The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase
Abstract
AIMS: Endothelial dysfunction is a key event that links obesity, diabetes, hypertension, and cardiovascular diseases. The aim of the present study was to examine the protective effect of the alkaloid drug berberine against hyperglycemia-induced cellular injury and endothelial dysfunction. METHODS AND RESULTS: In both cultured endothelial cells and blood vessels isolated from rat aorta, berberine concentration dependently enhanced phosphorylation of endothelial nitric oxide synthase (eNOS) at Ser1177 and promoted the association of eNOS with heat shock protein 90 (HSP90), leading to an increased production of nitric oxide. Furthermore, berberine attenuated high glucose-induced generation of reactive oxygen species, cellular apoptosis, nuclear factor-kappaB activation, and expression of adhesion molecules, thus suppressing monocyte attachment to endothelial cells. In mouse aortic rings, berberine elicited endothelium-dependent vasodilatations and alleviated high glucose-mediated endothelial dysfunction. All these beneficial effects of berberine on the endothelium were abolished by either pharmacological inhibition of adenosine monophosphate-activated protein kinase (AMPK) or adenovirus-mediated overexpression of a dominant negative version of AMPK. CONCLUSION: Berberine protects against endothelial injury and enhances the endothelium-dependent vasodilatation, which is mediated in part through activation of the AMPK signalling cascade. Berberine or its derivatives may be useful for the treatment and/or prevention of endothelial dysfunction associated with diabetes and cardiovascular disease.
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Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
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Self-citationEndothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace
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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
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Self-citationEndothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)
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Self-citationTreatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine
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Cited by
Current knowledge and pharmacological profile of berberine: An update
Kumar, A., Ekavali, Chopra, K., Mukherjee, M., Pottabathini, R., & Dhull, D. K. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.05.068 · Cited by 530
Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics
Feng, X., Sureda, A., Jafari, S., Memariani, Z., Tewari, D., Annunziata, G., Barrea, L., Hassan, S. T. S., Šmejkal, K., Malaník, M., et al. (2019) · Theranostics · doi:10.7150/thno.30787 · Cited by 465
Molecular Insights and Therapeutic Targets for Diabetic Endothelial Dysfunction
Xu, J., & Zou, M.-H. (2009) · Circulation · doi:10.1161/circulationaha.108.835223 · Cited by 353
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Berberine and Its Role in Chronic Disease
Cicero, A. F. G., & Baggioni, A. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-41334-1_2 · Cited by 285
Metadata
- Authors
- Wang, Y., Huang, Y., Lam, K. S. L., Li, Y., Wong, W. T., Ye, H., Lau, C.-W., Vanhoutte, P. M., & Xu, A.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-02-27
- Volume
- 82
- Issue
- 3
- Pages
- 484-492
- ISSN
- 0008-6363 (ISSN-L)
- 1755-3245
- OpenAlex
- W2152506438
- Cited by
- 165
- References
- 12
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, Y., Huang, Y., Lam, K. S. L., Li, Y., Wong, W. T., Ye, H., Lau, C.-W., Vanhoutte, P. M., & Xu, A. (2009). Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. Cardiovascular Research. https://doi.org/10.1093/cvr/cvp078
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