Risk of dementia in diabetes mellitus: a systematic review

Diagnostic and Statistical Manual of Mental Disorders

Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works

Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)

Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works

Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works

Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works

Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>

Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623 · see citing works

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

Biochemistry and molecular cell biology of diabetic complications

Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works

Global and societal implications of the diabetes epidemic

Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883 · see citing works

Vascular dementia: Diagnostic criteria for research studies: Report of the NINDS‐AIREN International Workshop*

Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921 · see citing works

Diabetes mellitus and the risk of dementia: The Rotterdam Study

Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175 · see citing works

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

Steen, E., Terry, B. M., J. Rivera, E., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer's Disease · doi:10.3233/jad-2005-7107 · Cited by 1,703 · see citing works

Practice parameter: Management of dementia (an evidence-based review) [RETIRED]

Doody, R. S., Stevens, J. E., Beck, C., Dubinsky, R., Kaye, J. A., Gwyther, L. P., Mohs, R. C., Thal, L. J., Whitehouse, P. J., DeKosky, S. T., et al. (2001) · Neurology · doi:10.1212/wnl.56.9.1154 · Cited by 1,703 · see citing works

Practice parameter: Diagnosis of dementia (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology

Knopman, D. S., DeKosky, S. T., Cummings, J. L., Chui, H., Corey–Bloom, J., Relkin, N., Small, G. W., Miller, B., & Stevens, J. C. (2001) · Neurology · doi:10.1212/wnl.56.9.1143 · Cited by 1,410 · see citing works

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E., Frosch, M., Eckman, C., Tanzi, R., Selkoe, D., & Guénette, S. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0230450100 · Cited by 1,361 · see citing works

Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales

(2001) · The Lancet · doi:10.1016/s0140-6736(00)03589-3 · Cited by 1,338 · see citing works

Risk Factors for Alzheimer's Disease: A Prospective Analysis from the Canadian Study of Health and Aging

Lindsay, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf074 · Cited by 1,261 · see citing works

Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function

Arvanitakis, Z., Wilson, R. S., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2004) · Archives of Neurology · doi:10.1001/archneur.61.5.661 · Cited by 1,258 · see citing works

Midlife cardiovascular risk factors and risk of dementia in late life

Whitmer, R. A., Sidney, S., Selby, J., Johnston, S. C., & Yaffe, K. (2005) · Neurology · doi:10.1212/01.wnl.0000149519.47454.f2 · Cited by 1,238 · see citing works

Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies

Peila, R., Rodriguez, B. L., & Launer, L. J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1256 · Cited by 1,207 · see citing works

Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers

Chui, H. C., Victoroff, J. I., Margolin, D., Jagust, W., Shankle, R., & Katzman, R. (1992) · Neurology · doi:10.1212/wnl.42.3.473 · Cited by 1,201 · see citing works

The age-dependent relation of blood pressure to cognitive function and dementia

Qiu, C., Winblad, B., & Fratiglioni, L. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70141-1 · Cited by 1,138 · see citing works

The metabolic syndrome, inflammation, and risk of cognitive decline

Yaffe, K. (2004) · JAMA · doi:10.1001/jama.292.18.2237 · Cited by 1,025 · see citing works

Increased Risk of Type 2 Diabetes in Alzheimer Disease

Janson, J., Laedtke, T., Parisi, J. E., O’Brien, P., Petersen, R. C., & Butler, P. C. (2004) · Diabetes · doi:10.2337/diabetes.53.2.474 · Cited by 950 · see citing works

Insulin and neurodegenerative disease: shared and specific mechanisms

Craft, S., & Stennis Watson, G. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00681-7 · Cited by 830 · see citing works

Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: The Hisayama Study

Yoshitake, T., Kiyohara, Y., Kato, I., Ohmura, T., Iwamoto, H., Nakayama, K., Ohmori, S., Nomiyama, K., Kawano, H., Ueda, K., et al. (1995) · Neurology · doi:10.1212/wnl.45.6.1161 · Cited by 829 · see citing works

Aggregation of vascular risk factors and risk of incident Alzheimer disease

Luchsinger, J. A., Reitz, C., Honig, L. S., Tang, M. X., Shea, S., & Mayeux, R. (2005) · Neurology · doi:10.1212/01.wnl.0000172914.08967.dc · Cited by 790 · see citing works

Cognition and synaptic plasticity in diabetes mellitus

Gispen, W. H., & Biessels, G. J. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01656-8 · Cited by 772 · see citing works

Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease

Frölich, L., Blum-Degen, D., Bernstein, H.-G., Engelsberger, S., Humrich, J., Laufer, S., Muschner, D., Thalheimer, A., Türk, A., Hoyer, S., et al. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050068 · Cited by 748 · see citing works

The Effects of Type 1 Diabetes on Cognitive Performance

Brands, A. M. A., Biessels, G. J., de Haan, E. H. F., Kappelle, L. J., & Kessels, R. P. C. (2005) · Diabetes Care · doi:10.2337/diacare.28.3.726 · Cited by 738 · see citing works

Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan

Tang, M. ‐., Cross, P. S., Andrews, H., Jacobs, D. M., Small, S. A., Bell, K., Merchant, C., Lantigua, R., Costa, R., Stern, Y., et al. (2001) · Neurology · doi:10.1212/wnl.56.1.49 · Cited by 721 · see citing works

Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study

Leibson, C. L., Rocca, W. A., Hanson, V. A., Cha, R., Kokmen, E., O'Brien, P. C., & Palumbo, P. J. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009106 · Cited by 700 · see citing works

Hyperinsulinemia and risk of Alzheimer disease

Luchsinger, J. A., Tang, M.-X., Shea, S., & Mayeux, R. (2004) · Neurology · doi:10.1212/01.wnl.0000140292.04932.87 · Cited by 683 · see citing works

Diabetes Mellitus and Risk of Alzheimer's Disease and Dementia with Stroke in a Multiethnic Cohort

Luchsinger, J. A. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.7.635 · Cited by 682 · see citing works

Incidence and Risk Factors of Silent Brain Infarcts in the Population-Based Rotterdam Scan Study

Vermeer, S. E., den Heijer, T., Koudstaal, P. J., Oudkerk, M., Hofman, A., & Breteler, M. M. B. (2003) · Stroke · doi:10.1161/01.str.0000052631.98405.15 · Cited by 680 · see citing works

Vascular risk factors for Alzheimer’s disease:

Breteler, M. M. B. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00110-4 · Cited by 664 · see citing works

The Independent Effect of Type 2 Diabetes Mellitus on Ischemic Heart Disease, Stroke, and Death: A Population-Based Study of 13 000 Men and Women With 20 Years of Follow-up

Almdal, T., Scharling, H., Jensen, J. S., & Vestergaard, H. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.13.1422 · Cited by 650 · see citing works

Hemodynamic actions of insulin

Baron, A. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.267.2.e187 · Cited by 605 · see citing works

Lacunar Infarcts Defined by Magnetic Resonance Imaging of 3660 Elderly People: The Cardiovascular Health Study

Longstreth, W. T. (1998) · Archives of Neurology · doi:10.1001/archneur.55.9.1217 · Cited by 573 · see citing works

Type 2 diabetes mellitus, cognitive impairment and dementia

Stewart, R., & Liolitsa, D. (1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00027.x · Cited by 562 · see citing works

The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function

Awad, N., Gagnon, M., & Messier, C. (2004) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390490514875 · Cited by 551 · see citing works

Is Type II Diabetes Associated With an Increased Risk of Cognitive Dysfunction?: A critical review of published studies

Strachan, M. W. J., Deary, I. J., Ewing, F. M. E., & Frier, B. M. (1997) · Diabetes Care · doi:10.2337/diacare.20.3.438 · Cited by 529 · see citing works

Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI

den Heijer, T., Vermeer, S. E., van Dijk, E. J., Prins, N. D., Koudstaal, P. J., Albert Hofman, D., & Breteler, M. M. B. (2003) · Diabetologia · doi:10.1007/s00125-003-1235-0 · Cited by 512 · see citing works

Role of insulin and insulin receptor in learning and memory

Zhao, W., & Alkon, D. L. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00455-5 · Cited by 492 · see citing works

The source of cerebral insulin

Banks, W. A. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.040 · Cited by 489 · see citing works

Radical AGEing in Alzheimer's disease

Smith, M. A., Sayre, L. M., Monnier, V. M., & Perry, G. L. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93897-7 · Cited by 462 · see citing works

Ageing and diabetes: implications for brain function

Biessels, G. J., van der Heide, L. P., Kamal, A., Bleys, R. L. A. W., & Gispen, W. H. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01486-3 · Cited by 458 · see citing works

A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies

Chatfield, M. D., Brayne, C., & Matthews, F. E. (2005) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2004.05.006 · Cited by 456 · see citing works

Development of dementing illnesses in an 80‐year‐old volunteer cohort

Katzman, R., Aronson, M., Fuld, P. A., Kawas, C. H., Brown, T., Morgenstern, H., Frishman, W. H., Gidez, L. I., Eder, H., & Ooi, W. L. (1989) · Annals of Neurology · doi:10.1002/ana.410250402 · Cited by 453 · see citing works

Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study

Kuusisto, J., Koivisto, K. J., Mykkänen, L. M., Helkala, E.-L., Vanhanen, M., Hänninen, T., Kervinen, K., Kesäniemi, Y. A., Riekkinen, P. J., & Laakso, M. (1997) · BMJ · doi:10.1136/bmj.315.7115.1045 · Cited by 426 · see citing works

Metabolic Cardiovascular Syndrome and Risk of Dementia in Japanese-American Elderly Men: The Honolulu-Asia Aging Study

Kalmijn, S., Foley, D., White, L., Burchfiel, C. M., Curb, J. D., Petrovitch, H., Ross, G. W., Havlik, R. J., & Launer, L. J. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.10.2255 · Cited by 417 · see citing works

Place Learning and Hippocampal Synaptic Plasticity in Streptozotocin-Induced Diabetic Rats

Biessels, G. J., Kamal, A., Ramakers, G. M. J., Urban, I. J. A., Spruijt, B. M., Erkelens, D. W., & Gispen, W. H. (1996) · Diabetes · doi:10.2337/diab.45.9.1259 · Cited by 413 · see citing works

Structural magnetic resonance imaging in the practical assessment of dementia: beyond exclusion

Scheltens, P., Fox, N. C., Barkhof, F., & DeCarli, C. S. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00002-9 · Cited by 410 · see citing works

Diabetes mellitus and risk of dementia in the Kungsholmen project

Xu, W., Qiu, C., Wåhlin, Å., Winblad, B. G., & Fratiglioni, L. (2004) · Neurology · doi:10.1212/01.wnl.0000140291.86406.d1 · Cited by 409 · see citing works

Invited Commentary: Insulin Resistance Syndrome? Syndrome X? Multiple Metabolic Syndrome? A Syndrome At All? Factor Analysis Reveals Patterns in the Fabric of Correlated Metabolic Risk Factors

Meigs, J. B. (2000) · American Journal of Epidemiology · doi:10.1093/aje/152.10.908 · Cited by 397 · see citing works

APPENDIX B: PRACTICE PARAMETER: DIAGNOSIS OF DEMENTIA (AN EVIDENCE-BASED REVIEW)

(2007) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000267232.84626.41 · Cited by 390 · see citing works

Quality of reporting of observational longitudinal research.

Tooth, L. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi042 · Cited by 363 · see citing works

Cerebrovascular Pathology and Dementia in Autopsied Honolulu‐Asia Aging Study Participants

WHITE, L., PETROVITCH, H., HARDMAN, J., NELSON, J., DAVIS, D. G., ROSS, G. W., MASAKI, K., LAUNER, L., & MARKESBERY, W. R. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04794.x · Cited by 357 · see citing works

Trends in the Prevalence and Ratio of Diagnosed to Undiagnosed Diabetes According to Obesity Levels in the U.S.

Gregg, E. W., Cadwell, B. L., Cheng, Y. J., Cowie, C. C., Williams, D. E., Geiss, L. S., Engelgau, M. M., & Vinicor, F. (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2806 · Cited by 330 · see citing works

Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-ε4 Allele

Cook, D. G., Leverenz, J. B., McMillan, P. J., Kulstad, J. J., Ericksen, S., Roth, R. A., Schellenberg, G. D., Jin, L., Kovacina, K. S., & Craft, S. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63822-9 · Cited by 329 · see citing works

Vascular Dementia

Hébert, R., Lindsay, J., Verreault, R., Rockwood, K. J., Hill, G. B., & Dubois, M. (2000) · Stroke · doi:10.1161/01.str.31.7.1487 · Cited by 328 · see citing works

Signaling by insulin-like growth factor 1 in brain

Bondy, C. A., & Cheng, C. M. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.042 · Cited by 323 · see citing works

The relationship between type 2 diabetes and cognitive dysfunction: longitudinal studies and their methodological limitations

Allen, K. V., Frier, B. M., & Strachan, M. W. J. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.054 · Cited by 319 · see citing works

Diabetes mellitus and the Risk of Dementia, Alzheimer’s Disease and Vascular Cognitive Impairment in the Canadian Study of Health and Aging

MacKnight, C., Rockwood, K., Awalt, E., & McDowell, I. (2002) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000064928 · Cited by 313 · see citing works

Modulation of memory by insulin and glucose: Neuropsychological observations in Alzheimer’s disease

Watson, G. S., & Craft, S. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.048 · Cited by 307 · see citing works

Age- and region-dependent alterations in Aβ-degrading enzymes: implications for Aβ-induced disorders

Caccamo, A., Oddo, S., Sugarman, M. C., Akbari, Y., & LaFerla, F. M. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.06.013 · Cited by 299 · see citing works

Critically attained threshold of cerebral hypoperfusion: the CATCH hypothesis of Alzheimer’s pathogenesis

de la Torre, J. C. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00111-1 · Cited by 284 · see citing works

Insulin resistance and risk for stroke

Kernan, W. N., Inzucchi, S. E., Viscoli, C. M., Brass, L. M., Bravata, D. M., & Horwitz, R. I. (2002) · Neurology · doi:10.1212/wnl.59.6.809 · Cited by 280 · see citing works

Potential roles of insulin and IGF-1 in Alzheimer's disease

Gasparini, L., & Xu, H. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00163-2 · Cited by 275 · see citing works

Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men

Kalmijn, S., Feskens, E. J. M., Launer, L. J., Stijnen, T., & Kromhout, D. (1995) · Diabetologia · doi:10.1007/bf00402181 · Cited by 274 · see citing works

Diabetes mellitus in midlife and the risk of dementia three decades later

Beeri, M. S., Goldbourt, U., Silverman, J. M., Noy, S., Schmeidler, J., Ravona‐Springer, R., Sverdlick, A., & Davidson, M. (2004) · Neurology · doi:10.1212/01.wnl.0000144278.79488.dd · Cited by 263 · see citing works

Change in Cognitive Function by Glucose Tolerance Status in Older Adults: A 4-Year Prospective Study of the Rancho Bernardo Study Cohort

Kanaya, A. M., Barrett-Connor, E., Gildengorin, G., & Yaffe, K. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.12.1327 · Cited by 255 · see citing works

Association Between Dementia and Midlife Risk Factors: the Radiation Effects Research Foundation Adult Health Study

Yamada, M., Kasagi, F., Sasaki, H., Masunari, N., Mimori, Y., & Suzuki, G. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51117.x · Cited by 255 · see citing works

Magnetic Resonance Imaging of the Brain in Diabetes

Schmidt, R., Launer, L. J., Nilsson, L., Pająk, A., Sans, S., Berger, K., Breteler, M. M. B., de Ridder, M. A. J., Dufouil, C., Fuhrer, R., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.3.687 · Cited by 250 · see citing works

Comorbid type 2 diabetes mellitus and hypertension exacerbates cognitive decline: evidence from a longitudinal study

Hassing, L. B. (2004) · Age and Ageing · doi:10.1093/ageing/afh100 · Cited by 249 · see citing works

Magnetic Resonance Imaging Signal Hyperintensities in the Deep and Subcortical White Matter

Schmidt, R. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530320049011 · Cited by 246 · see citing works

Emerging Therapies for Vascular Dementia and Vascular Cognitive Impairment

Erkinjuntti, T., Román, G., Gauthier, S., Feldman, H., & Rockwood, K. (2004) · Stroke · doi:10.1161/01.str.0000120731.88236.33 · Cited by 232 · see citing works

Longitudinal association of vascular and Alzheimer’s dementias, diabetes, and glucose tolerance

Curb, J. D., Rodríguez, B. L., Abbott, R. D., Petrovitch, H., Ross, G. W., Masaki, K., Foley, D. J., Blanchette, P. L., Harris, T. B., Chen, R., et al. (1999) · Neurology · doi:10.1212/wnl.52.5.971 · Cited by 231 · see citing works

Clinicopathological Validation Study of Four Sets of Clinical Criteria for Vascular Dementia

Gold, G., Bouras, C., Canuto, A., Bergallo, M. F., Herrmann, F. R., Hof, P. R., Mayor, P.-A., Michel, J.-P., & Giannakopoulos, P. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.1.82 · Cited by 217 · see citing works

Cognitive Consequences of Thalamic, Basal Ganglia, and Deep White Matter Lacunes in Brain Aging and Dementia

Gold, G., Kövari, E., Herrmann, F. R., Canuto, A., Hof, P. R., Michel, J., Bouras, C., & Giannakopoulos, P. (2005) · Stroke · doi:10.1161/01.str.0000166052.89772.b5 · Cited by 198 · see citing works

Type 2 Diabetes Is Negatively Associated With Alzheimer's Disease Neuropathology

Beeri, M. S., Silverman, J. M., Davis, K. L., Marin, D. B., Grossman, H. T., Schmeidler, J., Purohit, D. P., Perl, D. P., Davidson, M. H., Mohs, R. C., et al. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.4.471 · Cited by 187 · see citing works

Diabetes Mellitus Is a Risk Factor for Vascular Dementia, but Not for Alzheimer’s Disease: A Population-Based Study of the Oldest Old

Hassing, L. B., Johansson, B. E. A., Nilsson, S. E., Berg, S., Pedersen, N. L., Gatz, M., & McClearn, G. E. (2002) · International Psychogeriatrics · doi:10.1017/s104161020200844x · Cited by 175 · see citing works

Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects

Heitner, J., & Dickson, D. (1997) · Neurology · doi:10.1212/wnl.49.5.1306 · Cited by 173 · see citing works

Vascular Risks and Incident Dementia: Results from a Cohort Study of the Very Old

Brayne, C., Gill, C., Huppert, F. A., Barkley, C., Gehlhaar, E., Girling, D. M., O’Connor, D., & Paykel, E. S. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017043 · Cited by 159 · see citing works

Are Alzheimer Patients Healthier?

Wolf‐Klein, G. P., Silverstone, F. A., Brod, M. S., Levy, A. P., Foley, C. J., Termotto, V., & Breuer, J. (1988) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1988.tb01804.x · Cited by 140 · see citing works

Changes in Blood Glucose and Insulin Secretion in Patients with Senile Dementia of Alzheimer Type

Bucht, G., Adolfsson, R., Lithner, F., & Winblad, B. G. (1983) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1983.tb03756.x · Cited by 140 · see citing works

Incidence, prevalence, and mortality of diabetes in a large population. A report from the Skaraborg Diabetes Registry.

Berger, B., Stenström, G., & Sundkvist, G. (1999) · Diabetes Care · doi:10.2337/diacare.22.5.773 · Cited by 137 · see citing works

MRI of the brain in diabetes mellitus

Araki, Y., Nomura, M., Tanaka, H., Yamamoto, H., Yamamoto, T., Tsukaguchi, I., & Nakamura, H. (1994) · Neuroradiology · doi:10.1007/bf00588069 · Cited by 136 · see citing works

Stroke in patients with diabetes mellitus

Mankovsky, B., & Ziegler, D. (2004) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.490 · Cited by 121 · see citing works

Thickened cerebral cortical capillary basement membranes in diabetics.

Pc, J., Brendel, K., & Meezan, E. (1982) · PubMed · Cited by 115 · see citing works

Brain insulin and feeding: a bi-directional communication

Gerozissis, K. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.044 · Cited by 108 · see citing works

Central Nervous System Findings in a Tenth Decade Autopsy Population

Peress, N. S., Kane, W. C., & Aronson, S. M. (1973) · Progress in Brain Research · doi:10.1016/s0079-6123(08)60707-4 · Cited by 84 · see citing works

Role of White Matter Lesions in Cognitive Impairment of Vascular Origin

Pantoni, L., Leys, D., Fazekas, F., Longstreth, W. T., Inzitari, D., Wallin, A., Filippi, M., Scheltens, P., Erkinjuntti, T., & Hachinski, V. (1999) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199912001-00008 · Cited by 80 · see citing works

The Validity and Reliability of 6 Sets of Clinical Criteria to Classify Alzheimer’s Disease and Vascular Dementia in Cases Confirmed Post-Mortem: Added Value of a Decision Tree Approach

Hogervorst, E., Bandelow, S., Combrinck, M. I., Irani, S. R., & Smith, A. D. (2003) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000071006 · Cited by 78 · see citing works

Apolipoprotein‐E Genotyping of Diabetic Dementia Patients: Is Diabetes Rare in Alzheimer's Disease?

Nielson, K. A., Nolan, J. H., Berchtold, N. C., Sandman, C. A., Mulnard, R. A., & Cotman, C. W. (1996) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1996.tb01857.x · Cited by 72 · see citing works

Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor

Xie, L., Martins, R. N., Racchi, M., Craft, S., & Helmerhorst, E. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4504 · Cited by 61 · see citing works

The metabolic syndrome, inflammation, and risk of cognitive decline

Yaffe, K. S., Kanaya, A. M., & Lindquist, K. J. (2005) · ACC Current Journal Review · doi:10.1016/j.accreview.2004.12.135 · Cited by 57 · see citing works

Prevalence of undiagnosed Type 2 diabetes and impaired fasting glucose in older B ritish men and women

Thomas, M. C., Walker, M., Emberson, J., Thomson, A. G., Lawlor, D. A., Ebrahim, S. B. J., & Whincup, P. H. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01516.x · Cited by 51 · see citing works

Role of White Matter Lesions in Cognitive Impairment of Vascular Origin

Pantoni, L., Leys, D., Fazekas, F., et al. (1999) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199912003-00008 · Cited by 34 · see citing works

Dementia prevention, intervention, and care

Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072 · see citing works

Standards of medical care in diabetes—2014

American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s014 · Cited by 4,572 · see citing works

Standards of medical care in diabetes—2013

American Diabetes Association (2013) · Diabetes Care · doi:10.2337/dc13-s011 · Cited by 4,369 · see citing works

Inflammation as a central mechanism in Alzheimer's disease

Kinney, J. W., Bemiller, S. M., Murtishaw, A. S., Leisgang, A. M., Salazar, A. M., & Lamb, B. T. (2018) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.06.014 · Cited by 2,253 · see citing works

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Talbot, K., Wang, H.-Y., Kazi, H., Han, L.-Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59903 · Cited by 1,871 · see citing works

Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population‐based perspective

Baumgart, M., Snyder, H. M., Carrillo, M. C., Fazio, S., Kim, H., & Johns, H. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.05.016 · Cited by 1,660 · see citing works

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Arnold, S. E., Arvanitakis, Z., Macauley-Rambach, S. L., Koenig, A. M., Wang, H.-Y., Ahima, R. S., Craft, S., Gandy, S., Buettner, C., Stoeckel, L. E., et al. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.185 · Cited by 1,597 · see citing works

Effects of intermittent fasting on health, aging, and disease

de Cabo, R., & Mattson, M. P. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1905136 · Cited by 1,605 · see citing works

Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

Biessels, G. J., & Despa, F. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0048-7 · Cited by 1,454 · see citing works

Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention

Qiu, C., Kivipelto, M., & von Strauss, E. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.2/cqiu · Cited by 1,261 · see citing works

Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors

Kalaria, R. N., Maestre, G. E., Arizaga, R., Friedland, R. P., Galasko, D., Hall, K., Luchsinger, J. A., Ogunniyi, A., Perry, E. K., Potocnik, F., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70169-8 · Cited by 1,233 · see citing works

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

Soto, C., & Pritzkow, S. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0235-9 · Cited by 1,180 · see citing works

Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus

Whitmer, R. A. (2009) · JAMA · doi:10.1001/jama.2009.460 · Cited by 1,128 · see citing works

Diabetes mellitus and risk of dementia: A meta‐analysis of prospective observational studies

Gudala, K., Bansal, D., Schifano, F., & Bhansali, A. (2013) · Journal of Diabetes Investigation · doi:10.1111/jdi.12087 · Cited by 727 · see citing works

Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Cooper, C., Sommerlad, A., Lyketsos, C. G., & Livingston, G. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14070878 · Cited by 570 · see citing works

Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy

Launer, L. J., Miller, M. E., Williamson, J. D., Lazar, R. M., Gerstein, H. C., Murray, A. M., Sullivan, M., Horowitz, K. R., Ding, J., Marcovina, S., et al. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70188-0 · Cited by 574 · see citing works

Trends in Prevalence and Control of Diabetes in the United States, 1988–1994 and 1999–2010

Selvin, E., Parrinello, C. M., Sacks, D. B., & Coresh, J. (2014) · Annals of Internal Medicine · doi:10.7326/m13-2411 · Cited by 532 · see citing works

How does diabetes accelerate Alzheimer disease pathology?

Sims-Robinson, C., Kim, B., Rosko, A., & Feldman, E. L. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.130 · Cited by 492 · see citing works

Type 2 diabetes and cognitive dysfunction–towards effective management of both comorbidities

Srikanth, V., Sinclair, A. J., Hill-Briggs, F., Moran, C., & Biessels, G. J. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30118-2 · Cited by 465 · see citing works

Comorbidity and dementia: a scoping review of the literature

Bunn, F., Burn, A.-M., Goodman, C., Rait, G., Norton, S., Robinson, L., Schoeman, J., & Brayne, C. (2014) · BMC Medicine · doi:10.1186/s12916-014-0192-4 · Cited by 451 · see citing works

Insulin signaling in the central nervous system: Learning to survive

van der Heide, L. P., Ramakers, G. M. J., & Smidt, M. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.06.003 · Cited by 444 · see citing works

Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia

Bunch, T. J., Weiss, J. P., Crandall, B. G., May, H. T., Bair, T. L., Osborn, J. S., Anderson, J. L., Muhlestein, J. B., Horne, B. D., Lappe, D. L., et al. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2009.12.004 · Cited by 405 · see citing works

Magnitude of cognitive dysfunction in adults with type 2 diabetes: a meta-analysis of six cognitive domains and the most frequently reported neuropsychological tests within domains

Palta, P., Schneider, A. L. C., Biessels, G. J., Touradji, P., & Hill-Briggs, F. (2014) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617713001483 · Cited by 364 · see citing works

Diabetes and other vascular risk factors for dementia: Which factor matters most? A systematic review

Kloppenborg, R. P., van den Berg, E., Kappelle, L. J., & Biessels, G. J. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.049 · Cited by 368 · see citing works

Risk factors associated with the onset and progression of Alzheimer's disease: a systematic review of the evidence

Hersi, M., Irvine, B., Gupta, P., Gomes, J., Birkett, N., & Krewski, D. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.03.006 · Cited by 332 · see citing works

Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study

Schrijvers, E. M. C., Witteman, J. C. M., Sijbrands, E. J. G., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2010) · Neurology · doi:10.1212/wnl.0b013e3181ffe4f6 · Cited by 328 · see citing works

Insulin resistance in the nervous system

Kim, B., & Feldman, E. L. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.12.004 · Cited by 321 · see citing works

Type 2 diabetes mellitus and Alzheimer’s disease

Barbagallo, M. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i6.889 · Cited by 313 · see citing works

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

Querfurth, H., & Lee, H.-K. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00428-5 · Cited by 288 · see citing works

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

Zhao, N., Liu, C.-C., Van Ingelgom, A. J., Martens, Y. A., Linares, C., Knight, J. A., Painter, M. M., Sullivan, P. M., & Bu, G. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.003 · Cited by 289 · see citing works

Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions

Andrieu, S., Coley, N., Lovestone, S., Aisen, P. S., & Vellas, B. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00153-2 · Cited by 293 · see citing works

HbA1c, diabetes and cognitive decline: the English Longitudinal Study of Ageing

Zheng, F., Yan, L., Yang, Z., Zhong, B., & Xie, W. (2018) · Diabetologia · doi:10.1007/s00125-017-4541-7 · Cited by 280 · see citing works

4. Comprehensive Medical Evaluation and Assessment of Comorbidities: <i>Standards of Medical Care in Diabetes—2022</i>

American Diabetes Association Professional Practice Committee (2022) · Diabetes Care · doi:10.2337/dc22-s004 · Cited by 285 · see citing works

Body mass index in midlife and dementia: systematic review and meta-regression analysis of 589,649 men and women followed in longitudinal studies

Albanese, E., Launer, L. J., Egger, M., Prince, M. J., Giannakopoulos, P., Wolters, F. J., & Egan, K. (2017) · Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring · doi:10.1016/j.dadm.2017.05.007 · Cited by 272 · see citing works

Mid- and Late-Life Diabetes in Relation to the Risk of Dementia

Xu, W., Qiu, C., Gatz, M., Pedersen, N. L., Johansson, B., & Fratiglioni, L. (2009) · Diabetes · doi:10.2337/db08-0586 · Cited by 284 · see citing works

The Impact of Disease Comorbidities in Alzheimer’s Disease

Santiago, J. A., & Potashkin, J. A. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.631770 · Cited by 259 · see citing works

Cognition in people with end-stage kidney disease treated with hemodialysis: a systematic review and meta-analysis.

O’Lone, E., Connors, M., Masson, P., Wu, S., Kelly, P. J., Gillespie, D., Parker, D., Whiteley, W., Strippoli, G. F. M., Palmer, S. C., et al. (2016) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2015.12.028 · Cited by 266 · see citing works

Accelerated Progression From Mild Cognitive Impairment to Dementia in People With Diabetes

Xu, W., Caracciolo, B., Wang, H.-X., Winblad, B., Bäckman, L., Qiu, C., & Fratiglioni, L. (2010) · Diabetes · doi:10.2337/db10-0539 · Cited by 260 · see citing works

The impact of diabetes on cognitive impairment and its progression to dementia

Dove, A., Shang, Y., Xu, W., Grande, G., Laukka, E. J., Fratiglioni, L., & Marseglia, A. (2021) · Alzheimer's &amp; Dementia · doi:10.1002/alz.12482 · Cited by 252 · see citing works

Risk score for prediction of 10 year dementia risk in individuals with type 2 diabetes: A cohort study

Exalto, L. G., Biessels, G. J., Karter, A. J., Huang, E. S., Katon, W. J., Minkoff, J. R., & Whitmer, R. A. (2013) · The Lancet Diabetes &amp; Endocrinology · doi:10.1016/s2213-8587(13)70048-2 · Cited by 244 · see citing works

Advanced BrainAGE in older adults with type 2 diabetes mellitus

Franke, K., Gaser, C., Manor, B., & Novak, V. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00090 · Cited by 221 · see citing works

Prevention of dementia in an ageing world: Evidence and biological rationale

Grande, G., Qiu, C., & Fratiglioni, L. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101045 · Cited by 229 · see citing works

The relationship between cognitive impairment in schizophrenia and metabolic syndrome: a systematic review and meta-analysis

Bora, E., Akdede, B. B., & Alptekin, K. (2017) · Psychological Medicine · doi:10.1017/s0033291716003366 · Cited by 219 · see citing works

The Relationship between Obstructive Sleep Apnea and Alzheimer’s Disease

Andrade, A. G., Bubu, O. M., Varga, A. W., & Osorio, R. S. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179936 · Cited by 216 · see citing works

Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research

Cunningham, C., & Hennessy, E. (2015) · Alzheimer's Research &amp; Therapy · doi:10.1186/s13195-015-0117-2 · Cited by 211 · see citing works

An update on type 2 diabetes, vascular dementia and Alzheimer’s disease.

Exalto, L. G., Whitmer, R. A., Kappele, L. J., & Biessels, G. J. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.07.014 · Cited by 194 · see citing works

Cognitive Function and Brain Structure in Persons With Type 2 Diabetes Mellitus After Intensive Lowering of Blood Pressure and Lipid Levels: A Randomized Clinical Trial

Williamson, J. D., Launer, L. J., Bryan, R. N., Coker, L. H., Lazar, R. M., Gerstein, H. C., Murray, A. M., Sullivan, M. D., Horowitz, K. R., Ding, J., et al. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.13656 · Cited by 187 · see citing works

Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood

Lee, S.-H., Zabolotny, J. M., Huang, H., Lee, H., & Kim, Y.-B. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.011 · Cited by 176 · see citing works

Metabolic syndrome and dementia risk in a multiethnic elderly cohort

Muller, M., Tang, M.-X., Schupf, N., Manly, J. J., Mayeux, R., & Luchsinger, J. A. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000105927 · Cited by 175 · see citing works

Dietary nitrate supplementation improves reaction time in type 2 diabetes: Development and application of a novel nitrate-depleted beetroot juice placebo

Gilchrist, M., Winyard, P. G., Fulford, J., Anning, C., Shore, A. C., & Benjamin, N. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.05.003 · Cited by 167 · see citing works

Type 2 Diabetes and Antidiabetic Medications in Relation to Dementia Diagnosis

Cheng, C., Lin, C.-H., Tsai, Y.-W., Tsai, C.-J., Chou, P.-H., & Lan, T.-H. (2014) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glu073 · Cited by 167 · see citing works

Effect of Intranasal Insulin on Cognitive Function: A Systematic Review

Shemesh, E., Rudich, A., Harman-Boehm, I., & Cukierman-Yaffe, T. (2012) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2011-1802 · Cited by 162 · see citing works

A claims data-based comparison of comorbidity in individuals with and without dementia

Bauer, K., Schwarzkopf, L., Graessel, E., & Holle, R. (2014) · BMC Geriatrics · doi:10.1186/1471-2318-14-10 · Cited by 157 · see citing works

Comorbid Depression Is Associated with an Increased Risk of Dementia Diagnosis in Patients with Diabetes: A Prospective Cohort Study

Katon, W. J., Lin, E. H. B., Williams, L. H., Ciechanowski, P., Heckbert, S. R., Ludman, E., Rutter, C., Crane, P. K., Oliver, M., & Von Korff, M. (2010) · Journal of General Internal Medicine · doi:10.1007/s11606-009-1248-6 · Cited by 141 · see citing works

Progression of Mild Cognitive Impairment to Dementia: Contribution of Cerebrovascular Disease Compared With Medial Temporal Lobe Atrophy

Staekenborg, S. S., Koedam, E. L. G. E., Henneman, W. J. P., Stokman, P., Barkhof, F., Scheltens, P., & van der Flier, W. M. (2009) · Stroke · doi:10.1161/strokeaha.108.531343 · Cited by 139 · see citing works

Coronary Artery Calcium, Brain Function and Structure: The AGES-Reykjavik Study

Vidal, J.-S., Sigurdsson, S., Jonsdottir, M. K., Eiriksdottir, G., Thorgeirsson, G., Kjartansson, O., Garcia, M. E., van Buchem, M. A., Harris, T. B., Gudnason, V., et al. (2010) · Stroke · doi:10.1161/strokeaha.110.579581 · Cited by 139 · see citing works

Insulin Resistance Promotes Parkinson’s Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling

Hong, C.-T., Chen, K.-Y., Wang, W., Chiu, J.-Y., Wu, D., Chao, T.-Y., Hu, C.-J., Chau, K.-Y., & Bamodu, O. (2020) · Cells · doi:10.3390/cells9030740 · Cited by 133 · see citing works

Blood-Brain Barrier Disruption Induced Cognitive Impairment Is Associated With Increase of Inflammatory Cytokine

Geng, J., Wang, L., Zhang, L., Qin, C., Song, Y., Ma, Y., Chen, Y., Chen, S., Wang, Y., Zhang, Z., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00129 · Cited by 123 · see citing works

Low BDNF is associated with cognitive deficits in patients with type 2 diabetes

Zhen, Y. F., Zhang, J., Liu, X. Y., Fang, H., Tian, L. B., Zhou, D. H., Kosten, T. R., & Zhang, X. Y. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2942-3 · Cited by 126 · see citing works

Methodological challenges in designing dementia prevention trials—the European Dementia Prevention Initiative (EDPI)

Richard, E., Andrieu, S., Solomon, A., Mangialasche, F., Ahtiluoto, S., van Charante, E. P. M., Coley, N., Fratiglioni, L., Neely, A. S., Vellas, B., et al. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.06.012 · Cited by 121 · see citing works

Medical comorbidities and ethnicity impact plasma Alzheimer's disease biomarkers: Important considerations for clinical trials and practice

O'Bryant, S. E., Petersen, M., Hall, J., Johnson, L. A., & for the HABS‐HD Study Team (2023) · Alzheimer's &amp; Dementia · doi:10.1002/alz.12647 · Cited by 110 · see citing works

Type 2 diabetes mellitus, dyslipidemia, and Alzheimer’s disease

Carlsson, C. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100012 · Cited by 109 · see citing works

A Primary Care Agenda for Brain Health: A Scientific Statement From the American Heart Association

Lazar, R. M., Howard, V. J., Kernan, W. N., Aparicio, H. J., Levine, D. A., Viera, A. J., Jordan, L. C., Nyenhuis, D. L., Possin, K. L., Sorond, F. A., et al. (2021) · Stroke · doi:10.1161/str.0000000000000367 · Cited by 109 · see citing works

Prevention of Vascular Cognitive Impairment

Dichgans, M., & Zietemann, V. (2012) · Stroke · doi:10.1161/strokeaha.112.651778 · Cited by 107 · see citing works

Vascular and Psychosocial Factors in Alzheimer's Disease: Epidemiological Evidence Toward Intervention

Qiu, C., Xu, W., & Fratiglioni, L. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091663 · Cited by 107 · see citing works

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

Garwood, C. J., Ratcliffe, L. E., Morgan, S. V., Simpson, J. E., Owens, H., Vazquez-Villaseñor, I., Heath, P. R., Romero, I. A., Ince, P. G., & Wharton, S. B. (2015) · Molecular Brain · doi:10.1186/s13041-015-0138-6 · Cited by 101 · see citing works

Metformin and Risk of Alzheimer’s Disease Among Community-Dwelling People With Diabetes: A National Case-Control Study

Sluggett, J. K., Koponen, M., Bell, J. S., Taipale, H., Tanskanen, A., Tiihonen, J., Uusitupa, M., Tolppanen, A.-M., & Hartikainen, S. (2020) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/clinem/dgz234 · Cited by 95 · see citing works

Assessment of common infections and incident dementia using UK primary and secondary care data: a historical cohort study

Muzambi, R., Bhaskaran, K., Smeeth, L., Brayne, C., Chaturvedi, N., & Warren-Gash, C. (2021) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00118-5 · Cited by 84 · see citing works

Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old

Polvikoski, T. M., van Straaten, E. C. W., Barkhof, F., Sulkava, R., Aronen, H. J., Niinistö, L., Oinas, M., Scheltens, P., Erkinjuntti, T., & Kalaria, R. N. (2010) · Neurology · doi:10.1212/wnl.0b013e318200d6f9 · Cited by 88 · see citing works

Obesity, Insulin Resistance, and Alzheimer's Disease

Hildreth, K. L., Van Pelt, R. E., & Schwartz, R. S. (2012) · Obesity · doi:10.1038/oby.2012.19 · Cited by 86 · see citing works

MicroRNA 7 Impairs Insulin Signaling and Regulates A <i>β</i> Levels through Posttranscriptional Regulation of the Insulin Receptor Substrate 2, Insulin Receptor, Insulin-Degrading Enzyme, and Liver X Receptor Pathway

Fernández-de Frutos, M., Galán-Chilet, I., Goedeke, L., Kim, B., Pardo-Marqués, V., Pérez-García, A., Herrero, J. I., Fernández-Hernando, C., Kim, J., & Ramírez, C. M. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00170-19 · Cited by 82 · see citing works

Comorbidity and dementia: a mixed-method study on improving health care for people with dementia (CoDem)

Bunn, F., Burn, A.-M., Goodman, C., Robinson, L., Rait, G., Norton, S., Bennett, H., Poole, M., Schoeman, J., & Brayne, C. (2016) · Health Services and Delivery Research · doi:10.3310/hsdr04080 · Cited by 72 · see citing works

Activation of glucagon-like peptide-1 receptor ameliorates cognitive decline in type 2 diabetes mellitus through a metabolism-independent pathway

Li, Q., Jia, M., Yan, Z., Li, Q., Sun, F., He, C., Li, Y., Zhou, X., Zhang, H., Liu, X., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.020734 · Cited by 77 · see citing works

Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration

van Dijk, G., van Heijningen, S., Reijne, A. C., Nyakas, C., van der Zee, E. A., & Eisel, U. L. M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00173 · Cited by 75 · see citing works

Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes

Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works

Clinical and Subclinical Macrovascular Disease as Predictors of Cognitive Decline in Older Patients With Type 2 Diabetes

Feinkohl, I., Keller, M., Robertson, C. M., Morling, J. R., Williamson, R. M., Nee, L. D., McLachlan, S., Sattar, N., Welsh, P., Reynolds, R. M., et al. (2013) · Diabetes Care · doi:10.2337/dc12-2241 · Cited by 69 · see citing works

Alterations in Hippocampal Oxidative Stress, Expression of AMPA Receptor GluR2 Subunit and Associated Spatial Memory Loss by Bacopa monnieri Extract (CDRI-08) in Streptozotocin-Induced Diabetes Mellitus Type 2 Mice

Pandey, S. P., Singh, H. K., & Prasad, S. (2015) · PLOS ONE · doi:10.1371/journal.pone.0131862 · Cited by 64 · see citing works

The Protective Effect of Exercise in Neurodegenerative Diseases: The Potential Role of Extracellular Vesicles

Fuller, O. K., Whitham, M., Mathivanan, S., & Febbraio, M. A. (2020) · Cells · doi:10.3390/cells9102182 · Cited by 60 · see citing works

Relationship Between Markers of Insulin Resistance, Markers of Adiposity, HbA1c, and Cognitive Functions in a Middle-Aged Population–Based Sample: the MONA LISA Study

Sanz, C. M., Ruidavets, J.-B., Bongard, V., Marquié, J.-C., Hanaire, H., Ferrières, J., & Andrieu, S. (2013) · Diabetes Care · doi:10.2337/dc12-1017 · Cited by 60 · see citing works

Central and peripheral circadian clocks and their role in Alzheimer's disease

Chauhan, R., Chen, K.-F., Kent, B. A., & Crowther, D. C. (2017) · Disease Models &amp; Mechanisms · doi:10.1242/dmm.030627 · Cited by 58 · see citing works

The effects of caloric restriction and its mimetics in Alzheimer's disease through autophagy pathways

Yang, Y., & Zhang, L. (2020) · Food &amp; Function · doi:10.1039/c9fo02611h · Cited by 57 · see citing works

Brain insulin, insulin‐like growth factor 1 and glucagon‐like peptide 1 signalling in Alzheimer’s disease

Ferreira, S. T. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12959 · Cited by 59 · see citing works

High-fat diet-induced activation of SGK1 promotes Alzheimer’s disease-associated tau pathology

Elahi, M., Motoi, Y., Shimonaka, S., Ishida, Y., Hioki, H., Takanashi, M., Ishiguro, K., Imai, Y., & Hattori, N. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab115 · Cited by 57 · see citing works

A web-based cognitive behavior therapy intervention to improve social and occupational functioning in adults with type 2 diabetes (the SpringBoarD trial): Randomized controlled trial

Clarke, J., Sanatkar, S., Baldwin, P. A., Fletcher, S., Gunn, J., Wilhelm, K., Campbell, L., Zwar, N., Harris, M., Lapsley, H., et al. (2019) · Journal of Medical Internet Research · doi:10.2196/12246 · Cited by 52 · see citing works

Normal physical activity obliterates the deleterious effects of a high-caloric intake

Krogh-Madsen, R., Pedersen, M., Solomon, T. P. J., Knudsen, S. H., Hansen, L. S., Karstoft, K., Lehrskov-Schmidt, L., Pedersen, K. K., Thomsen, C., Holst, J. J., et al. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00155.2013 · Cited by 53 · see citing works

Is there a role for physical activity in preventing cognitive decline in people with mild cognitive impairment?

Barber, S. E., Clegg, A. P., & Young, J. B. (2012) · Age and Ageing · doi:10.1093/ageing/afr138 · Cited by 52 · see citing works

Fasting Insulin Levels and Cognitive Decline in Older Women without Diabetes

van Oijen, M., Okereke, O. I., Kang, J. H., Pollak, M. N., Hu, F. B., Hankinson, S. E., & Grodstein, F. (2008) · Neuroepidemiology · doi:10.1159/000126909 · Cited by 44 · see citing works

Mitochondria-Targeted Small Peptide, SS31 Ameliorates Diabetes Induced Mitochondrial Dynamics in Male TallyHO/JngJ Mice

Bhatti, J. S., Thamarai, K., Kandimalla, R., Manczak, M., Yin, X., Kumar, S., Vijayan, M., & Reddy, P. H. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02142-7 · Cited by 41 · see citing works

Effects of aspirin on dementia and cognitive function in diabetic patients: the ASCEND trial

Parish, S., Mafham, M., Offer, A., Barton, J., Wallendszus, K., Stevens, W., Buck, G., Haynes, R., Collins, R., Bowman, L., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac179 · Cited by 40 · see citing works

The Inositol Phosphatase SHIP2 Negatively Regulates Insulin/IGF-I Actions Implicated in Neuroprotection and Memory Function in Mouse Brain

Soeda, Y., Tsuneki, H., Muranaka, H., Mori, N., Hosoh, S., Ichihara, Y., Kagawa, S., Wang, X., Toyooka, N., Takamura, Y., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0163 · Cited by 38 · see citing works

Onset age of diabetes and incident dementia: A prospective cohort study

Wang, Y., Li, C., Liang, J., Gao, D., Pan, Y., Zhang, W., Zhang, Y., Zheng, F., & Xie, W. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.02.138 · Cited by 36 · see citing works

Relationship between amyloid-β positivity and progression to mild cognitive impairment or dementia over 8 years in cognitively normal older adults

Dang, C., Harrington, K. D., Lim, Y. Y., Ames, D., Hassenstab, J., Laws, S. M., Yassi, N., Hickey, M., Rainey-Smith, S., Robertson, J., et al. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-180507 · Cited by 31 · see citing works

Metformin and Its Sulfenamide Prodrugs Inhibit Human Cholinesterase Activity

Markowicz-Piasecka, M., Sikora, J., Mateusiak, Ł., Mikiciuk-Olasik, E., & Huttunen, K. M. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7303096 · Cited by 32 · see citing works

The metabolic syndrome and cognitive decline in the Atherosclerosis Risk in Communities Study (ARIC).

Dearborn, J. L., Knopman, D., Sharrett, A. R., Schneider, A. L. C., Jack Jr., C. R., Coker, L. H., Alonso, A., Selvin, E., Mosley, T. H., Wagenknecht, L. E., et al. (2014) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000362265 · Cited by 32 · see citing works

Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice

Bhatti, J. S., Tamarai, K., Kandimalla, R., Manczak, M., Yin, X., Ramasubramanian, B., Sawant, N., Pradeepkiran, J. A., Vijayan, M., Kumar, S., et al. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.02.007 · Cited by 30 · see citing works

The utility of brief cognitive tests for patients with type 2 diabetes mellitus: a systematic review

Dong, Y., Kua, Z. J., Khoo, E. Y. H., Koo, E. H., & Merchant, R. A. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.06.010 · Cited by 29 · see citing works

Apathy in Older Patients with Type 2 Diabetes

Bruce, D. G., Nelson, M. E., Mace, J. L., Davis, W. A., Davis, T. M. E., & Starkstein, S. E. (2015) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2014.09.010 · Cited by 26 · see citing works

Association of sodium‐glucose cotransporter 2 inhibitors with risk of incident dementia and all‐cause mortality in older patients with type 2 diabetes: A retrospective cohort study using the <scp>TriNetX US</scp> collaborative networks

Pai, Y., Chen, I., Lin, J., Chen, X., Chen, H., Chang, M., Huang, J., & Lin, C. (2024) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15918 · Cited by 26 · see citing works

Long-term change in physiological markers and cognitive performance in type 2 diabetes: the Look AHEAD Study

Carmichael, O. T., Neiberg, R. H., Dutton, G. R., Hayden, K. M., Horton, E., Pi-Sunyer, F. X., Johnson, K. C., Rapp, S. R., Spira, A. P., & Espeland, M. A. (2020) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/clinem/dgaa591 · Cited by 24 · see citing works

The effect of diabetes on the cognitive trajectory of older adults in Mexico and the United States

Avila, J. C., Mejia-Arangom, S., Jupiter, D., Downer, B., & Wong, R. (2021) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbaa094 · Cited by 18 · see citing works

The incidence of dementia in an Australian community population: the Sydney older persons study

Waite, L. M., Broe, G. A., Grayson, D. A., & Creasey, H. M. (2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.404 · Cited by 30 · see citing works

Dementia 3. Vascular dementia: diagnosis, treatment and medical management

Nazarko, L. (2019) · British Journal of Healthcare Assistants · doi:10.12968/bjha.2019.13.8.382

Prevalence and incidence of dementia in an older Chinese population over two decades: the role of education

Ding, D., Zhao, Q., Wu, W., Xiao, Z., Liang, X., Luo, J., & Hong, Z. (2020) · Alzheimer's &amp; Dementia · doi:10.1002/alz.12159 · Cited by 41 · see citing works

Clinical study on P300 as the method for early diagnosis of the vascular dementia

Zhang, X. (2000) · Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Disease

Prevalence of Associated Diseases in Different Types of Dementia Among Elderly Institutionalized Patients: Analysis of 3447 Records

Holstein, J., Châtellier, G., Piette, F., & Moulias, R. (1994) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1994.tb06590.x · Cited by 56 · see citing works