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Cited by 551Dementia and Cognitive Impairment ResearchDiabetes Treatment and ManagementCancer-related cognitive impairment studies

The DOI matches its Crossref record; 175 of the 175 references it cites were found in a registry or an index.

The Relationship between Impaired Glucose Tolerance, Type 2 Diabetes, and Cognitive Function

Awad, Nesrine, Gagnon, Michèle, Messier, Claude·2004·Journal of Clinical and Experimental Neuropsychology
DOI 10.1080/13803390490514875
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Abstract

The present review integrates findings of published studies that have evaluated the cognitive function of treated and untreated type 2 diabetic patients and provides a detailed overview of the neuropsychological assessments conducted. Cognitive deficits are observed in older people with glucose intolerance or untreated diabetes but these deficits appear to be attenuated by treatments that improve glycemic control. Cognitive decrements in treated type 2 diabetic patients are most consistently observed on measures of verbal memory (35% of the measures) and processing speed (45% of the measures) while preserved function is observed on measures of visuospatial, attention, semantic and language function. Some studies suggest that deficits in cognitive functions are associated with poorer glycemic control. A number of other factors, such as depression, cardiovascular and cerebrovascular disease, increase these deficits. We conclude that, in diabetic patients who achieve and maintain good glycemic control, type 2 diabetes only has a small impact on cognitive functions before the age of 70 years. However, early onset of type 2 diabetes, poor glycemic control and the presence of micro- and macrovascular disease may interact to produce early cognitive deficits. In older adults (70 years and over), diabetes likely interacts with other dementing processes such as vascular disease and Alzheimer's disease to hasten cognitive decline.

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Crossref · 10.1080/13803390490514875

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175 of 175 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 174 references

Research works printed but not linked: 13

  1. Amato L., 1996, Diabetes & Metabolism, 22, 314
  2. American Diabetes Association, 2002, Diabetes Care, S5
  3. Brandt J., 1988, Neurpsychiatry, Neuropsychology, and Behavioral Neurology, 1, 111
  4. Buschke H., 1973, Journal of Verbal Learning and Verbal Behavior, 9, 176
  5. Jagusch W., 1992, Diabetes Nutrition & Metabolism, 5, 265
  6. Kaplan E., 1991, WAIS-R NI. Manual
  7. Matthews C. G., 1964, Instruction manual for the adult neuropsychology test battery
  8. Meuter F., 1980, Hormones and Metabolic Research, 9, 9
  9. Perlmuter L. C., 1997, Diabetes Spectrum, 10, 57
  10. Spreen O., 1998, A Compendium of Neuropsychological Tests
  11. van Boxtel M. P., 1998, Journal of Gerontology. Series A, Biological Sciences & Medical Sciences, 53, M147
  12. Wechsler D., 1981, Wechsler Adult Intelligence Scale-Revised
  13. Worrall G., 1993, Journal of Family Practice, 36, 639

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Metadata

Authors
Awad, N., Gagnon, M., & Messier, C.
Affiliations
  • University of Ottawa (CA)
  • Institute of Mental Health Research (CA)
ORCID
Messier, Claude
Venue
Journal of Clinical and Experimental Neuropsychology
Publisher
Informa UK Limited
Published
2004-11
Volume
26
Issue
8
Pages
1044-1080
ISSN
  • 0165-0475 (ISSN-L)
  • 1380-3395
  • 1744-411X
DOI
10.1080/13803390490514875
OpenAlex
W2025771431
Cited by
551
References
174
Citations by year
2026: 3 · 2025: 10 · 2024: 14 · 2023: 12 · 2022: 15 · 2021: 12 · 2020: 47 · 2019: 29 · 2018: 18 · 2017: 29 · 2016: 32 · 2015: 22 · 2014: 35 · 2013: 36 · 2012: 31
FWCI
11.20
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical and Experimental Neuropsychology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords
type 2 diabetes, impaired glucose tolerance, cognitive function, glycemic control, verbal memory, processing speed, depression, cardiovascular disease, cerebrovascular disease, microangiopathy, macroangiopathy, Alzheimer's disease, vascular dementia, cognitive decline, older adults
MeSH terms
Cognition, Cognition Disorders, Dementia, Diabetes Mellitus, Type 2, Humans, Intelligence Tests, Longitudinal Studies, Neuropsychological Tests, Glucose Intolerance, Diabetes Complications

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