Cited by 118Redox biology and oxidative stressMitochondrial Function and PathologyNitric Oxide and Endothelin Effects

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Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite

Packer, Michael A., Porteous, Carolyn M., Murphy, Michael P.·1996·IUBMB Life

DOI 10.1080/15216549600201103

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Abstract

The mitochondrial respiratory chain continually produces superoxide leading to high levels of mitochondrial oxidative stress. This oxidative damage has been attributed to the formation of hydroxyl radicals and hydrogen peroxide from superoxide. Alternatively, mitochondrial superoxide may react with nitric oxide forming the potent oxidant peroxynitrite, thus damaging mitochondrial protein, lipid and DNA. To test this hypothesis we induced mitochondrial superoxide formation in the presence of nitric oxide. Here we demonstrate that mitochondrial superoxide reacts with nitric oxide to form peroxynitrite, suggesting that mitochondria may be a significant intracellular source of peroxynitrite.

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Authors: Packer, M. A., Porteous, C. M., & Murphy, M. P.
Affiliations: University of Otago (NZ)
Corresponding author: Murphy, Michael P.
ORCID: Packer, Michael A.
Murphy, Michael P.
Venue: IUBMB Life
Publisher: Wiley
Published: 1996-10
Volume: 40
Issue: 3
Pages: 527-534
ISSN: 1521-6543 (ISSN-L)
1521-6551
DOI: 10.1080/15216549600201103
OpenAlex: W2060263803
Cited by: 118
References: 0
Citations by year: 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 2
FWCI: 1.88
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4124 d)
Locations: IUBMB Life (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: superoxide, nitric oxide, peroxynitrite, mitochondria, mitochondrial respiratory chain, oxidative stress, nitrosative stress, mitochondrial DNA damage, lipid peroxidation
MeSH terms: Animals, Antimycin A, Cattle, Cell Membrane, DNA Damage, DNA, Mitochondrial, Mitochondria, Heart, Nitrates, Nitric Oxide, Superoxides, Oxidative Stress

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Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite

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