Cited by 148Cancer, Hypoxia, and MetabolismAutophagy in Disease and TherapyAmino Acid Enzymes and Metabolism

The DOI matches its Crossref record; 144 of the 145 references it cites were found in a registry or an index.

Glutaminolysis and autophagy in cancer

Open access

Villar, Victor H, Merhi, Faten, Djavaheri-Mergny, Mojgan, Durán, Raúl V·2015·Autophagy

DOI 10.1080/15548627.2015.1053680PMC PMC4590661

Open this paper in CoChat — free account Open PDF

Abstract

The remarkable metabolic differences between cancer cells and normal cells result in the potential for targeted cancer therapy. The upregulation of glutaminolysis provides energetic advantages to cancer cells. The recently described link between glutaminolysis and autophagy, mediated by MTORC1, may constitute an attractive target for therapeutic strategies. A combination of therapies targeting simultane-ously cell signaling, cancer metabolism, and autophagy can solve therapy resistance and tumor relapse problems, commonly observed in patients treated with most of the current targeted therapies. In this review we summarize the mechanistic link between glutaminolysis and autophagy, and discuss the impacts of these processes on cancer progression and the potential for therapeutic intervention.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1080/15548627.2015.1053680

Cites

144 of 144 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation
Csibi, A., Lee, G., Yoon, S.-O., Tong, H., Ilter, D., Elia, I., Fendt, S., Roberts, T. M., & Blenis, J. (2014) · Current Biology · doi:10.1016/j.cub.2014.08.007 · Cited by 253
Retracted
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
mTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506

Show all 145 references

Research works printed but not linked: 3

Kovacevic Z, 1972, Cancer Res, 32, 326
Icard P, 2012, Biochim Biophys Acta, 1825, 111
Catane R, 1979, Cancer Treat Rep, 63, 1033

Sorted by citations

Items 101–148 of 148

Cellular metabolism and hypoxia interfacing with allergic diseases
Kellett, S. K., & Masterson, J. C. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae126 · Cited by 5
Surviving the siege: A review on the metabolic hallmarks of cancer dormancy
Djelti, F., Hani, M., Chetbani, Y., Belaadi, A., & Ammarullah, M. I. (2026) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2026.101123 · Cited by 3
Riluzole preserves brain endothelial integrity in ischemic stroke via SLC7A11-dependent GPX4 and HIF-1α/VEGFA signaling
Wang, H., Feng, Y., Jiang, W., Wang, H., Zhang, R., Li, G., Duan, C., Zhou, Y., Bao, W., Shui, K., et al. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112378 · Cited by 2
Compound 275# Induces Mitochondria-Mediated Apoptosis and Autophagy Initiation in Colorectal Cancer Cells through an Accumulation of Intracellular ROS
Yang, D., Li, Y., Ma, S.-Q., Zhang, Y., Huang, J., & He, L. (2023) · Molecules · doi:10.3390/molecules28073211 · Cited by 3
Autophagy in Cancer Metastasis
Polara, R., van Rinsum, D., & Robinson, N. (2022) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-031-17362-2_11 · Cited by 2
Overview of Positron-Emission Tomography Tracers for Metabolic Imaging
Parent, E. E., & McConathy, J. (2017) · Springer eBooks · doi:10.1007/978-3-319-61401-4_3 · Cited by 2
Integrated regulatory-metabolic network model reveals critical mechanism and potential targets for Hepatocellular CarcinomaPreprint
Xu, Y., Zhang, H., Yang, Q., Sun, R., Wang, K., Shi, Y., & Wang, Z. (2020) · doi:10.21203/rs.3.rs-21615/v1 · Cited by 2
Grainyhead-like 2 Reverses the Metabolic Changes Induced by the Oncogenic Epithelialmesenchymal Transition: Effects on Anoikis
Farris, J. C. (2016) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.5579 · Cited by 2
Ferroptosis rewired: ncRNA gatekeepers as pharmacological targets in hepatocellular carcinoma
Ahmed, A. T., Jawad, M., Sanghvi, G., R., R., Kashyap, A., Al-Hetty, H. R. A. K., Gayathri, S., Panigrahi, R., Mustafa, Y., & Kadhim, W. (2025) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-025-04404-4 · Cited by 1
Baseline metabolic signatures predict clinical outcomes in immunotherapy-treated melanoma patients: a pilot study
Summa, S. D., Palma, G. D., Ghini, V., Apollonio, B., Risi, I. D., Tufaro, A., Strippoli, S., Luchinat, C., Tenori, L., & Guida, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1536710 · Cited by 1
Metabolic Imaging and Molecular Signatures Reveal Metabolic Phenotypes in Recurrent Glioblastoma
Li, E. J., Kraya, A., Costa‐Pinheiro, P., Scheuermann, J. S., Young, A. J., Schubert, E. K., Aboian, M., Doot, R. K., Ware, J. B., Pantel, A. R., et al. (2026) · Journal of Nuclear Medicine · doi:10.2967/jnumed.125.271476 · Cited by 1
Comparative metabolomic analysis of polyphenic horn development in the dung beetle Onthophagus taurus
Williamson, N. G., Walsh, C. M., & Kijimoto, T. (2022) · PLoS ONE · doi:10.1371/journal.pone.0265222 · Cited by 1
Optimization of Physicochemical Properties of Polymeric Nanoparticles for Targeting Solid Tumors
Prasher, P., Sharma, M., & Mudila, H. (2022) · Environmental chemistry for a sustainable world · doi:10.1007/978-3-031-14848-4_4 · Cited by 1
Current Concepts and Advances in Oncobiology
Gosipatala, S. B., Reddy, P., Khalko, R. K., Bisht, N., Kuril, S. R., Madhuri, K., Kasaudhan, R., Yadav, S., Chand, G., Kaur, T., et al. (2023) · Springer eBooks · doi:10.1007/978-981-99-2196-6_80-1 · Cited by 1
Bayesian identification of differentially expressed isoforms using a novel joint model of RNA-seq data
Shi, X., Wang, X., Lu, J., Halakivi-Clarke, L., Clarke, R. C., Neuwald, A. F., & Xuan, J. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012750 · Cited by 1
Grainyhead-like-2 inhibits the co-activator p300, suppressing tubulogenesis and the epithelial-mesenchymal transition
Pifer, P. M. (2016) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.6420
SIRT4 enhances the sensitivity of colorectal cancer cells to 5-FU by inhibiting ammonia-mediated autophagyPreprint
Xu, B., Cai, L., Xiao, H., Cai, G., Sun, P., & Huang, G. (2022) · Research Square · doi:10.21203/rs.3.rs-1695035/v1 · Cited by 1
The Role of Cell Autophagy in Toxicity Caused by Dental Nanomaterials
Limin, W. (2017) · Nanotechnology Nanomedicine & Nanobiotechnology · doi:10.24966/ntmb-2044/100011
The role of glutamine in the regulation of mTOR signalling in pancreatic β-cells
Alghanim, G. (2017) · Leicester Research Archive (University of Leicester)
Role of ammonium ions on the modulation of apoptosis in glutamine-starved cells
Abusneina, A. M. (2017) · Lu Zone Ul (Laurentian University)
The effects of internal physiology on polyphenic horn development in the dung beetle Onthophagus taurus
Williamson, N. G. (2020) · doi:10.33915/etd.7556
Sijunzi Tang Enhances The Sensitivity of Lung Cancer Cells To Gefitinib Based On Glutamine MetabolismPreprint
Wang, Z., Wang, S., Liu, X., Cao, B., Zhang, M., Li, C., & Li, G. (2021) · Research Square · doi:10.21203/rs.3.rs-960276/v1
Dietary Polyphenols and its Molecular Mechanism in the Management of Breast Cancer
Rai, G., & Shekhar, S. K. (2022) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781681089522112010012
2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identifiedPreprint
Neto, N. G. B., Suku, M., Hoey, D. A., & Monaghan, M. G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.13.523892
SIRT4 enhances the sensitivity of colorectal cancer cells to 5-FU by inhibiting ammonia-mediated autophagyPreprint
Xu, B., Cai, L., Xiao, H., Cai, G., Sun, P., & Huang, G. (2023) · Research Square · doi:10.21203/rs.3.rs-1695035/v2
2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identifiedPreprint
Neto, N. G. B., Suku, M., Hoey, D. A., & Monaghan, M. G. (2023) · Research Square · doi:10.21203/rs.3.rs-2585806/v1
SIRT4 Overcomes 5-Fluorouracil Associated Chemoresistance by Inhibiting Autophagy through Inhibition of ammonia productionPreprint
Xu, B., Cai, X., Xiao, H., & Huang, G. (2023) · Research Square · doi:10.21203/rs.3.rs-3136901/v1
Additional file 2 of A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma
Wu, S., Ai, Y., Huang, H., Wu, G., Zhou, S., Hong, W., Akuetteh, P. D. P., Jin, G., Zhao, X., Zhang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19501043
Additional file 3 of A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma
Wu, S., Ai, Y., Huang, H., Wu, G., Zhou, S., Hong, W., Akuetteh, P. D. P., Jin, G., Zhao, X., Zhang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19501046
Additional file 4 of A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma
Wu, S., Ai, Y., Huang, H., Wu, G., Zhou, S., Hong, W., Akuetteh, P. D. P., Jin, G., Zhao, X., Zhang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19501049
Additional file 5 of A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma
Wu, S., Ai, Y., Huang, H., Wu, G., Zhou, S., Hong, W., Akuetteh, P. D. P., Jin, G., Zhao, X., Zhang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19501052
Additional file 1 of A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma
Wu, S., Ai, Y., Huang, H., Wu, G., Zhou, S., Hong, W., Akuetteh, P. D. P., Jin, G., Zhao, X., Zhang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19501040
Delving into the Metabolism of Sézary Cells: A Brief Review
Cherfan, C., Chebly, A., Rezvani, H. R., Beylot-Barry, M., & Chevret, E. (2024) · Genes · doi:10.3390/genes15050635
Current Concepts and Advances in Oncobiology
Gosipatala, S. B., Reddy, P., Khalko, R. K., Bisht, N., Kuril, S. R., Madhuri, K., Kasaudhan, R., Yadav, S., Chand, G., Kaur, T., et al. (2024) · Springer eBooks · doi:10.1007/978-981-99-6263-1_80
Glutaminase 2-Mediated Yes Associated Protein 1 Glutamylation Facilitates Immune Evasion in Pancreatic Ductal Adenocarcinoma
Houchen, C. W., & Li, M. (2025) · Gastroenterology · doi:10.1053/j.gastro.2025.02.029
Dual inhibition of glutaminolysis and autophagy suppresses proliferation of Rheumatoid arthritis fibroblast-like synoviocytes and mitigates arthritis in SKG micePreprint
Naka, I., Sendo, S., Okano, T., Uto, K., Takahashi, S., Hayashi, S., Kuroda, R., Morinobu, A., & Saegusa, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.25.661649
SIRT 4 positively regulates autophagy via ULK 1, but independently of HDAC 6 and OPA 1
Lehmkuhl, I., Amin, K., Gabriel, L., Hampel, N., Iram, A., Hesse, J., Wiek, C., Nguyen, J. T. V., Hanenberg, H., Scheller, J., et al. (2025) · FEBS Open Bio · doi:10.1002/2211-5463.70164
Additional file 8 of A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma
Wu, S., Ai, Y., Huang, H., Wu, G., Zhou, S., Hong, W., Akuetteh, P. D. P., Jin, G., Zhao, X., Zhang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19501061
Additional file 6 of A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma
Wu, S., Ai, Y., Huang, H., Wu, G., Zhou, S., Hong, W., Akuetteh, P. D. P., Jin, G., Zhao, X., Zhang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19501055
Additional file 7 of A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma
Wu, S., Ai, Y., Huang, H., Wu, G., Zhou, S., Hong, W., Akuetteh, P. D. P., Jin, G., Zhao, X., Zhang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19501058
Biochemical and cellular characterization of the interplay between glutamine metabolism, mTOR and Notch1 signaling in cancer therapy
Nguyen, T.-L. (2018) · doi:10.70675/fb826854z4f83z4c8azb180ze7e3db6a280c
Xeroderma pigmentosum : understanding pigmentation in addition to the initiation and progression of skin cancer
Kasraian, Z. (2018) · theses.fr (ABES) · doi:10.70675/a1868dd1z7486z4a30z9abbz9078cd2b51e3
Biochemical characterization of mTORC1 regulation by glutamine metabolism
Bodineau, C. (2020) · theses.fr (ABES) · doi:10.70675/9d5aaabdz81bdz4118zb3edze237bdd8dee0
Étude de l’influence de la glutaminolyse des macrophages dans les maladies cardio-métaboliques
Merlin, J. (2020) · theses.fr (ABES) · doi:10.70675/68e10f28zf840z48bfz9bacz5511a3a2b208
Role of lysosome positioning in bladder cancer progression
Mathur, P. (2022) · theses.fr (ABES) · doi:10.70675/c0ae8691z03b0z41dcz9d39ze3270db6d1e1
Crosstalk between m6A modification and metabolic reprogramming in colorectal cancer: from the immune microenvironment to clinical applications
Zhao, L., Yin, Z., Ji, C., Wu, Y., Gao, H., & Yuan, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1911067
Glutamine metabolism and its roles in tumor radiotherapy by regulating DNA damage repair
Huang, Y., Wang, H., Zhang, S., Jiang, Z., Shen, R., Chang, W., & Jiang, X. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1915673
Metabolic Reprogramming Of Macrophages In Breast Cancer: Mechanisms And Therapeutic Implications
Zhang, J., & Yang, R. (2026) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2026.101376

Authors: Villar, V. H., Merhi, F., Djavaheri-Mergny, M., & Durán, R. V.
Affiliations: Université de Bordeaux (FR)
INSERM U916 VINCO; Institut Bergonié; Bordeaux, France
Corresponding author: Durán, Raúl V
ORCID: Villar, Victor H
Merhi, Faten
Durán, Raúl V
Venue: Autophagy
Publisher: Informa UK Limited
Published: 2015-08-03
Volume: 11
Issue: 8
Pages: 1198-1208
ISSN: 1554-8627 (ISSN-L)
1554-8635
DOI: 10.1080/15548627.2015.1053680
PMC: PMC4590661
OpenAlex: W1768966319
Cited by: 143
References: 145
Citations by year: 2026: 6 · 2025: 15 · 2024: 14 · 2023: 9 · 2022: 18 · 2021: 18 · 2020: 18 · 2019: 12 · 2018: 15 · 2017: 12 · 2016: 5 · 2015: 1
FWCI: 1.07
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Autophagy (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Institut National de la Santé et de la Recherche Médicale
Fondation ARC pour la Recherche sur le Cancer
Ligue Contre le Cancer
Institut National Du Cancer
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords: glutaminolysis, cancer metabolism, mTORC1 signaling, cancer cell energy metabolism, targeted cancer therapy, treatment resistance, tumor recurrence, tumor progression
MeSH terms: Mechanistic Target of Rapamycin Complex 1, Animals, Autophagy, Cell Transformation, Neoplastic, Glutamine, Humans, Ketoglutaric Acids, Neoplasm Recurrence, Local, Neoplasms, Signal Transduction, Gene Expression Regulation, Neoplastic, Reactive Oxygen Species, Drug Resistance, Neoplasm, Multiprotein Complexes, Cell Proliferation, TOR Serine-Threonine Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Glutaminolysis and autophagy in cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks