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The Role of Oxidative Stress in Diabetic Vascular and Neural Disease
Abstract
This review will focus on the impact of hyperglycemia-induced oxidative stress in the development of diabetes-induced vascular and neural dysfunction. Oxidative stress occurs when the balance between the production of oxidation products and the ability of antioxidant mechanisms to neutralize these products is tilted in the favor of the former. The production of reactive oxygen species has been shown to be increased in patients with diabetes. The possible sources for the overproduction of reactive oxygen species is widespread and include enzymatic pathways, autoxidation of glucose and the mitochondria. Increase in oxidative stress has clearly been shown to contribute to the pathology of vascular disease not only in diabetes but also in hypertension, stroke and ischemia. Since the etiology of diabetic neuropathy is considered to have a large vascular component, prevention of oxidative stress in diabetes is considered by many investigators to be a primary defense against the development of diabetic vascular disease. Potential therapies for preventing increased oxidative stress in diabetes and the neural vasculature will be discussed.
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“However, the therapeutic use of CoQ10 and other antioxidants in vivo, particularly in human studies directed at vascular events, has been disappointing (341, 345).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [341]
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Dalle‐Donne, I., Aldini, G., Carini, M., Colombo, R., Rossi, R., & Milzani, A. (2006) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2006.tb00407.x · Cited by 857
Sivitz, W. I., & Yorek, M. A. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2531 · Cited by 742
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Self-citationBhatti, J. S., Sehrawat, A., Mishra, J., Sidhu, I. S., Navik, U., Khullar, N., Kumar, S., Bhatti, G. K., & Reddy, P. H. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.03.019 · Cited by 753
PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells
VALLE, I., ALVAREZBARRIENTOS, A., ARZA, E., LAMAS, S., & MONSALVE, M. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.01.026 · Cited by 556
“Excessive production of reactive oxygen species (ROS) in the mitochondria plays a major role in the development of several diseases including the vascular and neurological complications of diabetes [29,46], neurodegenerative diseases like Parkinson’s disease [13], Alzheimer [1] and epilepsy [9], ageing [11] and cancer…”
BackgroundOxidative stress and diabetic cardiovascular complications
Jay, D., Hitomi, H., & Griendling, K. K. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.06.018 · Cited by 464
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Houten, B. V., Woshner, V. M., & Santos, J. H. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.03.002 · Cited by 461
Dalle‐Donne, I., Scaloni, A., Giustarini, D., Cavarra, E., Tell, G., Lungarella, G., Colombo, R., Rossi, R., & Milzani, A. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.20006 · Cited by 461
Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers
Giustarini, D., Dalle‐Donne, I., Tsikas, D., & Rossi, R. (2009) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408360903142326 · Cited by 452
Prussian Blue Based Nanoelectrode Arrays for H2O2 Detection
Karyakin, A. A., Puganova, E. A., Budashov, I. A., et al. (2003) · Analytical Chemistry · doi:10.1021/ac034859l · Cited by 325
Mitochondrial DNA damage and its potential role in retinal degeneration
Jarrett, S. G., Lin, H., Godley, B. F., & Boulton, M. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.09.001 · Cited by 279
Diabetic neuropathy: cutting-edge research and future directions
Yang, Y., Zhao, B. T., Wang, Y., Lan, H. H., Liu, X., Hu, Y., & Cao, P. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02175-1 · Cited by 320
“338,339 In contrast, patients with T1DM often bene fi t from insulin therapy regarding neuropathic outcomes, as they typically do not exhibit signi fi cant insulin resistance.”
Chen, J., Shu, Y., Li, H., et al. (2018) · Talanta · doi:10.1016/j.talanta.2018.06.075 · Cited by 201
Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes
Moreira, P. I., Santos, M. S., Seiça, R. M. F., & Oliveira, C. R. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.017 · Cited by 190
“Increased oxidative stress has been implicated in the pathology of several diseases including diabetes and AD [78,79].”
BackgroundAntioxidant Strategies in the Management of Diabetic Neuropathy
Oyenihi, A. B., Ayeleso, A. O., Mukwevho, E., & Masola, B. (2015) · BioMed Research International · doi:10.1155/2015/515042 · Cited by 192
“Chronic hyperglycaemia (an abnormally high glucose concentration in the blood) resulting fromdefects in insulin secretion/action, or both, is the major hallmark of diabetes in which it is known to be involved in the progression of the condition to different complications that include diabetic…”
BackgroundMikhed, Y., Görlach, A., Knaus, U. G., & Daiber, A. (2015) · Redox Biology · doi:10.1016/j.redox.2015.05.008 · Cited by 189
“Many diseases and drug-induced complications are associated or even based on an imbalance between the formation of reactive oxygen and nitrogen species (ROS and RNS), and antioxidant enzymes catalyzing the break-down of harmful oxidants [76,77].”
BackgroundMitochondrial Redox Cycling of Mitoquinone Leads to Superoxide Production and Cellular Apoptosis
Doughan, A. K., & Dikalov, S. I. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1693 · Cited by 172
“R EACTIVE OXYGEN SPECIES (ROS) derived from mitochondria play a major role in promoting age-related human diseases, vascular and neurologic complications of diabetes, and cell damage in neurodegenerative disorders (10, 25, 30).”
Pt nanoparticle-based highly sensitive platform for the enzyme-free amperometric sensing of H2O2
Chakraborty, S., & Raj, C. R. (2009) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2009.04.015 · Cited by 166
Park, J., Choe, S. S., Choi, A. H., Kim, K. H., Yoon, M. J., Suganami, T., Ogawa, Y., & Kim, J. B. (2006) · Diabetes · doi:10.2337/db05-1570 · Cited by 157
Lee, J., Jo, D., Park, D., Chung, H. Y., & Mattson, M. P. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.007757 · Cited by 155
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BackgroundChowdhury, S. R., Zherebitskaya, E., Smith, D. R., Akude, E., Chattopadhyay, S., Jolivalt, C. G., Calcutt, N. A., & Fernyhough, P. (2010) · Diabetes · doi:10.2337/db09-1299 · Cited by 145
“Oxidative damage to lipids in the sciatic nerve was increased in the present study, supporting previous work (9,42,43).”
ResultCojocaru, K.-A., Luchian, I. A., Goriuc, A., Antoci, L.-M., Ciobanu, C.-G., Popescu, R. M., Vlad, C.-E., Blaj, M., & Foia, L. G. (2023) · Antioxidants · doi:10.3390/antiox12030658 · Cited by 160
“An increase in antioxidants, such as vitamin E, vitamin C, coenzyme Q, and N-acetylcysteine (NAC), is indicated for their oxidative stress reduction [133,134].”
BackgroundMitochondrial stress and the pathogenesis of diabetic neuropathy
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Superstable Advanced Hydrogen Peroxide Transducer Based on Transition Metal Hexacyanoferrates
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Kusaka, I., Kusaka, G., Zhou, C., Ishikawa, M., Nanda, A., Granger, D. N., Zhang, J. H., & Tang, J. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01169.2003 · Cited by 127
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BackgroundCoppey, L. J., Davidson, E. P., Rinehart, T. W., Gellett, J. S., Oltman, C. L., Lund, D. D., & Yorek, M. A. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-0885 · Cited by 127
Self-citationSitnikova, N. A., Komkova, M. A., Khomyakova, I., et al. (2014) · Analytical Chemistry · doi:10.1021/ac500595v · Cited by 124
Reactive Oxygen and Targeted Antioxidant Administration in Endothelial Cell Mitochondria
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“of vascular disease in stroke, hypertension, and diabetes.(229) Observations that mitochondrial function is dis-”
BackgroundMass spectrometry and redox proteomics: Applications in disease
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Karam, P., & Halaoui, L. I. (2008) · Analytical Chemistry · doi:10.1021/ac702358d · Cited by 113
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Steven, S., Daiber, A., Dopheide, J. F., Münzel, T. F., & Espinola–Klein, C. (2017) · Redox Biology · doi:10.1016/j.redox.2017.04.017 · Cited by 115
“There is ample evidence that many diseases and drug-induced complications are associated with or even based on increased levels of reactive oxygen and nitrogen species (ROS and RNS), so-called oxidative stress [1,2].”
BackgroundApoptosis: A Key in Neurodegenerative Disorders
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Brito, M. A., Brites, D. M. T. O., & Butterfield, D. A. (2004) · Brain Research · doi:10.1016/j.brainres.2004.07.063 · Cited by 101
“Therefore, the present data indicate that oxidative stress plays a role in brain damage by Bb similarly to what happens in several pathological conditions [10,29,72], and in the same order of magnitude of some other neurotoxins [32,33,50].”
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Jarrett, S. G., Lewin, A. S., & Boulton, M. E. (2010) · Ophthalmic Research · doi:10.1159/000316480 · Cited by 100
Fatima, G., Sharma, V. P., Das, S. K., & Mahdi, A. A. (2014) · Spinal Cord · doi:10.1038/sc.2014.178 · Cited by 100
Nanotechnology in ophthalmology
Zarbin, M. A., Montemagno, C. D., Leary, J. F., & Ritch, R. H. (2010) · Canadian Journal of Ophthalmology · doi:10.3129/i10-090 · Cited by 97
Ceretta, L. B., Réus, G. Z., Abelaira, H. M., Ribeiro, K. F., Zappellini, G., Felisbino, F. F., Steckert, A. V., Dal‐Pizzol, F., & Quevedo, J. (2012) · Experimental Diabetes Research · doi:10.1155/2012/302682 · Cited by 94
“ROS and reactive nitrogen species (RNS) production by the mitochondrial respiratory system [10], glucose autoxidation [11], activation of the polyol pathway [12], formation of advanced glycation end products (AGEs) [13], antioxidant enzyme inactivation [14] and an imbalance of glutathione redox status [15].”
BackgroundInsulin protects against amyloid β-peptide toxicity in brain mitochondria of diabetic rats
Moreira, P. I., Santos, M. S., Sena, C. M., Seiça, R. M. F., & Oliveira, C. R. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.10.017 · Cited by 89
Yamagishi, S., Ogasawara, S., Mizukami, H., Yajima, N., Wada, R., Sugawara, A., & Yagihashi, S. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05050.x · Cited by 86
Predonzani, A. (2015) · World Journal of Experimental Medicine · doi:10.5493/wjem.v5.i2.64 · Cited by 83
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“In addition, damage to nucleic acids can activate the mechanisms of apoptosis [25].”
BackgroundLi, F., Drel, V. R., Szabó, C., Stevens, M. J., & Obrosova, I. G. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1514 · Cited by 84
“Almost all ingredients of the combination therapies tested so far have direct or indirect antioxidant properties, consistent with the role of oxidative stress as a convergence point for hyperglycemia-driven pathogenetic pathways (35,36).”
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Stavniichuk, R., Shevalye, H., Lupachyk, S., Obrosov, A. A., Groves, J. T., Obrosova, I. G., & Yorek, M. A. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2549 · Cited by 79
“Evidence for important role for oxidative stress in both experimental [3,9,21,22] and clinical [23,24] diabetic neuropathy is emerging.”
BackgroundSelf-citationNarang, J., Chauhan, N., & Pundir, C. S. (2011) · The Analyst · doi:10.1039/c1an15543a · Cited by 82
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Yang, X., Bai, J., Wang, Y., Jiang, X., & Xiao-ying, H. (2012) · The Analyst · doi:10.1039/c2an35407a · Cited by 80
Davidson, E. P., Coppey, L. J., Lu, B., Arballo, V., Calcutt, N. A., Gerard, C. J., & Yorek, M. A. (2009) · Experimental Diabetes Research · doi:10.1155/2009/431980 · Cited by 81
“Diabetic neuropathy is considered to be a multifactorial disease arising from interactions between abnormal metabolic activity and impaired vascular function [2, 6, 7].”
BackgroundSelf-citationROS production in neutrophils from alloxan-induced diabetic rats treated in vivo with astaxanthin
Marin, D. P., Bolin, A. P., Macedo, R. D. C. S., Sampaio, S. C., & Otton, R. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2010.10.013 · Cited by 75
“Accumulated evidence points out that hyperglycemia can lead to an elevated reactive oxygen (ROS) and nitrogen species (RNS) production by the mitochondrial respiratory system [6], glucose autoxidation [7], activation of the polyol pathway [8], formation of advanced glycation end-products (AGEs) [9], antioxidant enzyme…”
BackgroundMethionine sulfoxides in serum proteins as potential clinical biomarkers of oxidative stress
Suzuki, S., Kodera, Y., Saito, T., Fujimoto, K., Momozono, A., Hayashi, A., Kamata, Y., & Shichiri, M. (2016) · Scientific Reports · doi:10.1038/srep38299 · Cited by 81
Parameters of oxidative stress in saliva from diabetic and parenteral drug addict patients
Arana, C., Cutando, A., Ferrera, M. J., Moreno, G. G., Worf, C. V., Bolaños, M. J., Escames, G., & Acuña-Castroviejo, D. (2006) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2006.00469.x · Cited by 73
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Ceretta, L. B., Réus, G. Z., Abelaira, H. M., Jornada, L. K., Schwalm, M. T., Hoepers, N., Tomazi, C., Gulbis, K. C., Ceretta, R. A., & Quevedo, J. (2012) · Acta Diabetologica · doi:10.1007/s00592-012-0435-9 · Cited by 73
“Such changes occur in both depression and diabetes [13–17], which may also explain, at least in part, the relationship between them.”
BackgroundOxidative stress, type 2 diabetes and vitamin D: past, present and future
Nikooyeh, B., & Neyestani, T. R. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2718 · Cited by 76
“There is a huge body of evidence suggesting a crucial role for OS in diabetic complications, including cardiovascular disease [5,20,21], bone disorders [22] and neural disease [23].”
BackgroundPourvali, K., Abbasi, M., & Mottaghi, A. (2016) · Europe PMC (PubMed Central) · Cited by 67
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Lv, C., Di, W., Liu, Z., Zheng, K., & Qin, W. (2014) · The Analyst · doi:10.1039/c4an00952e · Cited by 68
Lata, S., Batra, B., Karwasra, N., et al. (2012) · Process Biochemistry · doi:10.1016/j.procbio.2012.03.018 · Cited by 67
Borisova, A. V., Karyakina, E. E., Cosnier, S., et al. (2009) · Electroanalysis · doi:10.1002/elan.200804408 · Cited by 65
Yorek, M. S., Obrosov, A. A., Shevalye, H., Holmes, A. J., Harper, M. M., Kardon, R. H., & Yorek, M. A. (2015) · Journal of the Peripheral Nervous System · doi:10.1111/jns.12111 · Cited by 63
“Increased oxidative stress is widely thought to be a contributing factor to the development of peripheral diabetic neuropathy (Obrosova, 2003; Yorek, 2003).”
BackgroundSelf-citationVascular and neural dysfunction in Zucker diabetic fatty rats: a difficult condition to reverse
Oltman, C. L., Davidson, E. P., Coppey, L. J., Kleinschmidt, T. L., Lund, D. D., Adebara, E. T., & Yorek, M. A. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00814.x · Cited by 61
Self-citationDaiber, A., Oelze, M. W., Steven, S., Kröller‐Schön, S., & Münzel, T. F. (2017) · Redox Biology · doi:10.1016/j.redox.2017.02.001 · Cited by 65
“Excessive formation or insufficient break-down of reactive oxygen and nitrogen species (ROS and RNS) plays an important role for the development and progression of many diseases and drug-induced complications [1,2].”
BackgroundBhatti, J. S., Kumar, S., Vijayan, M., Bhatti, G. K., & Reddy, P. H. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.012 · Cited by 61
Lee, B. Y., Al-Waili, N., Stubbs, D., Wendell, K., Butler, G. J., Al-Waili, T. N., & Al-Waili, A. N. (2010) · International Journal of Medical Sciences · doi:10.7150/ijms.7.29 · Cited by 57
Altered redox status in patients with Diabetes Mellitus type I
del Valle, L. G., Milian, L. D. L. C., Toledo, A., VILARO, N., Tápanes, R. D., & Otero, M. D. C. M. (2005) · Pharmacological Research · doi:10.1016/j.phrs.2004.10.012 · Cited by 56
Duan, J., Yin, Y., Cui, J., Yan, J., Zhu, Y., Guan, Y., Wei, G., Weng, Y., Wu, X., Guo, C., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-9033-x · Cited by 57
New materials based on nanostructured Prussian blue for development of hydrogen peroxide sensors
Puganova, E. A., & Karyakin, A. A. (2005) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2005.03.094 · Cited by 51
Yorek, M. S., Obrosov, A. A., Shevalye, H., Lupachyk, S., Harper, M. M., Kardon, R. H., & Yorek, M. A. (2014) · Journal of the Peripheral Nervous System · doi:10.1111/jns.12086 · Cited by 50
“The mechanisms contributing to diabetic peripheral neuropathy are uncertain, although studies in animal models have implicated oxidative and nitrosative stress as likely contributors (Yorek, 2003; Obrosova, 2009).”
BackgroundSelf-citationSpanidis, Y., Mpesios, A., Stagos, D., Goutzourelas, N., Bar‐Or, D., Karapetsa, M., Zakynthinos, E. G., Spandidos, D. A., Tsatsakis, A. M., Leon, G., et al. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.2968 · Cited by 48
“Oxidative stress occurring in patients with MetS and T2D may further aggravate the associated complications, particularly those involving the cardiovascular system (14,16,35,36).”
Demiot, C., Tartas, M., Fromy, B., Abraham, P., Saumet, J. L., & Sigaudo‐Roussel, D. (2006) · Diabetes · doi:10.2337/db05-1433 · Cited by 53
“In contrast to experimental studies, clinical trials of various ARIs conducted to date have failed to provide a convincing rationale for their use in the treatment of patients with diabetic neuropathy (25,26,40,41).”
ResultEffect of licorice extract on the complications of diabetes nephropathy in rats
Kataya, H. H., Hamza, A. A., Ramadan, G. A., & Khasawneh, M. A. (2011) · Drug and Chemical Toxicology · doi:10.3109/01480545.2010.510524 · Cited by 49
“Diabetic nephropathy is one of the major microvascular complications of diabetes and one of the leading causes of end-stage renal failure and death in diabetic patients (Evans et al., 2002; Yorek, 2003).”
BackgroundInfluentialIncreased methionine sulfoxide content of apoA-I in type 1 diabetes
Brock, J. W. C., Jenkins, A. J., Lyons, T. J., Klein, R. L., Yim, E., Lopes-Virella, M. F., Carter, R. E., Thorpe, S. R., & Baynes, J. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800015-jlr200 · Cited by 49
“Despite the evidence for increased oxidative stress in diabetes (2–4, 50), in the present study diabetic patients with nephropathy, which is thought to increase oxidative stress and CVD risk (50–52), did not show a statistically significant increase in Met oxidation.”
InfluentialEnhanced hydrogen peroxide sensing based on Prussian Blue modified macroporous microelectrodes
Mokrushina, A. V., Heim, M., Karyakina, E. E., et al. (2013) · Electrochemistry Communications · doi:10.1016/j.elecom.2013.01.004 · Cited by 48
Impact of antioxidants on seminal vesicles function and fertilizing potential in diabetic rats
Honda, M., Tsounapi, P., Dimitriadis, F., Kawamoto, B., Hikita, K., Muraoka, K., Saito, M., Sofikitis, N., & Takenaka, A. (2016) · Asian Journal of Andrology · doi:10.4103/1008-682x.186871 · Cited by 48
Jayeoye, T. J., & Rujiralai, T. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116657 · Cited by 47
Vitamin D receptor gene FokI variant in diabetic foot ulcer and its relation with oxidative stress
Soroush, N., Radfar, M., Hamidi, A. K., Abdollahi, M. R., Qorbani, M., Razi, F., Nasli‐Esfahani, E., & Amoli, M. M. (2016) · Gene · doi:10.1016/j.gene.2016.11.012 · Cited by 43
“OS also contributes to the development and progression of vascular and neural dysfunction in diabetic patients (Yorek, 2003).”
BackgroundPt-MWCNT modified carbon electrode strip for rapid and quantitative detection of H 2 O 2 in food
Chou, T.-C., Wu, K., Hsu, F.-X., & Lee, C. (2017) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2017.08.005 · Cited by 45
Aroua, L. M., Alosaimi, A. H., Alminderej, F. M., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020457 · Cited by 43
“Furthermore, free radical scavengers and chelators have been reported for their potential role in diabetes management, such as reducing the vascular relaxation and neurovascular impairments associated with hyperalgesia, improving endoneurial blood flow, and overall reducing the production of OH- and the initiation of…”
BackgroundCarlo, M. D., Picone, P., Carrotta, R., Giacomazza, D., & Biagio, P. L. S. (2010) · BioMed Research International · doi:10.1155/2010/147835 · Cited by 41
“Caspase 9 activation is a consequence of mitochondrial dysfunction often provoked by oxidative stress, and increased oxidative stress has been implicated in the etiology of several pathology including diabetes and AD [22, 23].”
Carvalho, C., Katz, P. S., Dutta, S., Katakam, P. V. G., Moreira, P. I., & Busija, D. W. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130464 · Cited by 42
“…severaldeleteriouspathwaysculminatinginseveral ahyperglycemicstate,highlevelsofreactiveoxygen species(ROS )areproducedactivatingseveraldeleteri-ouspathways factornuclearfactor κ B (NF κ B) enhancing monocytes adhesion to the vessel walls, which may initiate an atherosclerotic state [6].”
Tamura, S., Tsukahara, H., Ueno, M., Maeda, M., Kawakami, H., Sekine, K., & Mayumi, M. (2006) · Free Radical Research · doi:10.1080/10715760600895191 · Cited by 42
“carcinogenesis and many other inflammatory and degenerative conditions [1,2].”
BackgroundNeuroprotection by α-Lipoic Acid in Streptozotocin-Induced Diabetes
Baydaş, G., Dönder, E., Kiliboz, M., et al. (2004) · Biochemistry (Moscow) · doi:10.1023/b:biry.0000043542.39691.95 · Cited by 42
Rehni, A. K., Nautiyal, N., Pérez‐Pinzón, M. A., & Dave, K. R. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9538-z · Cited by 43
“, lipids, proteins and nucleic acids ultimately contributing to ischemic damage (Yorek 2003).”
Prow, T. W., Grebe, R. R., Merges, C. A., Smith, J. N., McLeod, D. S., Leary, J. F., & Lutty, G. A. (2006) · PubMed · Cited by 41
Eguílaz, M., Dalmasso, P. R., Rubianes, M. D., Gutierrez, F. A., Rodrı́guez, M. C., Gallay, P. A., Mujica, M. L., Ramírez, M. L., Tettamanti, C. S., Montemerlo, A., et al. (2019) · Current Opinion in Electrochemistry · doi:10.1016/j.coelec.2019.02.007 · Cited by 41
Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders
Sorriento, D., Pascale, A. V., Finelli, R., Carillo, A. L., Annunziata, R., Trimarco, B., & Iaccarino, G. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/604685 · Cited by 39
“Various vitamins and chemical compounds with antioxidant properties have been developed, including coenzymeQ [120], vitamin E [121], a-lipoic acid [122], N-acetylcysteine (NAC) [123], vitamin C, and inducers of heme oxygenase [124], which are able to reduce ROS production.”
BackgroundRetractedNanostructured ZnO thin film for hydrogen peroxide sensing
Sivalingam, D., Jeyaprakash, B. G., Krishnan, U. M., et al. (2011) · Physica E Low-dimensional Systems and Nanostructures · doi:10.1016/j.physe.2011.06.015 · Cited by 35
Sophia, J., & Muralidharan, G. (2015) · Materials Research Bulletin · doi:10.1016/j.materresbull.2015.04.058 · Cited by 35
Yin, G., XING, L. X., Ma, X., et al. (2013) · Chemical Papers · doi:10.2478/s11696-013-0473-y · Cited by 35
“H2O2 is cytotoxic to cellular life and acts as an indicator of oxidative stress (Lases et al., 2000; Yorek, 2003); it is the product of several biological, enzymecatalysed reactions (Clark, 1970; Ruiz et al., 1993; Yang et al., 1995, 2006; Thomé-Duret et al., 1996; Niwa et al., 1998; Armstrong &…”
BackgroundHermans, N., Cos, P., Berghe, D. V., Vlietinck, A. J., & de Bruyne, T. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.05.040 · Cited by 34
Enzyme integrated silicate–Pt nanoparticle architecture: A versatile biosensing platform
Jena, B. K., & Raj, C. R. (2010) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2010.11.046 · Cited by 35
“…H2O2 is the most valuable marker for oxidative stress; oxidative damages resulting from the cellular imbalance of H2O2 and other reactive oxygen species generated from H2O2 are connected to aging and severe human diseases like cancer and cardiovascular disorders (Lazrus et al., 1985; Yorek, 2003).”
BackgroundJayeoye, T. J., Eze, F. N., Olatunde, O. O., Benjakul, S., & Rujiralai, T. (2021) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2021.105224 · Cited by 35
Xia, P., Liu, H., & Tian, Y. (2008) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2008.12.029 · Cited by 34
“…of hydrogen peroxide (H2O2) with high selectivty and sensitivity is of great importance, because H2O2 is cytoxic to ellular life and is an indicator of oxidative stress (Yorek, 2003) and a roduct of several biological, enzyme-catalyzed reactions (Thomeuret et al., 1996; You et al., 2003).”
BackgroundMukhopadhyay, S., & Mukherjee, T. K. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.03.010 · Cited by 34
“[90] M.”
BackgroundKinetic approach for evaluation of total antioxidant activity
Karyakina, E. E., Vokhmyanina, D. V., Sizova, N. V., et al. (2009) · Talanta · doi:10.1016/j.talanta.2009.07.059 · Cited by 33
Redox Proteomes in Human Physiology and Disease Mechanisms
Mannaa, A. M., & Hanisch, F. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00586 · Cited by 34
Ahmad, K., & Kim, H. (2022) · Nanomaterials · doi:10.3390/nano12142443 · Cited by 32
Neuropathy and the vascular-bone axis in diabetes: lessons from Charcot osteoarthropathy
Petrova, N. L., & Shanahan, C. M. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2511-6 · Cited by 31
El-Askary, H., Salem, H., & Motaal, A. A. A. (2022) · Molecules · doi:10.3390/molecules27030857 · Cited by 23
“It is worth mentioning that diabetes development has been proven to be associated with a state of increased oxidative stress that is crucially involved in the pathogenesis of diabetes complications [20,21].”
BackgroundOxidative Stress in Insulin-Resistant Conditions
Stump, C. S., Clark, S. E., & Sowers, J. R. (2005) · Treatments in Endocrinology · doi:10.2165/00024677-200504060-00003 · Cited by 31
Metadata
- Authors
- Yorek, M. A.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Yorek, Mark A.
- ORCID
- Yorek, Mark A.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 37
- Issue
- 5
- Pages
- 471-480
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2086273061
- Cited by
- 219
- References
- 0
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 13 · 2019: 5 · 2018: 2 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 16 · 2013: 12 · 2012: 13
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Keywords
- oxidative stress, hyperglycemia, diabetes mellitus, diabetic vascular disease, diabetic neuropathy, reactive oxygen species, antioxidant defense, mitochondrial oxidative stress, hypertension, stroke, ischemia, neurovascular dysfunction, antioxidant therapy
- MeSH terms
- Animals, Diabetes Mellitus, Diabetic Angiopathies, Diabetic Neuropathies, Endothelium, Vascular, Free Radicals, Humans, Models, Biological, Neural Conduction, Reactive Oxygen Species, Oxidative Stress, Diabetes Complications
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