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Definition, course, and outcome of mild cognitive impairment
Abstract
Mild Cognitive Impairment (MCI) is a term which can be applied to a boundary area between dementia and normal aging. Criteria which reliably describe persons falling in this range of the cognitive continuum can be defined. These persons are at very high risk for developing dementia. Biologic and cognitive parameters including Apolipoprotein E genotype help to differentiate MCI persons who will progress to dementia in 2-4 years from those who will remain free from dementia over this interval.
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“This intermediate state has been termed mild cognitive impairment (MCI) and clinical criteria for this diagnosis have been suggested(1–3).”
From Rates of hippocampal atrophy correlate with change in clinical status in aging and AD (2000) · cites this paper as [2]
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Metadata
- Authors
- Smith, G. E., Petersen, R. C., Parisi, J. E., Ivnik, R. J., Kokmen, E., Tangalos, E. G., & Waring, S.
- Affiliations
- Mayo Clinic (US)
- Venue
- Aging, Neuropsychology, and Cognition
- Publisher
- Informa UK Limited
- Published
- 1996-04
- Volume
- 3
- Issue
- 2
- Pages
- 141-147
- ISSN
- 0928-9917 (ISSN-L)
- 1382-5585
- 1744-4128
- OpenAlex
- W2030120755
- Cited by
- 186
- References
- 31
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 1 · 2022: 7 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 8 · 2015: 2 · 2014: 4 · 2013: 10 · 2012: 6
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Aging Neuropsychology and Cognition (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- mild cognitive impairment, dementia risk, cognitive continuum, APOE genotype, conversion to dementia, diagnostic criteria, aging, cognitive decline
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