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Iron-deficiency anaemia enhances red blood cell oxidative stress
Open accessAbstract
Oxidative stress associated with iron deficiency anaemia in a murine model was studied feeding an iron-deficient diet. Anaemia was monitored by a decrease in hematocrit and haemoglobin. For the 9 week study an increase in total iron binding capacity was also demonstrated. Anaemia resulted in an increase in red blood cells (RBC) oxidative stress as indicated by increased levels of fluorescent heme degradation products (1.24-fold after 5 weeks; 2.1-fold after 9 weeks). The increase in oxidative stress was further confirmed by elevated levels of methemoglobin for mice fed an iron-deficient diet. Increased haemoglobin autoxidation and subsequent generation of ROS can account for the shorter RBC lifespan and other pathological changes associated with iron-deficiency anaemia.
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“Since the ROS concentration can be increased near the membrane, not only are the RBCs themselves damaged, ROS can be released to the vasculature and neighboring tissues (Nagababu et al., 2008).”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Nagababu et al., 2008
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“Heme degradation has been reported to correlate with immunoglobulin G binding to the RBC membrane, which in turn is associated with denaturation of Hb.Denatured Hb and heme degradation products as well as free iron, promote removal of RBCs from circulation.”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Nagababu et al., 2008
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Sorted by citations
Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging
Mohanty, J. G., Nagababu, E., & Rifkind, J. M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00084 · Cited by 595
Self-citationOxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases
Bissinger, R., Bhuyan, A. A. M., Qadri, S. M., & Lang, F. (2019) · The FEBS Journal · doi:10.1111/febs.14606 · Cited by 239
The pathophysiology of extracellular hemoglobin associated with enhanced oxidative reactions
Rifkind, J. M., Mohanty, J. G., & Nagababu, E. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2014.00500 · Cited by 240
Self-citationElsayed, M., Sharif, M., & Stack, A. G. (2016) · Advances in clinical chemistry · doi:10.1016/bs.acc.2016.03.002 · Cited by 184
Mechanisms and pathophysiological significance of eryptosis, the suicidal erythrocyte death
Lang, E., & Lang, F. J. W. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.01.009 · Cited by 170
Metadata
- Authors
- Nagababu, E., Gulyani, S., Earley, C. J., Cutler, R. G., Mattson, M. P., & Rifkind, J. M.
- Affiliations
- National Institutes of Health (US)
- Johns Hopkins Bayview Medical Center (US)
- Corresponding author
- Rifkind, Joseph M.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2008-01
- Volume
- 42
- Issue
- 9
- Pages
- 824-829
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- PMC
- PMC2730642
- OpenAlex
- W2160940874
- Cited by
- 155
- References
- 38
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 9 · 2021: 11 · 2020: 15 · 2019: 13 · 2018: 10 · 2017: 13 · 2016: 6 · 2015: 9 · 2014: 10 · 2013: 7 · 2012: 12
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Free Radical Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P01AG021190, Z01AG000047)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
- Keywords
- iron deficiency anemia, heme degradation products, methemoglobin, reactive oxygen species, red blood cell lifespan, iron-deficient diet, total iron binding capacity, mouse model
- MeSH terms
- Animals, Body Weight, Erythrocytes, Hematocrit, Heme, Hemoglobins, Iron, Male, Methemoglobin, Mice, Inbred C57BL, Microscopy, Fluorescence, Oxygen, Oxidative Stress, Anemia, Iron-Deficiency, Mice
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