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Cited by 1,245

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Exposure to Carbon Nanotube Material: Assessment of Nanotube Cytotoxicity using Human Keratinocyte Cells

Shvedova, Anna, Castranova, Vincent, Kisin, Elena, Schwegler-Berry, Diane, Murray, Ashley, Gandelsman, Vadim, Maynard, Andrew, Baron, Paul·2003·Journal of Toxicology and Environmental Health, Part A

Abstract

Carbon nanotubes are new members of carbon allotropes similar to fullerenes and graphite. Because of their unique electrical, mechanical, and thermal properties, carbon nanotubes are important for novel applications in the electronics, aerospace, and computer industries. Exposure to graphite and carbon materials has been associated with increased incidence of skin diseases, such as carbon fiber dermatitis, hyperkeratosis, and naevi. We investigated adverse effects of single-wall carbon nanotubes (SWCNT) using a cell culture of immortalized human epidermal keratinocytes (HaCaT). After 18 h of exposure of HaCaT to SWCNT, oxidative stress and cellular toxicity were indicated by formation of free radicals, accumulation of peroxidative products, antioxidant depletion, and loss of cell viability. Exposure to SWCNT also resulted in ultrastructural and morphological changes in cultured skin cells. These data indicate that dermal exposure to unrefined SWCNT may lead to dermal toxicity due to accelerated oxidative stress in the skin of exposed workers.

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Metadata

Authors
Shvedova, A., Castranova, V., Kisin, E., Schwegler-Berry, D., Murray, A., Gandelsman, V., Maynard, A., & Baron, P.
Venue
Journal of Toxicology and Environmental Health, Part A
Published
2003-06
Volume
66
Issue
20
Pages
1909-1926
ISSN
  • 0098-4108 (ISSN-L)
  • 1528-7394
  • 1087-2620
OpenAlex
W2037831947
Cited by
1,245
References
1
FWCI
31.26
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Exposure to Carbon Nanotube Material: Assessment of Nanotube Cytotoxicity using Human Keratinocyte Cells. https://app.cochat.ai/papers/10.1080/713853956
The paper
Shvedova, A., Castranova, V., Kisin, E., Schwegler-Berry, D., Murray, A., Gandelsman, V., Maynard, A., & Baron, P. (2003). Exposure to Carbon Nanotube Material: Assessment of Nanotube Cytotoxicity using Human Keratinocyte Cells. Journal of Toxicology and Environmental Health, Part A. https://doi.org/10.1080/713853956

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.