The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Part of the Series: From Dietary Antioxidants to Regulators in Cellular Signalling and Gene ExpressionRole of reactive oxygen species and (phyto)oestrogens in the modulation of adaptive response to stress: Review
Abstract
There is increasing evidence that reactive oxygen species (ROS) are not only toxic but play an important role in cellular signalling and in the regulation of gene expression. We, here, discuss two examples of improved adaptive response to an altered cellular redox state. First, differences in longevity between males and females may be explained by a higher expression of antioxidant enzymes in females resulting in a lower yield of mitochondrial ROS. Oestrogens are made responsible for these phenomena. Oestradiol induces glutathione peroxidase-1 and MnSOD by processes requiring the cell surface oestrogen receptor (ER) and the activation of pathways usually involved in oxidative stress response. Second, oxygen radicals produced during moderate exercise as performed during training up-regulate the expression of antioxidant enzymes in muscle cells. An increased level of these enzymes might prevent oxidative damage during exhaustive exercise and should, therefore, not be prevented by antioxidants. The relevance of these findings is discussed in the context with observations made in transgenic animals overexpressing MnSOD or catalase.
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“Another study reported that the administration of PEs in the form of phytoestrogen inhibited glucogenic and lipogenic enzymes and were associated with the regulation of the antioxidant enzymes activity, especially catalase, glutathione peroxidase, and SOD.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [167]
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Metadata
- Authors
- Vina, J., Borras, C., Gomez-Cabrera, M.-C., & Orr, W. C.
- Affiliations
- Southern Methodist University (US)
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 40
- Issue
- 2
- Pages
- 111-119
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2026299334
- Cited by
- 125
- References
- 46
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 11 · 2012: 6
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto de Salud Carlos III
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- reactive oxygen species, phytoestrogens, estrogen, estradiol, antioxidant enzymes, glutathione peroxidase 1, manganese superoxide dismutase, oxidative stress response, sex differences in longevity, mitochondrial reactive oxygen species, exercise-induced oxidative stress, skeletal muscle, catalase, dietary antioxidants, signal transduction, gene expression regulation
- MeSH terms
- Glutathione Peroxidase GPX1, Aging, Animals, Antioxidants, Catalase, Estradiol, Female, Glutathione Peroxidase, Humans, Male, Oxidation-Reduction, Receptors, Estrogen, Superoxide Dismutase, Signal Transduction, Gene Expression, Reactive Oxygen Species, Oxidative Stress, Dietary Supplements, Phytoestrogens, Rats
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