The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Toxicity of Cerium Oxide Nanoparticles in Human Lung Cancer Cells
Open accessAbstract
With the fast development of nanotechnology, the nanomaterials start to cause people’s attention for potential toxic effect. In this paper, the cytotoxicity and oxidative stress caused by 20-nm cerium oxide (CeO 2) nanoparticles in cultured human lung cancer cells was investigated. The sulforhodamine B method was employed to assess cell viability after exposure to 3.5, 10.5, and 23.3 μg/ml of CeO 2 nanoparticles for 24, 48, and 72 h. Cell viability decreased significantly as a function of nanoparticle dose and exposure time. Indicators of oxidative stress and cytotoxicity, including total reactive oxygen species, glutathione, malondialdehyde, α-tocopherol, and lactate dehydrogenase, were quantitatively assessed. It is concluded from the results that free radicals generated by exposure to 3.5 to 23.3 μg/ml CeO 2 nanoparticles produce significant oxidative stress in the cells, as reflected by reduced glutathione and α-tocopherol levels; the toxic effects of CeO 2 nanoparticles are dose dependent and time dependent; elevated oxidative stress increases the production of malondialdehyde and lactate dehydrogenase, which are indicators of lipid peroxidation and cell membrane damage, respectively.
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Cerium Oxide Nanoparticles: Applications and Prospects in Nanomedicine
Das, S., Dowding, J. M., Klump, K. E., McGinnis, J. F., Self, W., & Seal, S. (2013) · Nanomedicine · doi:10.2217/nnm.13.133 · Cited by 561
Angel Ezhilarasi, A., Judith Vijaya, J., Kaviyarasu, K., John Kennedy, L., Ramalingam, R. J., & Al-Lohedan, H. A. (2018) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2018.01.023 · Cited by 451
Metadata
- Authors
- Lin, W., Huang, Y.-W., Zhou, X.-D., & Ma, Y.
- Venue
- International Journal of Toxicology
- Publisher
- SAGE Publications
- Published
- 2006-11
- Volume
- 25
- Issue
- 6
- Pages
- 451-457
- ISSN
- 1091-5818 (ISSN-L)
- 1092-874X
- OpenAlex
- W2110639369
- Cited by
- 537
- References
- 45
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lin, W., Huang, Y.-W., Zhou, X.-D., & Ma, Y. (2006). Toxicity of Cerium Oxide Nanoparticles in Human Lung Cancer Cells. International Journal of Toxicology. https://doi.org/10.1080/10915810600959543
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
