Cited by 155Iron Metabolism and DisordersAntioxidant Activity and Oxidative StressErythrocyte Function and Pathophysiology

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Iron-deficiency anaemia enhances red blood cell oxidative stress

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Nagababu, Enika, Gulyani, Seema, Earley, Christopher J., Cutler, Roy G., Mattson, Mark P., Rifkind, Joseph M.·2008·Free Radical Research

DOI 10.1080/10715760802459879PMC PMC2730642

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Abstract

Oxidative stress associated with iron deficiency anaemia in a murine model was studied feeding an iron-deficient diet. Anaemia was monitored by a decrease in hematocrit and haemoglobin. For the 9 week study an increase in total iron binding capacity was also demonstrated. Anaemia resulted in an increase in red blood cells (RBC) oxidative stress as indicated by increased levels of fluorescent heme degradation products (1.24-fold after 5 weeks; 2.1-fold after 9 weeks). The increase in oxidative stress was further confirmed by elevated levels of methemoglobin for mice fed an iron-deficient diet. Increased haemoglobin autoxidation and subsequent generation of ROS can account for the shorter RBC lifespan and other pathological changes associated with iron-deficiency anaemia.

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Authors: Nagababu, E., Gulyani, S., Earley, C. J., Cutler, R. G., Mattson, M. P., & Rifkind, J. M.
Affiliations: National Institutes of Health (US)
Johns Hopkins Bayview Medical Center (US)
Corresponding author: Rifkind, Joseph M.
ORCID: Gulyani, Seema
Earley, Christopher J.
Cutler, Roy G.
Mattson, Mark P.
Venue: Free Radical Research
Publisher: Informa UK Limited
Published: 2008-01
Volume: 42
Issue: 9
Pages: 824-829
ISSN: 1029-2470 (ISSN-L)
1071-5762
DOI: 10.1080/10715760802459879
PMC: PMC2730642
OpenAlex: W2160940874
Cited by: 155
References: 38
Citations by year: 2026: 4 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 9 · 2021: 11 · 2020: 15 · 2019: 13 · 2018: 10 · 2017: 13 · 2016: 6 · 2015: 9 · 2014: 10 · 2013: 7 · 2012: 12
FWCI: 1.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Free Radical Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (P01AG021190, Z01AG000047)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
Keywords: iron deficiency anemia, heme degradation products, methemoglobin, reactive oxygen species, red blood cell lifespan, iron-deficient diet, total iron binding capacity, mouse model
MeSH terms: Animals, Body Weight, Erythrocytes, Hematocrit, Heme, Hemoglobins, Iron, Male, Methemoglobin, Mice, Inbred C57BL, Microscopy, Fluorescence, Oxygen, Oxidative Stress, Anemia, Iron-Deficiency, Mice

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