Efficacy of probiotic supplement for gestational diabetes mellitus: a systematic review and meta-analysis
Abstract
BACKGROUND: Probiotic supplement might be beneficial for gestational diabetes mellitus. However, the results remained controversial. We conducted a systematic review and meta-analysis to explore the efficacy of probiotic supplement in gestational diabetes mellitus. METHODS: PubMed, Embase, Web of science, EBSCO, and Cochrane Library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of probiotic supplement in gestational diabetes mellitus were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies. The primary outcome were fasting serum insulin and fasting plasma glucose. Meta-analysis was performed using the fixed-effect or random-effect model. RESULTS: Six RCTs involving 830 patients were included in the meta-analysis. Overall, compared with control intervention in gestational diabetes mellitus, probiotic supplementation intervention was found to significantly reduce fasting serum insulin (Std. mean difference = -0.95; 95% CI = -1.73 to -0.17; p < .00001) and HOMA-IR (Std. mean difference = -1.12; 95% CI = -2.05 to -0.18; p = .02), but showed no substantial impact on fasting plasma glucose (Std. mean difference = -0.49; 95% CI = -1.05-0.08; p = .09), gestational age (Std. mean difference = 0.07; 95% CI = -0.20-0.34; p = .63), and gestational weight (Std. mean difference = -0.11; 95% CI = -0.38-0.16; p = .43). CONCLUSIONS: Compared with control intervention in gestational diabetes mellitus, probiotic supplementation was found to significantly reduce insulin resistance (HOMA-IR) and fasting serum insulin, but had no substantial influence on fasting plasma glucose, gestational age and gestational weight.
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Studies on the beneficial effects of probiotics in the prevention or treatment of GDM have inconclusive results.
“However, in the conducted studies on the beneficial effects of probiotics in the prevention or treatment of GDM, the results are still inconclusive [88,89,90,91].”
From Gestational Diabetes Mellitus—Recent Literature Review (2022) · cites this paper as [90]
Cites
1 retracted
Badehnoosh, B., Karamali, M., Zarrati, M., Jamilian, M., Bahmani, F., Ebrahimi, M. T., Jafari, P., Rahmani, E., & Asemi, Z. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1310193 · Cited by 131 · see citing works
RetractedPreferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859 · see citing works
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582 · see citing works
Gestational Diabetes and the Incidence of Type 2 Diabetes
Kim, C., Newton, K. M., & Knopp, R. H. (2002) · Diabetes Care · doi:10.2337/diacare.25.10.1862 · Cited by 2,276 · see citing works
Gluud, L. L., Villumsen, J., & Gluud, C. N. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-135-11-200112040-00010 · Cited by 2,262 · see citing works
A Metagenomic Approach to Characterization of the Vaginal Microbiome Signature in Pregnancy
Aagaard, K. M., Riehle, K. P., Ma, J., Segata, N., Mistretta, T., Coarfa, C., Raza, S., Rosenbaum, S., den Veyver, I. B. V., Milosavljevic, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036466 · Cited by 714 · see citing works
Yadav, H., Jain, S., & Sinha, P. R. (2006) · Nutrition · doi:10.1016/j.nut.2006.09.002 · Cited by 590 · see citing works
Antioxidative Ability of Lactic Acid Bacteria
Lin, M., & Yen, C.-L. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf981149l · Cited by 511 · see citing works
Asemi, Z., Zare, Z., Shakeri, H., Sabihi, S.-S., & Esmaillzadeh, A. (2013) · Annals of Nutrition and Metabolism · doi:10.1159/000349922 · Cited by 393 · see citing works
Gut microbiota, probiotics and diabetes
Gomes, A. C., Bueno, A. A., de Souza, R. G. M., & Mota, J. F. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-60 · Cited by 363 · see citing works
Laitinen, K., Poussa, T. A., Isolauri, E., & the Nutrition, A. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508111461 · Cited by 309 · see citing works
Percentage of Gestational Diabetes Mellitus Attributable to Overweight and Obesity
Kim, S. Y., England, L., Wilson, H. G., Bish, C., Satten, G. A., & Dietz, P. (2010) · American Journal of Public Health · doi:10.2105/ajph.2009.172890 · Cited by 302 · see citing works
Gut microbiota in obesity and metabolic disorders
Sanz, Y., Santacruz, A., & Gauffin-Cano, P. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110001813 · Cited by 281 · see citing works
Lambert, J. M., Bongers, R. S., de Vos, W. M., & Kleerebezem, M. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00137-08 · Cited by 212 · see citing works
Diet and exercise interventions for preventing gestational diabetes mellitus
Bain, E., Crane, M., Tieu, J., Han, S., Crowther, C. A., & Middleton, P. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010443.pub2 · Cited by 188 · see citing works
Ovesen, P., Jensen, D. M., Damm, P., Rasmussen, S. C., & Kesmodel, U. S. (2014) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.966677 · Cited by 174 · see citing works
Wickens, K. L., Barthow, C. A., Murphy, R., Abels, P. R., Maude, R., STONE, P. R., Mitchell, E. A., Stanley, T., Purdie, G., Kang, J., et al. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517000289 · Cited by 173 · see citing works
Karamali, M., Dadkhah, F., Sadrkhanlou, M., Jamilian, M., Ahmadi, S., Ebrahimi, M. T., Jafari, P., & Asemi, Z. (2016) · Diabetes & Metabolism · doi:10.1016/j.diabet.2016.04.009 · Cited by 168 · see citing works
Lindsay, K. L., Brennan, L., Kennelly, M. A., Maguire, O. C., Smith, T., Curran, S., Coffey, M., Foley, M. E., Hatunic, M., Shanahan, F., et al. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.02.008 · Cited by 136 · see citing works
Jafarnejad, S., Saremi, S., Jafarnejad, F., & Arab, A. (2016) · Journal of Nutrition and Metabolism · doi:10.1155/2016/5190846 · Cited by 134 · see citing works
Dolatkhah, N., Hajifaraji, M., Abbasalizadeh, F., Aghamohammadzadeh, N., Mehrabi, Y., & Abbasi, M. M. (2015) · Journal of Health Population and Nutrition · doi:10.1186/s41043-015-0034-9 · Cited by 133 · see citing works
Dietary advice interventions in pregnancy for preventing gestational diabetes mellitus
Tieu, J., Shepherd, E. S., Middleton, P., & Crowther, C. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006674.pub3 · Cited by 131 · see citing works
Zarrati, M., Salehi, E., Nourijelyani, K., Mofid, V., Zadeh, M. J. H., Najafi, F., Ghaflati, Z., Bidad, K., Chamari, M., Karimi, M., et al. (2014) · Journal of the American College of Nutrition · doi:10.1080/07315724.2013.874937 · Cited by 130 · see citing works
Taylor, B., Woodfall, G., Sheedy, K., O’Riley, M., Rainbow, K., Bramwell, E., & Kellow, N. J. (2017) · Nutrients · doi:10.3390/nu9050461 · Cited by 128 · see citing works
Interventions for Preventing Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis
Oostdam, N., van Poppel, M. N. M., Wouters, M. G. A. J., & van Mechelen, W. (2011) · Journal of Women s Health · doi:10.1089/jwh.2010.2703 · Cited by 113 · see citing works
Bruno, R., Petrella, E., Bertarini, V., Pedrielli, G., Neri, I., & Facchinetti, F. (2016) · Maternal and Child Nutrition · doi:10.1111/mcn.12333 · Cited by 101 · see citing works
Probiotics as beneficial agents in the management of diabetes mellitus: a systematic review
Razmpoosh, E., Javadi, M., Ejtahed, H., & Mirmiran, P. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2665 · Cited by 95 · see citing works
Kim, S., England, L., Sappenfield, W. M., WILSON, H. G. E., Bish, C., Salihu, H., & Sharma, A. J. (2012) · Preventing Chronic Disease · doi:10.5888/pcd9.110249 · Cited by 94 · see citing works
Neonatal complications and risk factors among women with gestational diabetes mellitus
Schneider, S. O., Hoeft, B., Freerksen, N., Fischer, B., Roehrig, S., Yamamoto, S. S., & Maul, H. (2010) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/j.1600-0412.2010.01040.x · Cited by 82 · see citing works
The Role of Adipokines in Gestational Diabetes Mellitus
Al-Badri, M. R., Zantout, M. S., & Azar, S. T. (2015) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018815577039 · Cited by 71 · see citing works
Impact of Fetal Reduction on the Incidence of Gestational Diabetes
Sivan, E., Maman, E., Homko, C. J., Lipitz, S., Cohen, S., & Schiff, E. (2002) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(01)01661-1 · Cited by 68 · see citing works
Hung, T., & Hsieh, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122261 · Cited by 61 · see citing works
Yu, X., Li, S., Yang, D. L., Qiu, L., Wu, Y., Wang, D., Shah, N. P., Xu, F., & Wei, H. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-10265 · Cited by 53 · see citing works
Perinatal Outcomes of Prenatal Probiotic and Prebiotic Administration
VandeVusse, L., Hanson, L., & Safdar, N. (2013) · The Journal of Perinatal & Neonatal Nursing · doi:10.1097/jpn.0b013e3182a1e15d · Cited by 43 · see citing works
Wang, C., Wei, Y., Zhang, X., Zhang, Y., Xu, Q., Su, S., Zhang, L., Liu, C., Feng, Y., Shou, C., et al. (2016) · Diabetes Care · doi:10.2337/dc16-1320 · Cited by 42 · see citing works
Tobias, D. K., Zhang, C., Chavarro, J. E., Olsen, S. F., Bao, W., Bjerregaard, A. A., Fung, T. T., Manson, J. E., & Hu, F. B. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.156 · Cited by 40 · see citing works
Sreelakshmi, P., Nair, S., Soman, B., Alex, R., Vijayakumar, K., & Kutty, V. (2015) · Journal of Family Medicine and Primary Care · doi:10.4103/2249-4863.161331 · Cited by 37 · see citing works
Facchinetti, F., Dante, G., Petrella, E., & Neri, I. (2014) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000121 · Cited by 32 · see citing works
Renzaho, A. M. N., Skouteris, H., & Oldroyd, J. C. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2010.09.017 · Cited by 24 · see citing works
Nicklas, J. M., Skurnik, G., Zera, C., Reforma, L. G., Levkoff, S. E., & Seely, E. W. (2015) · Maternal and Child Health Journal · doi:10.1007/s10995-015-1825-8 · Cited by 13 · see citing works
Flagged first, then by citations
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Kampmann, U., Knorr, S., Fuglsang, J., & Ovesen, P. (2019) · Journal of Diabetes Research · doi:10.1155/2019/5320156 · Cited by 400 · see citing works
Diet and Healthy Lifestyle in the Management of Gestational Diabetes Mellitus
Rasmussen, L., Poulsen, C. W., Kampmann, U., Smedegaard, S. B., Ovesen, P. G., & Fuglsang, J. (2020) · Nutrients · doi:10.3390/nu12103050 · Cited by 304 · see citing works
Gestational Diabetes Mellitus—Recent Literature Review
Modzelewski, R., Stefanowicz-Rutkowska, M. M., Matuszewski, W., & Bandurska-Stankiewicz, E. M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11195736 · Cited by 223 · see citing works
Mafi, A., Namazi, G., Soleimani, A., Bahmani, F., Aghadavod, E., & Asemi, Z. (2018) · Food & Function · doi:10.1039/c8fo00888d · Cited by 102 · see citing works
Gut Microbiome Changes in Gestational Diabetes
Ionescu, R. F., Enache, R. M., Creţoiu, S. M., & Gașpar, B. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112839 · Cited by 66 · see citing works
The gut microbiome in pregnancy and pregnancy complications
Turjeman, S. C., Collado, M. C., & Koren, O. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.03.004 · Cited by 50 · see citing works
Łagowska, K., Malinowska, A. M., Zawieja, B. E., & Zawieja, E. E. (2020) · Scientific Reports · doi:10.1038/s41598-020-74773-8 · Cited by 46 · see citing works
Zarezadeh, M., Musazadeh, V., Faghfouri, A. H., Sarmadi, B., Jamilian, P., Jamilian, P., Tutunchi, H., & Dehghan, P. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106397 · Cited by 43 · see citing works
Chan, K. Y., Wong, M. M. H., Pang, S. S. H., & Lo, K. K.-H. (2021) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-021-06023-9 · Cited by 43 · see citing works
Shahriari, A., Karimi, E., Shahriari, M., Aslani, N., Khooshideh, M., & Arab, A. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111915 · Cited by 39 · see citing works
Shabani, A., Noshadian, M., Jamilian, M., Chamani, M., Mohammadi, S., & Asemi, Z. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.04.071 · Cited by 34 · see citing works
Pan, Y., Zheng, Q., Jiang, X., Chen, X.-Q., Zhang, X., & Wu, J.-L. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/9830200 · Cited by 33 · see citing works
Hasain, Z., Roos, N. A. C., Rahmat, F., Mustapa, M., Ali, R. A. R., & Mokhtar, N. M. (2021) · Nutrients · doi:10.3390/nu13093045 · Cited by 30 · see citing works
Ma, H., Qiao, Z., Li, N., Zhao, Y., & Zhang, S. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-21-1036 · Cited by 27 · see citing works
Yang, J., Wang, J., Wu, W., Su, C., Wu, Y., & Li, Q. (2024) · Food & Function · doi:10.1039/d3fo04681h · Cited by 27 · see citing works
Ding, Q., Hu, Y., Fu, Y., & Qian, L. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-21-2061 · Cited by 25 · see citing works
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Xu, D., Fu, L., Pan, D., Chu, Y., Feng, M., Lü, Y., Yang, C., Wang, Y., Xia, J., & Sun, G. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2117783 · Cited by 18 · see citing works
Skonieczna‐Żydecka, K., Kaźmierczak-Siedlecka, K., Kaczmarczyk, M., Śliwa‐Dominiak, J., Maciejewska, D., Janda, K., Stachowska, E., Łoniewska, B., Malinowski, D., Borecki, K., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061788 · Cited by 16 · see citing works
Gray, S. G., Sweeting, A., McGuire, T., Cohen, N. D., Ross, G. P., & Little, P. J. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12660 · Cited by 16 · see citing works
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Suastika, A. V., Widiana, I. G. R., Fatmawati, N. N. D., Suastika, K., Paulus, I. B., & Sujaya, I. N. (2023) · AJOG Global Reports · doi:10.1016/j.xagr.2023.100285 · Cited by 9 · see citing works
Chen, X., Pan, L., Zhang, Z., Niu, R., Zhang, H., & Ma, T. (2022) · Zeitschrift für Geburtshilfe und Neonatologie · doi:10.1055/a-1956-3927 · Cited by 7 · see citing works
Self-citationProbiotic therapy as a promising strategy for gestational diabetes mellitus management
Lemos, D. E. D. A., Alves, J. L. D. B., & de Souza, E. L. (2024) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2024.2409880 · Cited by 7 · see citing works
Byrne, D. F., Geraghty, A. A., Yelverton, C. A., Murphy, E. F., van Sinderen, D., Cotter, P. D., & McAuliffe, F. M. (2020) · Food & Function · doi:10.1039/d0fo01727b · Cited by 5 · see citing works
Kang, D., Zhang, F., Yang, Y., Liu, C., Xiao, J., Long, Y., Huang, J., Peng, X., Wang, W., Wang, X., et al. (2021) · medRxiv · doi:10.1101/2021.02.16.21251872 · Cited by 3 · see citing works
Nikpour, S., Ghaemi, N., Moazzen, N., Bagheri, S., Asl, S. N., Ahanchian, H., & Sadeghi, T. (2025) · Journal of Comprehensive Pediatrics · doi:10.5812/jcp-162615 · Cited by 2 · see citing works
McKerracher, L., Moffat, T., Barker, M., Murray‐Davis, B., Kennedy, K. M., Bellissimo, C. J., Yeo, E., Høtoft, D., Zalot, L. C., Parlette, V., et al. (2023) · PharmaNutrition · doi:10.1016/j.phanu.2023.100344 · Cited by 2 · see citing works
Ren, H., Zhang, N., Li, Y., Li, Y., Wang, M., Bu, H., & Wang, H. (2026) · International Journal of General Medicine · doi:10.2147/ijgm.s576626 · Cited by 2 · see citing works
Current Resources for Evidence-Based Practice, July 2019
Bovbjerg, M. L. (2019) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1016/j.jogn.2019.05.006
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Saunders, C., & dos Santos, K. (2021) · Springer eBooks · doi:10.1007/978-3-030-83434-0_8
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SKOREK, K., BABIAK, R., BAJAK, K., CZUCHRYTA, P., Domańska, A., Gawęda, A., Grabek, A., RUTKOWSKA, J., RZĘSA-TOKARCZYK, Ż., & URBAŃCZYK, A. (2023) · Journal of Education Health and Sport · doi:10.12775/jehs.2023.38.01.014
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- Authors
- Pan, J., Pan, Q., Chen, Y., Zhang, H., & Zheng, X.
- Affiliations
- Department of Obstetrics and Gynecology, Wenzhou People’s Hospital, Wenzhou Maternal and Child Health Hospital, Wenzhou Zhejiang, PR China
- Corresponding author
- Pan, Qiangwei
- Zheng, Xiaodong
- Venue
- The Journal of Maternal-Fetal & Neonatal Medicine
- Publisher
- Informa UK Limited
- Published
- 2017-09-19
- Volume
- 32
- Issue
- 2
- Pages
- 317-323
- ISSN
- 1476-4954 (ISSN-L)
- 1476-7058
- OpenAlex
- W2756238344
- Cited by
- 35
- References
- 41
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 4 · 2019: 3 · 2018: 3
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- probiotics, gestational diabetes mellitus, insulin resistance, fasting insulin, fasting blood glucose, HOMA-IR, gestational weight, gestational age, probiotic supplementation
- MeSH terms
- Blood Glucose, Female, Humans, Insulin Resistance, Pregnancy, Diabetes, Gestational, Treatment Outcome, Dietary Supplements, Probiotics
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