Fibromyalgia patients should always be screened for post-traumatic stress disorder
Open accessAbstract
Fibromyalgia (FM) is a chronic, painful non-progressive condition with a multifactorial etiopathogenesis [1,2]. Its prevalence varies worldwide from 2 to 6% in different studies [2,3], and constitu...
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Physical and psychological stressful events, including early life traumatic experience, are fibromyalgia predisposing factors.
“there is strong evidence that physical and psychological stressful events, including early life traumatic experience, are FM predisposing factors [16,17].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [17]
The main text (page not provided) describes traumatic brain injury and severe emotional stress, including childhood sexual abuse, as possible FM triggers. But it frames the role of early-life and later trauma as a hypothesis involving genetically susceptible people, rather than establishing unqualified strong evidence that these events are predisposing factors. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThe model is in tune with a bulk of data suggesting a role of HPA and HPG axes in FM pathogenesis.
“Third, it is in tune with a bulk of data suggesting a role of HPA and HPG axes in FM pathogenesis [10–17]”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [17]
In the paper’s main text (page unavailable), Nardi says FM patients might have a distinctive HPA dysfunction pattern and describes HPA-cycle dysregulation in FM and PTSD. The copy does not address the HPG axis, so it supports only the HPA portion of the attributed claim. (LLM, conf=0.85)
Experimental — accuracy not yet measured
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“● Clinical implications include prevention, diagnosis, and treatment, highlighting the need for an interdisciplinary and biopsychosocial approach.”
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“The importance of these epidemiological and clinical findings is linked to the negative impact on therapy and prognosis that the presence of PTSD and also partial or subthreshold forms (post-traumatic stress symptoms) can have in patients suffering from FM [47,48].”
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“Notably, a history of childhood sexual abuse is prevalent and reported in up to 64% of cases (Anderberg et al., 2000; Goldberg et al., 1999; Häuser et al., 2011; Nardi et al., 2020).”
Fibromyalgia in patients infected with HTLV-1 and HTLV-2
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- Authors
- Nardi, A. E., Karam, E. G., & Carta, M. G.
- Affiliations
- Institute of Psychiatry, Laboratory of Panic & Respiration, Federal University of Rio De Janeiro, Brazil
- University of Balamand (LB)
- University of Cagliari (IT)
- Venue
- Expert Review of Neurotherapeutics
- Publisher
- Informa UK Limited
- Published
- 2020-07-23
- Volume
- 20
- Issue
- 9
- Pages
- 891-893
- ISSN
- 1473-7175 (ISSN-L)
- 1744-8360
- OpenAlex
- W3043584153
- Cited by
- 15
- References
- 19
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 3 · 2021: 2 · 2020: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Expert Review of Neurotherapeutics (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion, public-domain)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- fibromyalgia, post-traumatic stress disorder, screening, comorbidities, chronic pain, etiopathogenesis
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