The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs
Open accessAbstract
Circular RNAs (circRNAs) are widely expressed in animal cells, but their biogenesis and functions are poorly understood. CircRNAs have been shown to act as sponges for miRNAs and may also potentially sponge RNA-binding proteins (RBPs) and are thus predicted to function as robust posttranscriptional regulators of gene expression. The joint analysis of large-scale transcriptome data coupled with computational analyses represents a powerful approach to elucidate possible biological roles of ribonucleoprotein (RNP) complexes. Here, we present a new web tool, CircInteractome (circRNA interactome), for mapping RBP- and miRNA-binding sites on human circRNAs. CircInteractome searches public circRNA, miRNA, and RBP databases to provide bioinformatic analyses of binding sites on circRNAs and additionally analyzes miRNA and RBP sites on junction and junction-flanking sequences. CircInteractome also allows the user the ability to (1) identify potential circRNAs which can act as RBP sponges, (2) design junction-spanning primers for specific detection of circRNAs of interest, (3) design siRNAs for circRNA silencing, and (4) identify potential internal ribosomal entry sites (IRES). In sum, the web tool CircInteractome, freely accessible at http://circinteractome.nia.nih.gov, facilitates the analysis of circRNAs and circRNP biology.
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Cites
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Circular RNAs are a large class of animal RNAs with regulatory potency
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Circular RNAs are abundant, conserved, and associated with ALU repeats
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Cited by
The biogenesis, biology and characterization of circular RNAs
Kristensen, L. S., Andersen, M. S., Stagsted, L. V. W., Ebbesen, K. K., Hansen, T. B., & Kjems, J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0158-7 · Cited by 4,823
The emerging roles of circRNAs in cancer and oncology
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Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1
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Self-citationZang, J., Lu, D., & Xu, A. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24356 · Cited by 641
Non-coding RNA regulatory networks
Panni, S., Lovering, R. C., Porras, P., & Orchard, S. (2020) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.194417 · Cited by 479
Metadata
- Authors
- Dudekula, D. B., Panda, A. C., Grammatikakis, I., De, S., Abdelmohsen, K., & Gorospe, M.
- Venue
- RNA Biology
- Publisher
- Informa UK Limited
- Published
- 2015-12-15
- Volume
- 13
- Issue
- 1
- Pages
- 34-42
- ISSN
- 1547-6286 (ISSN-L)
- 1555-8584
- OpenAlex
- W2210577735
- Cited by
- 1,255
- References
- 48
- FWCI
- 16.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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