Relationships between 25(OH)D concentration, sarcopenia and HOMA-IR in postmenopausal Korean women
Open accessAbstract
OBJECTIVE: Sarcopenia and insulin resistance are common co-morbidities in the elderly and are known to be associated with vitamin D deficiency. However, no previous studies have investigated interactions between all three of these factors. We aimed to investigate the relationship between 25-hydroxyvitamin D concentration, sarcopenia, and insulin resistance in postmenopausal Korean women. METHODS: This study used data from the Korea National Health and Nutrition Examination Survey 2008-2011. Participants were 3744 postmenopausal Korean women. Sarcopenia was defined as appendicular skeletal muscle mass divided by body weight >1 standard deviation below the mean for women aged 20-40 years. The serum 25-hydroxyvitamin D and fasting insulin levels were measured, and insulin resistance was calculated using the formula: fasting plasma glucose (mg/dl) × fasting insulin (mIU/l)/405. RESULTS: We found a strong inverse association between 25-hydroxyvitamin D concentration and sarcopenia in postmenopausal Korean women (p = 0.0009). There was also a significant association between sarcopenia and insulin resistance, independent of vitamin D and obesity status (p < 0.0001). However, there was no significant association between 25-hydroxyvitamin D concentration and insulin resistance. In the subgroup analysis, insulin resistance was found to be determined by sarcopenic rather than vitamin D status. CONCLUSIONS: Sarcopenia was associated with both insulin resistance and 25-hydroxyvitamin D concentration in postmenopausal Korean women, regardless of obesity status. However, 25-hydroxyvitamin D concentration was not associated with insulin resistance. Sarcopenia is therefore of greater clinical importance due to its close relationship with insulin resistance.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Even if a majority of articles depicted protective effect of protein and derivates on SO development, two studies found higher intakes in SO group compared to sarcopenia group and compared to people without sarcopenia, expressed as % of energy.
“Even if a majority of articles depicted protective effect of protein and derivates on SO development, two studies found higher intakes in SO group compared to sarcopenia group [49] and compared to people without sarcopenia, expressed as % of energy [50].”
From Identification of factors associated with sarcopenic obesity development: Literature review and expert panel voting (2024) · cites this paper as [50]
Cites
Holick, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmra070553 · Cited by 13,720 · see citing works
Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139 · see citing works
Hypovitaminosis D is associated with insulin resistance and β cell dysfunction
Chiu, K. C., Chu, A. Y., Go, V. L. W., & Saad, M. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.820 · Cited by 1,643 · see citing works
Bischoff-Ferrari, H. A., Dawson‐Hughes, B., Staehelin, H. B., Orav, E. J., Stuck, A. E., Theiler, R., Wong, J. B., Egli, A., Kiel, D. P., & Henschkowski, J. (2009) · BMJ · doi:10.1136/bmj.b3692 · Cited by 1,279 · see citing works
The I.A.N.A. task force on frailty assessment of older people in clinical practice
Van Kan, G. A., Rolland, Y., Bergman, H., Morley, J. E., Kritchevsky, S. B., & Vellas, B. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982161 · Cited by 1,099 · see citing works
Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study
Landi, F., Liperoti, R., Russo, A., Giovannini, S., Tosato, M., Capoluongo, E., Bernabei, R., & Onder, G. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.02.007 · Cited by 938 · see citing works
Appendicular skeletal muscle mass: measurement by dual-photon absorptiometry
Heymsfield, S. B., Smith, R. C., Aulet, M., Bensen, B., Lichtman, S. W., Wang, J., & Pierson, R. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/52.2.214 · Cited by 819 · see citing works
Srikanthan, P., & Karlamangla, A. S. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0435 · Cited by 785 · see citing works
Lips, P. T. A. M., Hosking, D. J., Lippuner, K., Norquist, J. M., Wehren, L. E., Maalouf, G., Ragi-Eis, S., & Chandler, J. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01685.x · Cited by 620 · see citing works
Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance
Forouhi, N. G., Luan, J., Cooper, A., Boucher, B. J., & Wareham, N. J. (2008) · Diabetes · doi:10.2337/db08-0593 · Cited by 613 · see citing works
Srikanthan, P., Hevener, A. L., & Karlamangla, A. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010805 · Cited by 600 · see citing works
Insulin resistance and sarcopenia: mechanistic links between common co-morbidities
Cleasby, M. E., Jamieson, P. M., & Atherton, P. J. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0533 · Cited by 596 · see citing works
Lim, S., Kim, J. H., Yoon, J. W., Kang, S. M., Choi, S. H., Park, Y. J., Kim, K. W., Lim, J. Y., Park, K. S., & Jang, H. C. (2010) · Diabetes Care · doi:10.2337/dc10-0107 · Cited by 588 · see citing works
Vitamin D and Its Role in Skeletal Muscle
Ceglia, L., & Harris, S. S. (2012) · Calcified Tissue International · doi:10.1007/s00223-012-9645-y · Cited by 388 · see citing works
2014 Clinical Practice Guidelines for Overweight and Obesity in Korea
Kim, M. K., Lee, W., Kang, J., Kang, J., Kim, B. T., Kim, S. M., Kim, E. M., Suh, S., Shin, H. J., Lee, K. R., et al. (2014) · Endocrinology and Metabolism · doi:10.3803/enm.2014.29.4.405 · Cited by 318 · see citing works
Reis, J. P., von Mühlen, D. G., Kritz‐Silverstein, D. C., Wingard, D. L., & Barrett-Connor, E. L. (2007) · Diabetes Care · doi:10.2337/dc06-2438 · Cited by 281 · see citing works
Moon, S.-S. (2014) · Endocrine Journal · doi:10.1507/endocrj.ej13-0244 · Cited by 268 · see citing works
Seida, J. C., Mitri, J., Colmers-Gray, I. N., Majumdar, S. R., Davidson, M. B., Edwards, A. L., Hanley, D. A., Pittas, A. G., Tjosvold, L., & Johnson, J. A. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2136 · Cited by 264 · see citing works
Vitamin D: A Review on Its Effects on Muscle Strength, the Risk of Fall, and Frailty
Halfon, M., Phan, O., & Teta, D. (2015) · BioMed Research International · doi:10.1155/2015/953241 · Cited by 261 · see citing works
Vitamin D: emerging new roles in insulin sensitivity
Teegarden, D., & Donkin, S. S. (2009) · Nutrition Research Reviews · doi:10.1017/s0954422409389301 · Cited by 260 · see citing works
Bouillon, R., Auwerx, J. H., Lissens, W. D., & Pelemans, W. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/45.4.755 · Cited by 233 · see citing works
Is the Vitamin D Receptor Found in Muscle?
Wang, Y., & DeLuca, H. F. (2010) · Endocrinology · doi:10.1210/en.2010-1109 · Cited by 231 · see citing works
Kim, T. N., Park, M. S., Lim, K. I., Choi, H. Y., Yang, S. J., Yoo, H. J., Kang, H. J., Song, W., Choi, H., Baik, S. H., et al. (2013) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04433.x · Cited by 208 · see citing works
Jorde, R., Sollid, S. T., Svartberg, J. B., Schirmer, H., Joakimsen, R. M., Njølstad, I., Fuskevåg, O., Figenschau, Y., & Hutchinson, M. Y. S. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-4013 · Cited by 204 · see citing works
Khan, H., Kunutsor, S. K., Franco, O. H., & Chowdhury, R. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112002765 · Cited by 199 · see citing works
Srikuea, R., Zhang, X., Park-Sarge, O.-K., & Esser, K. A. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00014.2012 · Cited by 177 · see citing works
Kim, M. K., Baek, K. H., Song, K.-H., Il Kang, M., Park, C. Y., Lee, W. Y., & Oh, K. W. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1602 · Cited by 171 · see citing works
Self-citationOh, J., Riek, A. E., Darwech, I., Funai, K., Shao, J.-S., Chin, K., Sierra, O. L., Carmeliet, G., Ostlund, R. E., & Bernal‐Mizrachi, C. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.043 · Cited by 157 · see citing works
Abbatecola, A. M., Paolisso, G., Fattoretti, P., Evans, W. J., Fiore, V., Dicioccio, L., & Lattanzio, F. (2011) · The Journal of nutrition, health and aging · doi:10.1007/s12603-011-0366-0 · Cited by 137 · see citing works
Ju, S.-Y., Jeong, H. S., & Kim, D. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3577 · Cited by 122 · see citing works
Lee, S. W., Youm, Y., Lee, W. J., Choi, W., Chu, S. H., Park, Y.-R., & Kim, H. C. (2015) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2015.39.1.37 · Cited by 113 · see citing works
Ceglia, L., Morais, M. D. S., Park, L. K., Morris, E. P., Harris, S. S., Bischoff-Ferrari, H. A., Fielding, R. A., & Dawson‐Hughes, B. (2010) · Journal of Molecular Histology · doi:10.1007/s10735-010-9270-x · Cited by 104 · see citing works
Oosterwerff, M. M., Eekhoff, E. M. W., van Schoor, N. M., Boeke, A. J. P., Nanayakkara, P. W. B., Meijnen, R., Knol, D. L., Kramer, M. H. H., & Lips, P. T. A. M. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.069260 · Cited by 88 · see citing works
Chon, S. J., Yun, B. H., Jung, Y. S., Cho, S., Choi, Y. S., Kim, S. Y., Lee, B. S., & Seo, S. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089721 · Cited by 57 · see citing works
Seo, S. K., Cho, S., Kim, H. Y., Choi, Y. S., Park, K. H., Cho, D. J., & Lee, B. S. (2009) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181a15552 · Cited by 53 · see citing works
Mitochondrial Function and Insulin Resistance during Aging – A Mini-Review
Phielix, E., Szendroedi, J., & Roden, M. (2011) · Gerontology · doi:10.1159/000317691 · Cited by 47 · see citing works
Yoo, K.-O., Cho, J., & Ly, S. Y. (2016) · Nutrients · doi:10.3390/nu8100610 · Cited by 42 · see citing works
McCarthy, E. K., & Kiely, M. E. (2014) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12268 · Cited by 39 · see citing works
Yun, B. H., Choi, Y., Choi, Y. S., Cho, S., Lee, B. S., & Seo, S. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123665 · Cited by 19 · see citing works
Min, J., & Min, K. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13010136 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Nutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review
Inglis, J. E., Lin, P., Kerns, S. L., Kleckner, I. R., Kleckner, A. S., Castillo, D. A., Mustian, K. M., & Peppone, L. J. (2019) · Nutrition and Cancer · doi:10.1080/01635581.2018.1513046 · Cited by 135 · see citing works
Impact of Cortisol on Reduction in Muscle Strength and Mass: A Mendelian Randomization Study
Katsuhara, S., Yokomoto-Umakoshi, M., Umakoshi, H., Matsuda, Y., Iwahashi, N., Kaneko, H., Ogata, M., Fukumoto, T., Terada, E., Sakamoto, R., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab862 · Cited by 55 · see citing works
Vitamin D: Not Just Bone Metabolism but a Key Player in Cardiovascular Diseases
Izzo, M., Carrizzo, A., Izzo, C., Cappello, E., Cecere, D., Ciccarelli, M., Iannece, P., Damato, A., Vecchione, C., & Pompeo, F. (2021) · Life · doi:10.3390/life11050452 · Cited by 52 · see citing works
Zhang, F., & Li, W. (2024) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s471191 · Cited by 35 · see citing works
The Role of Micronutrients in Ageing Asia: What Can Be Implemented with the Existing Insights
Inui, T., Hanley, B., Tee, E. S., Nishihira, J., Tontisirin, K., Dael, P. V., & Eggersdorfer, M. L. (2021) · Nutrients · doi:10.3390/nu13072222 · Cited by 25 · see citing works
Pinel, A., Guillet, C., Capel, F., Pouget, M., De Antonio, M., Pereira, B., Topinkova, E., Eglseer, D., Barazzoni, R., Cruz-Jentoft, A. J., et al. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.04.033 · Cited by 24 · see citing works
Pan, R., Wang, T., Tang, R., & Qian, Z. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1437379 · Cited by 17 · see citing works
Yang, C., Dai, Y., Li, Z., Peng, Y., Zhang, L., & Jia, H. (2023) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2023.06.004 · Cited by 13 · see citing works
Farber, P. L., Dias, A., Freitas, T., Pinho, A. C., Viggiano, D., Saldanha, C., & Silva-Herdade, A. S. (2020) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-200956 · Cited by 8 · see citing works
Kim, D., Lee, Y. J., Song, E., Kim, A., Bang, C. H., & Jung, J. H. (2023) · Healthcare · doi:10.3390/healthcare11101401 · Cited by 6 · see citing works
Zhang, G., Wang, X., Tong, M., Chen, J., & Ji, Q. (2023) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s420963 · Cited by 3 · see citing works
- Authors
- Lee, J. H., Kim, S., Kim, M. K., Yun, B. H., Cho, S., Choi, Y. S., Lee, B. S., & Seo, S. K.
- Affiliations
- Yonsei University (KR)
- CHA University Gangnam Medical Center (KR)
- Corresponding author
- Seo, S. K.
- Venue
- Climacteric
- Publisher
- Informa UK Limited
- Published
- 2017-11-09
- Volume
- 21
- Issue
- 1
- Pages
- 40-46
- ISSN
- 1369-7137 (ISSN-L)
- 1473-0804
- OpenAlex
- W2767723662
- Cited by
- 11
- References
- 40
- Citations by year
- 2024: 3 · 2023: 3 · 2021: 3 · 2020: 1 · 2019: 1
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- Locations
- Climacteric (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Yonsei University College of Medicine
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- 25-hydroxyvitamin D, sarcopenia, insulin resistance, postmenopausal women, vitamin D deficiency, appendicular skeletal muscle mass, obesity, Korean women
- MeSH terms
- Aged, Cross-Sectional Studies, Female, Humans, Insulin, Insulin Resistance, Middle Aged, Nutrition Surveys, Obesity, Vitamin D, Vitamin D Deficiency, Body Mass Index, Logistic Models, Postmenopause, Sarcopenia, Republic of Korea
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
