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Mammalian Hyaluronan Synthases
Abstract
Three mammalian hyaluronan (HA) synthase genes, HAS1, HAS2, and HAS3, have been cloned and expressed, allowing the mechanisms for regulation of HA biosynthesis and function to be studied. The hyaluronan synthase (HAS) isoforms differ in kinetic characteristics and product size. The expression of each HAS isoform is controlled in a different fashion when mammalian cells are stimulated by various cytokines and the expression patterns are both spatially and temporally regulated during embryonic development. The existence of three different HAS isoforms with different characteristics implies that the broad range of biological and physiological roles performed by HA are regulated by controlling the activities and expression of the HAS isoforms. This review focuses on recent findings on the regulatory mechanisms for controlling HA biosynthesis and provides new insights into the enzymic basis for the functional regulation of HA.
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Cited by
Hyaluronan as an Immune Regulator in Human Diseases
Jiang, D., Liang, J., & Noble, P. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00052.2009 · Cited by 1,060
Hyaluronic acid: A key molecule in skin aging
Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012) · Dermato-Endocrinology · doi:10.4161/derm.21923 · Cited by 1,031
Misra, S., Hascall, V. C., Markwald, R. R., & Ghatak, S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00201 · Cited by 830
Taylor, K. R., & Gallo, R. L. (2006) · The FASEB Journal · doi:10.1096/fj.05-4682rev · Cited by 639
Hyaluronic Acid: Redefining Its Role
Abatangelo, G., Vindigni, V., Avruscio, G., Pandis, L., & Brun, P. (2020) · Cells · doi:10.3390/cells9071743 · Cited by 533
Metadata
- Authors
- Itano, N., & Kimata, K.
- Venue
- IUBMB Life
- Publisher
- Wiley
- Published
- 2002-10
- Volume
- 54
- Issue
- 4
- Pages
- 195-199
- ISSN
- 1521-6543 (ISSN-L)
- 1521-6551
- OpenAlex
- W2057267126
- Cited by
- 426
- References
- 0
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- closed
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