Comparison of different methods for the extraction of cannabinoids from cannabis
Open accessAbstract
Cannabis oils, namely concentrated cannabis extracts, are getting plenty of attention because of their therapeutic potential for treatment of patients with cancer, HIV, multiple sclerosis and several other pathologies. Here we propose the use of ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE) as alternative methods to the current protocols followed by pharmacists, the only authorized to manipulate standardized Cannabis. A third method, consisting of the use of Tween 20 as surfactant, was considered. Our best extraction methodology for commercial hemp extraction was applied to medicinal cannabis. Here we report the results obtained for ‘Eletta campana’, ‘Carmagnola selezionata’, Bediol®, FM2® and Bedrocan®.
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Ultrasound-assisted extraction was used to produce extracts from cannabis containing cannabinoids, flavonoids, anthocyanin, stilbenoids, lignans, and oil.
“ultrasound-assisted extraction (UAE) was used to produce extracts from cannabis containing cannabinoids, flavonoids, anthocyanin, stilbenoids, lignans, and oil [43,44,45,46].”
From Supercritical Carbon Dioxide Technology for Recovering Valuable Phytochemicals from Cannabis sativa L. and Valorization of Its Biomass for Food Applications (2023) · cites this paper as [43]
Cites
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis
Whiting, P. F., Wolff, R. F., Deshpande, S., Di Nisio, M., Duffy, S., Hernandez, A. V., Keurentjes, J. C., Lang, S., Misso, K., Ryder, S., et al. (2015) · JAMA · doi:10.1001/jama.2015.6358 · Cited by 2,169 · see citing works
Giacoppo, S., Bramanti, P., & Mazzon, E. (2017) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2017.06.015 · Cited by 92 · cited 1× · see citing works
“…sativa, used as oromucosal spray (Sativex, GW Pharma Ltd.) obtained approval for pharmaceutical uses (Badowski and Yanful 2018; Nielsen et al. 2018; Giacoppo et al. 2017) In addition, several standardized cannabinoid preparations from dried female flower tops of the plant, which must be handled…”
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Processing and extraction methods of medicinal cannabis: a narrative review
Lazarjani, M. P., Young, O., Kebede, L., & Seyfoddin, A. (2021) · Journal of Cannabis Research · doi:10.1186/s42238-021-00087-9 · Cited by 144 · see citing works
Baldino, L., Scognamiglio, M., & Reverchon, E. (2020) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2020.104960 · Cited by 129 · see citing works
de Aguiar, A. C., Vardanega, R., Viganó, J., & Silva, E. K. (2023) · Molecules · doi:10.3390/molecules28093849 · Cited by 51 · see citing works
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Cannabis Extraction Technologies: Impact of Research and Value Addition in Latin America
Suárez-Jacobo, Á., Díaz Pacheco, A., Bonales-Alatorre, E., Castillo-Herrera, G. A., & García-Fajardo, J. A. (2023) · Molecules · doi:10.3390/molecules28072895 · Cited by 13 · see citing works
- Authors
- De Vita, D., Madia, V. N., Tudino, V., Saccoliti, F., De Leo, A., Messore, A., Roscilli, P., Botto, A., Pindinello, I., Santilli, G., Scipione, L., Costi, R., & Di Santo, R.
- Affiliations
- Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti, Università di Roma La Sapienza, Roma, Italy;
- Istituto Pasteur (IT)
- Exenia group srl Albignasego, Padova, Italy
- Corresponding author
- Costi, Roberta
- ORCID
- Venue
- Natural Product Research
- Publisher
- Informa UK Limited
- Published
- 2019-04-29
- Volume
- 34
- Issue
- 20
- Pages
- 2952-2958
- ISSN
- 1478-6419 (ISSN-L)
- 1478-6427
- OpenAlex
- W2943047807
- Cited by
- 50
- References
- 2
- Citations by year
- 2025: 7 · 2024: 4 · 2023: 9 · 2022: 13 · 2021: 14 · 2020: 2 · 2019: 1
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- cc-by
- Locations
- Natural Product Research (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Iris (Roma Tre University) (submittedVersion)
- Figshare (cc-by)
- Funders
- AbbVie
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural and Biological Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Keywords
- cannabinoids, cannabis, medical cannabis, hemp, ultrasound-assisted extraction, microwave-assisted extraction, Tween 20, surfactant-assisted extraction, extraction method comparison
- MeSH terms
- Cannabinoids, Cannabis, Chemical Fractionation, Microwaves, Plant Extracts, Polysorbates, Surface-Active Agents, Ultrasonics, Molecular Structure
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