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Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite
Abstract
The mitochondrial respiratory chain continually produces superoxide leading to high levels of mitochondrial oxidative stress. This oxidative damage has been attributed to the formation of hydroxyl radicals and hydrogen peroxide from superoxide. Alternatively, mitochondrial superoxide may react with nitric oxide forming the potent oxidant peroxynitrite, thus damaging mitochondrial protein, lipid and DNA. To test this hypothesis we induced mitochondrial superoxide formation in the presence of nitric oxide. Here we demonstrate that mitochondrial superoxide reacts with nitric oxide to form peroxynitrite, suggesting that mitochondria may be a significant intracellular source of peroxynitrite.
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“In addition, peroxynitrite is capable of nitrating tyrosine or tryptophan residues, or oxidising methionine residues [123,124,125,126,127,128].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [124]
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Metadata
- Authors
- Packer, M. A., Porteous, C. M., & Murphy, M. P.
- Affiliations
- University of Otago (NZ)
- Corresponding author
- Murphy, Michael P.
- Venue
- IUBMB Life
- Publisher
- Wiley
- Published
- 1996-10
- Volume
- 40
- Issue
- 3
- Pages
- 527-534
- ISSN
- 1521-6543 (ISSN-L)
- 1521-6551
- OpenAlex
- W2060263803
- Cited by
- 118
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IUBMB Life (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- superoxide, nitric oxide, peroxynitrite, mitochondria, mitochondrial respiratory chain, oxidative stress, nitrosative stress, mitochondrial DNA damage, lipid peroxidation
- MeSH terms
- Animals, Antimycin A, Cattle, Cell Membrane, DNA Damage, DNA, Mitochondrial, Mitochondria, Heart, Nitrates, Nitric Oxide, Superoxides, Oxidative Stress
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