Preparation and In Vivo. Antitumor Activity of κ-Carrageenan Oligosaccharides
Open accessAbstract
Carrageenan oligosaccharides were produced from the final products of commercial extractions of gelling carrageenan and thickening carrageenan, which were specifically depolymerized by κ-carrageenase extracted from the marine bacterium Cytophaga. MCA-2. The weight-average molecular weights of the two oligosaccharides produced were 681 and 798 Da. The sulfate contents were assayed as 17.2% and 21.8%. Antitumor activities of the oligosaccharides were tested on Sarcoma 180 tumor transplanted in mice. The carrageenan oligosaccharide from the thickening carrageenan product showed much higher tumor inhibition (70.8%) and catalase activity at a dosage of 100 mg kg−1 compared with the control group. The gelling and thickening carrageenan oligosaccarides could also significantly increase the weight of immune organs such as the thymus, which suggests that the antitumor mechanism of the carrageenan oligosaccharides may be initiated via organ-mediated defense reactions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Carrageenan oligosaccharides from Kappaphycus striatum administered perorally for 14 days to mice inoculated with S180 tumor cells resulted in enhanced antibody production.
“This resulted in growth inhibition of transplantable sarcoma cells, increased macrophage phagocytosis, enhanced antibody production, increased lymphocyte proliferation, stronger NK cell activity, and elevated levels of IL-2 and TNF-α.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [95]
Carrageenan oligosaccharides from Kappaphycus striatum administered perorally for 14 days to mice inoculated with S180 tumor cells resulted in increased macrophage phagocytosis.
“This resulted in growth inhibition of transplantable sarcoma cells, increased macrophage phagocytosis, enhanced antibody production, increased lymphocyte proliferation, stronger NK cell activity, and elevated levels of IL-2 and TNF-α.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [95]
Carrageenan oligosaccharides from Kappaphycus striatum administered perorally for 14 days to mice inoculated with S180 tumor cells resulted in increased lymphocyte proliferation.
“This resulted in growth inhibition of transplantable sarcoma cells, increased macrophage phagocytosis, enhanced antibody production, increased lymphocyte proliferation, stronger NK cell activity, and elevated levels of IL-2 and TNF-α.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [95]
Carrageenan oligosaccharides from Kappaphycus striatum administered perorally for 14 days to mice inoculated with S180 tumor cells resulted in growth inhibition of transplantable sarcoma cells.
“This resulted in growth inhibition of transplantable sarcoma cells, increased macrophage phagocytosis, enhanced antibody production, increased lymphocyte proliferation, stronger NK cell activity, and elevated levels of IL-2 and TNF-α.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [95]
Carrageenan oligosaccharides from Kappaphycus striatum administered perorally for 14 days to mice inoculated with S180 tumor cells resulted in elevated levels of IL-2 and TNF-α.
“This resulted in growth inhibition of transplantable sarcoma cells, increased macrophage phagocytosis, enhanced antibody production, increased lymphocyte proliferation, stronger NK cell activity, and elevated levels of IL-2 and TNF-α.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [95]
The studied carrageenan oligosaccharides exert their antitumor effects by promoting the immune system.
“These results suggested that the studied oligosaccharides exert their antitumor effects by promoting the immune system [95].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [95]
Carrageenan oligosaccharides from Kappaphycus striatum administered perorally for 14 days to mice inoculated with S180 tumor cells resulted in stronger NK cell activity.
“This resulted in growth inhibition of transplantable sarcoma cells, increased macrophage phagocytosis, enhanced antibody production, increased lymphocyte proliferation, stronger NK cell activity, and elevated levels of IL-2 and TNF-α.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [95]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Somogyi, M. (1926) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)84465-9 · Cited by 5,601 · see citing works
Somogyi, M. (1952) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50870-5 · Cited by 5,310 · see citing works
A note on the determination of the ester sulphate content of sulphated polysaccharides
Dodgson, K. S., & Price, R. (1962) · Biochemical Journal · doi:10.1042/bj0840106 · Cited by 1,645 · see citing works
Ruiter, G. A. D., & Rudolph, B. (1997) · Trends in Food Science & Technology · doi:10.1016/s0924-2244(97)01091-1 · Cited by 332 · see citing works
Marine Algae in pharmaceutical science
Woodhead, H. (1980) · Endeavour · doi:10.1016/0160-9327(80)90084-8 · Cited by 269 · see citing works
Alban, S. (2002) · Carbohydrate Polymers · doi:10.1016/s0144-8617(01)00178-3 · Cited by 244 · see citing works
(1997) · European Journal of Medicinal Chemistry · doi:10.1016/s0223-5234(97)82768-7 · Cited by 239 · see citing works
Carlucci, M. J., Pujol, C. A., Ciancia, M., Noseda, M. D., Matulewicz, M. C., Damonte, E. B., & Cerezo, A. S. (1997) · International Journal of Biological Macromolecules · doi:10.1016/s0141-8130(96)01145-2 · Cited by 224 · see citing works
Matsubara, K., Matsuura, Y., Bacic, A., Liao, M., Hori, K., & Miyazawa, K. (2001) · International Journal of Biological Macromolecules · doi:10.1016/s0141-8130(01)00137-4 · Cited by 186 · see citing works
Cáceres, P. J., Carlucci, M. J., Damonte, E. B., Matsuhiro, B., & Zúñiga, E. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(99)00461-6 · Cited by 157 · see citing works
Chemical characters and antioxidative properties of sulfated polysaccharides from Laminaria japonica
Xue, C., Fang, Y., Lin, H., Chen, L., Li, Z., Deng, D., & Lu, C.-X. (2001) · Journal of Applied Phycology · doi:10.1023/a:1008103611522 · Cited by 147 · see citing works
Tutour, B. L., Benslimane, F., Gouleau, M., Gouygou, J., Saadan, B., & Quéméneur, F. (1998) · Journal of Applied Phycology · doi:10.1023/a:1008007313731 · Cited by 138 · see citing works
Promotive effects of alginate-derived oligosaccharide on maize seed germination
Hu, X., Jiang, X., Hwang, H., et al. (2004) · Journal of Applied Phycology · doi:10.1023/b:japh.0000019139.35046.0c · Cited by 135 · see citing works
Self-citationHaijin, M., Xiaolu, J., & Hua-shi, G. (2003) · Journal of Applied Phycology · doi:10.1023/a:1025103530534 · Cited by 132 · see citing works
Oligosaccharide recognition signals and defence reactions in marine plant-microbe interactions
Potin, P., Bouarab, K., Küpper, F. C., & Kloareg, B. (1999) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)80048-4 · Cited by 123 · see citing works
Oceanography and marine biology: An annual review
Blackman, R. A. A. (1987) · Marine Pollution Bulletin · doi:10.1016/0025-326x(87)90325-0 · Cited by 101 · see citing works
Immune parameters in carpet shell clams naturally infected with
Ordás, M. C., Ordás, A., Beloso, C., et al. (2000) · Fish & Shellfish Immunology · doi:10.1006/fsim.2000.0274 · Cited by 100 · see citing works
Sulfated polysaccharides in inflammation.
Arfors, K. ‐., & Ley, K. F. (1993) · PubMed · Cited by 78 · see citing works
Yuan, H., & Song, J. (2005) · Journal of Applied Phycology · doi:10.1007/s10811-005-5513-8 · Cited by 76 · see citing works
Hu, X., Jiang, X., Hwang, H., et al. (2004) · European Journal of Phycology · doi:10.1080/09670260310001636695 · Cited by 73 · see citing works
Self-citationAnggadiredja, Andyani, Hayati, et al. (1997) · Journal of Applied Phycology · doi:10.1023/a:1008075625735 · Cited by 68 · see citing works
Suzuki, N., Kitazato, K., Takamatsu, J., et al. (1991) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1648154 · Cited by 61 · see citing works
Antibacterial activity of lyase-depolymerized products of alginate
Hu, X., Jiang, X., Gong, J., et al. (2005) · Journal of Applied Phycology · doi:10.1007/s10811-005-5524-5 · Cited by 53 · see citing works
Self-citationCaram-Lelham, N., Sundelöf, L., & Andersson, T. (1995) · Carbohydrate Research · doi:10.1016/0008-6215(95)00119-e · Cited by 24 · see citing works
Dwek, R. A. (1991) · Glycoconjugate Journal · doi:10.1007/bf00731288 · Cited by 22 · see citing works
γ-Propoxy-sulfo-lichenin, an antitumor polysaccharide derived from lichenin
Hensel, A. (1995) · Pharmaceutica Acta Helvetiae · doi:10.1016/0031-6865(94)00048-z · Cited by 13 · see citing works
Marchant, H. J. (1977) · Journal of Phycology · doi:10.1111/j.1529-8817.1977.tb00551.x · Cited by 4 · see citing works
[Induction of CuZn-SOD mRNA expression and activity by PGMS in rat liver].
Hu, X., Yu, W., Lu, X.-Z., et al. (2002) · PubMed · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Aebi HE (1983): Catalase. In: Bergmeyer HU, ed., Methods of Enzymatic Analysis, 3rd ed., Vol. 3. Verlag Chemie, Weinheim, Germany, pp. 273-286.
- Zheng JX (1999): Function Food, Vol. 3. Beijing, Chinese Light Industry Press, 106-107, 208-209 [in Chinese].
Cited by
Sorted by citations
Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
Fedorov, S., Ermakova, S., Zvyagintseva, T., & Stonik, V. (2013) · Marine Drugs · doi:10.3390/md11124876 · Cited by 189 · see citing works
Degradation and antioxidant activity of κ-Carrageenans
Sun, T., Tao, H., Xie, J., Zhang, S., & Xu, X. (2010) · Journal of Applied Polymer Science · doi:10.1002/app.31955 · Cited by 91 · see citing works
- Authors
- Hu, X., Jiang, X., Aubree, E., Boulenguer, P., & Critchley, A. T.
- Affiliations
- Ocean University of China (CN)
- Cargill (France) (FR)
- Venue
- Pharmaceutical Biology
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 44
- Issue
- 9
- Pages
- 646-650
- ISSN
- 0925-1618 (ISSN-L)
- 1388-0209
- 1744-5116
- OpenAlex
- W2053505183
- Cited by
- 77
- References
- 28
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 9 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmaceutical Biology (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Keywords
- κ-carrageenase, Cytophaga, anticancer activity, sarcoma 180, sulfate content, catalase activity, thymus weight, immune organs, marine polysaccharides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
