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Cited by 105Carcinogens and Genotoxicity AssessmentWater Treatment and DisinfectionPolyamine Metabolism and Applications

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

N‐nitroso compounds: Their chemical and in vivo formation and possible importance as environmental carcinogens

Mirvish, Sidney S.·1977·Journal of Toxicology and Environmental Health
DOI 10.1080/15287397709529529
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Abstract

Brief reviews are presented on the occurrence of N-nitroso (NNO) compounds, the chemistry and kinetics of NNO compound formation from nitrite and amines or amides, the in vivo formation of these compounds (as detected by tumor induction) on feeding nitrite with amines or amides to rodents, and the carcinogenicity for rats of some new nitrosamides. The possible human hazard caused by exposure to specific readily nitrosated compounds is reviewed. Whether NNO compounds might be causing human cancer of various organs (e.g., pancreatic, nasopharyngeal, and esophageal cancer) is discussed. Some of our results in [3H]thymidine incorporation in the rat esophageal epithelium are presented. Nitrosamines that cause esophageal cancer in rats were found to inhibit [3H]thymidine incorporation, both in vivo and in vitro, when esophagi were incubated with nitrosamines. With reference to the hypothesis that human gastric cancer is caused by nitrosamides (e.g., nitrosoureas), certain correlations were examined between gastric cancer and environmental exposure to nitrate, nitrite, and nitrosatable amides. In studies from our laboratory, dried, salted fish, which was treated with excess nitrite at pH 1 and then "denitrosated" at pH O, yielded 16 mg methylurae/kh fish, possibly derived from methylguanidine.

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Citations

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Research works printed but not linked: 19

  1. Barnes J. M., 1954, Br. J. Ind. Med., 11, 167
  2. Burrell R. J. W., 1966, J. Natl. Cancer Inst., 36, 201
  3. Endo H., 1975, Gann Monogr., 17, 17
  4. Fong Y. Y., 1973, J. Natl. Cancer Inst., 243, 421
  5. Fujinaka N., 1976, Gann, 67, 679
  6. Geleperin A., 1976, III. Med. J, 149, 251
  7. Graham S., 1975, Cancer Res., 35, 3463
  8. Greenblatt M., 1971, J. Natl. Cancer Inst., 46, 1029
  9. Haenszel W., 1975, Cancer Res., 35, 3452
  10. Marquardt H., Food Cosmet. Toxlcol.
  11. Mirvish S. S., 1971, J. Natl. Cancer Inst., 46, 1183
  12. Mirvish S. S., 1972, Topics in chemical carcinogenesis, 279
  13. Mirvish S. S., 1975, J. Natl. Cancer Inst., 54, 869
  14. Mirvish S. S., 1975, Proc. Am. Assoc. Cancer Res., 16, 122
  15. Mirvish S. S., 1976, Proc. Am. Assoc. Cancer Res., 17, 121
  16. Pour P., 1975, Cancer Res., 35, 2249
  17. Preussmann R., 1972, N‐Nitroso compounds: Analysis and formation, 81
  18. Sato T., 1959, Bull. Inst. Public Health Jpn., 8, 187
  19. Weisburger J. H., 1975, cancer. Cancer Res., 35, 3469

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Metadata

Authors
Mirvish, S. S.
Affiliations
University of Nebraska Medical Center (US)
Corresponding author
Mirvish, Sidney S.
Venue
Journal of Toxicology and Environmental Health
Publisher
Informa UK Limited
Published
1977-07
Volume
2
Issue
6
Pages
1267-1277
ISSN
0098-4108 (ISSN-L)
DOI
10.1080/15287397709529529
OpenAlex
W1968587550
Cited by
105
References
46
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 2 · 2018: 1 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 1
FWCI
1.41
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Toxicology and Environmental Health (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Water Treatment and Disinfection
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
Keywords
N-nitroso compounds, nitrosamines, nitrosamides, nitrite, amides, tumor induction, carcinogenicity, environmental carcinogens, esophageal cancer, gastric cancer, nitrate exposure, dried salted fish, methylguanidine, methylurea, thymidine incorporation, esophageal epithelium, pancreatic cancer, nasopharyngeal carcinoma
MeSH terms
Animals, Carcinogens, Environmental, Chemistry, Esophageal Neoplasms, Esophagus, Humans, Kinetics, Nitrosamines, Nitroso Compounds, Stomach Neoplasms, Thymidine, Chemical Phenomena

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