

Cotten, M. L., Wagner, E., Zatloukal, K., Phillips, S., Curiel, D. T., & Birnstiel, M. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.6094 · Cited by 319 · see citing works

New Class of Polymers for the Delivery of Macromolecular Therapeutics

Gonzalez, H., Hwang, S., & Davis, M. E. (1999) · Bioconjugate Chemistry · doi:10.1021/bc990072j · Cited by 312 · see citing works

Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system

Goula, D., Rémy, J.-S., Erbacher, P., Wąsowicz, M., Levi, G., Abdallah, B., & DEMENEIX, B. A. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300635 · Cited by 309 · see citing works

Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake.

Perales, J. C., Ferkol, T. W., Beegen, H., Ratnoff, O. D., & Hanson, R. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.4086 · Cited by 301 · see citing works

Cyclodextrin-Modified Polyethylenimine Polymers for Gene Delivery

Pun, S. H., Bellocq, N. C., Liu, A., Jensen, G., Machemer, T., Quijano, E., Schluep, T., Wen, S.-F., Engler, H., Heidel, J. D., et al. (2004) · Bioconjugate Chemistry · doi:10.1021/bc049891g · Cited by 297 · see citing works

The pH-dependent bilayer destabilization by an amphipathic peptide

Subbarao, N. K., Parente, R. A., Szoka, F. C., Nádasdi, L., & Pongracz, K. (1987) · Biochemistry · doi:10.1021/bi00385a002 · Cited by 297 · see citing works

A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs

Bulmuş, V. (2003) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.06.001 · Cited by 290 · see citing works

Targeting Genes: Delivery and Persistent Expression of a Foreign Gene Driven by Mammalian Regulatory Elements in Vivo

Wu, C. H., Wilson, J. M., & Wu, G. Y. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71447-6 · Cited by 286 · see citing works

Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells

Midoux, P., Mendes, C., Legrand, A., Raimond, J., Mayer, R., Monsigny, M. L. P., & Roche, A. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.4.871 · Cited by 285 · see citing works

Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells.

Zenke, M., Steinlein, P., Wagner, E., Cotten, M. L., Beug, H., & Birnstiel, M. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3655 · Cited by 272 · see citing works

DNA vector chemistry: The covalent attachment of signal peptides to plasmid DNA

Sebestyén, M. G., Ludtke, J. J., Bassik, M. C., Zhang, G., Budker, V. G., Lukhtanov, E. A., Hagstrom, J. E., & Wolff, J. A. (1998) · Nature Biotechnology · doi:10.1038/nbt0198-80 · Cited by 270 · see citing works

A polymer library approach to suicide gene therapy for cancer

Anderson, D. G., Peng, W., Akinc, A., Hossain, N., Kohn, A., Padera, R. F., Langer, R., & Sawicki, J. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407218101 · Cited by 258 · see citing works

Polyelectrolyte Vectors for Gene Delivery: Influence of Cationic Polymer on Biophysical Properties of Complexes Formed with DNA

Wolfert, M. A., Dash, P. R., Nazarova, O. V., Oupický, D., Seymour, L. W., Smart, S., Strohalm, J., & Ulbrich, K. (1999) · Bioconjugate Chemistry · doi:10.1021/bc990025r · Cited by 253 · see citing works

Putative Role of Chloroquine in Gene Transfer into a Human Hepatoma Cell Line by DNA/Lactosylated Polylysine Complexes

Erbacher, P., Roche, A., Monsigny, M. L. P., & Midoux, P. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0169 · Cited by 252 · see citing works

Mannose Polyethylenimine Conjugates for Targeted DNA Delivery into Dendritic Cells

Diebold, S. S., Kursa, M., Wagner, E., Cotten, M. L., & Zenke, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19087 · Cited by 248 · see citing works

Partial Acetylation of Polyethylenimine Enhances In Vitro Gene Delivery

Forrest, M. L., Meister, G. E., Koerber, J. T., & Pack, D. W. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000016251.42392.1e · Cited by 247 · see citing works

Novel vectors for gene delivery formed by self-assembly of DNA with poly(l-lysine) grafted with hydrophilic polymers

Toncheva, V. D., Wolfert, M. A., Dash, P. R., Oupický, D., Ulbrich, K., Seymour, L. W., & Schacht, E. H. (1998) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00004-x · Cited by 243 · see citing works

Nuclear targeting peptide scaffolds for lipofection of nondividing mammalian cells

Subramanian, A., Ranganathan, P. N., & Diamond, S. L. (1999) · Nature Biotechnology · doi:10.1038/12860 · Cited by 233 · see citing works

Bioinspired pH-Responsive Polymers for the Intracellular Delivery of Biomolecular Drugs

Murthy, N., Campbell, J. S., Fausto, N., Hoffman, A. S., & Stayton, P. S. (2003) · Bioconjugate Chemistry · doi:10.1021/bc020056d · Cited by 233 · see citing works

Cancer gene therapy: hard lessons and new courses

Vile, R. G., Russell, S. J., & Lemoine, N. R. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301084 · Cited by 232 · see citing works

Branched Cationic Peptides for Gene Delivery: Role of Type and Number of Cationic Residues in Formation and in Vitro Activity of DNA Polyplexes

Plank, C., Tang, M. X., Wolfe, A. R., & Szoka, F. C. (1999) · Human Gene Therapy · doi:10.1089/10430349950019101 · Cited by 230 · see citing works

Poly-β amino ester-containing microparticles enhance the activity of nonviral genetic vaccines

Little, S. R., Lynn, D. M., Ge, Q., Anderson, D. G., Puram, S. V., Chen, J., Eisen, H. N., & Langer, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403549101 · Cited by 227 · see citing works

Enhancement of Gene Expression by Polyamidoamine Dendrimer Conjugates with α-, β-, and γ-Cyclodextrins

Arima, H., Kihara, F., Hirayama, F., & Uekama, K. (2001) · Bioconjugate Chemistry · doi:10.1021/bc000111n · Cited by 223 · see citing works

Development of a Nonviral Gene Delivery Vehicle for Systemic Application

Pun, S. H., & Davis, M. E. (2002) · Bioconjugate Chemistry · doi:10.1021/bc0155768 · Cited by 222 · see citing works

Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides

Murthy, N., Campbell, J. S., Fausto, N., Hoffman, A. S., & Stayton, P. S. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00099-3 · Cited by 221 · see citing works

Advances in Duchenne muscular dystrophy gene therapy

van Deutekom, J. C. T., & van Ommen, G. B. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1180 · Cited by 220 · see citing works

Peptide-Mediated Gene Delivery: Influence of Peptide Structure on Gene Expression

Wadhwa, M. S., Collard, W. T., Adami, R. C., McKenzie, D. L., & Rice, K. G. (1997) · Bioconjugate Chemistry · doi:10.1021/bc960079q · Cited by 219 · see citing works

Effects of Structure of β-Cyclodextrin-Containing Polymers on Gene Delivery

Hwang, S. J., Bellocq, N. C., & Davis, M. E. (2001) · Bioconjugate Chemistry · doi:10.1021/bc0001084 · Cited by 217 · see citing works

In Vivo Delivery to Tumors of DNA Complexed with Linear Polyethylenimine

Coll, J., Chollet, P., Brambilla, E. M., Desplanques, D., Behr, J., & Favrot, M. (1999) · Human Gene Therapy · doi:10.1089/10430349950017662 · Cited by 206 · see citing works

pH-Sensitive polymers that enhance intracellular drug delivery in vivo

Kyriakides, T. R., Cheung, C., Murthy, N., BORNSTEIN, P. K., Stayton, P. S., & Hoffman, A. S. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00504-1 · Cited by 202 · see citing works

Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles

Pun, S. H., Tack, F., Bellocq, N. C., Cheng, J., Grubbs, B. H., Jensen, G. S., Davis, M. E., Brewster, M. E., Janicot, M., Janssens, B., et al. (2004) · Cancer Biology & Therapy · doi:10.4161/cbt.3.7.918 · Cited by 201 · see citing works

An RGD–Oligolysine Peptide: A Prototype Construct for Integrin-Mediated Gene Delivery

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Nonviral Gene Delivery to the Rat Kidney with Polyethylenimine

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