Cited by 148Cancer, Hypoxia, and MetabolismAutophagy in Disease and TherapyAmino Acid Enzymes and Metabolism

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Glutaminolysis and autophagy in cancer

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Villar, Victor H, Merhi, Faten, Djavaheri-Mergny, Mojgan, Durán, Raúl V·2015·Autophagy

DOI 10.1080/15548627.2015.1053680PMC PMC4590661

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Abstract

The remarkable metabolic differences between cancer cells and normal cells result in the potential for targeted cancer therapy. The upregulation of glutaminolysis provides energetic advantages to cancer cells. The recently described link between glutaminolysis and autophagy, mediated by MTORC1, may constitute an attractive target for therapeutic strategies. A combination of therapies targeting simultane-ously cell signaling, cancer metabolism, and autophagy can solve therapy resistance and tumor relapse problems, commonly observed in patients treated with most of the current targeted therapies. In this review we summarize the mechanistic link between glutaminolysis and autophagy, and discuss the impacts of these processes on cancer progression and the potential for therapeutic intervention.

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RETRACTED: The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation
Csibi, A., Lee, G., Yoon, S.-O., Tong, H., Ilter, D., Elia, I., Fendt, S., Roberts, T. M., & Blenis, J. (2014) · Current Biology · doi:10.1016/j.cub.2014.08.007 · Cited by 253
Retracted
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
mTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506

Show all 145 references

Research works printed but not linked: 3

Kovacevic Z, 1972, Cancer Res, 32, 326
Icard P, 2012, Biochim Biophys Acta, 1825, 111
Catane R, 1979, Cancer Treat Rep, 63, 1033

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A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma
Wu, S., Ai, Y., Huang, H., Wu, G., Zhou, S., Hong, W., Akuetteh, P. D. P., Jin, G., Zhao, X., Zhang, Y., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02562-6 · Cited by 9
Circ_0000144 functions as a miR-623 sponge to enhance gastric cancer progression via up-regulating GPRC5A
Mi, L., Lei, L., Yin, X., Li, N., Shi, J., Han, X., Duan, X., Zhao, M., Han, G., Wang, J., et al. (2020) · Bioscience Reports · doi:10.1042/bsr20201313 · Cited by 8
Erratum: Urine-derived stem cells accelerate the recovery of injured mouse hepatic tissue.
Hu, C., He, Y., Fang, S., Tian, N., Gong, M., Xu, X., Zhao, L., Wang, Y., He, T., Zhang, Y., et al. (2020) · PubMed Central · Cited by 7
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[Changes in autophagy during maturation and differentiation of Hepa1-6 cells induced by all-trans retinoic acid].
Fang, S., Cui, J., Gong, M., He, Y., Zhang, J., & Bi, Y. (2018) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-4254.2018.05.04 · Cited by 5
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Authors: Villar, V. H., Merhi, F., Djavaheri-Mergny, M., & Durán, R. V.
Affiliations: Université de Bordeaux (FR)
INSERM U916 VINCO; Institut Bergonié; Bordeaux, France
Corresponding author: Durán, Raúl V
ORCID: Villar, Victor H
Merhi, Faten
Durán, Raúl V
Venue: Autophagy
Publisher: Informa UK Limited
Published: 2015-08-03
Volume: 11
Issue: 8
Pages: 1198-1208
ISSN: 1554-8627 (ISSN-L)
1554-8635
DOI: 10.1080/15548627.2015.1053680
PMC: PMC4590661
OpenAlex: W1768966319
Cited by: 143
References: 145
Citations by year: 2026: 6 · 2025: 15 · 2024: 14 · 2023: 9 · 2022: 18 · 2021: 18 · 2020: 18 · 2019: 12 · 2018: 15 · 2017: 12 · 2016: 5 · 2015: 1
FWCI: 1.07
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Autophagy (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Institut National de la Santé et de la Recherche Médicale
Fondation ARC pour la Recherche sur le Cancer
Ligue Contre le Cancer
Institut National Du Cancer
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords: glutaminolysis, cancer metabolism, mTORC1 signaling, cancer cell energy metabolism, targeted cancer therapy, treatment resistance, tumor recurrence, tumor progression
MeSH terms: Mechanistic Target of Rapamycin Complex 1, Animals, Autophagy, Cell Transformation, Neoplastic, Glutamine, Humans, Ketoglutaric Acids, Neoplasm Recurrence, Local, Neoplasms, Signal Transduction, Gene Expression Regulation, Neoplastic, Reactive Oxygen Species, Drug Resistance, Neoplasm, Multiprotein Complexes, Cell Proliferation, TOR Serine-Threonine Kinases

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