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Contrasting respirable quartz and kaolin retention of lecithin surfactant and expression of membranolytic activity following phospholipase A2digestion
Abstract
Respirable-sized quartz, a well-established fibrogenic mineral dust, is compared with kaolin in erythrocyte hemolysis assays after treatment with saline dispersion of dipalmitoyl phosphatidylcholine, a primary phospholipid component of pulmonary surfactant. Both dusts are rendered inactive after treatment, but the membranolytic activity is partly to fully restored after treatment with phospholipase A2, an enzyme normally associated with cellular plasma membranes and lysosomes. Phospholipid-coated dusts were incubated for periods of 2-72 h at a series of applied enzyme concentrations, and the adsorbed lipid species and hemolytic activity were quantitated at each time for both dusts. Surfactant was lost more readily from quartz than from kaolin, with consequent more rapid restoration of mineral surface hemolytic activity for quartz. Interactions of surfactant and mineral surface functional groups responsible for the mineral-specific rate differences, and implications for determining the mineral surface bioavailability of silica and silicate dusts, are discussed.
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“and that differences in this adsorptive property correlated with differences in their toxicity [356].”
From Particle toxicology and health - where are we? (2019) · cites this paper as [356]
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Research works printed but not linked: 17
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Respiratory Health Hazards in Agriculture
(1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.supplement_1.rccm1585s1 · Cited by 495
Silica binding and toxicity in alveolar macrophages
Hamilton, R. F., Thakur, S. A., & Holian, A. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.12.027 · Cited by 415
Particle toxicology and health - where are we?
Riediker, M., Zink, D., Kreyling, W., Oberdörster, G., Elder, A., Graham, U., Lynch, I., Duschl, A., Ichihara, G., Ichihara, S., et al. (2019) · Particle and Fibre Toxicology · doi:10.1186/s12989-019-0302-8 · Cited by 237
Metadata
- Authors
- Wallace, W. E., Keane, M. J., Mike, P. S., Hill, C. A., Vallyathan, V., & Regad, E. D.
- Venue
- Journal of Toxicology and Environmental Health
- Publisher
- Informa UK Limited
- Published
- 1992-11
- Volume
- 37
- Issue
- 3
- Pages
- 391-409
- ISSN
- 0098-4108
- Cited by
- 36
- References
- 0
- Language
- en
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- The paper
- Wallace, W. E., Keane, M. J., Mike, P. S., Hill, C. A., Vallyathan, V., & Regad, E. D. (1992). Contrasting respirable quartz and kaolin retention of lecithin surfactant and expression of membranolytic activity following phospholipase A2digestion. Journal of Toxicology and Environmental Health. https://doi.org/10.1080/15287399209531679
