The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
The long noncoding RNA Malat1: Its physiological and pathophysiological functions
Open accessAbstract
Recent studies suggest that in humans, DNA sequences responsible for protein coding regions comprise only 2% of the total genome. The rest of the transcripts result in RNA transcripts without protein-coding ability, including long noncoding RNAs (lncRNAs). Different from most members in the lncRNA family, the metastasis-associated lung adenocarcinoma transcript 1 (Malat1) is abundantly expressed and evolutionarily conserved throughout various mammalian species. Malat1 is one of the first identified lncRNAs associated with human disease, and cumulative studies have indicated that Malat1 plays critical roles in the development and progression of various cancers. Malat1 is also actively involved in various physiologic processes, including alternative splicing, epigenetic modification of gene expression, synapse formation, and myogenesis. Furthermore, extensive evidences show that Malat1 plays pivotal roles in multiple pathological conditions as well. In this review, we will summarize latest findings related to the physiologic and pathophysiological processes of Malat1 and discuss its therapeutic potentials.
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1 retracted
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Cited by
Barker, S. J., Thayer, M. B., Kim, C., Tatarakis, D., Simon, M. J., Dial, R., Nilewski, L., Wells, R. C., Zhou, Y., Afetian, M., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adi2245 · Cited by 142
Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics
Liang, Y., Kaneko, K., Xin, B., Lee, J., Sun, X., Zhang, K., & Feng, G.-S. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.01.004 · Cited by 116
Potential Therapeutic Targeting of lncRNAs in Cholesterol Homeostasis
Ye, W.-C., Huang, S.-F., Hou, L.-J., Long, H.-J., Yin, K., Hu, C. Y., & Zhao, G.-J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.688546 · Cited by 19
Self-citationMiyake, S., & Masuda, S. (2022) · RNA Biology · doi:10.1080/15476286.2022.2146919 · Cited by 4
Metadata
- Authors
- Zhang, X., Hamblin, M. H., & Yin, K.-J.
- Venue
- RNA Biology
- Publisher
- Informa UK Limited
- Published
- 2017-10-06
- Volume
- 14
- Issue
- 12
- Pages
- 1705-1714
- ISSN
- 1547-6286 (ISSN-L)
- 1555-8584
- OpenAlex
- W2747089052
- Cited by
- 482
- References
- 128
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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