Intranasal administration of dauricine loaded on graphene oxide: Multi-target therapy for Alzheimer’s disease
Open accessAbstract
Alzheimer's disease (AD) is a degenerative disease of the central nervous system characterized by progressive cognitive and memory-related impairment. However, current therapeutic treatments have not proved sufficiently effective, mainly due to the complicated pathogenesis of the disease. In this study, a nano-formulation of graphene oxide (GO) loaded with dauricine (Dau) was investigated in terms of the combined anti-inflammatory and anti-oxidative stress effects of Dau and the inhibition of misfolding and aggregation of the amyloid-β (Aβ) protein by GO. Both in vivo and in vitro models were induced using Aβ1-42, and the formulation was administered nasally in mice. The results showed that GO loaded with Dau greatly reduced oxidative stress through increasing superoxide dismutase levels and decreasing reactive oxygen species and malondialdehyde levels in vitro; it also alleviated the cognitive memory deficits and brain glial cell activation in mice with Aβ1-42-induced AD. This proved that GO loaded with Dau could protect against Aβ1-42-induced oxidative damage and apoptosis in both in vitro and in vivo AD models; therefore, GO loaded with Dau has the potential to be an effective and agent for the rapid treatment of AD.
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Intranasal administration of a nano-formulation of graphene oxide loaded with dauricine has potential as a non-invasive drug delivery system that can pass the BBB and reach the brain.
“This report highlights also the potential of non-invasive drug delivery system based on nanoparticles that can pass the BBB and reach the brain [135].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [135]
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- Authors
- Wang, K., Wang, L., Chen, L., Peng, C., Luo, B., Mo, J., & Chen, W.
- Affiliations
- Guilin Medical University (CN)
- Zhejiang Chinese Medical University (CN)
- Corresponding author
- Mo, Jingxin
- Chen, Wei
- Venue
- Drug Delivery
- Publisher
- Informa UK Limited
- Published
- 2021-01
- Volume
- 28
- Issue
- 1
- Pages
- 580-593
- ISSN
- 1071-7544 (ISSN-L)
- 1521-0464
- PMC
- PMC7971267
- OpenAlex
- W3137955774
- Cited by
- 55
- References
- 54
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 15 · 2023: 10 · 2022: 6 · 2021: 8
- FWCI
- 6.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Drug Delivery (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Major Science and Technology Project of Guangxi Science and Technology Department (AA17292001)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- Alzheimer's disease, dauricine, graphene oxide, intranasal drug delivery, nanoformulations, amyloid-beta 42, oxidative stress, anti-inflammatory activity, superoxide dismutase, malondialdehyde, reactive oxygen species, glial activation, amyloid aggregation inhibition, apoptosis
- MeSH terms
- Administration, Intranasal, Alzheimer Disease, Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Chemistry, Pharmaceutical, Disease Models, Animal, Drug Carriers, Graphite, Humans, Male, Mice, Inbred C57BL, Neuroglia, Particle Size, Superoxide Dismutase, Surface Properties, Amyloid beta-Peptides, Reactive Oxygen Species, Oxidative Stress, Tetrahydroisoquinolines, Benzylisoquinolines, Mice, Nanoparticles
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