The DOI matches its Crossref record.
The Role of Oxidative Stress in Diabetic Vascular and Neural Disease
Abstract
This review will focus on the impact of hyperglycemia-induced oxidative stress in the development of diabetes-induced vascular and neural dysfunction. Oxidative stress occurs when the balance between the production of oxidation products and the ability of antioxidant mechanisms to neutralize these products is tilted in the favor of the former. The production of reactive oxygen species has been shown to be increased in patients with diabetes. The possible sources for the overproduction of reactive oxygen species is widespread and include enzymatic pathways, autoxidation of glucose and the mitochondria. Increase in oxidative stress has clearly been shown to contribute to the pathology of vascular disease not only in diabetes but also in hypertension, stroke and ischemia. Since the etiology of diabetic neuropathy is considered to have a large vascular component, prevention of oxidative stress in diabetes is considered by many investigators to be a primary defense against the development of diabetic vascular disease. Potential therapies for preventing increased oxidative stress in diabetes and the neural vasculature will be discussed.
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“However, the therapeutic use of CoQ10 and other antioxidants in vivo, particularly in human studies directed at vascular events, has been disappointing (341, 345).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [341]
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“However, the therapeutic use of CoQ10 and other antioxidants in vivo , particularly in human studies directed at vascular events, has been disappointing (341, 345).”
Self-citationBhatti, J. S., Sehrawat, A., Mishra, J., Sidhu, I. S., Navik, U., Khullar, N., Kumar, S., Bhatti, G. K., & Reddy, P. H. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.03.019 · Cited by 753
Metadata
- Authors
- Yorek, M. A.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Yorek, Mark A.
- ORCID
- Yorek, Mark A.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 37
- Issue
- 5
- Pages
- 471-480
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2086273061
- Cited by
- 219
- References
- 0
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 13 · 2019: 5 · 2018: 2 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 16 · 2013: 12 · 2012: 13
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Keywords
- oxidative stress, hyperglycemia, diabetes mellitus, diabetic vascular disease, diabetic neuropathy, reactive oxygen species, antioxidant defense, mitochondrial oxidative stress, hypertension, stroke, ischemia, neurovascular dysfunction, antioxidant therapy
- MeSH terms
- Animals, Diabetes Mellitus, Diabetic Angiopathies, Diabetic Neuropathies, Endothelium, Vascular, Free Radicals, Humans, Models, Biological, Neural Conduction, Reactive Oxygen Species, Oxidative Stress, Diabetes Complications
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