The biogenesis, biology and characterization of circular RNAs

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Circular RNAs are abundant, conserved, and associated with ALU repeats

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circRNA biogenesis competes with pre-mRNA splicing

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Exon-intron circular RNAs regulate transcription in the nucleus

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Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

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Detecting and characterizing circular RNAs

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Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

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Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

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Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

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Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures

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Circular intronic long noncoding RNAs

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Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

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The RNA Binding Protein Quaking Regulates Formation of circRNAs

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Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis

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RNA targeting with CRISPR–Cas13

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Direct multiplexed measurement of gene expression with color-coded probe pairs

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Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs

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The Biogenesis, Functions, and Challenges of Circular RNAs

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Complementary Sequence-Mediated Exon Circularization

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Cell-Type Specific Features of Circular RNA Expression

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circBase: a database for circular RNAs

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Nanopore sequencing and assembly of a human genome with ultra-long reads

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Extensive translation of circular RNAs driven by N6-methyladenosine

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Endogenous microRNA sponges: evidence and controversy

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5′ UTR m6A Promotes Cap-Independent Translation

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Translation of CircRNAs

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Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

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Expanded identification and characterization of mammalian circular RNAs

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IFNα activates dormant haematopoietic stem cells in vivo

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Single-Cell RNA-Seq Reveals Dynamic, Random Monoallelic Gene Expression in Mammalian Cells

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Circular RNAs in cancer: opportunities and challenges in the field

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Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi

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CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs

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Dynamic m6A mRNA methylation directs translational control of heat shock response

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Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

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Mis-splicing yields circular RNA molecules.

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Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

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Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

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Circular transcripts of the testis-determining gene Sry in adult mouse testis

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Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

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Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals

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Context-dependent control of alternative splicing by RNA-binding proteins

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Diverse alternative back-splicing and alternative splicing landscape of circular RNAsPreprint

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Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells

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Genome-wide Analysis of Drosophila Circular RNAs Reveals Their Structural and Sequence Properties and Age-Dependent Neural Accumulation

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miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA

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CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

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Short intronic repeat sequences facilitate circular RNA productionPreprint

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Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma

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A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223

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Circular RNAs: analysis, expression and potential functions

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Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by <i>CircPABPN1</i>

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Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma

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Coupling mRNA processing with transcription in time and space

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Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity

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Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

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Exon Circularization Requires Canonical Splice Signals

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Initiation of Protein Synthesis by the Eukaryotic Translational Apparatus on Circular RNAs

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Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor

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Circular RNA Is Expressed across the Eukaryotic Tree of Life

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A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma

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Correlation of circular RNA abundance with proliferation – exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis and normal human tissues

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Assessing the ceRNA Hypothesis with Quantitative Measurements of miRNA and Target Abundance

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A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis

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Circular RNA identification based on multiple seed matching

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Detecting circular RNAs: bioinformatic and experimental challenges

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Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis

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Efficient backsplicing produces translatable circular mRNAs

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The Landscape of MicroRNA, Piwi-Interacting RNA, and Circular RNA in Human Saliva

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The Biogenesis of Nascent Circular RNAs

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Identification and characterization of circular RNAs As a new class of putative biomarkers in human blood

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Circular RNA (circRNA) in Alzheimer’s disease (AD)

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Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection

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A-to-I RNA editing — immune protector and transcriptome diversifier

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Identifying and Characterizing circRNA-Protein Interaction

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Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development

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DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome

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A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain

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Discriminating self from non-self in nucleic acid sensing

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Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

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CircHIPK3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells

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FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

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The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells

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Human long non‐coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors

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Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer

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circRNADb: A comprehensive database for human circular RNAs with protein-coding annotations

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Combinatorial control of Drosophila circular RNA expression by intronic repeats, hnRNPs, and SR proteinsPreprint

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RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo

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Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development

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Sensing Self and Foreign Circular RNAs by Intron Identity

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Rolling Circle Translation of Circular RNA in Living Human Cells

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A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1

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The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting

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Single-cell RNA-seq transcriptome analysis of linear and circular RNAs in mouse preimplantation embryos

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The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis

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Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon–dependent exhaustion

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A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair

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Comparison of circular RNA prediction tools

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A map of human circular RNAs in clinically relevant tissues

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PRMT5 Circular RNA Promotes Metastasis of Urothelial Carcinoma of the Bladder through Sponging miR-30c to Induce Epithelial–Mesenchymal Transition

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Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance

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Exon Skipping Is Correlated with Exon Circularization

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CircRNA accumulation in the aging mouse brain

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Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes

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Circular RNAs open a new chapter in cardiovascular biology

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The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency

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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

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Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes

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A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAsPreprint

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A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion

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The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex

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Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection

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Identification of spatially associated subpopulations by combining scRNAseq and sequential fluorescence in situ hybridization data

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Selective release of circRNAs in platelet‐derived extracellular vesicles

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CircRNAs in the brain

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Circular RNAs as novel regulators of β-cell functions in normal and disease conditions

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CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13

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Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis

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Improved silencing properties using small internally segmented interfering RNAs

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CircSMARCA5 Inhibits Migration of Glioblastoma Multiforme Cells by Regulating a Molecular Axis Involving Splicing Factors SRSF1/SRSF3/PTB

Barbagallo, D., Caponnetto, A., Cirnigliaro, M., Brex, D., Barbagallo, C., D’Angeli, F., Morrone, A., Caltabiano, R., Barbagallo, G. M. V., Ragusa, M., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020480 · Cited by 189 · see citing works

Global accumulation of circRNAs during aging in Caenorhabditis elegans

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Circular RNA Splicing

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Discovery of Kaposi’s sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA

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Improved circRNA Identification by Combining Prediction Algorithms

Hansen, T. B. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00020 · Cited by 178 · see citing works

Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation

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CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs

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The circular RNA ci RS ‐7 promotes APP and BACE 1 degradation in an NF ‐κB‐dependent manner

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Circular mRNA can direct translation of extremely long repeating-sequence proteins in vivo

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Screening of circular RNAs and validation of circANKRD36 associated with inflammation in patients with type 2 diabetes mellitus

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Circular RNAs: Novel Regulators of Neuronal Development

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Enzyme-free digital counting of endogenous circular RNA molecules in B-cell malignancies

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Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer

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Novel tumour suppressive protein encoded by circular RNA, circ-SHPRH, in glioblastomas

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The circular RNome of primary breast cancer

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Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus

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Functional Characterization of Novel Circular RNA Molecule, circzip-2 and Its Synthesizing Gene zip-2 in C. elegans Model of Parkinson’s Disease

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ciRS-7 exonic sequence is embedded in a long non-coding RNA locus

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CRISPR–Cas13 Precision Transcriptome Engineering in Cancer

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Noncoding AUG circRNAs constitute an abundant and conserved subclass of circles

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Dicer-independent processing of short hairpin RNAs

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Integrative transcriptome sequencing reveals extensive alternative trans -splicing and cis -backsplicing in human cells

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Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution

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A Novel Ultrasensitive In Situ Hybridization Approach to Detect Short Sequences and Splice Variants with Cellular Resolution

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High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome

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SMARTer single cell total RNA sequencing

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Analysis of human ES cell differentiation establishes that the dominant isoforms of the lncRNAs RMST and FIRRE are circular

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RNA-seq of circular RNAs identified circPTPN22 as a potential new activity indicator in systemic lupus erythematosus

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Repetitive RNA unwinding by RNA helicase A facilitates RNA annealing

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Circular RNA CpG island hypermethylation-associated silencing in human cancer

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NF90 Exerts Antiviral Activity through Regulation of PKR Phosphorylation and Stress Granules in Infected Cells

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Application of droplet digital PCR in quantitative detection of the cell-free circulating circRNAs

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Exon repetition: a major pathway for processing mRNA of some genes is allele-specific

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Probing Long Non-coding RNA-Protein Interactions

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Micro RNA ‐23b‐3p regulates human keratinocyte differentiation through repression of TGIF 1 and activation of the TGF ‐ß– SMAD 2 signalling pathway

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A Method for Expressing and Imaging Abundant, Stable, Circular RNAs In Vivo Using tRNA Splicing

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Influence of the loop size and nucleotide composition on AgoshRNA biogenesis and activity

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Construction of Modular Lentiviral Vectors for Effective Gene Expression and Knockdown

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) ¹

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Exosomes: key players in cancer and potential therapeutic strategy

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Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants

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Targeting mitochondria-located circrna scar alleviates nash via reducing mros output

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Extracellular Vesicle–Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models

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COVID-19 mRNA vaccines: Platforms and current developments

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Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of <i>in vivo</i> imaging

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microRNA strand selection: Unwinding the rules

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Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases

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RNA polymerase II speed: a key player in controlling and adapting transcriptome composition

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Mesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p/PTEN/AKT pathway in human liver fibrosis

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Potential clinical value of circular RNAs as peripheral biomarkers for the diagnosis and treatment of major depressive disorder

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MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Redox Control of Cell Senescence

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