Murphy, Michael P.

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 8,207

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Chouchani, E. T., Pell, V. R., Gaude, E., Aksentijević, D., Sundier, S. Y., Robb, E. L., Logan, A., Nadtochiy, S. M., Ord, E. N. J., Smith, A. C., et al. (2014) · Nature

Cardiac Ischemia and ReperfusionMitochondrial Function and Pathology

Cited by 2,907

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Mills, E. L., Kelly, B., Logan, A., Costa, A. S. H., Varma, M., Bryant, C. E., Tourlomousis, P., Däbritz, J. H. M., Gottlieb, E., Latorre, I., et al. (2016) · Cell

Immune cells in cancerMitochondrial Function and Pathology

Cited by 2,291

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., et al. (2018) · Nature

Genomics, phytochemicals, and oxidative stressImmune cells in cancer

Cited by 1,885

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

Sies, H., Belousov, V. V., Chandel, N. S., Davies, M. J., Jones, D. P., Mann, G. E., Murphy, M. P., Yamamoto, M., & Winterbourn, C. (2022) · Nature Reviews Molecular Cell Biology

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 1,735

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

Murphy, M. P., Bayir, H., Belousov, V., Chang, C. J., Davies, K. J. A., Davies, M. J., Dick, T. P., Finkel, T., Forman, H. J., Janssen-Heininger, Y., et al. (2022) · Nature Metabolism

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 1,514

Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations

Murphy, M. P., & Smith, R. A. J. (2007) · Annual Review of Pharmacology and Toxicology

Mitochondrial Function and PathologyCoenzyme Q10 studies and effects

Cited by 1,173

Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells

Kelso, G. F., Porteous, C. M., Coulter, C. V., Hughes, G., Porteous, W. K., Ledgerwood, E. C., Smith, R. A. J., & Murphy, M. P. (2001) · Journal of Biological Chemistry

Coenzyme Q10 studies and effectsMitochondrial Function and Pathology

Cited by 1,091

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Cunnane, S. C., Trushina, E., Morland, C., Prigione, A., Casadesus, G., Andrews, Z. B., Beal, M. F., Bergersen, L. H., Brinton, R. D., de la Monte, S., et al. (2020) · Nature Reviews Drug Discovery

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 1,003

Unraveling the biological roles of reactive oxygen species

Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., et al. (2011) · Cell Metabolism

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 836

Selective fluorescent imaging of superoxide in vivo using ethidium-based probes

Robinson, K. M., Janes, M. S., Pehar, M., Monette, J. S., Ross, M. F., Hagen, T. M., Murphy, M. P., & Beckman, J. S. (2006) · Proceedings of the National Academy of Sciences

Molecular Sensors and Ion DetectionRedox biology and oxidative stress

Cited by 777

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

Chouchani, E. T., Pell, V. R., James, A. M., Work, L. M., Saeb-Parsy, K., Frezza, C., Krieg, T., & Murphy, M. P. (2016) · Cell Metabolism

Cardiac Ischemia and ReperfusionMitochondrial Function and Pathology

Cited by 752

Delivery of bioactive molecules to mitochondria in vivo

Smith, R. A. J., Porteous, C. M., Gane, A. M., & Murphy, M. P. (2003) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyCoenzyme Q10 studies and effects

Cited by 725

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

Chouchani, E. T., Methner, C., Nadtochiy, S. M., Logan, A., Pell, V. R., Ding, S., James, A. M., Cochemé, H. M., Reinhold, J., Lilley, K. S., et al. (2013) · Nature Medicine

Cardiac Ischemia and ReperfusionMitochondrial Function and Pathology

Cited by 619

Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury

Adlam, V. J., Harrison, J. C., Porteous, C. M., James, A. M., Smith, R. A. J., Murphy, M. P., & Sammut, I. A. (2005) · The FASEB Journal

Cardiac Ischemia and ReperfusionMitochondrial Function and Pathology

Cited by 618

A double‐blind, placebo‐controlled study to assess the mitochondria‐targeted antioxidant MitoQ as a disease‐modifying therapy in Parkinson's disease

Snow, B. J., Rolfe, F. L., Lockhart, M. M., Frampton, C. M., O'Sullivan, J. D., Fung, V., Smith, R. A. J., Murphy, M. P., Taylor, K. M., & On behalf of the Protect Study Group (2010) · Movement Disorders

Parkinson's Disease Mechanisms and TreatmentsCoenzyme Q10 studies and effects

Cited by 606

Targeting lipophilic cations to mitochondria

Murphy, M. P. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Mitochondrial Function and PathologyMolecular Sensors and Ion Detection

Cited by 598

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88

Tarallo, V., Hirano, Y., Gelfand, B. D., Dridi, S., Kerur, N., Kim, Y., Cho, W. G., Kaneko, H., Fowler, B. J., Bogdanovich, S., et al. (2012) · Cell

Inflammasome and immune disordersRetinal Diseases and Treatments

Cited by 592

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

Bell, E. L., Klimova, T. A., Eisenbart, J., Moraes, C. T., Murphy, M. P., Budinger, G. R. S., & Chandel, N. S. (2007) · The Journal of Cell Biology

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 568

Accumulation of succinate controls activation of adipose tissue thermogenesis

Mills, E. L., Pierce, K. A., Jedrychowski, M. P., Garrity, R., Winther, S., Vidoni, S., Yoneshiro, T., Spinelli, J. B., Lu, G. Z., Kazak, L., et al. (2018) · Nature

Adipose Tissue and MetabolismLipid metabolism and biosynthesis

Cited by 539

Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes

Green, K., Brand, M. D., & Murphy, M. P. (2004) · Diabetes

Mitochondrial Function and PathologyPancreatic function and diabetes

Cited by 490

Mitochondria-targeted antioxidants protect against amyloid-β toxicity in Alzheimer's disease neurons

Manczak, M., Mao, P., Calkins, M. J., Cornea, A., Reddy, A. P., Murphy, M. P., Szeto, H. H., Park, B., & Reddy, P. H. (2010) · Journal of Alzheimer's Disease

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 469

Selective targeting of an antioxidant to mitochondria

Smith, R. A. J., Porteous, C. M., Coulter, C. V., & Murphy, M. P. (1999) · European Journal of Biochemistry

Mitochondrial Function and PathologyAntioxidant Activity and Oxidative Stress

Cited by 466

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults

Rossman, M. J., Santos-Parker, J. R., Steward, C. A. C., Bispham, N. Z., Cuevas, L. M., Rosenberg, H. L., Woodward, K. A., Chonchol, M., Gioscia-Ryan, R. A., Murphy, M. P., et al. (2018) · Hypertension

Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin Effects

Cited by 456