Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases
Abstract
The average lifespan of circulating erythrocytes usually exceeds hundred days. Prior to that, however, erythrocytes may be exposed to oxidative stress in the circulation which could cause injury and trigger their suicidal death or eryptosis. Oxidative stress activates Ca 2+ ‐permeable nonselective cation channels in the cell membrane, thus, stimulating Ca 2+ entry and subsequent cell membrane scrambling resulting in phosphatidylserine exposure and activation of Ca 2+ ‐sensitive K + channels leading to K + exit, hyperpolarization, Cl − exit, and ultimately cell shrinkage due to loss of KC l and osmotically driven water. While the mechanistic link between oxidative stress and anemia remains ill‐defined, several diseases such as diabetes, hepatic failure, malignancy, chronic kidney disease and inflammation have been identified to display both increased oxidative stress as well as eryptosis. Recent compelling evidence suggests that oxidative stress is an important perpetrator in accelerating erythrocyte loss in different systemic conditions and an underlying mechanism for anemia associated with these pathological states. In the present review, we discuss the role of oxidative stress in reducing erythrocyte survival and provide novel insights into the possible use of antioxidants as putative antieryptotic and antianemic agents in a variety of systemic diseases.
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The life-span of RBC can be pathologically reduced in hemolytic anemias such as G6PD deficiency, or when chronic kidney disease or inflammation cause premature erythrocyte decay, named eryptosis.
“The life-span of RBC can be pathologically reduced in hemolytic anemias, such as G6PD deficiency, or when chronic kidney disease or inflammation cause premature erythrocyte decay, named eryptosis (Bissinger et al., 2018).”
From Iron in infection and immunity (2020) · cites this paper as Bissinger et al., 2018
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Iron in infection and immunity
Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359 · see citing works
Morales-Ancajima, V. C., Tapia, V., Vu, B. N., Liu, Y., Alarcón-Yaquetto, D. E., & Gonzales, G. F. (2019) · Journal of Environmental and Public Health · doi:10.1155/2019/6127845 · Cited by 57 · see citing works
- Authors
- Bissinger, R., Bhuyan, A. A. M., Qadri, S. M., & Lang, F.
- Affiliations
- University of Tübingen (DE)
- Canadian Blood Services (CA)
- Heinrich Heine University Düsseldorf (DE)
- Corresponding author
- Bissinger, Rosi
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2018-08-18
- Volume
- 286
- Issue
- 5
- Pages
- 826-854
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2883478372
- Cited by
- 239
- References
- 290
- Citations by year
- 2026: 29 · 2025: 35 · 2024: 33 · 2023: 33 · 2022: 37 · 2021: 37 · 2020: 20 · 2019: 11 · 2018: 3
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- oxidative stress, eryptosis, anemia, erythrocyte survival, erythrocyte death, calcium-permeable cation channel, phosphatidylserine exposure, potassium channels, antioxidants, diabetes mellitus, chronic kidney disease, inflammation, liver failure, cancer
- MeSH terms
- Eryptosis, Anemia, Animals, Erythrocytes, Hematologic Diseases, Humans, Ion Channels, Signal Transduction, Ion Transport, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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