The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The neurobiology of tobacco dependence: A preclinical perspective on the role of the dopamine projections to the nucleus
Abstract
It is now widely accepted that nicotine is the primary addictive component of tobacco smoke and that a majority of habitual smokers find it difficult to quit smoking because of their dependence upon this component of the smoke. However, although nicotine replacement therapy elicits a clinically valuable and significant improvement in the number of quit attempts that are ultimately successful, its efficacy remains disappointingly low. This review considers some of the reasons for this problem. It focuses on the hypothesis that stimulation of the dopamine (DA) projections to the medial shell and the core of the nucleus accumbens play complementary roles in the development of nicotine dependence. The hypothesis proposes that increased extra-synaptic DA in the medial shell of the accumbens confers hedonic properties on behaviors, such as smoking, which deliver nicotine, and thereby increase the probability that the response is learned. It also summarizes the evidence that the primary role of the increased DA overflow, observed in the accumbal core of nicotine-pretreated individuals, challenged with nicotine, is the attribution of incentive salience to cues associated with delivery of the drug and the transition to Pavlovian responding to these conditioned stimuli. The review argues that sensitization of the DA projections to the accumbal core, and the behaviors that depend upon this process, play a pivotal role in the maintenance of the tobacco smoking habit and that it is this component of the dependence that is inadequately addressed by nicotine replacement therapy.
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“Dopamine release in the core appears to act to generate stimulus-impulse associations (10,11).”
From The Multiple Facets of Cigarette Addiction and What They Mean for Encouraging and Helping Smokers to Stop (2009) · cites this paper as [11]
In the citing paper
“The binding of nicotine to receptors in the ventral tegmental area (VTA), aside from generating the impulse to smoke by virtue of dopamine release in the core of the nucleus accumbens, results in pleasant sensations because of dopamine release in the nucleus accumbens shell (11).”
From The Multiple Facets of Cigarette Addiction and What They Mean for Encouraging and Helping Smokers to Stop (2009) · cites this paper as [11]
Citations
Cites
Accuracy and optimism in smokers' beliefs about quitting
Weinstein, N. D., Slovic, P., & Gibson, G. (2004) · Nicotine & Tobacco Research · doi:10.1080/14622200412331320789 · Cited by 113
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Malin, D. H., Anderson, A. N., & Goyarzu, P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802574-1.00008-9 · Cited by 1
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McGehee, D. S., Iacoviello, M. P., & Mitchum, R. D. (2006) · CRC Press eBooks · doi:10.1201/9781420005431.ch2 · Cited by 1
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“…neurons of the mesencephalon by activating the nicotinic acetylcholine receptors(nAChRs) on the dopaminergic somata (Livingstone and Wonnacott, 2009), inducing the dopamine release in the target areas, particularly the striatum(Pontieri et al., 1996; Balfour, 2004; Subramaniyan and Dani, 2015).”
BackgroundAddiction: A Comprehensive Approach
Brown, J., & West, R. (2017) · Addiction · doi:10.1002/9781118489710.ch1 · Cited by 1
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Cumming, P. D. (2005) · Psyke & Logos · doi:10.7146/pl.v26i1.8203
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Haight, J. R. (2011) · W&M Publish (College of William & Mary)
Muñoz, M. Á., Sanjuan, R., & Montoya, P. (2011)
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DePergola, & Peter, A. S. (2018)
Palmisano, A. N. (2019) · OpenCommons at University of Connecticut (University of Connecticut)
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“…be a good indicator of the addictive potency of cigarette smoke, but also a promising tracer of exposure to the other toxic or carcinogenic substances co-existing in tobacco cigarettes smoke (Balfour, 2004; Borgerding and Klus, 2005; Carter et al., 2009; Johnson et al., 1973; Tayoub et al., 2015).”
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La Neurobiologia della dipendenza
Carter, A., Hall, W., & Nutt, D. (2010)
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Metadata
- Authors
- Balfour, D.
- Affiliations
- University of Dundee (GB)
- Corresponding author
- Balfour, David
- ORCID
- Balfour, David
- Venue
- Nicotine & Tobacco Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-12-01
- Volume
- 6
- Issue
- 6
- Pages
- 899-912
- ISSN
- 1462-2203 (ISSN-L)
- 1469-994X
- OpenAlex
- W2322700613
- Cited by
- 251
- References
- 2
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 12 · 2016: 12 · 2015: 9 · 2014: 14 · 2013: 17 · 2012: 15
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nicotine & Tobacco Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotine dependence, smoking, nucleus accumbens, incentive salience, classical conditioning, nicotine replacement therapy, smoking cessation, hedonic behavior, dopamine sensitization
- MeSH terms
- Conditioning, Classical, Dopamine, Drug Administration Routes, Humans, Neurons, Nicotine, Nucleus Accumbens, Psychological Theory, Synapses, Tobacco Use Disorder, Smoking Cessation
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