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Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

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Wang, Jin, Wang, Lin, Lou, Guan-Hua, Zeng, Hai-Rong, Hu, Ju, Huang, Qin-Wan, Peng, Wei, Yang, Xiang-Bo·2019·Pharmaceutical Biology
DOI 10.1080/13880209.2019.1577466
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Abstract

CONTEXT: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall (Ranunculaceae). It has been widely used to treat bacillary dysentery, diabetes, pertussis, sore throat, aphtha, and eczema in China. OBJECTIVES: The present paper reviews the latest advances of CR, focusing on the botany, phytochemistry, traditional usages, pharmacokinetics, pharmacology and toxicology of CR and its future perspectives. METHODS: Studies from 1985 to 2018 were reviewed from books; PhD. and MSc. dissertations; the state and local drug standards; PubMed; CNKI; Scopus; the Web of Science; and Google Scholar using the keywords Coptis, Coptidis Rhizoma, Huanglian, and goldthread. RESULTS: Currently, 128 chemical constituents have been isolated and identified from CR. Alkaloids are the characteristic components, together with organic acids, coumarins, phenylpropanoids and quinones. The extracts/compounds isolated from CR cover a wide pharmacological spectrum, including antibacterial, antivirus, antifungal, antidiabetic, anticancer and cardioprotective effects. Berberine is the most important active constituent and the primary toxic component of CR. CONCLUSIONS: As an important herbal medicine in Chinese medicine, CR has the potential to treat various diseases. However, further research should be undertaken to investigate the clinical effects, toxic constituents, target organs and pharmacokinetics, and to establish criteria for quality control, for CR and its related medications. In addition, the active constituents, other than alkaloids, in both raw and processed products of CR should be investigated.

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Research works printed but not linked: 272

  1. Ashraf MJ, Baweja P. 2013. Obesity: the ‘huge' problem in cardiovascular diseases. Missouri Medicine. 110:499–504.
  2. 10.1007/s10059-013-2298-5 · DOI
  3. 10.1016/j.toxlet.2012.10.015 · DOI
  4. Bao TD, L YJ, Yang Q, Weng XG, Zhang YF, Dong Y, Wang YW, Zhu XX. 2010. LC/MS determination of berberine and palmatin in rats plasma after oral administration of extracts Rhizoma Coptidis and its pharmacokinetics study. Chin J Exp Trad Med Formul. 16:186–189.
  5. Bilian X, Daohua X, Wenshuang C. 2011. Effects of berberine on cancellous and cortical bone in rats induced by glucocorticoid. Chin Pharm Bull. 27:965–970.
  6. 10.1371/journal.pone.0021416 · DOI
  7. 10.1371/journal.pone.0013745 · DOI · Paper page
  8. 10.1007/s11418-013-0766-z · DOI
  9. 10.1155/2015/723093 · DOI
  10. 10.2174/138161281939131127110701 · DOI
  11. Cao Y, Pan Q, Cai W, Shen F, Chen GY, Xu LM, Fan JG. 2016. Modulation of gut microbiota by berberine improves steatohepatitis in high-fat diet-fed BALB/C mice. Arch Iran Med. 19:197–203.
  12. 10.1039/C8RA05806G · DOI
  13. 10.1016/j.biopha.2018.04.052 · doi:10.1016/j.biopha.2018.04.052
  14. 10.1016/j.canlet.2018.01.057 · DOI
  15. 10.1177/1074248415627873 · DOI
  16. 10.1371/journal.pone.0105362 · doi:10.1371/journal.pone.0105362
  17. Chen Z. 2006. Collation of complete effective preions for women’s diseases. Beijing: People's Medical Publishing House
  18. 10.1016/j.aca.2008.02.060 · doi:10.1016/j.aca.2008.02.060
  19. Chen L, Wang L, Zhang Q, Zhang S, Ye W. 2012. Non-alkaloid chemical constituents from Coptis chinensis. Chin J Chin Mater Med. 37:1241–1244.
  20. Chen R, Wu Y, Tian W. 2016. Research progress in chemical constituents and related metabolic pathways of Coptidis Rhizoma. Hunan J Trad Chin Med. 32:190–192.
  21. 10.1016/j.fitote.2011.09.014 · doi:10.1016/j.fitote.2011.09.014
  22. 10.1016/j.bbrc.2010.05.153 · DOI
  23. 10.3892/ijmm.2014.1868 · DOI
  24. 10.1016/j.ejphar.2012.05.004 · DOI
  25. Chinese Pharmacopoeia Commission. 2008. Xin yao zhuan zheng biao zhun. Vol. 70. Beijing: China Medical Science Press.
  26. Chinese Pharmacopoeia Commission. 2015. Chinese pharmacopoeia. Vol. 1. Beijing: Medical Science Press.
  27. 10.1055/s-2001-14322 · doi:10.1055/s-2001-14322
  28. 10.1007/s12272-015-0626-3 · DOI
  29. 10.1016/j.fitote.2014.08.006 · DOI
  30. Choi UK, Kim MH, Lee NH. 2007. Optimization of antibacterial activity by gold-thread (Coptidis Rhizoma Franch) against streptococcus mutans using evolutionary operation-factorial design technique. J Microbiol Biotechnol. 17:1880–1884.
  31. 10.1186/1472-6882-14-89 · DOI
  32. Chuanchong X. 2016. Berberine inhibits macrophages inflammatory depending on sirti [Master’s thesis]. Nanjing: Nanjing University of Chinese Medicine.
  33. 10.1021/jf201627w · DOI
  34. 10.1016/j.foodchem.2011.10.065 · doi:10.1016/j.foodchem.2011.10.065
  35. 10.1016/j.biochi.2011.04.013 · DOI
  36. 10.1055/s-0028-1099800 · doi:10.1055/s-0028-1099800
  37. Cui G, Huang X, Zhou K. 2008. Inhibitory effect of Rhizoma Coptidis and its main components berberine on the growth of human nasopharyngeal carcinoma CNE-2Z. Guangdong Med J. 29:737–739.
  38. 10.1016/j.biopha.2016.03.038 · DOI
  39. Dan L, Guangshang C, Xixi S, Qianqian C, Hongsheng S. 2017. An overview of the antiarrhythmic study of alkaloids in Coptidis Rhizoma. Shandong J Trad Chin Med. 2017:164–166.
  40. 10.1371/journal.pone.0104554 · DOI
  41. Dong J. 2003. Lv she bei yao fang. Shanghai: Shanghai science and technology publishing house.
  42. Fan G, Tang C, Yan L, Yang YD, Zhang Y. 2014. Analysis of monosaccharide compositions of polysaccharides in Coptidis Rhizoma by pre-column derivatization HPLC method. Chin J Exp Trad Med Formul. 20:74–78.
  43. 10.1016/j.tca.2008.09.008 · doi:10.1016/j.tca.2008.09.008
  44. Feng J. 2008. Clinical control study and propranolol in the treatment of arrhythmia associated with large doses of berberine and oryzanol and coenzyme Q10. Asia Pac Trad Med. 4:51–53.
  45. 10.1016/j.biopha.2017.07.002 · DOI
  46. 10.3109/13880209.2010.523428 · doi:10.3109/13880209.2010.523428
  47. 10.1016/j.intimp.2016.12.001 · DOI
  48. Feng L, Hao Z, Hua H. 2007. The protective effect of coptisine on gastric mucosal injury induced by irritable mice. West Chin J Pharm Sci. 22:713–714.
  49. Flora of China Committee of Chinese Academy of Sciences. 2004. Flora of China. Vol. 27. Beijing: Science Press; p. 593.
  50. 10.1155/2015/827308 · DOI
  51. 10.1142/S0192415X16500506 · DOI
  52. 10.1248/cpb.24.407 · doi:10.1248/cpb.24.407
  53. 10.3390/ijms15010456 · DOI
  54. Gu N, Zhang X, Yu H. 2017. Based on sequencing of 16s rRNA gene elaborate effect of Coptis chinensis on intestinal microbial diversity in type 2 diabetes mellitus. Chin Trad Herbal Drugs. 48:3998–4004.
  55. 10.1038/srep22612 · DOI
  56. 10.1016/j.atherosclerosis.2013.10.003 · DOI
  57. 10.3109/01480545.2011.589437 · DOI
  58. Han B, Kou S, He K, Han Y, Wang Y, Huang T, Zhou X, Xiao Y, Ye X, Li X. 2017. Anti-hypercholesterolemic effect of berbamine isolated from Rhizoma Coptidis in hypercholesterolemic zebrafish induced by high-cholesterol diet. Iran J Pharm Res. 17:292–306.
  59. 10.1016/j.bmcl.2006.12.085 · DOI · Paper page
  60. 10.1055/s-0035-1568261 · DOI
  61. 10.1016/j.jff.2017.04.041 · DOI
  62. Hirano H, Tokuhira T, Yokoi T, Shingu T. 1997. Isolation of free radical scavenger from Coptidis Rhizoma. Nat Med. 51:539–540.
  63. 10.1155/2014/871720 · DOI
  64. 10.1016/j.canlet.2009.01.033 · DOI
  65. 10.1007/s00204-006-0169-y · DOI · Paper page
  66. 10.1016/j.taap.2013.08.008 · DOI
  67. Huang Q. 2013. Effect of blood glucose on the expression of GLUT1 and GLUT4 in the myocardial of diabetic rats [Master's thesis]. Jinan: Shandong University.
  68. 10.1016/j.ejphar.2015.05.028 · DOI
  69. 10.1016/j.ijcard.2009.06.023 · DOI
  70. 10.1038/srep38524 · DOI
  71. 10.1055/s-2007-981615 · doi:10.1055/s-2007-981615
  72. 10.1016/j.tcm.2013.07.003 · DOI
  73. 10.1016/S0304-3835(00)00496-1 · DOI
  74. Ikuta A, Itokawa H. 1989. Protoberberine alkaloids from Coptis quinquefolia. Plant Med. 43:81–82.
  75. 10.1007/s10482-009-9394-8 · DOI
  76. 10.1152/ajpendo.90599.2008 · DOI · Paper page
  77. 10.3892/mmr.2017.6770 · DOI
  78. 10.1007/s00705-010-0702-4 · doi:10.1007/s00705-010-0702-4
  79. 10.3892/mmr.2017.7467 · DOI
  80. 10.3109/13880209.2014.952838 · DOI
  81. 10.1111/j.1440-1746.2010.06389.x · DOI
  82. 10.3892/or.2016.5327 · doi:10.3892/or.2016.5327
  83. Kai H. 2017. Rhizoma Coptidis alkaloids exert their anti-hyperlipidemic effects through modulation of bile acids signaling and gut microbiota in hyperlipidemia C57BL/6J mice [Dissertation]. Chongqing: Southwest University.
  84. 10.1016/j.bbadis.2016.06.006 · DOI
  85. 10.1093/carcin/bgi154 · DOI
  86. 10.1080/14786419.2014.1001388 · DOI
  87. 10.3390/molecules21091161 · DOI
  88. Ke W. 2007. Study on the effect of Rhizoma Coptidis alkaloids on colon cancer and its molecular mechanism [Master's thesis]. Chongqing: ChongQing Medical University.
  89. 10.1016/j.jcv.2007.10.011 · DOI
  90. 10.1016/j.fct.2009.05.031 · DOI
  91. Kim S, Han J, Kim NY, Lee SK, Cho DH, Choi MY, Kim JS, Kim JH, Choe JH, Nam SJ, et al. 2012. Effect of berberine on p53 expression by TPA in breast cancer cells. Oncol Rep. 27:210–215.
  92. 10.1159/000356591 · DOI
  93. 10.3892/or.2015.3768 · doi:10.3892/or.2015.3768
  94. 10.1248/bpb.30.2120 · DOI
  95. 10.1007/s10973-010-0778-9 · DOI
  96. Kong D, Lu L, Teng S, Sun T, Deng Z, Li Y. 2013. Research on export current situation and countermeasure of Coptis chinensis from Shizhu county. Morder Chin Med. 15:701–703.
  97. 10.1002/cjoc.200990199 · doi:10.1002/cjoc.200990199
  98. 10.1016/j.metabol.2008.08.013 · DOI · Paper page
  99. 10.1016/j.lfs.2016.02.046 · DOI
  100. 10.1016/j.bbrc.2016.09.061 · DOI
  101. 10.1021/jf302832n · DOI
  102. 10.18632/oncotarget.14959 · DOI
  103. 10.3109/13880209.2012.655377 · DOI
  104. 10.1016/j.fct.2009.10.004 · DOI
  105. 10.1016/j.jep.2014.01.011 · doi:10.1016/j.jep.2014.01.011
  106. Lei X. 1985. Master lei's discourse on drug processing. Jinan: Phoenix Science Press.
  107. Lei G, Dun B. 2002. Technical guide for the processing of traditional Chinese Medicine. Xi'an: World Book Publishing Xi'an Company.
  108. Li S. 2013. Processing technology of traditional Chinese medicine. Beijing: Chemical Industry Press.
  109. Li X. 2015. Coptis chinensis and its processed products and the material basis of comparative study on the antibacterial spectrum. [Master's thesis]. Wuhan: Hubei University of Traditional Medicine.
  110. Li H, Cai X, Li XF. 2008. New applications and the side effects of Rhizoma Coptidis in clinic. Med J Chin People Armed Police Forces. 19:661–663.
  111. 10.1016/j.biopha.2008.08.003 · doi:10.1016/j.biopha.2008.08.003
  112. 10.1155/2017/2376893 · DOI
  113. Li O, Pan Y, Wang Z. 2013. Berberine induced apoptosis of hepatoma cells by inhibiting the arachidonic acid metabolic pathway CPLA-COX2. Pharmacol Commun Chin. 4:31–32.
  114. 10.7314/APJCP.2014.15.14.5747 · doi:10.7314/apjcp.2014.15.14.5747
  115. 10.1007/s10600-013-0645-6 · doi:10.1007/s10600-013-0645-6
  116. Li YM, Wang LQ, Deng F, Zhou Q, Sun SQ. 2004. Analysis and assessment of Coptis chinensis for different parts, ages, and heights using fourier transform infrared spectroscopy. Acta Acad Med Sin. 26:614–617.
  117. Li ZF, Wang Q, Feng YL, Luo XJ, Fan MM, Yang SL. 2012. Chemical constituents from Coptis chinensis. Zhong Yao Cai. 35:1438–1441.
  118. 10.7314/APJCP.2014.15.4.1851 · DOI
  119. 10.11569/wcjd.v22.i18.2572 · doi:10.11569/wcjd.v22.i18.2572
  120. Li XG, Yang LG, Chen LX, Qiu F. 2012. Chemical constituents from the decoction of Coptis chinensis Franch. J Shenyang Pharm Univ. 29:193–198.
  121. Li B, Zhang M, Bao L. 1995. Study on the pharmacokinetics of berberine after oral administration in human being. J Harbin Med Univ. 29:382–385.
  122. 10.3727/096504016X14742891049073 · DOI
  123. 10.1002/ptr.2590 · DOI
  124. 10.1016/j.jep.2012.05.022 · DOI
  125. 10.1002/ptr.3617 · DOI
  126. 10.1097/CAD.0b013e328361ab28 · DOI
  127. Liu D, Cao G, Si X, Chen Q, Sun H. 2017. An overview of the antiarrhythmic study of alkaloids in Coptidis Rhizoma. Shandong J Trad Chin Med. 3:164–166.
  128. 10.1016/j.mce.2009.12.027 · DOI
  129. 10.1124/dmd.110.033936 · DOI · Paper page
  130. 10.1039/c3ay42000k · doi:10.1039/c3ay42000k
  131. Liu T, Liang ZS, Ding MH, Zhao YH. 2010. Optimal extraction process of berberine hydrochloride from the leaves of Coptis chinensis. J Northwest Forest Univ. 25:144–147.
  132. 10.1016/j.mrfmmm.2008.12.009 · DOI
  133. 10.1038/sj.bjc.6604167 · DOI
  134. 10.1007/s00210-010-0502-0 · DOI
  135. Liu XT, Chen X, Jin R. 2010. Protective effects of Rhizoma Coptidis on acute myocardial ischemia injured cardiomyocytes in vivo and in vitro. Chin J Infor Trad Chin Med. 28–30.
  136. 10.1016/j.jep.2017.07.023 · doi:10.1016/j.jep.2017.07.023
  137. 10.1016/j.ejphar.2014.01.061 · DOI
  138. 10.1007/s10753-010-9276-2 · DOI
  139. Lu YX. 2004. The complete works of Chinese traditional crafts the preparation of Chinese Medicine. Zhengzhou: Elephant Press.
  140. Luo T, Shen X, Li S, Ouyang T, Wang H. 2016. The protective effect of jatrorrhizine against oxidative stress in primary rat cortical neurons. CNS Neurol Disord Drug Targets. 16:617–623.
  141. Ma H, Chen G, Pei YH. 2013. Isolation and identification of chemical constituents from rhizoma of Coptis chinensis and their cytotoxic activities. J Shenyang Pharm Univ. 63:1–9.
  142. 10.1002/ddr.21302 · DOI
  143. Ma X, Liu H, Chen G. 2015. Effects of berberine combined with photodynamic on apoptosis of gastric cancer MGC-803 cell. Chin J Clin Pharm Ther. 20:961–966.
  144. 10.1517/17425255.2012.722995 · DOI
  145. 10.1016/j.jep.2011.08.074 · doi:10.1016/j.jep.2011.08.074
  146. 10.1016/j.jep.2010.01.047 · DOI
  147. 10.1016/j.jff.2013.07.010 · doi:10.1016/j.jff.2013.07.010
  148. 10.1016/0014-5793(82)80152-X · doi:10.1016/0014-5793(82)80152-x
  149. Mei J. 2008. Study on processing technology and quality control of Coptidis Rhizoma [Dissertation]. Wuhan: Hubei College of Traditional Chinese Medicine.
  150. Mei L. 2011. Analysis of 37 cases of frequent atrial premature beats in the treatment of berberine. Chin J Misdiagn. 11:4467–4467.
  151. 10.1186/s12967-016-0987-5 · DOI
  152. Meng F, Wang L, Zhang J, Yin Z, Zhang Q, Ye W. 2013. Non-alkaloid chemical constituents from the rhizome of Coptis teeta. J Chin Pharm Univ. 44:307–310.
  153. 10.1016/S0031-9422(00)81760-4 · doi:10.1016/s0031-9422(00)81760-4
  154. 10.1038/srep24748 · DOI
  155. Mishan MA, Ahmadiankia N, Matin MM, Heirani-Tabasi A, Shahriyari M, Bidkhori HR, Naderi-Meshkin H, Bahrami AR. 2015. Role of berberine on molecular markers involved in migration of esophageal cancer cells. Cell Mol Biol (Noisy-le-Grand). 61:37–43.
  156. Mizuno M, Kojima H, Iinuma M, Tanaka T, Goto K. 1992. Coumarin derivatives in Coptis trifolia. Ann Proc Gifu Coll Pharm. 42:717–719.
  157. Mizuno M Kojima H Tanaka T Iinuma M Min ZD Murata H. 1988. Benzophenanthridine alkaloids from the seeds of Coptis japonica var. Gifu: Disscta Annual Proceedings of Gifu College of Pharmacy 37.
  158. 10.1089/ars.2012.5116 · DOI · Paper page
  159. 10.1016/j.etap.2014.11.006 · DOI
  160. 10.1248/cpb.26.3652 · doi:10.1248/cpb.26.3652
  161. 10.1590/1414-431x20144293 · DOI
  162. Peng LC, Kang S, Yin ZQ, Jia RY, Song X, Li L, Li ZW, Zou YF, Liang XX, Li LX. 2015. Antibacterial activity and mechanism of berberine against Streptococcus agalactiae. Int J Clin Exp Pathol. 8:5217–5223.
  163. 10.1007/s00044-018-2215-8 · DOI
  164. 10.1093/toxsci/kfn131 · DOI
  165. 10.1039/JS8621500339 · doi:10.1039/js8621500339
  166. 10.3892/etm.2016.3018 · DOI
  167. 10.1016/j.phrs.2010.12.004 · DOI
  168. 10.1055/s-0030-1270920 · DOI
  169. 10.3892/or.2015.4312 · DOI
  170. Sha SM, Zhang YG, Bin XU, Wang HH, Kong XY. 2011. Effect of berberine on cell proliferation and apoptosis in gastric carcinoma cells. J Moder Oncol. 37:2109–2120.
  171. Shen J. 2006. The resource utilization and research progess of Coptidis Rhizoma. J Mod Med Health. 22:1038–1039.
  172. 10.1016/j.ejphar.2012.07.052 · DOI
  173. Sheng M, Sun Q, Wang H. 1993. Study on the pharmacokinetics of berberine hydrochloride in beagle dog vein and oral administration. Chin Pharmacol Bull. 9:64–67.
  174. 10.1016/S0140-6736(14)60886-2 · DOI · Paper page
  175. 10.1016/j.lfs.2013.09.010 · doi:10.1016/j.lfs.2013.09.010
  176. 10.1016/j.intimp.2015.04.045 · DOI
  177. 10.1016/j.freeradbiomed.2014.07.039 · DOI
  178. 10.1128/AAC.02427-14 · DOI
  179. Steenbergen C, Frangogiannis NG. 2012. Chapter 36 - Ischemic heart disease. In: Joseph A. Hill, Eric N. Olson, editors. New York (NY): Muscle, Academic Press; p. 495–521.
  180. 10.3390/molecules22111855 · doi:10.3390/molecules22111855
  181. 10.1159/000449507 · DOI
  182. 10.1016/j.pnpbp.2013.11.005 · DOI
  183. Sun Y, Xia M, Yan H, Han Y, Zhang F, Hu Z, Cui A, Ma F, Liu Z, Gong Q. 2017. Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21. Br J Pharmacol. 12:2139–2148.
  184. 10.1177/1534735413513635 · doi:10.1177/1534735413513635
  185. Tang S. 2011. Classified Materia Medica from historical classics for emergency. Beijing: China Medical Press.
  186. 10.1016/j.jep.2006.04.019 · DOI · Paper page
  187. 10.1074/jbc.M109.033795 · DOI
  188. 10.1016/j.ejps.2017.02.004 · DOI
  189. Ti H. 2017. Effect of Rhizoma Coptidis decoction on intestinal flora and GPR43 pathway GLP-1 and PYY in SD rats with metabolic syndrome [Master's thesis]. Beijing: Beijing University of Chinese Medicine.
  190. 10.1016/j.jep.2011.04.007 · DOI
  191. 10.1248/yakushi1947.76.12_1425 · doi:10.1248/yakushi1947.76.12_1425
  192. 10.1016/j.bbadis.2014.12.004 · DOI
  193. 10.1128/JVI.01382-16 · DOI
  194. Wang G. 1991. Bo ji fang. Beijing: Zhonghua Book Company.
  195. Wang W. 2016. A review on pharmacologic effects of effective ingredients in huanglian. Clin J Chin Med. 8:147–148.
  196. 10.1177/1534735410379121 · doi:10.1177/1534735410379121
  197. 10.1093/cvr/cvp078 · DOI · Paper page
  198. 10.1186/s12985-016-0674-4 · DOI
  199. 10.1186/1472-6882-13-105 · doi:10.1186/1472-6882-13-105
  200. Wang Y, Liu J, Ma A, Chen Y. 2015. Cardioprotective effect of berberine against myocardial ischemia/reperfusion injury via attenuating mitochondrial dysfunction and apoptosis. International J Clin Exp Med. 8:14513–14519.

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Metadata

Authors
Wang, J., Wang, L., Lou, G.-H., Zeng, H.-R., Hu, J., Huang, Q.-W., Peng, W., & Yang, X.-B.
Venue
Pharmaceutical Biology
Publisher
Informa UK Limited
Published
2019-01
Volume
57
Issue
1
Pages
193-225
ISSN
  • 0925-1618 (ISSN-L)
  • 1388-0209
  • 1744-5116
DOI
10.1080/13880209.2019.1577466
OpenAlex
W2936262893
Cited by
424
References
3
FWCI
45.88
Type
journal article
Language
en
Open access
gold
Licence
doi.org/10.1080/policies-text-data-mining (tdm)
Funders
the Sichuan Provincial Administration of Traditional Chinese Medicine (JC011)

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Wang, J., Wang, L., Lou, G.-H., Zeng, H.-R., Hu, J., Huang, Q.-W., Peng, W., & Yang, X.-B. (2019). Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. Pharmaceutical Biology. https://doi.org/10.1080/13880209.2019.1577466

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